{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:36:39Z","timestamp":1790987799177,"version":"4.1.0"},"reference-count":119,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.arcmed.2005.04.007","type":"journal-article","created":{"date-parts":[[2005,8,13]],"date-time":"2005-08-13T16:00:09Z","timestamp":1123948809000},"page":"425-435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["Innate Immune Responses to Dengue Virus"],"prefix":"10.1016","volume":"36","author":[{"given":"Erika","family":"Navarro-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Despr\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Cedillo-Barr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2005.04.007_bib1","series-title":"Flaviviridae: the viruses and their replication. Field's Virology","first-page":"931","author":"Rice","year":"1996"},{"key":"10.1016\/j.arcmed.2005.04.007_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0966-842X(01)02288-0","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century","volume":"10","author":"Gubler","year":"2002","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib3","series-title":"Strengthening implementation of the global strategy for Dengue fever and Dengue haemorrhagic fever, prevention and control. Report in the informal consultation","author":"World Health Organization","year":"1999"},{"key":"10.1016\/j.arcmed.2005.04.007_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(01)00171-2","article-title":"Dengue and update","volume":"2","author":"Guzman","year":"2002","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"10.1016\/j.arcmed.2005.04.007_bib5","first-page":"907","article-title":"Visualization of membrane protein domains by cryo-electron microscopy of dengue virus","volume":"10","author":"Zhang","year":"2003","journal-title":"Nat Struct Biol. Nov. Epub 2003 Oct 5"},{"key":"10.1016\/j.arcmed.2005.04.007_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(02)00660-8","article-title":"Structure of dengue virus: implications for flavivirus organization, maturation, and fusion","volume":"108","author":"Kuhn","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2005.04.007_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature02165","article-title":"Structure of the dengue virus envelope protein after membrane fusion","volume":"427","author":"Modis","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2005.04.007_bib8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0042-6822(92)90450-4","article-title":"Use of recombinant fusion proteins and monoclonal antibodies to define linear and discontinuous antigenic sites on the dengue virus envelope glycoprotein","volume":"187","author":"Megret","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.4269\/ajtmh.1989.40.676","article-title":"Identification of continuous epitopes of the envelope glycoprotein of dengue type 2 virus","volume":"40","author":"Innis","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib10","doi-asserted-by":"crossref","first-page":"19100","DOI":"10.1074\/jbc.270.32.19100","article-title":"Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5","volume":"270","author":"Kapoor","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2005.04.007_bib11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib12","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/jvi.65.5.2467-2475.1991","article-title":"Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins","volume":"65","author":"Falgout","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib13","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1128\/JVI.73.7.6104-6110.1999","article-title":"Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion","volume":"73","author":"Flamand","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib14","series-title":"Field's Virology","first-page":"1043","article-title":"Flaviviruses","author":"Burke","year":"2001"},{"key":"10.1016\/j.arcmed.2005.04.007_bib15","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1099\/0022-1317-71-8-1845","article-title":"Low pH-induced cell fusion in flavivirus-infected Aedes albopictus cell cultures","volume":"71","author":"Randolph","year":"1990","journal-title":"J Gen Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/viro.1993.1469","article-title":"Differences between cell membrane fusion activities of two dengue type-1 isolates reflect modifications of viral structure","volume":"196","author":"Despres","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.239.4839.476","article-title":"Pathogenesis of dengue: challenges to molecular biology","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2005.04.007_bib18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0035-9203(83)90219-5","article-title":"Dengue haemorrhagic fever","volume":"77","author":"Halstead","year":"1983","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.146.1.201","article-title":"Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody","volume":"146","author":"Halstead","year":"1977","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/265739a0","article-title":"Antibody-enhanced dengue virus infection in primate leukocytes","volume":"265","author":"Halstead","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2005.04.007_bib21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4269\/ajtmh.1983.32.154","article-title":"Original antigenic sin in dengue","volume":"32","author":"Halstead","year":"1983","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm887","article-title":"Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever","volume":"9","author":"Mongkolsapaya","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<335::AID-JMV13>3.0.CO;2-E","article-title":"Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures","volume":"59","author":"Chaturvedi","year":"1999","journal-title":"J Med Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0035-9203(98)90800-8","article-title":"Plasma levels of tumour necrosis factor alpha and transforming growth factor beta-1 in children with dengue 2 virus infection in French Polynesia","volume":"92","author":"Laur","year":"1998","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1078\/0171-2985-00058","article-title":"Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever","volume":"204","author":"Azeredo","year":"2001","journal-title":"Immunobiology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1086\/380762","article-title":"Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles","volume":"189","author":"Nguyen","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.arcmed.2005.04.007_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF02255946","article-title":"Immunopathogenesis of dengue virus infection","volume":"8","author":"Lei","year":"2001","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.arcmed.2005.04.007_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0065-3527(03)60005-9","article-title":"Mechanisms of dengue virus-induced cell death","volume":"60","author":"Courageot","year":"2003","journal-title":"Adv Virus Res"},{"key":"10.1016\/j.arcmed.2005.04.007_bib29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-3-540-74264-7_9","article-title":"Flaviviruses and apoptosis regulation","volume":"36","author":"Catteau","year":"2004","journal-title":"Prog Mol Subcell Biol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib30","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0300-9084(03)00139-1","article-title":"Expression