{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:37:27Z","timestamp":1788910647751,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["aobjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.archoralbio.2015.02.021","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T18:29:08Z","timestamp":1425061748000},"page":"845-853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts"],"prefix":"10.1016","volume":"60","author":[{"given":"Telma Blanca","family":"Lombardo Bedran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Palomari Spolidorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archoralbio.2015.02.021_bib0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0757.2012.00450.x","article-title":"Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts","volume":"62","author":"Bartold","year":"2013","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0285","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1600-0757.1999.tb00159.x","article-title":"Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment","volume":"20","author":"Slots","year":"1999","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0290","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0757.1999.tb00161.x","article-title":"Virulence factors of Actinobacillus actinomycetemcomitans","volume":"20","author":"Fives-Taylor","year":"1999","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0295","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/omi.12034","article-title":"MyD88 is essential for alveolar bone loss induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide in mice","volume":"28","author":"Madeira","year":"2013","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0300","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1600-0765.1997.tb00535.x","article-title":"Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria","volume":"32","author":"Yoshimura","year":"1997","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0305","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1993.tb00230.x","article-title":"Tissues and cells of the periodontium","volume":"3","author":"Hassell","year":"1993","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0310","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.archoralbio.2013.04.013","article-title":"The induction expression of human \u03b2-defensins in gingival epithelial cells and fibroblasts","volume":"58","author":"Liu","year":"2013","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0315","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/prd.12028","article-title":"Defensins and LL-37: a review of function in the gingival epithelium","volume":"63","author":"Greer","year":"2013","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0320","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0325","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0966-842X(00)01823-0","article-title":"The role of cationic antimicrobial peptides in innate host defences","volume":"8","author":"Hancock","year":"2000","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0330","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bbamem.2006.03.030","article-title":"LL-37, the only human member of the cathelicidin family of antimicrobial peptides","volume":"1758","author":"Durr","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0335","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/AAC.42.9.2206","article-title":"Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils","volume":"42","author":"Turner","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0340","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1600-0722.2010.00775.x","article-title":"Suppressive effect of the antimicrobial peptide LL-37 on expression of IL-6, IL-8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts","volume":"118","author":"Inomata","year":"2010","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0345","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.4049\/jimmunol.1002508","article-title":"Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses","volume":"186","author":"Brown","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0350","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cellimm.2010.05.005","article-title":"Effect of the antimicrobial peptide LL-37 on Toll-like receptors 2-, 3- and 4-triggered expression of IL-6, IL-8 and CXCL10 in human gingival fibroblasts","volume":"264","author":"Into","year":"2010","journal-title":"Cell Immunol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0355","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1074\/jbc.M504327200","article-title":"Endotoxin (lipopolysaccharide) neutralization by innate immunity host\u2013defense peptides. Peptide properties and plausible modes of action","volume":"281","author":"Rosenfeld","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0360","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/154405910608501012","article-title":"Salivary LL-37 secretion in individuals with Down syndrome is normal","volume":"85","author":"Bachrach","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0365","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000329673","article-title":"Antimicrobial peptides in periodontal innate defense","volume":"15","author":"Gorr","year":"2012","journal-title":"Front Oral Biol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0370","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1128\/IAI.00648-09","article-title":"Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis","volume":"77","author":"Gutner","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0375","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0140-6736(02)11201-3","article-title":"Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study","volume":"360","author":"Putsep","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0380","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0385","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2013.10.047","article-title":"Use of polyphenols in periodontal inflammation","volume":"720","author":"Palaska","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0390","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/mnfr.200700038","article-title":"Bioactive compounds in cranberries and their role in prevention of urinary tract infections","volume":"51","author":"Howell","year":"2007","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0395","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/mnfr.200600279","article-title":"Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases","volume":"51","author":"Neto","year":"2007","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0400","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0031-9422(99)00573-7","article-title":"The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro","volume":"54","author":"Foo","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0405","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/154405910608500306","article-title":"Anti-inflammatory activity of a high-molecular-weight cranberry fraction on macrophages stimulated by lipopolysaccharides from periodontopathogens","volume":"85","author":"Bodet","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0410","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/jac\/dkl031","article-title":"Inhibition of periodontopathogen-derived proteolytic enzymes by a high-molecular-weight fraction isolated from cranberry","volume":"57","author":"Bodet","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0415","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1128\/AAC.01432-09","article-title":"Anti-Porphyromonas gingivalis and anti-inflammatory activities of A-type cranberry proanthocyanidins","volume":"54","author":"La","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0420","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1021\/jf203304v","article-title":"Cranberry