{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:48:07Z","timestamp":1790718487029,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2023HXFH032"],"award-info":[{"award-number":["2023HXFH032"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703101"],"award-info":[{"award-number":["2022YFC2703101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.archger.2026.106252","type":"journal-article","created":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T16:27:42Z","timestamp":1776011262000},"page":"106252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Hepatic dysfunction and long-term risk of neurodegenerative diseases: A UK Biobank-based analysis"],"prefix":"10.1016","volume":"147","author":[{"given":"Wei-Ming","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Qing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Yin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Jin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Fu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-4192","authenticated-orcid":false,"given":"Yong-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.archger.2026.106252_bib0065","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2018.12.036","article-title":"Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease","volume":"156","author":"Castera","year":"2019","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.archger.2026.106252_bib0002","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1136\/gutjnl-2021-326269","article-title":"Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation","volume":"71","author":"Chen","year":"2022","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.archger.2026.106252_bib0013","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1053\/j.gastro.2020.01.052","article-title":"Nonalcoholic fatty liver disease 2020: The state of the disease","volume":"158","author":"Cotter","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0056","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s13311-020-00933-3","article-title":"Behavioral, hormonal, inflammatory, and metabolic effects associated with FGF21-pathway activation in an ALS mouse model","volume":"18","author":"Delaye","year":"2021","journal-title":"Neurotherapeutics"},{"issue":"6","key":"10.1016\/j.archger.2026.106252_bib0033","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.18314","article-title":"Associations between handgrip strength and dementia risk, cognition, and neuroimaging outcomes in the UK Biobank cohort study","volume":"5","author":"Duchowny","year":"2022","journal-title":"JAMA Network Open"},{"issue":"6","key":"10.1016\/j.archger.2026.106252_bib0064","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1111\/dom.16362","article-title":"Characterization of brain morphology associated with metabolic dysfunction-associated steatotic liver disease in the UK Biobank","volume":"27","author":"Fan","year":"2025","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"8","key":"10.1016\/j.archger.2026.106252_bib0040","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1111\/ene.15377","article-title":"Liver fibrosis-4 index indicates atrial fibrillation in acute ischemic stroke","volume":"29","author":"Fandler-H\u00f6fler","year":"2022","journal-title":"European Journal of Neurology"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0034","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jnc.15988","article-title":"Associations of liver dysfunction with incident dementia, cognition, and brain structure: A prospective cohort study of 431\u2009699 adults","volume":"168","author":"Gao","year":"2024","journal-title":"Journal of Neurochemistry"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41531-025-00888-2","article-title":"Early detection of Parkinson's disease through multiplex blood and urine biomarkers prior to clinical diagnosis","volume":"11","author":"Gao","year":"2025","journal-title":"NPJ Parkinson\u2019s Disease"},{"key":"10.1016\/j.archger.2026.106252_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2025.105845","article-title":"Associations of metabolic dysfunction-related fatty liver disease and dementia risk: A prospective study based on the UK biobank","volume":"135","author":"Geng","year":"2025","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"10.1016\/j.archger.2026.106252_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1589110","article-title":"Brain-acting hepatokines: Its impact on energy balance and metabolism","volume":"19","author":"Giovanini","year":"2025","journal-title":"Frontiers in Neuroscience"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0062","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70066","article-title":"Liver diseases and brain disorders: Genetic mechanisms and biomarker pathways in a prospective cohort study from the UK Biobank","volume":"169","author":"Guo","year":"2025","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0016","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3233\/JAD-220343","article-title":"Implications of liver enzymes in the pathogenesis of Alzheimer's disease","volume":"88","author":"Han","year":"2022","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"2","key":"10.1016\/j.archger.2026.106252_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2025.102176","article-title":"Is FIB-4 the right