{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:37:24Z","timestamp":1783024644778,"version":"3.54.6"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.archger.2026.106254","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:29:17Z","timestamp":1776108557000},"page":"106254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The metabolic-inflammatory axis in aging: A multi-organ framework anchored in Sarcopenia \u2014 A review"],"prefix":"10.1016","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5752-7377","authenticated-orcid":false,"given":"Tian","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2017.03.015","article-title":"\u03b2 cell aging markers have heterogeneous distribution and are induced by insulin resistance","volume":"25","author":"Aguayo-Mazzucato","year":"2017","journal-title":"Cell Metabolism"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0002","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41571-023-00734-5","article-title":"Cancer-associated cachexia - understanding the tumour macroenvironment and microenvironment to improve management","volume":"20","author":"Argil\u00e9s","year":"2023","journal-title":"Nature Reviews. Clinical Oncology"},{"key":"10.1016\/j.archger.2026.106254_bib0003","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clnesp.2021.10.011","article-title":"The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping systematic review and meta-analysis","volume":"46","author":"Bird","year":"2021","journal-title":"Clinical Nutrition ESPEN"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0004","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13024-017-0220-x","article-title":"Modulating the catalytic activity of AMPK has neuroprotective effects against \u03b1-synuclein toxicity","volume":"12","author":"Bobela","year":"2017","journal-title":"Molecular Neurodegeneration"},{"key":"10.1016\/j.archger.2026.106254_bib0005","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.archger.2016.10.012","article-title":"Health benefits of aerobic training programs in adults aged 70 and over: A systematic review","volume":"69","author":"Bouaziz","year":"2017","journal-title":"Archives of Gerontology and Geriatrics"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0006","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1172\/JCI64125","article-title":"The role of mitochondria in aging","volume":"123","author":"Bratic","year":"2013","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"10.1016\/j.archger.2026.106254_bib0007","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"5666","key":"10.1016\/j.archger.2026.106254_bib0008","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0009","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2012.11.003","article-title":"Neuroinflammation and neurodegeneration in overnutrition-induced diseases","volume":"24","author":"Cai","year":"2013","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbalip.2014.08.010","article-title":"Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance","volume":"1851","author":"Calder","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0011","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0735-1097(94)90305-0","article-title":"Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women","volume":"24","author":"Celermajer","year":"1994","journal-title":"Journal of the American College of Cardiology"},{"issue":"23","key":"10.1016\/j.archger.2026.106254_bib0012","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1093\/emboj\/cdf660","article-title":"Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB","volume":"21","author":"Chen","year":"2002","journal-title":"The EMBO Journal"},{"issue":"10","key":"10.1016\/j.archger.2026.106254_bib0013","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nature Immunology"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0014","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1080\/14756366.2021.1955873","article-title":"The role of mTOR in age-related diseases","volume":"36","author":"Chrienova","year":"2021","journal-title":"Journal of enzyme Inhibition and Medicinal Chemistry"},{"issue":"7","key":"10.1016\/j.archger.2026.106254_bib0015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tem.2009.04.002","article-title":"Role of IGF-I in skeletal muscle mass maintenance","volume":"20","author":"Clemmons","year":"2009","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0016","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age and Ageing"},{"issue":"11","key":"10.1016\/j.archger.2026.106254_bib0017","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S2213-8587(15)00291-0","article-title":"Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: The Diabetes Prevention Program Outcomes Study","volume":"3","year":"2015","journal-title":"The Lancet. Diabetes & Endocrinology"},{"issue":"Pt B","key":"10.1016\/j.archger.2026.106254_bib0018","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.yjmcc.2015.01.021","article-title":"Cellular and molecular biology of aging endothelial cells","volume":"89","author":"Donato","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"7676","key":"10.1016\/j.archger.2026.106254_bib0019","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature24050","article-title":"Cytoplasmic chromatin triggers inflammation in senescence and cancer","volume":"550","author":"Dou","year":"2017","journal-title":"Nature"},{"issue":"6016","key":"10.1016\/j.archger.2026.106254_bib0020","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0021","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s43587-021-00044-4","article-title":"Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy","volume":"1","author":"Elliott","year":"2021","journal-title":"Nature