{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:04Z","timestamp":1788397384973,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.archoralbio.2011.03.013","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T20:20:41Z","timestamp":1303417241000},"page":"1055-1063","source":"Crossref","is-referenced-by-count":7,"title":["Selective killing of Aggregatibacter actinomycetemcomitans by ciprofloxacin during development of a dual species biofilm with Streptococcus sanguinis"],"prefix":"10.1016","volume":"56","author":[{"given":"Peter","family":"Suci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archoralbio.2011.03.013_bib0005","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-0757.2005.00138.x","article-title":"Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease","volume":"40","author":"Southerland","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0010","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Mechanisms of disease \u2013 Nuclear factor \u03baB \u2013 A pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nri1786","article-title":"Lymphoid neogenesis in chronic inflammatory diseases","volume":"6","author":"Aloisi","year":"2006","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-302x.2000.150301.x","article-title":"Protective and destructive immune reactions in apical periodontitis","volume":"15","author":"Marton","year":"2000","journal-title":"Oral Microbiology and Immunology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0025","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2249.2006.03260.x","article-title":"The dual role of p55 tumor necrosis factor-\u03b1 receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction","volume":"147","author":"Garlet","year":"2007","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1902\/jop.2005.76.11-S.2033","article-title":"Immune response: the key to bone resorption in periodontal disease","volume":"76","author":"Taubman","year":"2005","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1600-0765.2008.01133.x","article-title":"Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection","volume":"44","author":"Trombone","year":"2009","journal-title":"Journal of Periodontal Research"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2004.02.005","article-title":"Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases","volume":"93","author":"Tlaskalova-Hogenova","year":"2004","journal-title":"Immunology Letters"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0045","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1126\/science.289.5484.1560","article-title":"Prokaryotic regulation of epithelial responses by inhibition of I \u03baB-alpha ubiquitination","volume":"289","author":"Neish","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1034\/j.1600-0757.2002.03004.x","article-title":"Beneficial bacteria of the periodontium","volume":"30","author":"Roberts","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1875-595X.2004.tb00246.x","article-title":"Topical and systemic antibiotics in the management of periodontal diseases","volume":"54","author":"Mombelli","year":"2004","journal-title":"International Dental Journal"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1399-302X.2008.00478.x","article-title":"Effects of oral commensal and pathogenic bacteria on human dendritic cells","volume":"24","author":"Chino","year":"2009","journal-title":"Oral Microbiology and Immunology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1399-302X.2008.00473.x","article-title":"Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17","volume":"24","author":"Beklen","year":"2009","journal-title":"Oral Microbiology and Immunology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0070","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1600-051X.1986.tb01485.x","article-title":"Pathogenesis of periodontitis","volume":"13","author":"Listgarten","year":"1986","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1600-0765.1996.tb00484.x","article-title":"Clinical, microbiological and immunological profile of healthy, gingivitis and putative active periodontal subjects","volume":"31","author":"Tanner","year":"1996","journal-title":"Journal of Periodontal Research"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-0757.2002.280102.x","article-title":"Dental biofilms: difficult therapeutic targets","volume":"28","author":"Socransky","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ctrv.2004.03.002","article-title":"Adding gram-positive prophylaxis to fluoroquinolone regimens reduces streptococcal bacteraemias, but prophylaxis remains controversial","volume":"30","author":"Avery","year":"2004","journal-title":"Cancer Treatment Reviews"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0924-8579(00)00192-8","article-title":"The fluoroquinolone antibacterials: past, present and future perspectives","volume":"16","author":"Appelbaum","year":"2000","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jac\/45.1.31","article-title":"Comparative in vitro activity of moxifloxacin against gram-positive clinical isolates","volume":"45","author":"Hoogkamp-Korstanje","year":"2000","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0100","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1034\/j.1600-051X.2002.290810.x","article-title":"In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics","volume":"29","author":"Muller","year":"2002","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0105","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-0757.2006.00189.x","article-title":"How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases","volume":"42","author":"Fine","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.micro.57.030502.090908","article-title":"Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans","volume":"57","author":"Henderson","year":"2003","journal-title":"Annual Review of Microbiology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0115","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0140-6736(01)05321-1","article-title":"Antibiotic resistance of bacteria in biofilms","volume":"358","author":"Stewart","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2958.2006.05099.x","article-title":"Streptococcus gordonii utilizes several distinct gene functions to recruit Porphyromonas gingivalis into a mixed community","volume":"60","author":"Kuboniwa","year":"2006","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0125","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/154405910408301013","article-title":"In situ biofilm formation by multi-species oral bacteria under flowing and anaerobic