proanthocyanidins: natural weapons against periodontal diseases","volume":"60","author":"Feghali","year":"2012","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0425","first-page":"157","article-title":"Green tea (Camellia sinensis): chemistry, traditional, medicinal uses and its pharmacological activities \u2013 a review","volume":"3","author":"Chopade","year":"2008","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0430","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.foodres.2013.01.038","article-title":"Tea: a new perspective on health benefits","volume":"53","author":"da Silva Pinto","year":"2013","journal-title":"Food Res Int"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0435","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/jam.12458","article-title":"Effects of the tea catechin epigallocatechin gallate on Porphyromonas gingivalis biofilms","volume":"116","author":"Asahi","year":"2014","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0440","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1254\/jphs.11082FP","article-title":"Tea polyphenols inhibit rat osteoclast formation and differentiation","volume":"118","author":"Oka","year":"2012","journal-title":"J Pharmacol Sci"},{"issue":"Suppl. 2","key":"10.1016\/j.archoralbio.2015.02.021_bib0445","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1002\/mnfr.200900549","article-title":"Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts","volume":"54","author":"Hosokawa","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0450","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/jn\/134.5.1039","article-title":"Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells","volume":"134","author":"Wheeler","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0455","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000257494","article-title":"Epigallocatechin-3-O-gallate decreases tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells by suppressing NF-kappaB","volume":"24","author":"Lee","year":"2009","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0460","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1034\/j.1600-0765.2002.01640.x","article-title":"Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study","volume":"37","author":"Hirasawa","year":"2002","journal-title":"J Periodont Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0465","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/JB.155.2.831-838.1983","article-title":"Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains","volume":"155","author":"Darveau","year":"1983","journal-title":"J Bacteriol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0470","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1902\/jop.2004.75.3.370","article-title":"Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2","volume":"75","author":"Kusumoto","year":"2004","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0475","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1902\/jop.2011.110177","article-title":"A novel organotypic dento-epithelial culture model: effect of Fusobacterium nucleatum biofilm on \u03b2-defensin-2, -3, and LL-37 expression","volume":"83","author":"Gursoy","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0480","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0485","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-0722.2007.00415.x","article-title":"Cranberry components inhibit interleukin-6, interleukin-8, and prostaglandin E production by lipopolysaccharide-activated gingival fibroblasts","volume":"115","author":"Bodet","year":"2007","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0490","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/0022034509339487","article-title":"Cranberry proanthocyanidins inhibit MMP production and activity","volume":"88","author":"La","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0495","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5051\/jpis.2012.42.6.185","article-title":"Anti-inflammatory effect of (-)-epigallocatechin-3-gallate on Porphyromonas gingivalis lipopolysaccharide-stimulated fibroblasts and stem cells derived from human periodontal ligament","volume":"42","author":"Jung","year":"2012","journal-title":"J Periodontal Implant Sci"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0500","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-0722.2010.00714.x","article-title":"Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors","volume":"118","author":"Nakanishi","year":"2010","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0505","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/jre.12142","article-title":"Green tea extract and its major constituent, epigallocatechin-3-gallate, induce epithelial beta-defensin secretion and prevent beta-defensin degradation by Porphyromonas gingivalis","volume":"49","author":"Lombardo Bedran","year":"2014","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0510","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1902\/jop.2005.76.11.1849","article-title":"Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis","volume":"76","author":"Kurtis","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0515","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5301\/jbm.5000014","article-title":"Comparative evaluation of cytokines in gingival crevicular fluid and saliva of patients with aggressive periodontitis","volume":"28","author":"Yue","year":"2013","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0520","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","article-title":"Cytokine expression in periodontal health and disease","volume":"9","author":"Okada","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0525","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1086\/515178","article-title":"The potential role of chemokines and inflammatory cytokines in periodontal disease progression","volume":"28","author":"Graves","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0530","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/0006-291X(91)91049-I","article-title":"Initial characterization of the carbohydrate structure of MCP-1","volume":"178","author":"Jiang","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0535","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1590\/S1678-77572012000200002","article-title":"Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease","volume":"20","author":"de Souza","year":"2012","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0540","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0757.2006.00166.x","article-title":"Novel host response therapeutic approaches to treat periodontal diseases","volume":"43","author":"Kirkwood","year":"2007","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0545","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1365-2672.2012.05329.x","article-title":"Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages","volume":"113","author":"Feldman","year":"2012","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.archoralbio.2015.02.021_bib0550","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1211\/0022357021778637","article-title":"Natural products as targeted modulators of the nuclear factor-kappaB pathway","volume":"54","author":"Bremner","year":"2002","journal-title":"J Pharm Pharmacol"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996915000497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996915000497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T10:50:08Z","timestamp":1598784608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996915000497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0003996915000497"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2015.02.021","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Archives of Oral Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archoralbio.2015.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}