{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:41:51Z","timestamp":1770547311231,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.arcmed.2005.06.014","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T14:37:51Z","timestamp":1141223871000},"page":"316-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Kinetic of Genotoxic Expression in the Pharmacodynamics of Busulfan"],"prefix":"10.1016","volume":"37","author":[{"given":"Pedro","family":"Morales-Ram\u00edrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindy","family":"Miranda-Pasaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia L.","family":"Cruz-Vallejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresita","family":"Vallarino-Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"Mendiola-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2005.06.014_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00007691-199810000-00017","article-title":"Therapeutic monitoring of busulfan in hematopoietic stem cell transplantation","volume":"20","author":"Slattery","year":"1998","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.arcmed.2005.06.014_bib2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.bmt.1703047","article-title":"Busulfan levels are influenced by prior treatment and early mortality but not with delayed complications following marrow transplantation","volume":"27","author":"Copelan","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.arcmed.2005.06.014_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/mutage\/geh018","article-title":"In vivo kinetics of micronuclei induction by bifunctional alkylating antineoplastics","volume":"19","author":"Morales-Ram\u00edrez","year":"2004","journal-title":"Mutagenesis"},{"key":"10.1016\/j.arcmed.2005.06.014_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0921-8777(98)00061-5","article-title":"Repair kinetics of gamma-ray induced DNA damage determined by the single cell gel electrophoresis assay in murine leukocytes in vivo","volume":"433","author":"Mendiola-Cruz","year":"1999","journal-title":"Mutat Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1023\/A:1019964331735","article-title":"Damage-repair kinetics and early adaptive response induced by gamma rays in murine leukocytes in vivo","volume":"25","author":"Mendiola-Cruz","year":"2002","journal-title":"Somat Cell Mol Genet"},{"key":"10.1016\/j.arcmed.2005.06.014_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib7","unstructured":"Eriksson S, Nyrgen J. Preparing dried slides. Comet Workshop, Prague, August 1995. pp. 19\u201320."},{"key":"10.1016\/j.arcmed.2005.06.014_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ Mol Mutagen"},{"key":"10.1016\/j.arcmed.2005.06.014_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0167-9473(92)90171-B","article-title":"Extension of Dunnett's multiple comparison procedure with different sample sizes to the case of several groups","volume":"14","author":"Cheung","year":"1992","journal-title":"Comput Stat Data Anal"},{"key":"10.1016\/j.arcmed.2005.06.014_bib10","first-page":"7559","article-title":"In vitro studies on the mechanism of action of hepsulfam in chronic myelogenous leukemia patients","volume":"50","author":"Hincks","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib11","first-page":"7555","article-title":"Mechanisms of toxicity of hepsulfam in human tumor cell lines","volume":"50","author":"Pacheco","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib12","first-page":"5108","article-title":"Comparison of the mechanism of action of busulfan with hepsulfam, a new antileukemic agent, in the L1210 cell line","volume":"49","author":"Pacheco","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0145-2126(90)90151-X","article-title":"DNA strand breaks in human leukocytes induced by chemotherapy and total body irradiation","volume":"14","author":"Franssen","year":"1990","journal-title":"Leuk Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00292863","article-title":"Repair of DNA interstrand crosslinks after busulphan. A possible mode of resistance","volume":"8","author":"Bedford","year":"1982","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.arcmed.2005.06.014_bib15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1349-7006.2004.tb03231.x","article-title":"DNA intrastrand cross-link at the 5\u2032-GA-3\u2032 sequence formed by busulfan and its role in the cytotoxic effect","volume":"95","author":"Iwamoto","year":"2004","journal-title":"Cancer Sci"},{"key":"10.1016\/j.arcmed.2005.06.014_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/(SICI)1098-2280(1998)32:3<260::AID-EM9>3.0.CO;2-M","article-title":"Signficance of formaldehyde-induced DNA-protein crosslinks for mutagenesis","volume":"32","author":"Merk","year":"1998","journal-title":"Environ Mol Mutagen"},{"key":"10.1016\/j.arcmed.2005.06.014_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/(SICI)1098-2280(1999)33:2<167::AID-EM9>3.0.CO;2-D","article-title":"Detection of crosslinks with the comet assay in relationship to genotoxicity and cytotoxicity","volume":"33","author":"Merk","year":"1999","journal-title":"Environ Mol Mutagen"},{"key":"10.1016\/j.arcmed.2005.06.014_bib18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0301-472X(01)00631-2","article-title":"O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells","volume":"29","author":"Westerhof","year":"2001","journal-title":"Exp Hematol"},{"key":"10.1016\/j.arcmed.2005.06.014_bib19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0968-0004(00)89095-7","article-title":"Cisplatin and DNA repair in cancer chemotherapy","volume":"20","author":"Zamble","year":"1995","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.arcmed.2005.06.014_bib20","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1093\/nar\/21.25.5846","article-title":"Instability of the monofunctional adducts in cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl](2+)-modified DNA: rates of cross-linking reactions in cis-platinum-modified DNA","volume":"21","author":"Payet","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib21","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/sj.leu.2402193","article-title":"The pharmacodynamic effect of busulfan in the P39 myeloid cell line in vitro","volume":"15","author":"Hassan","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.arcmed.2005.06.014_bib22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4065\/78.5.589","article-title":"Hepatic veno-occlusive disease (Sinusoidal Obstruction Syndrome) after hematopoietic stem cell transplantation","volume":"78","author":"Kumar","year":"2003","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.arcmed.2005.06.014_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.bmt.1701322","article-title":"Pharmacokinetics of intravenous busulfan and evaluation of the bioavailability of the oral formulation in conditioning for haematopoietic stem cell transplantation","volume":"22","author":"Schuler","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.arcmed.2005.06.014_bib24","first-page":"225","article-title":"Association of busulfan area under the curve with veno-occlusive disease following BMT","volume":"17","author":"Dix","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.arcmed.2005.06.014_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0027-5107(87)90057-1","article-title":"Effects of busulfan on murine spermatogenesis: cytotoxicity, sterility, sperm abnormalities, and dominant lethal mutations","volume":"176","author":"Bucci","year":"1987","journal-title":"Mutat Res"},{"key":"10.1016\/j.arcmed.2005.06.014_bib26","first-page":"199","article-title":"Growth retardation and depigmentation of hair after high-dose busulfan and congenic hematopoietic cell transplantation in mice","volume":"9","author":"Yeager","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.arcmed.2005.06.014_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mrgentox.2004.09.006","article-title":"Kinetics of micronucleated polychromatic erythrocytes (MN-PCE) induction in vivo by aneuploidogens","volume":"565","author":"Morales-Ram\u00edrez","year":"2004","journal-title":"Mutat Res"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440905002882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440905002882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:30:44Z","timestamp":1759260644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440905002882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0188440905002882"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2005.06.014","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinetic of Genotoxic Expression in the Pharmacodynamics of Busulfan","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2005.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}