{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:23:28Z","timestamp":1771943008269,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.archoralbio.2004.04.010","type":"journal-article","created":{"date-parts":[[2004,6,25]],"date-time":"2004-06-25T12:30:56Z","timestamp":1088166656000},"page":"945-950","source":"Crossref","is-referenced-by-count":18,"title":["Expression of growth factors in the gingival crevice fluid of patients with phenytoin-induced gingival enlargement"],"prefix":"10.1016","volume":"49","author":[{"given":"L.","family":"Kuru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.N.","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dc.","family":"Noyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.archoralbio.2004.04.010_BIB1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1001\/jama.1938.02790380010004","article-title":"Sodium diphenylhydantoine in the treatment of convulsive disorders","volume":"111","author":"Merritt","year":"1938","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1600-0757.1999.tb00175.x","article-title":"The role of drugs in the pathogenesis of gingival overgrowth","volume":"21","author":"Hallmon","year":"1999","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/0030-4220(72)90228-9","article-title":"Incidence of diphenylhydantoin gingival hyperplasia","volume":"34","author":"Angelopoulos","year":"1972","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1600-051X.1986.tb02241.x","article-title":"The effect of a plaque control program on the development of phenytoin-induced gingival overgrowth. A 2-year longitudinal study","volume":"13","author":"Dahll\u00f6f","year":"1986","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0714.1991.tb00419.x","article-title":"On the mechanism of drug-induced gingival hyperplasia","volume":"20","author":"Brown","year":"1991","journal-title":"J. Oral. Pathol. Med."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB6","first-page":"43","article-title":"The ultrastructural comparison of phenytoin and cyclosporin A-induced gingival hyperplasia","volume":"1","author":"Noyan","year":"1991","journal-title":"J. Marmara Univ. Dent. Fac."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1600-0765.1996.tb00519.x","article-title":"Immunohistochemical localization of transforming growth factor beta, basic fibroblast growth factor and heparan sulphate glycosaminoglycan in gingival hyperplasia induced by nifedipine and phenytoin","volume":"31","author":"Saito","year":"1996","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1902\/jop.1997.68.1.73","article-title":"Phenytoin and cyclosporine A specifically regulate macrophage and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible mechanism of drug-induced overgrowth","volume":"68","author":"Iacopino","year":"1997","journal-title":"J. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1902\/jop.1993.64.3.169","article-title":"Phenytoin increases gene expression for platelet-derived growth factor B chain in macrophages and monocytes","volume":"64","author":"Dill","year":"1993","journal-title":"J. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0714.1995.tb01142.x","article-title":"Heterogeneity of fibroblasts derived from human free and attached gingiva. Glycosaminoglycan synthesis and effects of phenytoin (PHT) treatment","volume":"24","author":"Pagliarini","year":"1995","journal-title":"J. Oral. Pathol. Med."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/10454411930040050401","article-title":"Role of growth factors in cutaneous wound healing: a review","volume":"4","author":"Kiritsy","year":"1993","journal-title":"Crit. Rev. Oral. Biol. Med."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB12","doi-asserted-by":"crossref","unstructured":"Sporn MB, Roberts AB. Polypeptide growth factors and their receptors. New York: Springer-Verlag; 1991.","DOI":"10.1007\/978-1-4612-3210-0"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB13","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2741\/A812","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front Biosci."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0360-3016(94)90187-2","article-title":"Early alterations in extracellular matrix and transforming growth factor \u03b2 gene expression in mouse lung indicative of late radiation fibrosis","volume":"28","author":"Finkelstein","year":"1994","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2741\/A798","article-title":"Molecular aspects of scleroderma","volume":"7","author":"Trojanowska","year":"2002","journal-title":"Front Biosci."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1600-051X.1985.tb01377.x","article-title":"The effects of phentoin and sodium valproate on the periodontal health of adult epileptic patients","volume":"12","author":"Seymour","year":"1985","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition","volume":"22","author":"L\u00f6e","year":"1964","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB18","first-page":"121","article-title":"Periodontal disease in pregnancy. I. Prevalance and severity","volume":"22","author":"L\u00f6e","year":"1963","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0765.1988.tb01024.x","article-title":"Selection of a filter paper with optimum properties for the collection of gingival crevicular fluid","volume":"23","author":"Griffiths","year":"1988","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB20","doi-asserted-by":"crossref","unstructured":"Cimasoni G, Giannopoulou C. Can