{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:19:09Z","timestamp":1788164349822,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.archger.2026.106373","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:34:23Z","timestamp":1786322063000},"page":"106373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multidomain perioperative physiological vulnerability, longitudinal recovery patterns, and clinical outcomes after gastrointestinal cancer surgery in older adults"],"prefix":"10.1016","volume":"150","author":[{"given":"Shengjie","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8864-7688","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0001","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/sleep\/26.3.342","article-title":"The role of actigraphy in the study of sleep and circadian rhythms","volume":"26","author":"Ancoli-Israel","year":"2003","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.archger.2026.106373_bib0002","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Research"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5665\/sleep.3298","article-title":"Sleep health: Can we define it? Does it matter?","volume":"37","author":"Buysse","year":"2014","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0004","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0002-9610(80)90246-9","article-title":"Prognostic nutritional index in gastrointestinal surgery","volume":"139","author":"Buzby","year":"1980","journal-title":"American Journal of Surgery"},{"issue":"5","key":"10.1016\/j.archger.2026.106373_bib0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nature Methods"},{"issue":"8","key":"10.1016\/j.archger.2026.106373_bib0006","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.bbi.2007.04.002","article-title":"One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients","volume":"21","author":"Carlson","year":"2007","journal-title":"Brain Behaviour of Immunology"},{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0007","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"Journal of American Medicine Direct Association"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0008","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0009","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/bja\/85.1.109","article-title":"The stress response to trauma and surgery","volume":"85","author":"Desborough","year":"2000","journal-title":"Br Journal Anaesth"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0010","doi-asserted-by":"crossref","first-page":"769","DOI":"10.5665\/sleep.1872","article-title":"A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application","volume":"35","author":"Espie","year":"2012","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.archger.2026.106373_bib0011","first-page":"362","article-title":"Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology","volume":"67","author":"Ethun","year":"2017","journal-title":"CA Cancer Journal Clinical"},{"issue":"2","key":"10.1016\/j.archger.2026.106373_bib0012","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41568-019-0222-9","article-title":"How the ageing microenvironment influences tumour progression","volume":"20","author":"Fane","year":"2020","journal-title":"Nature Review Cancer"},{"issue":"9","key":"10.1016\/j.archger.2026.106373_bib0013","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nature Reviews. Cardiology"},{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0014","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: Evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"Journal Gerontology A Biology Science Medicine Science"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0015","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0016","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00268-018-4844-y","article-title":"Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery Society recommendations: 2018","volume":"43","author":"Gustafsson","year":"2019","journal-title":"World Journal Surgery"},{"issue":"9920","key":"10.1016\/j.archger.2026.106373_bib0017","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"issue":"2065","key":"10.1016\/j.archger.2026.106373_bib0018","article-title":"Principal component analysis: A review and recent developments","volume":"374","author":"Jolliffe","year":"2016","journal-title":"Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences"},{"issue":"5\u20136","key":"10.1016\/j.archger.2026.106373_bib0019","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11357-018-0042-y","article-title":"A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: Report from the TAME Biomarkers Workgroup","volume":"40","author":"Justice","year":"2018","journal-title":"Geroscience"},{"issue":"4","key":"10.1016\/j.archger.2026.106373_bib0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: Linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"issue":"208","key":"10.1016\/j.archger.2026.106373_bib0021","article-title":"Sleep fragmentation and the risk of incident Alzheimer\u2019s disease and cognitive decline in older persons","volume":"5","author":"Lim","year":"2013","journal-title":"Science Translation of Medicine"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0022","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0023","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jamcollsurg.2010.01.028","article-title":"Frailty as a predictor of surgical outcomes in older patients","volume":"210","author":"Makary","year":"2010","journal-title":"Journal of American Coll Surgery"},{"issue":"11","key":"10.1016\/j.archger.2026.106373_bib0024","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/gps.4823","article-title":"Delirium pathophysiology: An updated hypothesis of the etiology of acute brain failure","volume":"33","author":"Maldonado","year":"2018","journal-title":"International Journal of Geriatr Psychiatry"},{"issue":"15","key":"10.1016\/j.archger.2026.106373_bib0025","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJMcp1605501","article-title":"Delirium in hospitalized older adults","volume":"377","author":"Marcantonio","year":"2017","journal-title":"N England Journal of Medicine"},{"issue":"2","key":"10.1016\/j.archger.2026.106373_bib0026","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/SLA.0000000000002967","article-title":"Frailty as a predictor of death or new disability after surgery: A prospective cohort study","volume":"271","author":"McIsaac","year":"2020","journal-title":"Annual Surgery"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0027","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.anes.0000296071.19434.1e","article-title":"Predictors of cognitive dysfunction after major noncardiac