tool for screening for liver fibrosis?","volume":"31","author":"Heyens","year":"2025","journal-title":"Annals of Hepatology"},{"issue":"7","key":"10.1016\/j.archger.2026.106252_bib0068","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.cmet.2024.05.003","article-title":"Metabolic reprogramming in liver fibrosis","volume":"36","author":"Horn","year":"2024","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.archger.2026.106252_bib0022","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jpsychires.2023.03.041","article-title":"NAFLD does not increase the risk of incident dementia: A prospective study and meta-analysis","volume":"161","author":"Huang","year":"2023","journal-title":"Journal of Psychiatric Research"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0059","doi-asserted-by":"crossref","first-page":"78","DOI":"10.31083\/j.jin2304078","article-title":"Causal relationship between sex hormones and risk of developing common neurodegenerative diseases: A Mendelian randomization study","volume":"23","author":"Huang","year":"2024","journal-title":"Journal of Integrative Neuroscience"},{"issue":"3","key":"10.1016\/j.archger.2026.106252_bib0012","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3350\/cmh.2021.0332","article-title":"Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adults","volume":"28","author":"Jeong","year":"2022","journal-title":"Clinical and Molecular Hepatology"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0061","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/dom.16232","article-title":"Association of metabolic dysfunction-associated fatty liver disease with white matter hyperintensity and cognitive decline: A longitudinal cohort study","volume":"27","author":"Jung","year":"2025","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"5","key":"10.1016\/j.archger.2026.106252_bib0001","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41583-024-00806-0","article-title":"Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases","volume":"25","author":"Kampmann","year":"2024","journal-title":"Nature Reviews Neuroscience"},{"issue":"2","key":"10.1016\/j.archger.2026.106252_bib0026","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jhep.2020.10.030","article-title":"Hepatokines and adipokines in NASH-related hepatocellular carcinoma","volume":"74","author":"Kucukoglu","year":"2021","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.archger.2026.106252_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106741","article-title":"ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity","volume":"203","author":"Li","year":"2024","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.archger.2026.106252_bib0054","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuroscience.2025.03.009","article-title":"Potential therapeutic targets for Alzheimer's disease: Fibroblast growth factors and their regulation of ferroptosis, pyroptosis and autophagy","volume":"573","author":"Li","year":"2025","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.archger.2026.106252_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00501","article-title":"Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease","volume":"22","author":"Lin","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"9","key":"10.1016\/j.archger.2026.106252_bib0044","doi-asserted-by":"crossref","DOI":"10.1002\/jgh3.70281","article-title":"Diagnostic performance of fibrosis-4 index, nonalcoholic fatty liver disease fibrosis score, AST-to-platelet ratio index, and BARD score among young and older adults for the diagnosis of advanced MASLD fibrosis: A retrospective cohort study","volume":"9","author":"Lin","year":"2025","journal-title":"JGH Open"},{"key":"10.1016\/j.archger.2026.106252_bib0053","article-title":"Mechanism of action, role in Parkinson's disease, and therapeutics","volume":"12","author":"Liu","year":"2021","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"3","key":"10.1016\/j.archger.2026.106252_bib0008","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/alz.13601","article-title":"Liver integrity and the risk of Alzheimer's disease and related dementias","volume":"20","author":"Lu","year":"2024","journal-title":"Alzheimers & Dementia"},{"issue":"7","key":"10.1016\/j.archger.2026.106252_bib0011","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209203","article-title":"Nonalcoholic fatty liver disease and longitudinal change in imaging and plasma biomarkers of Alzheimer disease and vascular pathology","volume":"102","author":"Lu","year":"2024","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00314034","article-title":"Functional and morphometric study of the liver in motor neuron disease","volume":"232","author":"Masui","year":"1985","journal-title":"Journal of Neurology"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35321-2","article-title":"Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants","volume":"13","author":"McCracken","year":"2022","journal-title":"Nature Communications"},{"issue":"7","key":"10.1016\/j.archger.2026.106252_bib0017","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.7978","article-title":"Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers","volume":"2","author":"Nho","year":"2019","journal-title":"JAMA Network