crevicular fluid component analysis assist in diagnosis and monitoring periodontal breakdown? In: Guggenheim B, editor. Periodontology today. Basel: Karger; 1988. p. 260\u201370.","DOI":"10.1159\/000416663"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB21","doi-asserted-by":"crossref","unstructured":"Kuru L, Griffiths GS, Petrie A, Olsen I. Changes in transforming growth factor-beta 1 in gingival crevicular fluid following periodontal surgery. J Clin Periodontol 2004 (in press).","DOI":"10.1111\/j.1600-051x.2004.00521.x"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB22","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1016\/S0021-9258(18)32345-7","article-title":"Transforming growth factor beta in human platelets. Identification of a major storage site, purification, and characterization","volume":"258","author":"Assoian","year":"1983","journal-title":"J. Biol. Chem."},{"issue":"Suppl","key":"10.1016\/j.archoralbio.2004.04.010_BIB23","first-page":"S672","article-title":"Growth factors in periodontal regeneration","volume":"18","author":"Graves","year":"1994","journal-title":"Compend. Contin. Educ. Dent."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1378\/chest.125.2.754","article-title":"The role of transforming growth factor beta in lung development and disease","volume":"125","author":"Bartram","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1053\/S0270-9295(03)00132-3","article-title":"Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up","volume":"23","author":"Chen","year":"2003","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB26","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1046\/j.1440-1746.2003.03162.x","article-title":"Parenchymal transforming growth factor beta-1: its type II receptor and Smad signaling pathway correlate with inflammation and fibrosis in chronic liver disease of viral etiology","volume":"18","author":"Calabrese","year":"2003","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB27","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1902\/jop.2001.72.4.526","article-title":"Evaluation of transforming growth factor-\u03b21 level in gingival crevicular fluid of cyclosporine A-treated patients","volume":"72","author":"Buduneli","year":"2001","journal-title":"J. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB28","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1902\/jop.2002.73.11.1313","article-title":"Expression of matrix metalloproteinases in cyclosporin-treated gingival fibroblasts is regulated by transforming growth factor (TGF)-beta1 autocrine stimulation","volume":"73","author":"Cotrim","year":"2002","journal-title":"J. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(86)90733-6","article-title":"The biology of platelet-derived growth factor","volume":"4","author":"Ross","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev.me.42.020191.003031","article-title":"Growth factors and wound healing: platelet-derived growth factor as a model cytokine","volume":"42","author":"Deuel","year":"1991","journal-title":"Ann. Rev. Med."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1034\/j.1600-0757.2003.03103.x","article-title":"Formation, collection and significance of gingival crevice fluid","volume":"31","author":"Griffiths","year":"2003","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-051X.1998.tb02362.x","article-title":"Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth","volume":"25","author":"Sasaki","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/00220345980770040801","article-title":"Flow cytometry analysis of gingival and periodontal ligament cells","volume":"77","author":"Kuru","year":"1998","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB34","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1902\/jop.2001.72.8.1016","article-title":"Flow cytometry analysis of regenerative human periodontal cells","volume":"72","author":"Kuru","year":"2001","journal-title":"J. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-0757.1993.tb00232.x","article-title":"Aspects of cell biology of the normal periodontium","volume":"3","author":"Hefti","year":"1993","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB36","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1600-051X.1994.tb00793.x","article-title":"Some microbiological, histopathological and immunohistochemical characteristics of progressive periodontal disease","volume":"21","author":"Liljenberg","year":"1994","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1902\/jop.2003.74.3.323","article-title":"Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients","volume":"74","author":"Pinheiro","year":"2003","journal-title":"J. Periodontol."},{"key":"10.1016\/j.archoralbio.2004.04.010_BIB38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0722.1997.tb00192.x","article-title":"Changes in TGF-beta 1 levels in gingiva, crevicular fluid and serum associated with periodontal inflammation in humans and dogs","volume":"105","author":"Skaleric","year":"1997","journal-title":"Eur. J. Oral. Sci."}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996904001013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996904001013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T19:22:53Z","timestamp":1624476173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996904001013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0003996904001013"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2004.04.010","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}