{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:59:49Z","timestamp":1778641189325,"version":"3.51.4"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602600"],"award-info":[{"award-number":["2022YFC3602600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82220108009"],"award-info":[{"award-number":["82220108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970996"],"award-info":[{"award-number":["81970996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.archger.2025.105845","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T02:28:13Z","timestamp":1743388093000},"page":"105845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Associations of metabolic dysfunction-related fatty liver disease and dementia risk: A prospective study based on the UK biobank"],"prefix":"10.1016","volume":"135","author":[{"given":"Chaofan","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2025.105845_bib0001","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD[J]","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0002","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): Functional analysis of lipid metabolism pathways[J]","volume":"136","author":"Badmus","year":"2022","journal-title":"Clinical Science (London)"},{"key":"10.1016\/j.archger.2025.105845_bib0003","doi-asserted-by":"crossref","DOI":"10.14309\/ajg.0000000000002796","article-title":"High concordance between nonalcoholic fatty liver disease and metabolic dysfunction associated steatotic liver disease in the TARGET-NASH real world cohort[J]","author":"Barritt","year":"2024","journal-title":"The American Journal of Gastroenterology"},{"key":"10.1016\/j.archger.2025.105845_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-190848","article-title":"Is Alzheimer's disease a liver disease of the brain?[J]","volume":"75","author":"Bassendine","year":"2020","journal-title":"Journal of Alzheimer's Disease : JAD"},{"key":"10.1016\/j.archger.2025.105845_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-230X-6-33","article-title":"The fatty liver index: A simple and accurate predictor of hepatic steatosis in the general population[J]","volume":"6","author":"Bedogni","year":"2006","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.archger.2025.105845_bib0006","first-page":"2801","article-title":"Adiponectin, a key adipokine in obesity related liver diseases[J]","volume":"17","author":"Buechler","year":"2011","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.archger.2025.105845_bib0007","first-page":"11","article-title":"Predictive value of fatty liver index for long-term cardiovascular events in patients receiving liver transplantation: The COLT study[J]","author":"Caturano","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.archger.2025.105845_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2023.11.019","article-title":"Associations between metabolic syndrome and anxiety, and the mediating role of inflammation: Findings from the UK biobank[J]","volume":"116","author":"Cen","year":"2024","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.archger.2025.105845_bib0009","first-page":"24","article-title":"Iron and ferroptosis more than a suspect: Beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and dementia[J]","author":"Cerasuolo","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.archger.2025.105845_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171125","article-title":"Nanoplastics and chrysene pollution: Potential new triggers for nonalcoholic fatty liver disease and hepatitis, insights from juvenile Siniperca chuatsi[J]","volume":"922","author":"Chen","year":"2024","journal-title":"The Science of the Total Environment"},{"key":"10.1016\/j.archger.2025.105845_bib0011","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-021-00456-1","article-title":"Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: A systematic review of symptom-general and -specific lesion patterns[J]","volume":"16","author":"Chen","year":"2021","journal-title":"Molecular Neurodegeneration"},{"key":"10.1016\/j.archger.2025.105845_bib0012","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s12088-022-01033-w","article-title":"Gut-brain axis, neurodegeneration and mental health: A personalized medicine perspective[J]","volume":"62","author":"Chunduri","year":"2022","journal-title":"Indian Journal of Microbiology"},{"key":"10.1016\/j.archger.2025.105845_bib0013","article-title":"Adiponectin and resistin modulate the progression of Alzheimer s disease in a metabolic syndrome model[J]","volume":"14","author":"Cisternas","year":"2023","journal-title":"Frontiers in Endocrinology(Lausanne)"},{"key":"10.1016\/j.archger.2025.105845_bib0014","doi-asserted-by":"crossref","first-page":"S405","DOI":"10.3233\/JAD-179911","article-title":"Metabolic dysfunction in alzheimer's disease: From basic neurobiology to clinical approaches[J]","volume":"64","author":"Clarke","year":"2018","journal-title":"Journal of Alzheimer's Disease : JAD"},{"key":"10.1016\/j.archger.2025.105845_bib0015","unstructured":"Collaborators G B D D F, Alzheimer's A 2016 Alzheimer's disease facts and figures[J]. Alzheimer's & Dementia : The Journal of the Alzheimer's Association,2016,12:459\u2013509."},{"key":"10.1016\/j.archger.2025.105845_bib0016","unstructured":"Collaborators G B D D F Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the global burden of disease study 2019[J]. The Lancet Public Health,2022,7:E105\u2013e125."