Open"},{"issue":"19","key":"10.1016\/j.archger.2026.106252_bib0060","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.21037\/atm-22-1156","article-title":"Causal effects of serum sex hormone binding protein levels on the risk of amyotrophic lateral sclerosis: A Mendelian randomization study","volume":"10","author":"Ou","year":"2022","journal-title":"Annals of Translational Medicine"},{"issue":"17","key":"10.1016\/j.archger.2026.106252_bib0010","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/WNL.0000000000003848","article-title":"Viral hepatitis and Parkinson disease: A national record-linkage study","volume":"88","author":"Pakpoor","year":"2017","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0009","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/alz.12795","article-title":"Association of liver fibrosis with cognitive test performance and brain imaging parameters in the UK Biobank study","volume":"19","author":"Parikh","year":"2023","journal-title":"Alzheimers & Dementia"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/23969873241259561","article-title":"Association between elevated fibrosis-4 index of liver fibrosis and risk of hemorrhagic stroke","volume":"10","author":"Parikh","year":"2025","journal-title":"European Stroke Journal"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0055","article-title":"Inflammatory biomarkers in newly diagnosed patients with Parkinson disease and related neurodegenerative disorders","volume":"10","author":"Pedersen","year":"2023","journal-title":"Neurology: Neuroimmunology & Neuroinflammation"},{"key":"10.1016\/j.archger.2026.106252_bib0007","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neurobiolaging.2022.08.004","article-title":"Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers","volume":"120","author":"Peng","year":"2022","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0066","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2036.2012.05121.x","article-title":"Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD","volume":"36","author":"Permutt","year":"2012","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"6","key":"10.1016\/j.archger.2026.106252_bib0037","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/dmrr.2655","article-title":"Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level","volume":"31","author":"Qian","year":"2015","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"issue":"7","key":"10.1016\/j.archger.2026.106252_bib0038","doi-asserted-by":"crossref","first-page":"796","DOI":"10.2174\/092986709787549271","article-title":"Neuro-transmitters in the central nervous system & their implication in learning and memory processes","volume":"16","author":"Reis","year":"2009","journal-title":"Current Medicinal Chemistry"},{"issue":"2","key":"10.1016\/j.archger.2026.106252_bib0021","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3233\/JAD-141755","article-title":"Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain","volume":"44","author":"Rueli","year":"2015","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"6","key":"10.1016\/j.archger.2026.106252_bib0052","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jalz.2013.09.016","article-title":"Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology","volume":"10","author":"Sattlecker","year":"2014","journal-title":"Alzheimer's & Dementia"},{"issue":"6","key":"10.1016\/j.archger.2026.106252_bib0031","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/jmri.27292","article-title":"Multiparametric MRI in patients with nonalcoholic fatty liver disease","volume":"53","author":"Schaapman","year":"2021","journal-title":"Journal of Magnetic Resonance Imaging"},{"key":"10.1016\/j.archger.2026.106252_bib0051","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-079475","article-title":"Risk of dementia after initiation of sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in adults aged 40-69 years with type 2 diabetes: Population based cohort study","volume":"386","author":"Shin","year":"2024","journal-title":"Bmj"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13024-025-00849-6","article-title":"Bridging systemic metabolic dysfunction and Alzheimer's disease: The liver interface","volume":"20","author":"Song","year":"2025","journal-title":"Molecular Neurodegeneration"},{"issue":"2","key":"10.1016\/j.archger.2026.106252_bib0025","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cmet.2023.01.006","article-title":"The role of hepatokines in NAFLD","volume":"35","author":"Stefan","year":"2023","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.archger.2026.106252_bib0027","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp-2023-331142","article-title":"Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer's disease","author":"Su","year":"2023","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"3","key":"10.1016\/j.archger.2026.106252_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"Plos Medicine"},{"key":"10.1016\/j.archger.2026.106252_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102689","article-title":"Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: An emulated trial study","volume":"73","author":"Tang","year":"2024","journal-title":"EClinicalMedicine"},{"issue":"5","key":"10.1016\/j.archger.2026.106252_bib0067","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jhep.2024.06.016","article-title":"Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation","volume":"81","author":"Taru","year":"2024","journal-title":"Journal