conditions","volume":"83","author":"Filoche","year":"2004","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0130","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1128\/IAI.00345-09","article-title":"Aggregatibacter actinomycetemcomitans builds mutualistic biofilm communities with Fusobacterium nucleatum and Veillonella species in saliva","volume":"77","author":"Periasamy","year":"2009","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0135","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1073\/pnas.0809533106","article-title":"Polymicrobial interactions stimulate resistance to host innate immunity through metabolite perception","volume":"106","author":"Ramsey","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0140","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1128\/IAI.00338-08","article-title":"Identification of Streptococcus sanguinis genes required for biofilm formation and examination of their role in endocarditis virulence","volume":"76","author":"Ge","year":"2008","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0145","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1128\/AAC.00059-10","article-title":"Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm","volume":"54","author":"Suci","year":"2010","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0150","first-page":"335","article-title":"Monoclonal antibodies for the rapid identification in clinical samples of Peptostreptococcus micros and Actinobacillus actinomycetemcomitans serotypes, a, d, and e","volume":"5","author":"Gm\u00fcr","year":"1996","journal-title":"Medical Microbiology Letters"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0155","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1128\/IAI.56.5.1150-1157.1988","article-title":"Cloning of a Streptococcus sanguis adhesin which mediates binding to saliva-coated hydroxyapatite","volume":"56","author":"Ganeshkumar","year":"1988","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0160","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/jac\/dkn464","article-title":"High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms","volume":"63","author":"Flemming","year":"2009","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0165","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1163\/156856200744408","article-title":"The use of immunoliposomes for specific delivery of antimicrobial agents to oral bacteria immobilized on polystyrene","volume":"11","author":"Robinson","year":"2000","journal-title":"Journal of Biomaterials Science-Polymer Edition"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0170","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1128\/AAC.49.9.3690-3696.2005","article-title":"Development of a novel targeting system for lethal photo sensitization of antibiotic-resistant strains of Staphylococcus aureus","volume":"49","author":"Embleton","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0175","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1902\/jop.2004.75.1.169","article-title":"Specific antibiotics in the treatment of periodontitis-a proposed strategy","volume":"75","author":"Beikler","year":"2004","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0180","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.14219\/jada.archive.2000.0087","article-title":"Nonsurgical periodontal therapy in 2000: a literature review","volume":"131","author":"Greenstein","year":"2000","journal-title":"Journal of the American Dental Association"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0185","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1902\/jop.2000.71.9.1448","article-title":"Gingival fluid ciprofloxacin levels at healthy and inflamed human periodontal sites","volume":"71","author":"Conway","year":"2000","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0190","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.14219\/jada.archive.2004.0127","article-title":"Serum and gingival crevicular fluid levels of ciprofloxacin in patients with periodontitis","volume":"135","author":"Tozum","year":"2004","journal-title":"Journal of the American Dental Association"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0195","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1902\/jop.1999.70.8.888","article-title":"Resistance profile survey of 50 periodontal strains of Actinobacillus actinomycetemcomitans","volume":"70","author":"Madinier","year":"1999","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0200","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1902\/jop.2008.070493","article-title":"Moxifloxacin as an adjunctive antibiotic in the treatment of severe chronic periodontitis","volume":"79","author":"Guentsch","year":"2008","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0205","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1902\/jop.2000.71.2.202","article-title":"Fluoroquinolones in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis","volume":"71","author":"Kleinfelder","year":"2000","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/dkl452","article-title":"Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures","volume":"59","author":"Takahashi","year":"2007","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0215","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/IAI.55.3.686-691.1987","article-title":"A Bacteriocin of Actinobacillus actinomycetemcomitans","volume":"55","author":"Hammond","year":"1987","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1099\/jmm.0.46844-0","article-title":"Evaluation of different iron sources and their influence in biofilm formation by the dental pathogen Actinobacillus actinomycetemcomitans","volume":"56","author":"Rhodes","year":"2007","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0225","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1128\/JB.185.4.1399-1404.2003","article-title":"Biofilm growth and detachment of Actinobacillus actinomycetemcomitans","volume":"185","author":"Kaplan","year":"2003","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.archoralbio.2011.03.013_bib0230","first-page":"9","article-title":"Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay","author":"Tamayo","year":"2009","journal-title":"BMC Microbiology"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911000938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911000938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T08:50:18Z","timestamp":1712393418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996911000938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0003996911000938"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2011.03.013","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}