},{"key":"10.1016\/j.archger.2025.105845_bib0018","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.eprac.2022.03.010","volume":"28","author":"Cusi","year":"2022","journal-title":"Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists"},{"key":"10.1016\/j.archger.2025.105845_bib0019","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s11357-022-00556-w","article-title":"Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: A systematic review and meta-analysis[J]","volume":"44","author":"Custodero","year":"2022","journal-title":"GeroScience"},{"key":"10.1016\/j.archger.2025.105845_bib0020","doi-asserted-by":"crossref","first-page":"e1150","DOI":"10.1212\/WNL.0000000000005214","article-title":"Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation[J]","volume":"90","author":"Ekblad","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.archger.2025.105845_bib0021","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement[J]","volume":"73","author":"Eslam","year":"2020","journal-title":"Journal of Hepatology"},{"issue":"1999\u20132014","key":"10.1016\/j.archger.2025.105845_bib0022","first-page":"e1","article-title":"MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J]","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.archger.2025.105845_bib0023","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/aje\/kwx246","article-title":"Comparison of sociodemographic and health-related characteristics of UK biobank participants with those of the general population[J]","volume":"186","author":"Fry","year":"2017","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.archger.2025.105845_bib0024","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1053\/j.gastro.2023.08.016","article-title":"Preventing overdiagnosis of nonalcoholic fatty liver disease: Established cutoff values for transient elastography are needed[J]","volume":"166","author":"Gao","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.archger.2025.105845_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130903","article-title":"Along the microbiota-gut-brain axis: Use of plant polysaccharides to improve mental disorders[J]","volume":"265","author":"Gao","year":"2024","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.archger.2025.105845_bib0026","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jnc.15988","article-title":"Associations of liver dysfunction with incident dementia, cognition, and brain structure: A prospective cohort study of 431 699 adults[J]","volume":"168","author":"Gao","year":"2024","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.archger.2025.105845_bib0027","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11011-011-9261-y","article-title":"Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction[J]","volume":"26","author":"Ghareeb","year":"2011","journal-title":"Metabolic Brain Disease"},{"key":"10.1016\/j.archger.2025.105845_bib0029","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1136\/gut.2007.146019","article-title":"Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease[J]","volume":"57","author":"Harrison","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.archger.2025.105845_bib0030","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009161","article-title":"Cohort profile of the UK biobank: Diagnosis and characteristics of cerebrovascular disease[J]","volume":"6","author":"Hewitt","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.archger.2025.105845_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111424","article-title":"Biomarkers for evaluating the effects of exercise interventions in patients with MCI or dementia: A systematic review and meta-analysis[J]","volume":"151","author":"Huang","year":"2021","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.archger.2025.105845_bib0032","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/jamainternmed.2023.8029","article-title":"Outcomes of various classes of oral antidiabetic drugs on nonalcoholic fatty liver disease[J]","volume":"184","author":"Jang","year":"2024","journal-title":"JAMA Internal Medicine"},{"key":"10.1016\/j.archger.2025.105845_bib0033","article-title":"Adiponectin gene polymorphisms: A case-control study on their role in late-onset Alzheimer's disease risk[J]","volume":"14","author":"Javor","year":"2024","journal-title":"Life (Basel)"},{"key":"10.1016\/j.archger.2025.105845_bib0034","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3350\/cmh.2021.0332","article-title":"Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adults[J]","volume":"28","author":"Jeong","year":"2022","journal-title":"Clinical and Molecular Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1474-4422(19)30290-X","article-title":"Dementia in China: Epidemiology, clinical management, and research advances[J]","volume":"19","author":"Jia","year":"2020","journal-title":"The Lancet. Neurology"},{"key":"10.1016\/j.archger.2025.105845_bib0036","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12920-022-01420-8","article-title":"Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease[J]","volume":"15","author":"Kaiyrlykyzy","year":"2022","journal-title":"BMC Medical Genomics"},{"key":"10.1016\/j.archger.2025.105845_bib0037","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s13105-023-00991-z","article-title":"Fatty liver index (FLI): More than a marker of hepatic steatosis[J]","volume":"80","author":"Kaneva","year":"2024","journal-title":"Journal of Physiology and Biochemistry"},{"key":"10.1016\/j.archger.2025.105845_bib0038","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1016\/j.jhep.2023.09.036","article-title":"Longitudinal changes in fatty liver index are associated with risk of hepatocellular carcinoma: A nationwide cohort study in