{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:14:43Z","timestamp":1793157283249,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Cooper Medical School of Rowan University BMS Research Seed Funds"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Oral Biology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.archoralbio.2018.08.020","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T12:11:50Z","timestamp":1535803910000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Differential cellular composition of human palatine and pharyngeal tonsils"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-6052","authenticated-orcid":false,"given":"Luke","family":"Stanisce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etty","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekaterina","family":"Koshkareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Gaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kuzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1712-6796","authenticated-orcid":false,"given":"Andrea","family":"Bottaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.archoralbio.2018.08.020_bib0005","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.immuni.2012.05.022","article-title":"Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2","volume":"37","author":"Acton","year":"2012","journal-title":"Immunity"},{"issue":"7523","key":"10.1016\/j.archoralbio.2018.08.020_bib0010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature13814","article-title":"Dendritic cells control fibroblastic reticular network tension and lymph node expansion","volume":"514","author":"Acton","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.archoralbio.2018.08.020_bib0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/archotol.134.5.477","article-title":"Proliferating active cells, lymphocyte subsets, and dendritic cells in recurrent tonsillitis: Their effect on hypertrophy","volume":"134","author":"Alatas","year":"2008","journal-title":"Archives of Otolaryngology\u2014head & Neck Surgery"},{"key":"10.1016\/j.archoralbio.2018.08.020_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/402038","article-title":"Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye?","volume":"2014","author":"Alvarenga","year":"2014","journal-title":"Journal of Immunology Research"},{"issue":"12","key":"10.1016\/j.archoralbio.2018.08.020_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167555","article-title":"A reproducible method for isolation and in vitro culture of functional human lymphoid stromal cells from tonsils","volume":"11","author":"Bar-Ephraim","year":"2016","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.archoralbio.2018.08.020_bib0030","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/08820139.2010.517589","article-title":"Identification and immunolocalization of the innate immune receptor CD14 in hypertrophic adenoids and tonsils","volume":"40","author":"Ben-Yaakov","year":"2011","journal-title":"Immunological Investigations"},{"issue":"6","key":"10.1016\/j.archoralbio.2018.08.020_bib0035","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0002-9440(10)64841-9","article-title":"Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils","volume":"157","author":"Boyaka","year":"2000","journal-title":"The American Journal of Pathology"},{"issue":"4-5","key":"10.1016\/j.archoralbio.2018.08.020_bib0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/08820131003680369","article-title":"Function of mucosa-associated lymphoid tissue in antibody formation","volume":"39","author":"Brandtzaeg","year":"2010","journal-title":"Immunological Investigations"},{"issue":"4","key":"10.1016\/j.archoralbio.2018.08.020_bib0045","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3233\/JAD-142412","article-title":"Double negative (IgG+IgD-CD27-) B cells are increased in a cohort of moderate-severe Alzheimer\u2019s disease patients and show a pro-inflammatory trafficking receptor phenotype","volume":"44","author":"Bulati","year":"2015","journal-title":"Journal of Alzheimer's Disease: JAD"},{"issue":"1","key":"10.1016\/j.archoralbio.2018.08.020_bib0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.it.2014.11.003","article-title":"Stromal infrastructure of the lymph node and coordination of immunity","volume":"36","author":"Chang","year":"2015","journal-title":"Trends in Immunology"},{"issue":"12","key":"10.1016\/j.archoralbio.2018.08.020_bib0055","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.1502448","article-title":"Age-associated B cells with proinflammatory characteristics are expanded in a proportion of multiple sclerosis patients","volume":"197","author":"Claes","year":"2016","journal-title":"Journal of Immunology"},{"issue":"1","key":"10.1016\/j.archoralbio.2018.08.020_bib0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/imm.12117","article-title":"Human dendritic cell subsets","volume":"140","author":"Collin","year":"2013","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.archoralbio.2018.08.020_bib0065","first-page":"1","article-title":"Ambulatory surgery in the United States, 2006","author":"Cullen","year":"2009","journal-title":"National Health Statistics Reports"},{"issue":"8 Pt 2 Suppl 100","key":"10.1016\/j.archoralbio.2018.08.020_bib0070","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00005537-200208001-00004","article-title":"Indications