Aging"},{"issue":"5","key":"10.1016\/j.archger.2026.106254_bib0022","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"The Lancet Oncology"},{"issue":"9","key":"10.1016\/j.archger.2026.106254_bib0023","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nature Reviews. Cardiology"},{"key":"10.1016\/j.archger.2026.106254_bib0024","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"10","key":"10.1016\/j.archger.2026.106254_bib0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: A new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nature Reviews. Endocrinology"},{"issue":"11\u201312","key":"10.1016\/j.archger.2026.106254_bib0026","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.drudis.2011.03.009","article-title":"Histone acetyltransferases are crucial regulators in NF-\u03bab mediated inflammation","volume":"16","author":"Ghizzoni","year":"2011","journal-title":"Drug Discovery Today"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endrev\/bnae021","article-title":"Adiponectin and Adiponectin receptors in atherosclerosis","volume":"46","author":"Gianopoulos","year":"2025","journal-title":"Endocrine Reviews"},{"issue":"12","key":"10.1016\/j.archger.2026.106254_bib0028","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1113\/jphysiol.2013.268680","article-title":"Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice","volume":"592","author":"Gioscia-Ryan","year":"2014","journal-title":"The Journal of Physiology"},{"issue":"10","key":"10.1016\/j.archger.2026.106254_bib0029","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.biocel.2005.04.018","article-title":"Skeletal muscle hypertrophy and atrophy signaling pathways","volume":"37","author":"Glass","year":"2005","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"7713","key":"10.1016\/j.archger.2026.106254_bib0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.archger.2026.106254_bib0031","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.2337\/dc14-0396","article-title":"\u03b2-cell failure in type 2 diabetes: Postulated mechanisms and prospects for prevention and treatment","volume":"37","author":"Halban","year":"2014","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0032","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0033","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042121","article-title":"Alterations of gut microbiota by overnutrition impact gluconeogenic gene expression and insulin signaling","volume":"22","author":"He","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.archger.2026.106254_bib0034","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2125.2012.04340.x","article-title":"Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man","volume":"75","author":"Hoffmann","year":"2013","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"10","key":"10.1016\/j.archger.2026.106254_bib0036","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biology"},{"issue":"5091","key":"10.1016\/j.archger.2026.106254_bib0037","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"issue":"7640","key":"10.1016\/j.archger.2026.106254_bib0038","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.archger.2026.106254_bib0039","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends in Cell Biology"},{"issue":"29","key":"10.1016\/j.archger.2026.106254_bib0040","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"J\u00e4ger","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.02.029","article-title":"Reassessment of exosome composition","volume":"177","author":"Jeppesen","year":"2019","journal-title":"Cell"},{"issue":"7432","key":"10.1016\/j.archger.2026.106254_bib0042","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"Kaeberlein M. mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.archger.2026.106254_bib0043","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.archger.2026.106254_bib0044","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2013.03.004","article-title":"Influence of metabolism on epigenetics and disease","volume":"153","author":"Kaelin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.archger.2026.106254_bib0046","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.arr.2016.09.008","article-title":"Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis","volume":"35","author":"Kalinkovich","year":"2017","journal-title":"Ageing Research Reviews"},{"issue":"5","key":"10.1016\/j.archger.2026.106254_bib0047","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2004.12.041","article-title":"Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases","volume":"120","author":"Kamata","year":"2005","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0048","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archinternmed.2009.499","article-title":"Exercise effects on bone mineral density, falls, coronary risk factors, and health care costs in older women: The randomized controlled senior fitness and prevention (SEFIP) study","volume":"170","author":"Kemmler","year":"2010","journal-title":"Archives of Internal Medicine"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0049","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: Linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.archger.2026.106254_bib0050","doi-asserted-by":"crossref","first-page":"529","DOI":"10.5483\/BMBRep.2016.49.10.115","article-title":"Mitophagy: a balance regulator of NLRP3 inflammasome activation","volume":"49","author":"Kim","year":"2016","journal-title":"BMB Reports"},{"issue":"8","key":"10.1016\/j.archger.2026.106254_bib0051","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nature Cell