{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T08:43:31Z","timestamp":1794645811932,"version":"4.9.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.archoralbio.2011.09.011","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T04:20:29Z","timestamp":1319602829000},"page":"413-420","source":"Crossref","is-referenced-by-count":101,"title":["Salivary biomarkers for predicting the progression of chronic periodontitis"],"prefix":"10.1016","volume":"57","author":[{"given":"Yoshiaki","family":"Nomura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Numabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuichi","family":"Kamoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Gomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archoralbio.2011.09.011_bib0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0757.2008.00288.x","article-title":"Saliva as a diagnostic tool for periodontal disease: current state and future directions","volume":"50","author":"Giannobile","year":"2009","journal-title":"Periodontol 2000"},{"issue":"7","key":"10.1016\/j.archoralbio.2011.09.011_bib0010","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1034\/j.1600-051x.2000.027007453.x","article-title":"Analysis of saliva for periodontal diagnosis\u2014a review","volume":"27","author":"Kaufman","year":"2000","journal-title":"J Clin Periodontol"},{"issue":"3","key":"10.1016\/j.archoralbio.2011.09.011_bib0015","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14219\/jada.archive.2006.0181","article-title":"Salivary biomarkers of existing periodontal disease: a cross-sectional study","volume":"137","author":"Miller","year":"2006","journal-title":"J Am Dent Assoc"},{"issue":"4","key":"10.1016\/j.archoralbio.2011.09.011_bib0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2334\/josnusd.48.177","article-title":"Screening of periodontitis with salivary enzyme tests","volume":"48","author":"Nomura","year":"2006","journal-title":"J Oral Sci"},{"issue":"3","key":"10.1016\/j.archoralbio.2011.09.011_bib0025","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1902\/jop.2007.060216","article-title":"Salivary enzyme levels after scaling and interleukin-1 genotypes in Japanese patients with chronic periodontitis","volume":"78","author":"Yoshie","year":"2007","journal-title":"J Periodontol"},{"issue":"5","key":"10.1016\/j.archoralbio.2011.09.011_bib0030","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1515\/CCLM.2006.096","article-title":"Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase: possible markers in periodontal diseases?","volume":"44","author":"Totan","year":"2006","journal-title":"Clin Chem Lab Med"},{"issue":"8","key":"10.1016\/j.archoralbio.2011.09.011_bib0035","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1034\/j.1600-051X.2003.00373.x","article-title":"Levels of aspartate aminotransferase (AST) in saliva of patients with different periodontal conditions","volume":"30","author":"Cesco","year":"2003","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2334\/josnusd.45.33","article-title":"Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters","volume":"45","author":"Barbosa e Silva","year":"2003","journal-title":"J Oral Sci"},{"issue":"10","key":"10.1016\/j.archoralbio.2011.09.011_bib0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.archoralbio.2007.04.008","article-title":"Relationship between lactate dehydrogenase activity in saliva and oral health status","volume":"52","author":"De La Pena","year":"2007","journal-title":"Arch Oral Biol"},{"issue":"9","key":"10.1016\/j.archoralbio.2011.09.011_bib0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.bdj.4809652","article-title":"Advances in periodontal diagnosis 9. Potential markers of cell death and tissue degradation","volume":"184","author":"Eley","year":"1998","journal-title":"Br Dent J"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0055","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/JCM.01824-08","article-title":"Detection of multiple pathogenic species in saliva is associated with periodontal infection in adults","volume":"47","author":"Paju","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"2","key":"10.1016\/j.archoralbio.2011.09.011_bib0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1600-0765.2010.01335.x","article-title":"Salivary infectious agents and periodontal disease status","volume":"46","author":"Saygun","year":"2011","journal-title":"J Periodontal Res"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jcp.20948","article-title":"Regulation of matrix metalloproteinase gene expression","volume":"211","author":"Yan","year":"2007","journal-title":"J Cell Physiol"},{"issue":"11","key":"10.1016\/j.archoralbio.2011.09.011_bib0070","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1600-051X.2009.01480.x","article-title":"Salivary interleukin-1beta concentration and the presence of multiple pathogens in periodontitis","volume":"36","author":"Gursoy","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"3","key":"10.1016\/j.archoralbio.2011.09.011_bib0075","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1902\/jop.2009.080480","article-title":"Identification of pathogen and host-response markers correlated with periodontal disease","volume":"80","author":"Ramseier","year":"2009","journal-title":"J Periodontol"},{"issue":"5 Suppl","key":"10.1016\/j.archoralbio.2011.09.011_bib0080","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1902\/jop.1994.65.5s.468","article-title":"Methods of assessing risk for periodontitis and developing multifactorial models","volume":"65","author":"Beck","year":"1994","journal-title":"J Periodontol"},{"issue":"8","key":"10.1016\/j.archoralbio.2011.09.011_bib0085","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1902\/jop.2005.76.8.1406","article-title":"Position paper: epidemiology of periodontal diseases","volume":"76","author":"Burt","year":"2005","journal-title":"J Periodontol"},{"issue":"Suppl 6","key":"10.1016\/j.archoralbio.2011.09.011_bib0090","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-051X.2005.00822.x","article-title":"Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. Group