{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:18:41Z","timestamp":1788164321365,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071285"],"award-info":[{"award-number":["82071285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022505533"],"award-info":[{"award-number":["2022505533"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.archger.2026.106324","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:15:18Z","timestamp":1780586118000},"page":"106324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Microglial PICALM: A novel genetic driver and therapeutic target in vascular dementia"],"prefix":"10.1016","volume":"150","author":[{"given":"Zhaohui","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongchi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiesheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbiao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2026.106324_bib0001","doi-asserted-by":"crossref","unstructured":"A Genome-Wide Association Meta-Analysis of All-Cause and Vascular Dementia. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2024, 20(9):5973\u20135995.","DOI":"10.1002\/alz.14115"},{"issue":"2021","key":"10.1016\/j.archger.2026.106324_bib0002","article-title":"JAMIR-eQTL: Japanese genome-wide identification of microRNA expression quantitative trait loci across dementia types","volume":"2021","author":"Akiyama","year":"2021","journal-title":"Database : The Journal of Biological Databases and Curation"},{"issue":"6","key":"10.1016\/j.archger.2026.106324_bib0003","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00401-013-1111-z","article-title":"Clathrin adaptor CALM\/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains","volume":"125","author":"Ando","year":"2013","journal-title":"Acta Neuropathologica"},{"issue":"8081","key":"10.1016\/j.archger.2026.106324_bib0004","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41586-025-09272-9","article-title":"Whole-genome sequencing of 490,640 UK Biobank participants","volume":"645","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.archger.2026.106324_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Scientific Reports"},{"issue":"6","key":"10.1016\/j.archger.2026.106324_bib0006","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41588-020-0622-5","article-title":"Exploring and visualizing large-scale genetic associations by using PheWeb","volume":"52","author":"Gagliano Taliun","year":"2020","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/j.archger.2026.106324_bib0007","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41588-024-02050-9","article-title":"Cell state-dependent allelic effects and contextual mendelian randomization analysis for human brain phenotypes","volume":"57","author":"Haglund","year":"2025","journal-title":"Nature Genetics"},{"issue":"1","key":"10.1016\/j.archger.2026.106324_bib0008","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Nie Q: Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nature Communications"},{"key":"10.1016\/j.archger.2026.106324_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121007","article-title":"Environmental risk factors for all-cause dementia, Alzheimer's disease dementia, vascular dementia, and mild cognitive impairment: An umbrella review and meta-analysis","volume":"270","author":"Jones","year":"2025","journal-title":"Environmental Research"},{"issue":"1","key":"10.1016\/j.archger.2026.106324_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1389557519666190913145423","article-title":"Benzocaine: review on a drug with unfold potential","volume":"20","author":"Khair-ul-Bariyah","year":"2020","journal-title":"Mini Reviews in Medicinal Chemistry"},{"issue":"D1","key":"10.1016\/j.archger.2026.106324_bib0011","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Research"},{"issue":"2","key":"10.1016\/j.archger.2026.106324_bib0012","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1099800420951633","article-title":"Effect of obesity on cognitive impairment in vascular dementia rat model via BDNF-ERK-CREB pathway","volume":"23","author":"Kim","year":"2021","journal-title":"Biological Research for Nursing"},{"issue":"3","key":"10.1016\/j.archger.2026.106324_bib0013","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3233\/JAD-201046","article-title":"PICALM mRNA expression in the blood of patients with neurodegenerative diseases and geriatric depression","volume":"79","author":"Kumon","year":"2021","journal-title":"Journal of Alzheimer's Disease : JAD"},{"issue":"7944","key":"10.1016\/j.archger.2026.106324_bib0014","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"issue":"7944","key":"10.1016\/j.archger.2026.106324_bib0015","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"NatureNature"},{"issue":"1","key":"10.1016\/j.archger.2026.106324_bib0016","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.gene.2012.12.032","article-title":"Complex genetic susceptibility to vascular dementia and an evidence for its underlying genetic factors associated with memory and associative learning","volume":"516","author":"Lee","year":"2013","journal-title":"Gene"},{"issue":"1899","key":"10.1016\/j.archger.2026.106324_bib0017","article-title":"Cell type-specific functions of Alzheimer's disease endocytic risk genes","volume":"379","author":"Maninger","year":"2024","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"issue":"7912","key":"10.1016\/j.archger.2026.106324_bib0018","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-022-04713-1","article-title":"Single-cell eQTL models reveal dynamic T cell state dependence of disease loci","volume":"606","author":"Nathan","year":"2022","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.archger.2026.106324_bib0019","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.archger.2026.106324_bib0020","first-page":"1412","article-title":"Genetic determinants of vascular dementia","volume":"40","author":"Pathan","year":"2024","journal-title":"The Canadian Journal of Cardiology"},{"issue":"1","key":"10.1016\/j.archger.2026.106324_bib0021","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/mds.28283","article-title":"Association of PICALM with cognitive impairment in Parkinson's disease","volume":"36","author":"Peri\u00f1\u00e1n","year":"2021","journal-title":"Movement Disorders : Official Journal of the Movement Disorder Society"},{"issue":"4","key":"10.1016\/j.archger.2026.106324_bib0022","doi-asserted-by":"crossref","first-page":"437","DOI":"10.31887\/DCNS.2016.18.4\/cepperson","article-title":"Considering sex and gender in Alzheimer disease and other dementias","volume":"18","author":"Podcasy","year":"2016","journal-title":"Dialogues in Clinical Neuroscience"},{"issue":"12","key":"10.1016\/j.archger.2026.106324_bib0023","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(21)00249-0","article-title":"Amantadine in the treatment of Parkinson's disease and other movement disorders","volume":"20","author":"Rascol","year":"2021","journal-title":"The Lancet Neurology"},{"issue":"2","key":"10.1016\/j.archger.2026.106324_bib0024","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166134","article-title":"Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice","volume":"134","author":"Romay","year":"2024","journal-title":"The Journal of Clinical Investigation"},{"issue":"8","key":"10.1016\/j.archger.2026.106324_bib0025","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1091\/mbc.10.8.2687","article-title":"Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic","volume":"10","author":"Tebar","year":"1999","journal-title":"Molecular Biology of the Cell"},{"issue":"19","key":"10.1016\/j.archger.2026.106324_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2025.06.002","article-title":"Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications","volume":"188","author":"Tian","year":"2025","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.archger.2026.106324_bib0027","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1248\/bpb.31.1368","article-title":"Effects of serum concentrations of disopyramide and its metabolite mono-N-dealkyldisopyramide on the anticholinergic side effects associated with disopyramide","volume":"31","author":"Tsuchishita","year":"2008","journal-title":"Biological & Pharmaceutical Bulletin"},{"issue":"6220","key":"10.1016\/j.archger.2026.106324_bib0028","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.archger.2026.106324_bib0029","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Current Protocols"},{"key":"10.1016\/j.archger.2026.106324_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101734","article-title":"Vascular dementia: A microglia's perspective","volume":"81","author":"Yang","year":"2022","journal-title":"Ageing Research Reviews"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326001949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:05:48Z","timestamp":1788163548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494326001949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":30,"alternative-id":["S0167494326001949"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2026.106324","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial PICALM: A novel genetic driver and therapeutic target in vascular dementia","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2026.106324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106324"}}