Korea[J]","volume":"80","author":"Kang","year":"2024","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0039","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1097\/HEP.0000000000000670","article-title":"Metabolic dysfunction-associated steatotic liver disease: Update and impact of new nomenclature on the American association for the study of liver diseases practice guidance on nonalcoholic fatty liver disease[J]","volume":"79","author":"Kanwal","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0040","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221139650","article-title":"Epidemiology, natural history, and diagnosis of metabolic dysfunction-associated fatty liver disease: A comparative review with nonalcoholic fatty liver disease[J]","volume":"13","author":"Kaya","year":"2022","journal-title":"Therapeutic Advances in Endocrinology and Metabolism"},{"key":"10.1016\/j.archger.2025.105845_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2024.101534","article-title":"Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3496 adults using serial echocardiography[J]","author":"Kim","year":"2024","journal-title":"Diabetes & Metabolism"},{"key":"10.1016\/j.archger.2025.105845_bib0042","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/liv.15244","article-title":"Association between non-alcoholic fatty liver disease and the risk of dementia: A nationwide cohort study[J]","volume":"42","author":"Kim","year":"2022","journal-title":"Liver International : Official Journal of the International Association for the Study of the Liver"},{"key":"10.1016\/j.archger.2025.105845_bib0043","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s10620-020-06644-1","article-title":"Incident dementia in elderly patients with nonalcoholic fatty liver disease in Germany[J]","volume":"66","author":"Labenz","year":"2021","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.archger.2025.105845_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.748888","article-title":"Liver health and dementia in an italian older population: Findings from the Salus in Apulia study[J]","volume":"13","author":"Lampignano","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"2809\u20132817","key":"10.1016\/j.archger.2025.105845_bib0045","first-page":"e28","article-title":"2019 Global NAFLD prevalence: A systematic review and meta-analysis[J]","volume":"20","author":"Le","year":"2022","journal-title":"Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association"},{"key":"10.1016\/j.archger.2025.105845_bib0046","first-page":"13","article-title":"The fatty liver index's association with incident chronic kidney disease in Korean middle-aged adults: A community-based cohort study[J]","author":"Lee","year":"2024","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/j.archger.2025.105845_bib0047","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease[J]","volume":"42","author":"Lee","year":"2010","journal-title":"Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver"},{"key":"10.1016\/j.archger.2025.105845_bib0048","article-title":"Metabolic-dysfunction associated steatotic liver disease-related diseases, cognition and dementia: A two-sample mendelian randomization study[J]","volume":"19","author":"Li","year":"2024","journal-title":"PloS One"},{"key":"10.1016\/j.archger.2025.105845_bib0049","article-title":"Non-alcoholic fatty liver disease and longitudinal cognitive changes in middle-aged and elderly adults[J]","volume":"8","author":"Liu","year":"2021","journal-title":"Frontiers in Medicine(Lausanne)"},{"key":"10.1016\/j.archger.2025.105845_bib0050","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jama.2019.9879","article-title":"Association of lifestyle and genetic risk with incidence of dementia[J]","volume":"322","author":"Lourida","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.archger.2025.105845_bib0051","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209203","article-title":"Nonalcoholic fatty liver disease and longitudinal change in imaging and plasma biomarkers of Alzheimer disease and vascular pathology[J]","volume":"102","author":"Lu","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.archger.2025.105845_bib0052","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/alz.13601","article-title":"Liver integrity and the risk of Alzheimer's disease and related dementias[J]","volume":"20","author":"Lu","year":"2024","journal-title":"Alzheimer's & Dementia : The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.archger.2025.105845_bib0053","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bbi.2023.02.009","article-title":"Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals[J]","volume":"109","author":"Ma","year":"2023","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.archger.2025.105845_bib0054","doi-asserted-by":"crossref","DOI":"10.1136\/gpsych-2019-100054","article-title":"Biomarkers for the diagnosis of Alzheimer's disease, dementia Lewy body, frontotemporal dementia and vascular dementia[J]","volume":"32","author":"Maclin","year":"2019","journal-title":"General Psychiatry"},{"key":"10.1016\/j.archger.2025.105845_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejim.2024.03.012","article-title":"Changes in the dynamic trajectory of remnant cholesterol affect the occurrence of nonalcoholic fatty liver disease[J]","author":"Miao","year":"2024","journal-title":"European Journal of Internal Medicine"},{"key":"10.1016\/j.archger.2025.105845_bib0056","doi-asserted-by":"crossref","DOI":"10.1177\/15333175231185236","article-title":"Dendrobium nobile polysaccharides attenuates ferroptosis and improves cognitive function in vascular