{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:29:52Z","timestamp":1789028992767,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,5,17]],"date-time":"2027-05-17T00:00:00Z","timestamp":1810512000000},"content-version":"am","delay-in-days":228,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21de0107002h0003"],"award-info":[{"award-number":["JP21de0107002h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.archger.2026.106289","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:22:29Z","timestamp":1778023349000},"page":"106289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multimodal intervention benefits: Responder analysis of J-MINT PRIME Kanagawa trial"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8258-5158","authenticated-orcid":false,"given":"Yuhei","family":"Chiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6116-2269","authenticated-orcid":false,"given":"Keiko","family":"Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7483-9458","authenticated-orcid":false,"given":"Shoko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-0056","authenticated-orcid":false,"given":"Masataka","family":"Taguri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7459-0034","authenticated-orcid":false,"given":"Hiroko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0699-5868","authenticated-orcid":false,"given":"Kie","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-3439","authenticated-orcid":false,"given":"Asuka","family":"Yoshimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1432-6938","authenticated-orcid":false,"given":"Tadahisa","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-856X","authenticated-orcid":false,"given":"Kyoko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7002-5339","authenticated-orcid":false,"given":"Shunsaku","family":"Mizushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2158-9245","authenticated-orcid":false,"given":"Taro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9405-8235","authenticated-orcid":false,"given":"Akitoyo","family":"Hishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2369-3095","authenticated-orcid":false,"given":"Takashi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-6849","authenticated-orcid":false,"given":"Hidenori","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-3578","authenticated-orcid":false,"given":"Takeshi","family":"Asami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-782X","authenticated-orcid":false,"given":"Toshinari","family":"Odawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2026.106289_bib0001","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.trci.2019.06.005","article-title":"Disease severity and minimal clinically important differences in Alzheimer\u2019s disease","volume":"5","author":"Andrews","year":"2019","journal-title":"Alzheimer's & Dementia : The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.archger.2026.106289_bib0002","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1474-4422(17)30040-6","article-title":"Effect of long-term omega-3 supplementation with or without multidomain intervention (MAPT)","volume":"16","author":"Andrieu","year":"2017","journal-title":"The Lancet. Neurology"},{"key":"10.1016\/j.archger.2026.106289_bib0003","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.47948","article-title":"Consensus-harmonized neuropsychological assessment for vascular cognitive impairment","volume":"8","author":"Bentvelzen","year":"2025","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.archger.2026.106289_bib0004","series-title":"Classification and regression trees","author":"Breiman","year":"1984"},{"key":"10.1016\/j.archger.2026.106289_bib0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state.\u201d A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.archger.2026.106289_bib0006","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1447-0594.2010.00585.x","article-title":"Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment","volume":"10","author":"Fujiwara","year":"2010","journal-title":"Geriatrics & Gerontology International"},{"key":"10.1016\/j.archger.2026.106289_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164492","article-title":"Practice effects on story memory and list learning tests in the neuropsychological assessment of older adults","volume":"11","author":"Gavett","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.archger.2026.106289_bib0008","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/87565648709540361","article-title":"Genuine memory deficits in dementia","volume":"3","author":"Grober","year":"1987","journal-title":"Developmental Neuropsychology"},{"key":"10.1016\/j.archger.2026.106289_bib0009","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/13872877251344222","article-title":"Japan-multimodal intervention trial for the prevention of dementia in older people with lifestyle-related diseases: A community-based, 18-month, randomized controlled trial","volume":"106","author":"Ide","year":"2025","journal-title":"Journal of Alzheimer's disease : JAD"},{"key":"10.1016\/j.archger.2026.106289_bib0010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/oxfordjournals.aje.a009137","article-title":"A 5-year longitudinal study of the Mini-Mental State Examination in normal aging","volume":"145","author":"Jacqmin-Gadda","year":"1997","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.archger.2026.106289_bib0011","series-title":"Neuropsychological assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.archger.2026.106289_bib0012","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1186\/s12889-024-19164-8","article-title":"U-shaped relationship between non-HDL cholesterol and cognitive impairment","volume":"24","author":"Li","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.archger.2026.106289_bib0013","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000528120","article-title":"Effects of eligibility criteria on patient selection and treatment implications from 10 multidomain dementia prevention trials: A population-based study","volume":"57","author":"Licher","year":"2023","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.archger.2026.106289_bib0014","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet."},{"key":"10.1016\/j.archger.2026.106289_bib0015","first-page":"82","article-title":"Usefulness of a Japanese version of the mini-mental state test in neurological patients","volume":"1","author":"Mori","year":"1985","journal-title":"Jpn J Neuropsychol"},{"key":"10.1016\/j.archger.2026.106289_bib0016","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.amjmed.2015.06.017","article-title":"Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults","volume":"128","author":"Ng","year":"2015","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/j.archger.2026.106289_bib0017","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.archger.2026.106289_bib0018","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/archneur.65.7.963","article-title":"Detecting dementia with the mini-mental state examination in highly educated individuals","volume":"65","author":"O\u2019Bryant","year":"2008","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.archger.2026.106289_bib0019","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1089\/ars.2011.4498","article-title":"Oxygen consumption and oxidative stress during physical exercise","volume":"18","author":"Radak","year":"2013","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.archger.2026.106289_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/036107398244300","article-title":"Serum cholesterol levels as a measure of frailty in elderly patients","volume":"24","author":"Ranieri","year":"1998","journal-title":"Experimental Aging Research"},{"key":"10.1016\/j.archger.2026.106289_bib0021","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/alz.13838","article-title":"Japan-multimodal intervention trial for the prevention of dementia","volume":"20","author":"Sakurai","year":"2024","journal-title":"Alzheimer's & Dementia : The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.archger.2026.106289_bib0022","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(16)30950-3","article-title":"Effectiveness of a 6-year multidomain vascular care intervention (PreDIVA)","volume":"388","author":"Van Charante","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.archger.2026.106289_bib0023","series-title":"Wechsler memory scale\u2013revised","author":"Wechsler","year":"1987"},{"key":"10.1016\/j.archger.2026.106289_bib0024","series-title":"WAIS\u2013III: Wechsler adult intelligence scale\u2013third edition","author":"Wechsler","year":"1997"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:04:01Z","timestamp":1783116241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494326001597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":24,"alternative-id":["S0167494326001597"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2026.106289","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal intervention benefits: Responder analysis of J-MINT PRIME Kanagawa trial","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2026.106289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106289"}}