of dengue ApoptoM sequence results in disruption of mitochondrial potential and caspase activation","volume":"85","author":"Catteau","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.arcmed.2005.04.007_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO;2-L","article-title":"Generation of IgM anti-platelet autoantibody in dengue patients","volume":"63","author":"Lin","year":"2001","journal-title":"J Med Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4049\/jimmunol.169.2.657","article-title":"Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide","volume":"169","author":"Lin","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/viro.1993.1015","article-title":"The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in mice","volume":"192","author":"Schlesinger","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4049\/jimmunol.174.1.395","article-title":"Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1","volume":"174","author":"Lin","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO;2-L","article-title":"Generation of IgM anti-platelet autoantibody in dengue patients","volume":"63","author":"Lin","year":"2001","journal-title":"J Med Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/viro.1997.8504","article-title":"Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas","volume":"230","author":"Rico-Hesse","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4269\/ajtmh.1998.58.96","article-title":"Molecular evolution of dengue type 2 virus in Thailand","volume":"58","author":"Rico-Hesse","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(01)00456-1","article-title":"Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity","volume":"106","author":"Liu","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2005.04.007_bib39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nri1549","article-title":"Close encounters of different kinds: dendritic cells and NK cells take centre stage","volume":"5","author":"Degli-Esposti","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib40","first-page":"101","article-title":"Strategies and mechanisms for host and pathogen survival in acute and persistent viral infections","author":"Hilleman","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.arcmed.2005.04.007_bib41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4049\/jimmunol.164.1.371","article-title":"IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2","volume":"164","author":"van Den Broek","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/89726","article-title":"Dendritic cell lineage, plasticity and cross-regulation","volume":"2","author":"Liu","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib43","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1084\/jem.185.6.1131","article-title":"A skin homing molecule defines the langerhans cell progenitor in human peripheral blood","volume":"185","author":"Strunk","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib44","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.4049\/jimmunol.163.3.1409","article-title":"A CD1a+\/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells","volume":"163","author":"Ito","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib45","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood.V90.4.1458","article-title":"CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis","volume":"90","author":"Caux","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.arcmed.2005.04.007_bib46","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0923-2494(99)80039-X","article-title":"The role of the macrophage in immune regulation","volume":"149","author":"Gordon","year":"1998","journal-title":"Res Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib47","first-page":"664","article-title":"In vivo and in vitro studies on the morphological change in the monkey epidermal Langerhans cells following exposure to dengue 2 (16681) virus","volume":"27","author":"Taweechaisupapong","year":"1996","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.arcmed.2005.04.007_bib48","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1099\/00222615-45-2-138","article-title":"Langerhans cell density and serological changes following intradermal immunisation of mice with dengue 2 virus","volume":"45","author":"Taweechaisupapong","year":"1996","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib49","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/77553","article-title":"Human skin Langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib50","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/77470","article-title":"Dengue virus and dendritic cells","volume":"6","author":"Palucka","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib51","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.00037.x","article-title":"Human dendritic cells as targets of dengue virus infection","volume":"6","author":"Marovich","year":"2001","journal-title":"J Invest Dermatol Symp Proc"},{"key":"10.1016\/j.arcmed.2005.04.007_bib52","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1128\/JVI.75.8.3501-3508.2001","article-title":"Human dendritic cells are activated by dengue virus infection: enhancement by gammainterferon and implications for disease pathogenesis","volume":"75","author":"Libraty","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib53","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.166.3.1499","article-title":"Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production","volume":"166","author":"Ho","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib54","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.4049\/jimmunol.171.10.5571","article-title":"A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity","volume":"171","author":"Pichyangkul","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib55","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1189\/jlb.71.6.921","article-title":"DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology","volume":"71","author":"Geijtenbeek","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib56","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1126\/science.1066371","article-title":"Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR","volume":"294","author":"Feinberg","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2005.04.007_bib57","doi-asserted-by":"crossref","first-page":"28939","DOI":"10.1074\/jbc.M104565200","article-title":"A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands","volume":"276","author":"Mitchell","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2005.04.007_bib58","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/sj.embor.embor866","article-title":"Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses","volume":"4","author":"Navarro-Sanchez","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.arcmed.2005.04.007_bib59","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells","volume":"197","author":"Tassaneetrithep","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib60","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1128\/JVI.77.22.12022-12032.2003","article-title":"DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses","volume":"77","author":"Klimstra","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib61","article-title":"A variant in the CD209 promoter is associated with severity of dengue disease","author":"Sakuntabhai","year":"2005","journal-title":"Nat