Biology"},{"issue":"11","key":"10.1016\/j.archger.2026.106254_bib0052","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.2337\/dc11-1032","article-title":"Insulin sensitizers may attenuate lean mass loss in older men with diabetes","volume":"34","author":"Lee","year":"2011","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0053","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ccr.2009.02.015","article-title":"Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors","volume":"15","author":"Lee","year":"2009","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.archger.2026.106254_bib0054","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jcsm.12784","article-title":"Understanding the gut microbiota and sarcopenia: A systematic review","volume":"12","author":"Liu","year":"2021","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0055","article-title":"Progressive resistance strength training for improving physical function in older adults","volume":"2009","author":"Liu","year":"2009","journal-title":"The Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0056","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"6","key":"10.1016\/j.archger.2026.106254_bib0057","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/jcsm.13101","article-title":"Reduction of senescent fibro-adipogenic progenitors in progeria-aged muscle by senolytics rescues the function of muscle stem cells","volume":"13","author":"Liu","year":"2022","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0058","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0059","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"The Journal of Clinical Investigation"},{"issue":"268","key":"10.1016\/j.archger.2026.106254_bib0060","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009892","article-title":"mTOR inhibition improves immune function in the elderly","volume":"6","author":"Mannick","year":"2014","journal-title":"Science Translational Medicine"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0061","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/157340606776056133","article-title":"Curcumin is an inhibitor of p300 histone acetylatransferase","volume":"2","author":"Marcu","year":"2006","journal-title":"Medicinal chemistry (Shariqah (United Arab Emirates))"},{"issue":"37","key":"10.1016\/j.archger.2026.106254_bib0062","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1073\/pnas.0704329104","article-title":"SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase","volume":"104","author":"Mattagajasingh","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7203","key":"10.1016\/j.archger.2026.106254_bib0063","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0064","first-page":"868","article-title":"The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats","volume":"118","author":"Morimoto","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0065","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cmet.2015.02.002","article-title":"Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells","volume":"21","author":"Moussaieff","year":"2015","journal-title":"Cell Metabolism"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0066","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/jama.2014.5559","article-title":"How to read a systematic review and meta-analysis and apply the results to patient care: Users' guides to the medical literature","volume":"312","author":"Murad","year":"2014","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0067","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cell.2008.06.051","article-title":"AMPK and PPARdelta agonists are exercise mimetics","volume":"134","author":"Narkar","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0068","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","article-title":"Review: Microglia of the aged brain: Primed to be activated and resistant to regulation","volume":"39","author":"Norden","year":"2013","journal-title":"Neuropathology and Applied Neurobiology"},{"issue":"7990","key":"10.1016\/j.archger.2026.106254_bib0069","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0070","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41467-018-07825-3","article-title":"Impaired immune surveillance accelerates accumulation of senescent cells and aging","volume":"9","author":"Ovadya","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.archger.2026.106254_bib0071","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exger.2016.02.013","article-title":"Aging and adipose tissue: Potential interventions for diabetes and regenerative medicine","volume":"86","author":"Palmer","year":"2016","journal-title":"Experimental Gerontology"},{"issue":"8","key":"10.1016\/j.archger.2026.106254_bib0072","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: Skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nature Reviews. Endocrinology"},{"issue":"3","key":"10.1016\/j.archger.2026.106254_bib0073","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.arr.2010.03.004","article-title":"Resistance exercise for muscular strength in older adults: A meta-analysis","volume":"9","author":"Peterson","year":"2010","journal-title":"Ageing Research Reviews"},{"issue":"12","key":"10.1016\/j.archger.2026.106254_bib0074","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with Canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"The New England Journal of Medicine"},{"issue":"10105","key":"10.1016\/j.archger.2026.106254_bib0075","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0140-6736(17)32247-X","article-title":"Effect of interleukin-1\u03b2 inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: Exploratory results from a randomised, double-blind, placebo-controlled