{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:10:13Z","timestamp":1769238613703,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015060","name":"Nagasaki University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.archoralbio.2011.07.006","type":"journal-article","created":{"date-parts":[[2011,8,7]],"date-time":"2011-08-07T10:06:09Z","timestamp":1312711569000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice"],"prefix":"10.1016","volume":"57","author":[{"given":"Masako","family":"Yoshimatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kitaura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Kohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.archoralbio.2011.07.006_bib0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0962-8924(00)01856-0","article-title":"The molecular basis of T helper 1 and T helper 2 cell differentiation","volume":"10","author":"O\u2019Garra","year":"2000","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0015","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.166.8.4915","article-title":"IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro","volume":"166","author":"Horwood","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0020","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S8756-3282(02)00722-6","article-title":"Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity","volume":"30","author":"Yamada","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0025","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/jcp.20563","article-title":"Interleukin (IL)-12 mediates the anti-osteoclastogenic activity of CpG-oligodeoxynucleotides","volume":"207","author":"Amcheslavsky","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/jcb.22104","article-title":"IL-12 stimulates the osteoclast inhibitory peptide-1 (OIP-1\/hSca) gene expression in CD4+ T cells","volume":"107","author":"Shanmugarajan","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0035","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.archoralbio.2004.09.001","article-title":"Mechanical deformation inhibits IL-10 and stimulates IL-12 production by mouse calvarial osteoblasts in vitro","volume":"50","author":"Garcia-Lopez","year":"2005","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cyto.2005.02.007","article-title":"Interleukin-12 and interleukin-16 in periodontal disease","volume":"31","author":"Tsai","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0045","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1600-0501.2008.01680.x","article-title":"Differential cytokine expressions affect the severity of peri-implant disease","volume":"20","author":"Duarte","year":"2009","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0050","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.4049\/jimmunol.169.9.4732","article-title":"Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: apoptosis mediated by Fas\/Fas ligand interaction","volume":"169","author":"Kitaura","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0055","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S8756-3282(03)00213-8","article-title":"Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: involvement of IFN-gamma possibly induced from non-T cell population","volume":"33","author":"Nagata","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2006.06.005","article-title":"IL-18 induces apoptosis of adherent bone marrow cells in TNF-alpha mediated osteoclast formation in synergy with IL-12","volume":"107","author":"Kitaura","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0065","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bone.2009.07.079","article-title":"IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivo","volume":"45","author":"Yoshimatsu","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0070","first-page":"2","article-title":"IL-18 Inhibits TNF-alpha-induced osteoclastogenesis possibly via a T cell-independent mechanism in synergy with IL-12 in vivo","volume":"24","author":"Morita","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0075","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/0022034509338914","article-title":"On a path to unfolding the biological mechanisms of orthodontic tooth movement","volume":"88","author":"Krishnan","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00774-005-0641-4","article-title":"Experimental model of tooth movement by orthodontic force in mice and its application to tumor necrosis factor receptor-deficient mice","volume":"24","author":"Yoshimatsu","year":"2006","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0085","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/154405910808700405","article-title":"An anti-c-Fms antibody inhibits orthodontic tooth movement","volume":"87","author":"Kitaura","year":"2008","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0090","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. Part I. The basic science aspects","volume":"72","author":"Brezniak","year":"2002","journal-title":"Angle Orthod"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1034\/j.1600-0544.2000.030202.x","article-title":"Orthodontically stressed periodontium of transgenic mouse as a model for studying mechanical response in bone: the effect on the number of osteoblasts","volume":"3","author":"Pavlin","year":"2000","journal-title":"Clin Orthod Res"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/ejo\/cjp068","article-title":"Influence of bisphosphonates on orthodontic tooth movement in mice","volume":"31","author":"Fujimura","year":"2009","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0105","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2319\/080708-412.1","article-title":"An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice","volume":"79","author":"Kitaura","year":"2009","journal-title":"Angle Orthod"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0110","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1177\/154405910708601113","article-title":"The role of tumor necrosis factor receptor type 1 in orthodontic tooth movement","volume":"86","author":"Andrade","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1369\/jhc.6A7018.2006","article-title":"Extracellular matrix-mediated tissue remodeling following axial movement of teeth","volume":"55","author":"Walker","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0120","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/jcp.21250","article-title":"OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application","volume":"214","author":"Chung","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0125","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0722.2009.00625.x","article-title":"Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice","volume":"117","author":"Okamoto","year":"2009","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0130","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1601-0825.2009.01597.x","article-title":"Comparative study of gene expression during tooth eruption and orthodontic tooth movement in mice","volume":"15","author":"Huang","year":"2009","journal-title":"Oral Dis"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2319\/051210-258.1","article-title":"M-CSF accelerates orthodontic tooth movement by targeting preosteoclasts in mice","volume":"81","author":"Brooks","year":"2011","journal-title":"Angle Orthod"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0140","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1034\/j.1600-0722.2003.00051.x","article-title":"Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth","volume":"111","author":"Fukushima","year":"2003","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0145","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jemt.10370","article-title":"Differentiation and functions of osteoclasts and odontoclasts in mineralized tissue resorption","volume":"61","author":"Sasaki","year":"2003","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00774-003-0441-7","article-title":"Calcitonin in human odontoclasts regulates root resorption activity via protein kinase A","volume":"22","author":"Takada","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0155","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1679\/aohc.71.89","article-title":"Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar","volume":"71","author":"Tsuchiya","year":"2008","journal-title":"Arch Histol Cytol"},{"key":"10.1016\/j.archoralbio.2011.07.006_bib0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ejo\/cjn080","article-title":"Hyalinization during orthodontic tooth movement: a systematic review on tissue reactions","volume":"31","author":"von Bohl","year":"2009","journal-title":"Eur J Orthod"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911002287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911002287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:32:56Z","timestamp":1757745176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996911002287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0003996911002287"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2011.07.006","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice","name":"articletitle","label":"Article Title"},{"value":"Archives of Oral Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archoralbio.2011.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}