dementia rats[J]","volume":"38","author":"Ming","year":"2023","journal-title":"American Journal of Alzheimer's Disease and Other Dementias"},{"key":"10.1016\/j.archger.2025.105845_bib0057","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cellsig.2013.11.017","article-title":"New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: Amyloid-beta1-42-induced reduction of proinsulin level via glycogen synthase kinase-3beta[J]","volume":"26","author":"Nemoto","year":"2014","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.archger.2025.105845_bib0058","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12974-024-03066-y","article-title":"Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer's disease[J]","volume":"21","author":"Ng","year":"2024","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.archger.2025.105845_bib0059","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.7978","article-title":"Association of altered liver enzymes with alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers[J]","volume":"2","author":"Nho","year":"2019","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.archger.2025.105845_bib0060","first-page":"2905","article-title":"Time to test antibacterial therapy in Alzheimer's disease[J]","volume":"142","author":"Panza","year":"2019","journal-title":"Brain : A Journal of Neurology"},{"key":"10.1016\/j.archger.2025.105845_bib0061","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits[J]","volume":"77","author":"Peiseler","year":"2022","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0062","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9050104","article-title":"Non-alcoholic fatty liver disease, and the underlying altered fatty acid metabolism, reveals brain hypoperfusion and contributes to the cognitive decline in APP\/PS1 mice[J]","volume":"9","author":"Pincon","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.archger.2025.105845_bib0063","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1002\/alz.13088","article-title":"Associations of blood cell indices and anemia with risk of incident dementia: A prospective cohort study of 313,448 participants[J]","volume":"19","author":"Qiang","year":"2023","journal-title":"Alzheimer's & Dementia : The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.archger.2025.105845_bib0064","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.psyneuen.2017.09.018","article-title":"Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular dementia[J]","volume":"86","author":"Quinlan","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.archger.2025.105845_bib0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.atherosclerosis.2016.10.037","article-title":"Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review[J]","volume":"255","author":"Rasmussen","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.archger.2025.105845_bib0066","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/acschemneuro.3c00127","article-title":"Gut Microbiome-brain alliance: A landscape view into mental and gastrointestinal health and disorders[J]","volume":"14","author":"Sasso","year":"2023","journal-title":"ACS Chemical Neuroscience"},{"key":"10.1016\/j.archger.2025.105845_bib0067","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12944-024-02094-0","article-title":"Association of the habitual dietary intake with the fatty liver index and effect modification by metabotypes in the population-based KORA-Fit study[J]","volume":"23","author":"Schepp","year":"2024","journal-title":"Lipids in Health and Disease"},{"key":"10.1016\/j.archger.2025.105845_bib0068","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/HYPERTENSIONAHA.121.17608","article-title":"The association of age at diagnosis of hypertension with brain structure and incident dementia in the UK biobank[J]","volume":"78","author":"Shang","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.archger.2025.105845_bib0069","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.1212\/WNL.0000000000200853","article-title":"Nonalcoholic fatty liver disease and risk of dementia: A population-based cohort study[J]","volume":"99","author":"Shang","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.archger.2025.105845_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnha.2024.100166","article-title":"The role of adiponectin in Alzheimer's disease: A translational review[J]","volume":"28","author":"Sindzingre","year":"2024","journal-title":"The Journal of Nutrition, Health & Aging"},{"key":"10.1016\/j.archger.2025.105845_bib0071","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbi.2023.02.010","article-title":"Association between inflammation and cognition: Triangulation of evidence using a population-based cohort and Mendelian randomization analyses[J]","volume":"110","author":"Slaney","year":"2023","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.archger.2025.105845_bib0072","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection[J]","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0073","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age[J]","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.archger.2025.105845_bib0074","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bja.2022.01.005","article-title":"Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: A prospective cohort study[J]","volume":"129","author":"Taylor","year":"2022","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.archger.2025.105845_bib0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12933-018-0670-7","article-title":"Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): A