of Hepatology"},{"issue":"10","key":"10.1016\/j.archger.2026.106252_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040297","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration","volume":"4","author":"Vandenbroucke","year":"2007","journal-title":"PLOS Medicine"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0020","doi-asserted-by":"crossref","first-page":"8792","DOI":"10.1038\/s41598-023-36084-6","article-title":"Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia","volume":"13","author":"Vinceti","year":"2023","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0032","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-024-03418-8","article-title":"Peripheral GFAP and NfL as early biomarkers for dementia: Longitudinal insights from the UK Biobank","volume":"22","author":"Wang","year":"2024","journal-title":"BMC Medicine"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0006","article-title":"Genetic evidence for the liver-brain axis: Lipid metabolism and neurodegenerative disease risk","volume":"24","author":"Wang","year":"2025","journal-title":"Lipids in Health and Disease"},{"issue":"2","key":"10.1016\/j.archger.2026.106252_bib0018","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-025-04350-w","article-title":"Improvements in exercise for Alzheimer's disease: Highlighting FGF21-induced cerebrovascular protection","volume":"50","author":"Wang","year":"2025","journal-title":"Neurochemical Research"},{"issue":"7958","key":"10.1016\/j.archger.2026.106252_bib0028","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41586-023-05857-4","article-title":"Clonal haematopoiesis and risk of chronic liver disease","volume":"616","author":"Wong","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0047","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202412020","article-title":"Injectable hierarchical bioactive hydrogels with fibroblast growth factor 21\/edaravone\/caffeic acid asynchronous delivery for treating Parkinson's disease","volume":"12","author":"Xu","year":"2025","journal-title":"Advanced Science"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0004","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut liver brain axis in diseases: The implications for therapeutic interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.archger.2026.106252_bib0058","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2022.11.003","article-title":"Focus on Alzheimer's disease: The role of fibroblast growth factor 21 and autophagy","volume":"511","author":"Yang","year":"2023","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.archger.2026.106252_bib0057","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1111\/cns.14302","article-title":"Fibroblast growth factor 21 ameliorates behavior deficits in Parkinson's disease mouse model via modulating gut microbiota and metabolic homeostasis","volume":"29","author":"Yang","year":"2023","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-58306-x","article-title":"Serum gamma-glutamyltransferase activity and Parkinson\u2019s disease risk in men and women","volume":"10","author":"Yoo","year":"2020","journal-title":"Scientific Reports"},{"issue":"4","key":"10.1016\/j.archger.2026.106252_bib0029","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10396-021-01135-w","article-title":"MRI-derived proton density fat fraction","volume":"48","author":"Yoshizawa","year":"2021","journal-title":"Journal of Medical Ultrasonics"},{"issue":"1","key":"10.1016\/j.archger.2026.106252_bib0003","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-023-00392-8","article-title":"Parkinson's disease and gut microbiota: From clinical to mechanistic and therapeutic studies","volume":"12","author":"Zhang","year":"2023","journal-title":"Translational Neurodegeneration"},{"issue":"6","key":"10.1016\/j.archger.2026.106252_bib0036","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s10072-023-07284-9","article-title":"Associations of liver function with plasma biomarkers for Alzheimer's disease","volume":"45","author":"Zhang","year":"2024","journal-title":"Neurological Sciences"},{"key":"10.1016\/j.archger.2026.106252_bib0041","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2147\/CIA.S469899","article-title":"Prognostic value of fibrosis-4 in acute ischemic stroke patients undergoing intravenous thrombolysis","volume":"19","author":"Zhu","year":"2024","journal-title":"Clinical Interventions in Aging"},{"key":"10.1016\/j.archger.2026.106252_bib0014","article-title":"Fighting amyotrophic lateral sclerosis by protecting the liver? A prospective cohort study","author":"Zhu","year":"2024","journal-title":"Annals of Neurology"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:39:08Z","timestamp":1778726348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494326001214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":67,"alternative-id":["S0167494326001214"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2026.106252","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic dysfunction and long-term risk of neurodegenerative diseases: A UK Biobank-based analysis","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2026.106252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106252"}}