C consensus report of the 5th European Workshop in Periodontology","volume":"32","author":"Tonetti","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"6","key":"10.1016\/j.archoralbio.2011.09.011_bib0095","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1128\/JCM.38.6.2362-2365.2000","article-title":"Quantitative real-time PCR for Porphyromonas gingivalis and total bacteria","volume":"38","author":"Lyons","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"7","key":"10.1016\/j.archoralbio.2011.09.011_bib0100","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1034\/j.1600-051X.2002.290702.x","article-title":"Risk factors for periodontal disease progression among elderly people","volume":"29","author":"Ogawa","year":"2002","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0105","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-051X.2008.01342.x","article-title":"Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis","volume":"36","author":"Lorentz","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0110","first-page":"2","article-title":"Periodontal status and cytoplasmic enzyme activities in gingival crevicular fluid of type 2 diabetic and\/or obese patients with chronic periodontitis","volume":"8","author":"Gursoy","year":"2006","journal-title":"J Int Acad Periodontol"},{"issue":"12","key":"10.1016\/j.archoralbio.2011.09.011_bib0115","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1046\/j.0303-6979.2003.00426.x","article-title":"Gingival crevicular fluid levels of aspartate amino transferase, sulfide ions and N-benzoyl-dl-arginine-2-naphthylamide in diabetic patients with chronic periodontitis","volume":"30","author":"Yucekal-Tuncer","year":"2003","journal-title":"J Clin Periodontol"},{"issue":"6","key":"10.1016\/j.archoralbio.2011.09.011_bib0120","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1177\/0022034511399908","article-title":"Saliva\/pathogen biomarker signatures and periodontal disease progression","volume":"90","author":"Kinney","year":"2011","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.archoralbio.2011.09.011_bib0125","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1902\/jop.1998.69.7.828","article-title":"The utility of whole saliva to detect the oral presence of periodontopathic bacteria","volume":"69","author":"Umeda","year":"1998","journal-title":"J Periodontol"},{"issue":"10","key":"10.1016\/j.archoralbio.2011.09.011_bib0130","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1600-051X.1991.tb00066.x","article-title":"Relation of baseline microbial parameters to future periodontal attachment loss","volume":"18","author":"Haffajee","year":"1991","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.1016\/j.archoralbio.2011.09.011_bib0135","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1600-051X.1997.tb00474.x","article-title":"Longitudinal study of prognostic factors in established periodontitis patients","volume":"24","author":"Machtei","year":"1997","journal-title":"J Clin Periodontol"},{"issue":"6","key":"10.1016\/j.archoralbio.2011.09.011_bib0140","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1399-302X.2009.00544.x","article-title":"Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque","volume":"24","author":"Byrne","year":"2009","journal-title":"Oral Microbiol Immunol"},{"issue":"12","key":"10.1016\/j.archoralbio.2011.09.011_bib0145","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1034\/j.1600-051x.2000.027012932.x","article-title":"Untreated periodontal disease in Indonesian adolescents. Longitudinal clinical data and prospective clinical and microbiological risk assessment","volume":"27","author":"Timmerman","year":"2000","journal-title":"J Clin Periodontol"},{"issue":"6","key":"10.1016\/j.archoralbio.2011.09.011_bib0150","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1034\/j.1600-051X.1999.260607.x","article-title":"Longitudinal study of predictive factors for periodontal disease and tooth loss","volume":"26","author":"Machtei","year":"1999","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/jop.2001.72.1.1","article-title":"Persistent presence of Bacteroides forsythus as a risk factor for attachment loss in a population with low prevalence and severity of adult periodontitis","volume":"72","author":"Tran","year":"2001","journal-title":"J Periodontol"},{"issue":"4","key":"10.1016\/j.archoralbio.2011.09.011_bib0160","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1399-302X.1987.tb00300.x","article-title":"Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius: predictors of attachment loss?","volume":"2","author":"Wennstrom","year":"1987","journal-title":"Oral Microbiol Immunol"},{"issue":"3","key":"10.1016\/j.archoralbio.2011.09.011_bib0165","first-page":"89","article-title":"Relationship between periodontitis and hepatic condition in Japanese women","volume":"8","author":"Saito","year":"2006","journal-title":"J Int Acad Periodontol"},{"issue":"1","key":"10.1016\/j.archoralbio.2011.09.011_bib0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/00016350903291913","article-title":"Relationship between periodontitis and hepatic abnormalities in young adults","volume":"68","author":"Furuta","year":"2010","journal-title":"Acta Odontol Scand"},{"issue":"10","key":"10.1016\/j.archoralbio.2011.09.011_bib0175","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1902\/jop.2007.070056","article-title":"Chronic administration of lipopolysaccharide and proteases induces periodontal inflammation and hepatic steatosis in rats","volume":"78","author":"Tomofuji","year":"2007","journal-title":"J Periodontol"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911003074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996911003074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T14:26:40Z","timestamp":1593181600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996911003074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0003996911003074"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2011.09.011","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}