{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:03:09Z","timestamp":1768482189120,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.archoralbio.2011.05.007","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T11:37:44Z","timestamp":1309174664000},"page":"1238-1246","source":"Crossref","is-referenced-by-count":31,"title":["Effect of PGE2 induced by compressive and tensile stresses on cementoblast differentiation in vitro"],"prefix":"10.1016","volume":"56","author":[{"given":"Emanuel Braga","family":"Rego","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Inubushi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Kawazoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tanne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.archoralbio.2011.05.007_bib0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0021-9290(94)00035-2","article-title":"Spatial organization of the haversian bone in man","volume":"29","author":"Petrtyl","year":"1996","journal-title":"J Biomech"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/8756-3282(96)00028-2","article-title":"In vivo measurement of human tibial strains during vigorous activity","volume":"18","author":"Burr","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1359\/jbmr.2002.17.1.77","article-title":"The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation","volume":"17","author":"Everts","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1359\/jbmr.2000.15.2.301","article-title":"Is BMU-coupling a strain-regulated phenomenon?. A finite element analysis","volume":"15","author":"Smit","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0025","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1359\/jbmr.2002.17.11.2021","article-title":"A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment","volume":"17","author":"Smit","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0030","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ajodo.2005.12.013","article-title":"Current concepts in the biology of orthodontic tooth movement","volume":"129","author":"Masella","year":"2006","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0035","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/0022034508330861","article-title":"Orthodontic force stimulates eNOS and iNOS in rat osteocytes","volume":"88","author":"Tan","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ajodo.2004.02.010","article-title":"Repair of orthodontically induced root resorption by ultrasound in humans","volume":"126","author":"El-Bialy","year":"2004","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0045","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ultrasmedbio.2010.03.008","article-title":"Ultrasound stimulation induces PGE2 synthesis promoting cementoblastic differentiation through EP2\/EP4 receptor pathway","volume":"36","author":"Rego","year":"2010","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0050","series-title":"The periodontium: oral histology, development, structure and function","author":"Ten Cate","year":"2003"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/ejo\/2.4.197-a","article-title":"Root resorption, marginal bone support and clinical crown length in orthodontically treated patients","volume":"2","author":"Hollender","year":"1980","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ejo\/10.1.30","article-title":"Evaluation of the risk of root resorption during orthodontic treatment: a study of upper incisors","volume":"10","author":"Levander","year":"1988","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0889-5406(05)81678-6","article-title":"Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment","volume":"99","author":"Linge","year":"1991","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ejo\/16.3.223","article-title":"Evaluation of root resorption in relation to two orthodontic treatment regimes. A clinical experimental study","volume":"16","author":"Levander","year":"1994","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0075","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0889-5406(96)80015-1","article-title":"Time related root resorption after application of a controlled continuous orthodontic force","volume":"110","author":"Kurol","year":"1996","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0080","first-page":"9","article-title":"Tooth resorption","volume":"30","author":"Rita","year":"1999","journal-title":"Quint Int"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/17453679308994530","article-title":"Effect of local prostaglandin E2 on fracture callus in rabbits","volume":"64","author":"Keller","year":"1993","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0765.1994.tb01097.x","article-title":"Local delivery of prostaglandin E1 induces periodontal regeneration in adult dogs","volume":"29","author":"Marks","year":"1994","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0095","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.archoralbio.2005.03.009","article-title":"Local application of prostaglandin E2 reduces trap, calcitonin receptor and metalloproteinase-2 immunoreactivity in the rat periodontium","volume":"50","author":"Ramirez-Y\u00e3nes","year":"2005","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1902\/jop.2005.76.2.303","article-title":"Prostaglandin E2 and F2alpha enhance differentiation of cementoblastic cells","volume":"76","author":"Camargo","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0105","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/03008200701541775","article-title":"Effect of compressive force on the production of prostaglandin E(2) and its receptors in osteoblastic Saos-2 cells","volume":"48","author":"Sanuki","year":"2007","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0110","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1146\/annurev.pharmtox.41.1.661","article-title":"Prostanoid receptors: subtypes and signaling","volume":"41","author":"Breyer","year":"2001","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0115","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00264-007-0406-x","article-title":"Prostaglandin E2 receptors in bone formation","volume":"31","author":"Li","year":"2007","journal-title":"Int Orthop"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/mol.60.1.36","article-title":"Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE2","volume":"60","author":"Machwate","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0125","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1073\/pnas.062053399","article-title":"Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation","volume":"99","author":"Yoshida","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1098-8823(03)00049-2","article-title":"Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures","volume":"71","author":"Raisz","year":"2003","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0135","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/jbmr.5650110909","article-title":"Anabolic effects of prostaglandins in cultured fetal calvarie: structure-activity relations and signal transduction pathway","volume":"9","author":"Woodiel","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0140","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bone.2004.01.002","article-title":"Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local up-regulation of bone turnover in mature rats","volume":"34","author":"Tanaka","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0145","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bone.2007.06.013","article-title":"Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation","volume":"41","author":"Nakagawa","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.prostaglandins.2008.02.001","article-title":"Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to