for tonsillectomy and adenoidectomy","volume":"112","author":"Darrow","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.archoralbio.2018.08.020_bib0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12865-014-0028-1","article-title":"Memory B cell subsets and plasmablasts are lower in early than in long-standing rheumatoid arthritis","volume":"15","author":"Fedele","year":"2014","journal-title":"BMC Immunology"},{"issue":"4","key":"10.1016\/j.archoralbio.2018.08.020_bib0080","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/cea.12878","article-title":"Chronic airway inflammation provides a unique environment for B cell activation and antibody production","volume":"47","author":"Feldman","year":"2017","journal-title":"Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology"},{"issue":"11","key":"10.1016\/j.archoralbio.2018.08.020_bib0085","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/CVI.00172-06","article-title":"Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium","volume":"13","author":"Hartmann","year":"2006","journal-title":"Clinical and Vaccine Immunology: CVI"},{"issue":"9","key":"10.1016\/j.archoralbio.2018.08.020_bib0090","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1172\/JCI24810","article-title":"Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance","volume":"115","author":"Hislop","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"10.1016\/j.archoralbio.2018.08.020_bib0095","first-page":"371","article-title":"Ultrastructure of the human palatine tonsil and its functional significance","volume":"56","author":"Jovi\u0106","year":"2015","journal-title":"Romanian Journal of Morphology and Embryology"},{"issue":"4","key":"10.1016\/j.archoralbio.2018.08.020_bib0100","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jaci.2013.02.023","article-title":"B-lymphocyte lineage cells and the respiratory system","volume":"131","author":"Kato","year":"2013","journal-title":"The Journal of Allergy and Clinical Immunology"},{"issue":"4","key":"10.1016\/j.archoralbio.2018.08.020_bib0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1203\/PDR.0b013e3181b453e3","article-title":"Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea","volume":"66","author":"Kim","year":"2009","journal-title":"Pediatric Research"},{"issue":"7","key":"10.1016\/j.archoralbio.2018.08.020_bib0110","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ijporl.2005.01.035","article-title":"Cytokines locally produced by lymphocytes removed from the hypertrophic nasopharyngeal and palatine tonsils","volume":"69","author":"Komorowska","year":"2005","journal-title":"International Journal of Pediatric Otorhinolaryngology"},{"issue":"2","key":"10.1016\/j.archoralbio.2018.08.020_bib0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ijporl.2010.11.014","article-title":"Dendritic cells and lymphocyte subpopulations of the adenoid in the pathogenesis of otitis media with effusion","volume":"75","author":"Kotowski","year":"2011","journal-title":"International Journal of Pediatric Otorhinolaryngology"},{"issue":"6","key":"10.1016\/j.archoralbio.2018.08.020_bib0120","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/bit.23055","article-title":"Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor","volume":"108","author":"Kuzin","year":"2011","journal-title":"Biotechnology and Bioengineering"},{"issue":"3","key":"10.1016\/j.archoralbio.2018.08.020_bib0125","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-0030-1253457","article-title":"Heterogeneity and plasticity of lymphatic endothelial cells","volume":"36","author":"Lee","year":"2010","journal-title":"Seminars in Thrombosis and Hemostasis"},{"issue":"5","key":"10.1016\/j.archoralbio.2018.08.020_bib0130","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/infdis\/jiw230","article-title":"Live attenuated influenza vaccine in children induces B-Cell responses in tonsils","volume":"214","author":"Mohn","year":"2016","journal-title":"The Journal of Infectious Diseases"},{"issue":"2","key":"10.1016\/j.archoralbio.2018.08.020_bib0135","doi-asserted-by":"crossref","first-page":"E80","DOI":"10.1002\/lary.25536","article-title":"Adenoidal follicular T helper cells provide stronger B-cell help than those from tonsils","volume":"126","author":"Morris","year":"2016","journal-title":"Laryngoscope"},{"issue":"9","key":"10.1016\/j.archoralbio.2018.08.020_bib0140","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nri2588","article-title":"Stromal cell contributions to the homeostasis and functionality of the immune system","volume":"9","author":"Mueller","year":"2009","journal-title":"Nature Reviews Immunology"},{"issue":"1","key":"10.1016\/j.archoralbio.2018.08.020_bib0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0165-5876(01)00422-0","article-title":"Lymphocyte subpopulations in hypertrophied adenoid in children","volume":"59","author":"Musiatowicz","year":"2001","journal-title":"International Journal of Pediatric Otorhinolaryngology"},{"issue":"5","key":"10.1016\/j.archoralbio.2018.08.020_bib0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s004290100210","article-title":"Morphology and immunology of the human palatine tonsil","volume":"204","author":"Nave","year":"2001","journal-title":"Anatomy and Embryology"},{"issue":"22","key":"10.1016\/j.archoralbio.2018.08.020_bib0155","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1007\/s00018-015-2005-0","article-title":"Human