Gen 2005"},{"key":"10.1016\/j.arcmed.2005.04.007_bib62","doi-asserted-by":"crossref","first-page":"14053","DOI":"10.1128\/JVI.78.24.14053-14056.2004","article-title":"Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection","volume":"78","author":"Martin","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib63","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.285.5428.736","article-title":"Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2","volume":"285","author":"Aliprantis","year":"1999","journal-title":"Science"},{"issue":"4 Pt 2","key":"10.1016\/j.arcmed.2005.04.007_bib64","first-page":"474","article-title":"The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity","volume":"29","author":"Beutler","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.arcmed.2005.04.007_bib65","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.4049\/jimmunol.172.12.7485","article-title":"Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG","volume":"172","author":"Hubert","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib66","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","article-title":"Cutting edge: a novel Toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling","volume":"169","author":"Yamamoto","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib67","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1097-2765(03)00053-4","article-title":"Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members","volume":"11","author":"Janssens","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.arcmed.2005.04.007_bib68","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S1471-4906(03)00242-4","article-title":"Leucine-rich repeats and pathogen recognition in Toll-like receptors","volume":"24","author":"Bell","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib69","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0968-0004(02)02145-X","article-title":"A universal role for MyD88 in TLR\/IL-1R-mediated signaling","volume":"27","author":"Janssens","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.arcmed.2005.04.007_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"Int Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib72","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2005.04.007_bib73","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2004.01.033","article-title":"Does Toll-like receptor 3 play a biological role in virus infections?","volume":"322","author":"Edelmann","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib74","doi-asserted-by":"crossref","first-page":"49751","DOI":"10.1074\/jbc.M305820200","article-title":"TIR-containing adapter molecule TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta","volume":"278","author":"Oshiumi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2005.04.007_bib75","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib76","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1002\/eji.200324238","article-title":"The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily","volume":"33","author":"Heil","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib77","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U","article-title":"Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments","volume":"32","author":"Ahmad-Nejad","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib78","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.arcmed.2005.04.007_bib79","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1189\/jlb.71.2.173","article-title":"Role of chemokines in the biology of natural killer cells","volume":"71","author":"Robertson","year":"2002","journal-title":"J Leukoc Biol Rev"},{"key":"10.1016\/j.arcmed.2005.04.007_bib80","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.immunol.22.012703.104711","article-title":"The dynamic life of natural killer cells","volume":"22","author":"Yokoyama","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib81","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.it.2004.09.008","article-title":"Different checkpoints in human NK-cell activation","volume":"25","author":"Moretta","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib82","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.1060042","article-title":"Vital involvement of a natural killer cell activation receptor in resistance to viral infection","volume":"294","author":"Brown","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2005.04.007_bib83","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.virol.2003.09.048","article-title":"Early activation of natural killer and B cells in response to primary dengue virus infection in A\/J mice","volume":"319","author":"Shresta","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib84","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1086\/315072","article-title":"Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever","volume":"180","author":"Green","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.arcmed.2005.04.007_bib85","first-page":"429","article-title":"Characterization with monoclonal antibodies of human lymphocytes active in natural killing and antibody-dependent cell-mediated cytotoxicity of dengue virus-infected cells","volume":"58","author":"Kurane","year":"1986","journal-title":"Immunology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib86","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.molimm.2004.04.004","article-title":"Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells","volume":"41","author":"Bottino","year":"2004","journal-title":"Mol Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib87","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1084\/jem.20011149","article-title":"Human dendritic cells activate resting natural killer (NK) cells and are recognized via theNKp30 receptor by activated NK cells","volume":"195","author":"Ferlazzo","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib88","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1084\/jem.20010934","article-title":"Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells","volume":"195","author":"Piccioli","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcmed.2005.04.007_bib89","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1074-7613(01)00095-4","article-title":"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor","volume":"2","author":"Cosman","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.arcmed.2005.04.007_bib90","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1070884","article-title":"Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors","volume":"296","author":"Arase","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2005.04.007_bib91","first-page":"303","article-title":"Related articles, links changes of natural killer cell activity in different mouse lines by acute and asymptomatic flavivirus infections","volume":"30","author":"Vargin","year":"1986","journal-title":"Acta Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib92","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tim.2005.01.006","article-title":"Pathogen-induced private conversations between natural killer and dendritic cells","volume":"13","author":"Della Chiesa","year":"2005","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib93","doi-asserted-by":"crossref","first-page":"953","DOI":"10.4049\/jimmunol.117.3.953","article-title":"Replication of dengue-2 virus in cultured human lymphoblastoid cells and subpopulations