prostaglandin E2 and a selective EP2 receptor agonist","volume":"86","author":"Choudhary","year":"2008","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0155","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bone.2009.02.010","article-title":"EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures","volume":"44","author":"Minamizaki","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0160","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/154405910508400501","article-title":"Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?","volume":"84","author":"Bosshardt","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1902\/jop.2000.71.1.63","article-title":"Employing a transgenic animal model to obtain cementoblasts in vitro","volume":"71","author":"D\u0301Errico","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0170","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1600-0765.1999.tb02276.x","article-title":"Evolution of periodontal regeneration: from the root's point of view","volume":"34","author":"Somerman","year":"1999","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/154405910308200106","article-title":"Bone morphogenetic protein-2 inhibits differentiation and mineralization of cementoblasts in vitro","volume":"82","author":"Zhao","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0180","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.lfs.2005.03.037","article-title":"Optimal compressive force induces bone formation via increasing bone sialoprotein and prostaglandin E2 production appropriately","volume":"77","author":"Mitsui","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0722.2010.00710.x","article-title":"Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system","volume":"118","author":"Lin","year":"2010","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0190","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00056-010-1031-7","article-title":"Contribution of orthodontic load to inflammation-mediated periodontal destruction","volume":"71","author":"Nokhbehsaim","year":"2010","journal-title":"J Orofac Orthop"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0195","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1902\/jop.2008.080081","article-title":"Effects of ultrasound on the proliferation and differentiation of cementoblast lineage cells","volume":"79","author":"Inubushi","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jcp.1041280204","article-title":"Prostaglandin E2 stimulates DNA synthesis by a cyclic AMP-independent pathway in osteoblastic clone MC3T3-E1 cells","volume":"128","author":"Hakeda","year":"1986","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0205","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3181\/00379727-80-19661","article-title":"A simple and sensitive histochemical method for calcium","volume":"80","author":"Dahl","year":"1952","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0210","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1359\/jbmr.081102","article-title":"Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts","volume":"3","author":"Young","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0215","first-page":"751","article-title":"Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain","volume":"273","author":"Smalt","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0220","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1152\/ajpendo.00501.2002","article-title":"Interactive effects of PTH and mechanical stress on nitric oxide and PGE2 production by primary mouse osteoblastic cells","volume":"285","author":"Bakker","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0225","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S8756-3282(99)00220-3","article-title":"Anabolic effect of prostaglandin E2 on cortical bone of aged male rats comes mainly from modeling-dependent bone gain","volume":"25","author":"Yao","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0230","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1677\/joe.0.1680131","article-title":"Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro","volume":"168","author":"Keila","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0235","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0003-9969(98)00079-X","article-title":"Role of epidermal growth factor and its receptor in mechanical stress-induced differentiation of human periodontal ligament cells in vitro","volume":"43","author":"Matsuda","year":"1998","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0240","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/10454411010120050401","article-title":"Effect of mechanical loading on periodontal cells","volume":"12","author":"Pavlin","year":"2001","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0245","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF01621888","article-title":"Prostaglandins: mechanisms of action and regulation of production in bone","volume":"1","author":"Raisz","year":"1993","journal-title":"Osteoporos Int Suppl"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0250","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/jbmr.5650110913","article-title":"DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated and labeling","volume":"11","author":"Bronckers","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0255","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclatogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0260","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1902\/jop.2004.75.9.1247","article-title":"The role of parathyroid hormone-related protein in the regulation of osteoclastogenesis by cementoblasts","volume":"75","author":"Boabaid","year":"2004","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0265","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1600-0722.2007.00469.x","article-title":"Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans","volume":"115","author":"Garlet","year":"2007","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0270","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.archoralbio.2007.10.007","article-title":"Prostaglandin E2 inhibits mineralization and enhances matrix metalloproteinase-13 in mature cementoblasts mainly via the EP4 pathway","volume":"53","author":"Oka","year":"2008","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0275","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1177\/154405910708601011","article-title":"PGE2 activates cementoclastogenesis by cementoblasts via EP4","volume":"86","author":"Oka","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0280","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1902\/jop.2006.060148","article-title":"Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30)","volume":"77","author":"Mada","year":"2006","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2011.05.007_bib0285","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1182\/blood-2005-07-2772","article-title":"Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses","volume":"107","author":"Feng","year":"2006","journal-title":"Blood"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911001610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911001610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T05:09:19Z","timestamp":1712552959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996911001610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0003996911001610"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2011.05.007","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}