dendritic cell subsets and function in health and disease","volume":"72","author":"O\u2019Keeffe","year":"2015","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"issue":"10","key":"10.1016\/j.archoralbio.2018.08.020_bib0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/gm378","article-title":"Shifts in human skin and nares microbiota of healthy children and adults","volume":"4","author":"Oh","year":"2012","journal-title":"Genome Medicine"},{"issue":"10","key":"10.1016\/j.archoralbio.2018.08.020_bib0165","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/icb.2014.59","article-title":"Human memory B cells isolated from blood and tonsils are functionally distinctive","volume":"92","author":"Perez","year":"2014","journal-title":"Immunology and Cell Biology"},{"issue":"3","key":"10.1016\/j.archoralbio.2018.08.020_bib0170","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/mi.2014.11","article-title":"The development and function of mucosal lymphoid tissues: A balancing act with micro-organisms","volume":"7","author":"Randall","year":"2014","journal-title":"Mucosal Immunology"},{"issue":"1","key":"10.1016\/j.archoralbio.2018.08.020_bib0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.smim.2007.12.006","article-title":"Phenotypic and functional heterogeneity of human memory B cells","volume":"20","author":"Sanz","year":"2008","journal-title":"Seminars in Immunology"},{"issue":"1","key":"10.1016\/j.archoralbio.2018.08.020_bib0180","doi-asserted-by":"crossref","first-page":"11077","DOI":"10.1038\/s41598-017-09689-x","article-title":"Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy","volume":"7","author":"Sarmiento Varon","year":"2017","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.archoralbio.2018.08.020_bib0185","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/eji.201041117","article-title":"Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation","volume":"41","author":"Schubert","year":"2011","journal-title":"European Journal of Immunology"},{"issue":"3","key":"10.1016\/j.archoralbio.2018.08.020_bib0190","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nature Reviews Immunology"},{"issue":"3","key":"10.1016\/j.archoralbio.2018.08.020_bib0195","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/GRF.0b013e3182993a0c","article-title":"Programming of the lung in early life by bacterial infections predisposes to chronic respiratory disease","volume":"56","author":"Starkey","year":"2013","journal-title":"Clinical Obstetrics and Gynecology"},{"issue":"5","key":"10.1016\/j.archoralbio.2018.08.020_bib0200","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/ismej.2014.250","article-title":"Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age","volume":"9","author":"Stearns","year":"2015","journal-title":"The ISME Journal"},{"issue":"3","key":"10.1016\/j.archoralbio.2018.08.020_bib0205","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.4049\/jimmunol.1003944","article-title":"Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells","volume":"188","author":"Wandel","year":"2012","journal-title":"Journal of Immunology"},{"issue":"10","key":"10.1016\/j.archoralbio.2018.08.020_bib0210","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.4049\/jimmunol.178.10.6624","article-title":"A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus","volume":"178","author":"Wei","year":"2007","journal-title":"Journal of Immunology"},{"issue":"4","key":"10.1016\/j.archoralbio.2018.08.020_bib0215","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1513\/AnnalsATS.201310-351OC","article-title":"The loss of topography in the microbial communities of the upper respiratory tract in the elderly","volume":"11","author":"Whelan","year":"2014","journal-title":"Annals of the American Thoracic Society"},{"issue":"7","key":"10.1016\/j.archoralbio.2018.08.020_bib0220","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s00405-012-1977-8","article-title":"Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion","volume":"269","author":"Zelazowska-Rutkowska","year":"2012","journal-title":"European Archives of Oto-rhino-laryngology"},{"issue":"8","key":"10.1016\/j.archoralbio.2018.08.020_bib0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002175","article-title":"Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: Relationships with pneumococcal colonization","volume":"7","author":"Zhang","year":"2011","journal-title":"PLoS Pathogens"}],"container-title":["Archives of Oral Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996918305582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003996918305582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:09:44Z","timestamp":1762088984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003996918305582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":45,"alternative-id":["S0003996918305582"],"URL":"https:\/\/doi.org\/10.1016\/j.archoralbio.2018.08.020","relation":{},"ISSN":["0003-9969"],"issn-type":[{"value":"0003-9969","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential cellular composition of human palatine and pharyngeal tonsils","name":"articletitle","label":"Article Title"},{"value":"Archives of Oral Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archoralbio.2018.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}