of human peripheral leukocytes","volume":"117","author":"Theofilopoulos","year":"1976","journal-title":"J Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib94","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1128\/IAI.68.2.702-707.2000","article-title":"Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation","volume":"68","author":"Juffrie","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.arcmed.2005.04.007_bib95","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/jmv.10198","article-title":"Transient CD4\/CD8 ratio inversion and aberrant immune activation during dengue virus infection","volume":"68","author":"Liu","year":"2002","journal-title":"J Med Virol"},{"issue":"Suppl 1","key":"10.1016\/j.arcmed.2005.04.007_bib96","first-page":"246","article-title":"Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever","volume":"24","author":"Butthep","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.arcmed.2005.04.007_bib97","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO;2-L","article-title":"Generation of IgM anti-platelet autoantibody in dengue patients","volume":"63","author":"Lin","year":"2001","journal-title":"J Med Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib98","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/0035-9203(92)90186-G","article-title":"Complement pathway activity in serum from patients with classical dengue fever","volume":"86","author":"Shaio","year":"1992","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib99","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/vim.2004.17.498","article-title":"Inverse interference: how viruses fight the interferon system","volume":"17","author":"Weber","year":"2004","journal-title":"Viral Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib100","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2005.04.007_bib101","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/08830180213277","article-title":"Viruses and the type I interferon antiviral system: induction and evasion","volume":"21","author":"Basler","year":"2002","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib102","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/088282403322396109","article-title":"Calling in the troops: regulation of inflammatory cell trafficking through innate cytokine\/chemokine networks","volume":"16","author":"Salazar-Mather","year":"2003","journal-title":"Viral Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib103","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0198-8859(02)00751-6","article-title":"Natural type I interferon-producing cells as a link between innate and adaptive immunity","volume":"63","author":"Kadowaki","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib104","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri888","article-title":"Viruses and interferon: a fight for supremacy","volume":"2","author":"Katze","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/08977199809017490","article-title":"Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes","volume":"16","author":"Lackmann","year":"1998","journal-title":"Growth Factors"},{"key":"10.1016\/j.arcmed.2005.04.007_bib106","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1128\/MCB.16.12.6957","article-title":"Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor3 transcription complex","volume":"16","author":"Horvath","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib107","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14","author":"Samuel","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.arcmed.2005.04.007_bib108","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1128\/JVI.78.6.2701-2710.2004","article-title":"Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical","volume":"78","author":"Shresta","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib109","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1128\/JVI.74.11.4957-4966.2000","article-title":"Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons","volume":"74","author":"Diamond","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib110","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/viro.2001.1114","article-title":"Interferon inhibits dengue virus infection by preventing translation of viral RNA through a PKR-independent mechanism","volume":"289","author":"Diamond","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.arcmed.2005.04.007_bib111","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.73.1.783-786.1999","article-title":"New mouse model for dengue virus vaccine testing","volume":"73","author":"Johnson","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib112","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1046\/j.1440-1711.2003.01166.x","article-title":"Infection of mouse neurones by West Nile virus is modulated by the interferon-inducible 2\u2032-5\u2032 oligoadenylate synthetase 1b protein","volume":"81","author":"Lucas","year":"2003","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib113","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0888-7543(03)00176-9","article-title":"Structural and functional genomics, and evolutionary relationships in the cluster of genes encoding murine 2\u2032-5\u2032-oligoadenylate synthetases","volume":"82","author":"Mashimo","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.arcmed.2005.04.007_bib114","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"AJ Infect Dis"},{"key":"10.1016\/j.arcmed.2005.04.007_bib115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4269\/ajtmh.1993.48.222","article-title":"High levels of interferon alpha in the sera of children with dengue virus infection","volume":"48","author":"Kurane","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.arcmed.2005.04.007_bib116","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/1096-9071(200101)63:1<29::AID-JMV1004>3.0.CO;2-S","article-title":"High levels of interferon alpha in the sera of children with dengue virus infection","volume":"63","author":"Sudiro","year":"2001","journal-title":"J Med Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib117","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1128\/JVI.77.3.2174-2181.2003","article-title":"Virus replication in engineered human cells that do not respond to interferons","volume":"77","author":"Young","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib118","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1099\/0022-1317-81-10-2341","article-title":"Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures","volume":"81","author":"Goodbourn","year":"2000","journal-title":"J Gen Virol"},{"key":"10.1016\/j.arcmed.2005.04.007_bib119","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","article-title":"Inhibition of interferon signaling by dengue virus","volume":"100","author":"Munoz-Jordan","year":"2003","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440905001852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440905001852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:29:35Z","timestamp":1759260575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440905001852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0188440905001852"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2005.04.007","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Innate Immune Responses to Dengue Virus","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2005.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}