case control study[J]","volume":"17","author":"Tuttolomondo","year":"2018","journal-title":"Cardiovascular Diabetology"},{"key":"10.1016\/j.archger.2025.105845_bib0076","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/105828","article-title":"Inflammation and oxidative stress: The molecular connectivity between insulin resistance, obesity, and Alzheimer's disease[J]","volume":"2015","author":"Verdile","year":"2015","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.archger.2025.105845_bib0077","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13727","article-title":"Optimized strategy among diet, exercise, and pharmacological interventions for nonalcoholic fatty liver disease: A network meta-analysis of randomized controlled trials[J]","author":"Wang","year":"2024","journal-title":"Obesity Reviews : An Official Journal of the International Association for the Study of Obesity"},{"key":"10.1016\/j.archger.2025.105845_bib0078","article-title":"Zheng Z Risk of dementia or cognitive impairment in non-alcoholic fatty liver disease: A systematic review and meta-analysis[J]","volume":"14","author":"Wang","year":"2022","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1016\/j.archger.2025.105845_bib0079","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainresbull.2022.12.003","article-title":"Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder[J]","volume":"193","author":"Wang","year":"2023","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.archger.2025.105845_bib0080","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/liv.14161","article-title":"Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham study[J]","volume":"39","author":"Weinstein","year":"2019","journal-title":"Liver International : Official Journal of the International Association for the Study of the Liver"},{"key":"10.1016\/j.archger.2025.105845_bib0081","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10654-019-00499-1","article-title":"Identifying dementia outcomes in UK biobank: A validation study of primary care, hospital admissions and mortality data[J]","volume":"34","author":"Wilkinson","year":"2019","journal-title":"European Journal of Epidemiology"},{"key":"10.1016\/j.archger.2025.105845_bib0082","article-title":"Gastrodin and gastrodigenin improve energy metabolism disorders and mitochondrial dysfunction to antagonize vascular dementia[J]","volume":"28","author":"Wu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.archger.2025.105845_bib0084","doi-asserted-by":"crossref","first-page":"e565","DOI":"10.1212\/WNL.0000000000200770","article-title":"Association of nonalcoholic fatty liver disease and fibrosis with incident dementia and cognition: The Rotterdam study[J]","volume":"99","author":"Xiao","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.archger.2025.105845_bib0085","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/hepr.13728","article-title":"Metabolic dysfunction-associated fatty liver disease and liver fibrosis: Prevalence and associated factors in the middle-aged and older US population[J]","volume":"52","author":"Yang","year":"2022","journal-title":"Hepatology Research : The Official Journal of the Japan Society of Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0086","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jhep.2023.11.004","article-title":"Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease[J]","volume":"80","author":"Younossi","year":"2024","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0087","first-page":"1034","article-title":"Association between metabolic dysfunction-associated fatty liver disease and cognitive impairment[J]","volume":"10","author":"Yu","year":"2022","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"10.1016\/j.archger.2025.105845_bib0088","article-title":"The alterations in and the role of the Th17\/Treg balance in metabolic diseases[J]","volume":"12","author":"Zhang","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.archger.2025.105845_bib0089","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbi.2024.06.014","article-title":"Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study[J]","volume":"120","author":"Zhao","year":"2024","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.archger.2025.105845_bib0090","article-title":"Age at onset of heart failure and subsequent risk of dementia: A longitudinal cohort study[J]","author":"Zheng","year":"2023","journal-title":"JACC. Heart Failure"},{"key":"10.1016\/j.archger.2025.105845_bib0091","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1021\/acs.jproteome.8b00847","article-title":"Tissue-specific metabolomics analysis identifies the liver as a major organ of metabolic disorders in amyloid precursor protein\/presenilin 1 mice of Alzheimer's disease[J]","volume":"18","author":"Zheng","year":"2019","journal-title":"Journal of Proteome Research"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494325001037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494325001037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:21:10Z","timestamp":1747902070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494325001037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":88,"alternative-id":["S0167494325001037"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2025.105845","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of metabolic dysfunction-related fatty liver disease and dementia risk: A prospective study based on the UK biobank","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2025.105845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105845"}}