trial","volume":"390","author":"Ridker","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"6","key":"10.1016\/j.archger.2026.106254_bib0076","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/HYPERTENSIONAHA.117.10787","article-title":"Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults","volume":"71","author":"Rossman","year":"2018","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"issue":"7334","key":"10.1016\/j.archger.2026.106254_bib0077","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.archger.2026.106254_bib0078","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/epirev\/mxs009","article-title":"Multimorbidity in older adults","volume":"35","author":"Salive","year":"2013","journal-title":"Epidemiologic Reviews"},{"issue":"7","key":"10.1016\/j.archger.2026.106254_bib0079","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00109-011-0748-0","article-title":"AMP-activated protein kinase inhibits NF-\u03bab signaling and inflammation: Impact on healthspan and lifespan","volume":"89","author":"Salminen","year":"2011","journal-title":"Journal of Molecular Medicine (Berlin, Germany)"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0080","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.archger.2026.106254_bib0081","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-021-00092-5","article-title":"Mendelian randomization","volume":"2","author":"Sanderson","year":"2022","journal-title":"Nature Reviews. Methods Primers"},{"issue":"7817","key":"10.1016\/j.archger.2026.106254_bib0082","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41586-020-2499-y","article-title":"Ageing hallmarks exhibit organ-specific temporal signatures","volume":"583","author":"Schaum","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.archger.2026.106254_bib0083","doi-asserted-by":"crossref","unstructured":"Sierra F. The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span. Cold Spring Harb Perspect Med. 2016;6(4):A025163. doi: 10.1101\/cshperspect.a025163.","DOI":"10.1101\/cshperspect.a025163"},{"issue":"1","key":"10.1016\/j.archger.2026.106254_bib0084","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3945\/ajcn.114.105833","article-title":"Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults","volume":"102","author":"Smith","year":"2015","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"12","key":"10.1016\/j.archger.2026.106254_bib0085","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41580-024-00738-8","article-title":"SenNet recommendations for detecting senescent cells in different tissues","volume":"25","author":"Suryadevara","year":"2024","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"6","key":"10.1016\/j.archger.2026.106254_bib0086","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.04.010","article-title":"Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes","volume":"27","author":"Sutton","year":"2018","journal-title":"Cell Metabolism"},{"issue":"4","key":"10.1016\/j.archger.2026.106254_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction","volume":"21","author":"Thevaranjan","year":"2017","journal-title":"Cell Host & Microbe"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0088","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ijo.2015.242","article-title":"Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1\/GDF15","volume":"40","author":"Tsai","year":"2016","journal-title":"International Journal of Obesity (2005)"},{"issue":"8","key":"10.1016\/j.archger.2026.106254_bib0089","doi-asserted-by":"crossref","first-page":"471","DOI":"10.18632\/aging.100189","article-title":"p53, ROS and senescence in the control of aging","volume":"2","author":"Vigneron","year":"2010","journal-title":"Aging"},{"issue":"7341","key":"10.1016\/j.archger.2026.106254_bib0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"issue":"7548","key":"10.1016\/j.archger.2026.106254_bib0091","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.archger.2026.106254_bib0092","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"The New England Journal of Medicine"},{"issue":"5","key":"10.1016\/j.archger.2026.106254_bib0093","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13238-020-00814-7","article-title":"The role of the gut microbiome and its metabolites in metabolic diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Protein & Cell"},{"issue":"20","key":"10.1016\/j.archger.2026.106254_bib0094","doi-asserted-by":"crossref","first-page":"20571","DOI":"10.1074\/jbc.M400884200","article-title":"p53 involvement in the pathogenesis of fatty liver disease","volume":"279","author":"Yahagi","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"issue":"12","key":"10.1016\/j.archger.2026.106254_bib0095","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"The EMBO Journal"},{"issue":"2","key":"10.1016\/j.archger.2026.106254_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.12.003","article-title":"Expansion of islet-resident macrophages leads to inflammation affecting \u03b2 cell proliferation and function in obesity","volume":"29","author":"Ying","year":"2019","journal-title":"Cell Metabolism"},{"issue":"7329","key":"10.1016\/j.archger.2026.106254_bib0097","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:02:29Z","timestamp":1778590949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494326001238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":97,"alternative-id":["S0167494326001238"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2026.106254","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The metabolic-inflammatory axis in aging: A multi-organ framework anchored in Sarcopenia \u2014 A review","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2026.106254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106254"}}