surgery","volume":"108","author":"Monk","year":"2008","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0028","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short-chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"issue":"10","key":"10.1016\/j.archger.2026.106373_bib0029","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/bjs.9582","article-title":"Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery after Surgery Society recommendations","volume":"101","author":"Mortensen","year":"2014","journal-title":"Br Journal of Surgery"},{"key":"10.1016\/j.archger.2026.106373_bib0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.clinpsy.121208.131413","article-title":"Group-based trajectory modeling in clinical research","volume":"6","author":"Nagin","year":"2010","journal-title":"Annual Review Clinical Psychology"},{"issue":"4","key":"10.1016\/j.archger.2026.106373_bib0031","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"10.1016\/j.archger.2026.106373_bib0032","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0885-3924(02)00508-0","article-title":"The cancer anorexia-cachexia syndrome: A survey of the Prognostic Inflammatory and Nutritional Index in advanced disease","volume":"24","author":"Nelson","year":"2002","journal-title":"Journal Pain Symptoms Management"},{"issue":"6265","key":"10.1016\/j.archger.2026.106373_bib0033","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aac8469","article-title":"Gut microbiota and aging","volume":"350","author":"O\u2019Toole","year":"2015","journal-title":"Science (New York, N.Y.)"},{"issue":"2","key":"10.1016\/j.archger.2026.106373_bib0034","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Medicine"},{"issue":"10","key":"10.1016\/j.archger.2026.106373_bib0035","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.clinph.2007.04.019","article-title":"Updating P300: An integrative theory of P3a and P3b","volume":"118","author":"Polich","year":"2007","journal-title":"Clinical Neurophysiology"},{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0036","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MOG.0000000000000057","article-title":"Bile acids and the gut microbiome","volume":"30","author":"Ridlon","year":"2014","journal-title":"Current Opinion of Gastroenterology"},{"issue":"7","key":"10.1016\/j.archger.2026.106373_bib0037","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41577-018-0008-4","article-title":"Clocking in to immunity","volume":"18","author":"Scheiermann","year":"2018","journal-title":"Nature Review Immunology"},{"issue":"6145","key":"10.1016\/j.archger.2026.106373_bib0038","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic regulatory T-cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.archger.2026.106373_bib0039","first-page":"164","article-title":"The microbiome in depressive and anxiety disorders","volume":"82","author":"Smith","year":"2017","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.archger.2026.106373_bib0040","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s00432-014-1714-3","article-title":"The prognostic significance of the prognostic nutritional index in cancer: A systematic review and meta-analysis","volume":"140","author":"Sun","year":"2014","journal-title":"Journal of Cancer Research of Clinical Oncology"},{"issue":"3","key":"10.1016\/j.archger.2026.106373_bib0041","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cell.2014.09.048","article-title":"Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis","volume":"159","author":"Thaiss","year":"2014","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.archger.2026.106373_bib0042","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.mad.2008.09.013","article-title":"Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty","volume":"129","author":"Varadhan","year":"2008","journal-title":"Mech Ageing Development"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0043","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0272989X06295361","article-title":"Decision curve analysis: A novel method for evaluating prediction models","volume":"26","author":"Vickers","year":"2006","journal-title":"Medicine of Decision Making"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0044","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"B\u00e4ckhed F. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.archger.2026.106373_bib0045","doi-asserted-by":"crossref","first-page":"8998","DOI":"10.1245\/s10434-025-18313-6","article-title":"Synergistic effects of psychological resilience training and nutritional support on postoperative recovery, nutritional reconstitution, sleep quality, and long-term survival in gastric cancer: A randomized controlled trial","volume":"32","author":"Wang","year":"2025","journal-title":"Annual Surgery of Oncology"},{"key":"10.1016\/j.archger.2026.106373_bib0046","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s12094-025-04101-x","article-title":"Integrated sleep and psychological interventions enhance postoperative recovery and quality of life in colorectal cancer: A randomized controlled trial","volume":"28","author":"Wang","year":"2025","journal-title":"Clin Translation Oncology"},{"issue":"4","key":"10.1016\/j.archger.2026.106373_bib0047","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/sim.4067","article-title":"Multiple imputation using chained equations: Issues and guidance for practice","volume":"30","author":"White","year":"2011","journal-title":"Stat Medicine"},{"issue":"1","key":"10.1016\/j.archger.2026.106373_bib0048","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12866-019-1616-2","article-title":"Aging progression of human gut microbiota","volume":"19","author":"Xu","year":"2019","journal-title":"BMC Microbiology"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0049","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital Anxiety and Depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"10.1016\/j.archger.2026.106373_bib0050","first-page":"611","article-title":"Anticancer effects of the microbiome and its products","volume":"14","author":"Zitvogel","year":"2017","journal-title":"Nature Reviews. Clinical Oncology"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326002426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494326002426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:07:59Z","timestamp":1788163679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494326002426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":50,"alternative-id":["S0167494326002426"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2026.106373","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidomain perioperative physiological vulnerability, longitudinal recovery patterns, and clinical outcomes after gastrointestinal cancer surgery in older adults","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2026.106373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106373"}}