{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:55:28Z","timestamp":1784228128724,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["aobjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.archoralbio.2016.05.010","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T13:45:18Z","timestamp":1462887918000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Porphyromonas gingivalis attenuates the insulin-induced phosphorylation and translocation of forkhead box protein O1 in human hepatocytes"],"prefix":"10.1016","volume":"69","author":[{"given":"Haruna","family":"Takamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaya","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.archoralbio.2016.05.010_bib0005","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2337\/diabetes.48.9.1885","article-title":"Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence","volume":"48","author":"Ayala","year":"1999","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.archoralbio.2016.05.010_bib0010","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1128\/IAI.01036-10","article-title":"The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes","volume":"79","author":"Belstrom","year":"2011","journal-title":"Infection and Immunity"},{"issue":"5","key":"10.1016\/j.archoralbio.2016.05.010_bib0015","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1600-051X.2011.01717.x","article-title":"Detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics","volume":"38","author":"Castillo","year":"2011","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1016\/j.archoralbio.2016.05.010_bib0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-051X.1998.tb02417.x","article-title":"Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results","volume":"25","author":"Christgau","year":"1998","journal-title":"Journal of Clinical Periodontology"},{"issue":"5","key":"10.1016\/j.archoralbio.2016.05.010_bib0025","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2337\/dc09-1778","article-title":"Periodontal status and A1C change: longitudinal results from the study of health in Pomerania (SHIP)","volume":"33","author":"Demmer","year":"2010","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.archoralbio.2016.05.010_bib0030","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1128\/IAI.66.11.5337-5343.1998","article-title":"Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis","volume":"66","author":"Deshpande","year":"1998","journal-title":"Infection and Immunity"},{"issue":"1","key":"10.1016\/j.archoralbio.2016.05.010_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2008.06.006","article-title":"Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation","volume":"8","author":"Dong","year":"2008","journal-title":"Cell Metabolism"},{"issue":"23","key":"10.1016\/j.archoralbio.2016.05.010_bib0040","first-page":"282431","article-title":"The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial","volume":"310","author":"Engebreston","year":"2013","journal-title":"JAMA"},{"issue":"18","key":"10.1016\/j.archoralbio.2016.05.010_bib0045","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1128\/MCB.00138-09","article-title":"The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis","volume":"29","author":"Guo","year":"2009","journal-title":"Molecular and Cellular Biology"},{"issue":"46","key":"10.1016\/j.archoralbio.2016.05.010_bib0050","doi-asserted-by":"crossref","first-page":"35245","DOI":"10.1074\/jbc.C110.175851","article-title":"FoxOs function synergistically to promote glucose production","volume":"285","author":"Haeusler","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.archoralbio.2016.05.010_bib0055","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nature Reviews Immunology"},{"issue":"12","key":"10.1016\/j.archoralbio.2016.05.010_bib0060","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.bbadis.2013.07.012","article-title":"Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt\/GSK-3beta signaling pathway","volume":"1832","author":"Ishikawa","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"issue":"6","key":"10.1016\/j.archoralbio.2016.05.010_bib0065","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1902\/jop.2001.72.6.774","article-title":"The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes","volume":"72","author":"Iwamoto","year":"2001","journal-title":"Journal of Periodontology"},{"issue":"12","key":"10.1016\/j.archoralbio.2016.05.010_bib0070","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1177\/154405910508401212","article-title":"Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies","volume":"84","author":"Janket","year":"2005","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.archoralbio.2016.05.010_bib0075","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1034\/j.1600-0757.2002.03006.x","article-title":"In or out: the invasiveness of oral bacteria","volume":"30","author":"Lamont","year":"2002","journal-title":"Periodontology 2000"},{"issue":"3","key":"10.1016\/j.archoralbio.2016.05.010_bib0080","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nm.2686","article-title":"Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1","volume":"18","author":"Lu","year":"2012","journal-title":"Nature Medicine"},{"issue":"4","key":"10.1016\/j.archoralbio.2016.05.010_bib0085","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1399-302X.2007.00426.x","article-title":"Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment","volume":"23","author":"Makiura","year":"2008","journal-title":"Oral Microbiology and Immunology"},{"issue":"3","key":"10.1016\/j.archoralbio.2016.05.010_bib0090","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2007.08.006","article-title":"Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver","volume":"6","author":"Matsumoto","year":"2007","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/j.archoralbio.2016.05.010_bib0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1530\/eje.0.1380240","article-title":"Autoregulation of hepatic glucose production","volume":"138","author":"Moore","year":"1998","journal-title":"European Journal of Endocrinology"},{"issue":"23","key":"10.1016\/j.archoralbio.2016.05.010_bib0100","doi-asserted-by":"crossref","first-page":"15982","DOI":"10.1074\/jbc.274.23.15982","article-title":"Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway","volume":"274","author":"Nakae","year":"1999","journal-title":"Journal of Biological Chemistry"},{"issue":"8","key":"10.1016\/j.archoralbio.2016.05.010_bib0105","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1074\/jbc.M114.591610","article-title":"Attenuation of the phosphatidylinositol 3-kinase\/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp","volume":"290","author":"Nakayama","year":"2015","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.archoralbio.2016.05.010_bib0110","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1600-051X.2004.00498.x","article-title":"Impact of oral health on the life quality of periodontal patients","volume":"31","author":"Needleman","year":"2004","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1016\/j.archoralbio.2016.05.010_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004714.pub2","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes","volume":"5","author":"Simpson","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.archoralbio.2016.05.010_bib0120","first-page":"807279","article-title":"Ghrelin protects against the detrimental consequences of Porphyromonas gingivalis-induced Akt inactivation through S-nitrosylation on salivary mucin synthesis","author":"Slomiany","year":"2011","journal-title":"International Journal of Inflammation"},{"issue":"Suppl. 14","key":"10.1016\/j.archoralbio.2016.05.010_bib0125","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1111\/jcpe.12059","article-title":"A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes","volume":"40","author":"Taylor","year":"2013","journal-title":"Journal of Clinical Periodontology"},{"issue":"29","key":"10.1016\/j.archoralbio.2016.05.010_bib0130","doi-asserted-by":"crossref","first-page":"11027","DOI":"10.1073\/pnas.0509813103","article-title":"A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion","volume":"103","author":"Tribble","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.archoralbio.2016.05.010_bib0135","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1092952","article-title":"Insulin signaling in health and disease","volume":"302","author":"White","year":"2003","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.archoralbio.2016.05.010_bib0140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jcb.23340","article-title":"Interaction between PKR and PACT mediated by LPS-inducible NF-kappaB in human gingival cells","volume":"113","author":"Yoshida","year":"2012","journal-title":"Journal of Cellular Biochemistry"},{"issue":"2","key":"10.1016\/j.archoralbio.2016.05.010_bib0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/en.2011-1527","article-title":"Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice","volume":"153","author":"Zhang","year":"2012","journal-title":"Endocrinology"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996916301194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996916301194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:52:23Z","timestamp":1692319943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996916301194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":29,"alternative-id":["S0003996916301194"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2016.05.010","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porphyromonas gingivalis attenuates the insulin-induced phosphorylation and translocation of forkhead box protein O1 in human hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Archives of Oral Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archoralbio.2016.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}