{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:55:35Z","timestamp":1761918935756,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.arcmed.2006.07.003","type":"journal-article","created":{"date-parts":[[2006,11,4]],"date-time":"2006-11-04T07:14:12Z","timestamp":1162624452000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nitrotyrosine Formation and Heme Oxygenase-1 Expression in Endotoxemic Cirrhotic Rats"],"prefix":"10.1016","volume":"38","author":[{"given":"Semra","family":"Do\u011fru-Abbaso\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande","family":"Par\u0131ldar-Karpuzo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jale","family":"Balkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u00e7in","family":"Ayka\u00e7-Toker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcjdat","family":"Uysal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2006.07.003_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/jsre.1997.5068","article-title":"Lipopolysaccharide-mediated hepatic glutathione depletion and progressive mitochondrial damage in mice: protective effect of glutathione monoethyl ester","volume":"70","author":"Uedono","year":"1997","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.arcmed.2006.07.003_bib2","first-page":"33","article-title":"The effects of N-acetyl cysteine tretment and nitric oxide synthase inhibition on oxidative stress induced by E. coli endotoxin","volume":"14","author":"Mutlu-T\u00fcrko\u011flu","year":"1998","journal-title":"Biochem Arch"},{"key":"10.1016\/j.arcmed.2006.07.003_bib3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/00042737-200509000-00006","article-title":"The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats","volume":"17","author":"Balkan","year":"2005","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/hep.510290231","article-title":"Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status","volume":"29","author":"Vos","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.arcmed.2006.07.003_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0168-8278(00)80272-X","article-title":"Effects of lipopolysaccharide on TNF-\u03b1 production, hepatic NOS2 activity, and hepatic toxicity in rats with cirrhosis","volume":"33","author":"Heller","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib6","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0024-3205(96)00651-0","article-title":"Peroxynitrite: a two-faced metabolite of nitric oxide","volume":"60","author":"Muijsers","year":"1997","journal-title":"Life Sci"},{"key":"10.1016\/j.arcmed.2006.07.003_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(97)00469-9","article-title":"What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?","volume":"411","author":"Halliwell","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.arcmed.2006.07.003_bib8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.200404-465SO","article-title":"Heme oxygenase-1: from bench to bedside","volume":"172","author":"Morse","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arcmed.2006.07.003_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0168-8278(99)80008-7","article-title":"Nitric oxide mediates the lipopolysaccharide dependent upregulation of the heme oxygenase-1 gene expression in cultured rat Kupffer cells","volume":"30","author":"Immenschuh","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib10","doi-asserted-by":"crossref","first-page":"G308","DOI":"10.1152\/ajpgi.00054.2005","article-title":"Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole","volume":"289","author":"Lu","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib11","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.3748\/wjg.v9.i8.1799","article-title":"TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-\u03b1 and IL-1\u03b2","volume":"9","author":"Song","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2005.06.014","article-title":"Mechanisms of liver fibrosis","volume":"364","author":"Tsukada","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.arcmed.2006.07.003_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0168-8278(01)00163-5","article-title":"Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers","volume":"35","author":"Bruck","year":"2001","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1191\/096032701678227758","article-title":"Taurine has protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress","volume":"20","author":"Balkan","year":"2001","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00726-004-0105-5","article-title":"Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication","volume":"27","author":"Erman","year":"2004","journal-title":"Amino Acids"},{"key":"10.1016\/j.arcmed.2006.07.003_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/cs0940637","article-title":"Increased nitric oxide synthesis and inducible nitric oxide synthase expression in patients with alcoholic and non-alcoholic liver cirrhosis","volume":"94","author":"Sanchez-Rodriguez","year":"1998","journal-title":"Clin Sci"},{"key":"10.1016\/j.arcmed.2006.07.003_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0168-8278(02)00266-0","article-title":"Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis","volume":"37","author":"Sanz-Cameno","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib19","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3109\/00365529709011206","article-title":"Prognostic value of plasma endotoxin levels in patients with cirrhosis","volume":"32","author":"Chan","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib20","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/hep.510300515","article-title":"Increased sensitivity to endotoxemia in the bile duct-ligated cirrhotic rat","volume":"30","author":"Harry","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.arcmed.2006.07.003_bib21","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(01)00647-5","article-title":"Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia","volume":"31","author":"Ottesen","year":"2001","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.arcmed.2006.07.003_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1191\/0960327102ht256oa","article-title":"Aminoguanidine, an inducible nitric oxide synthase inhibitor, plus N-acetylcysteine treatment reduce the lipopolysaccharide-augmented hepatotoxicity in rats with cirrhosis","volume":"21","author":"Do\u011fru-Abbaso\u011flu","year":"2002","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/meth.1995.1012","article-title":"Measurement of nitrate and nitrite in extracellular fluids: a window to systemic nitric oxide metabolism","volume":"7","author":"Grisham","year":"1995","journal-title":"Comp Methods Enzymol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.arcmed.2006.07.003_bib25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9150(02)00010-2","article-title":"Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modification","volume":"163","author":"Roberts","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arcmed.2006.07.003_bib27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"10.1016\/j.arcmed.2006.07.003_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage t4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature (London)"},{"key":"10.1016\/j.arcmed.2006.07.003_bib29","doi-asserted-by":"crossref","first-page":"13136","DOI":"10.1073\/pnas.96.23.13136","article-title":"Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine","volume":"96","author":"Balabanl\u0131","year":"1999","journal-title":"PNAS"},{"key":"10.1016\/j.arcmed.2006.07.003_bib30","first-page":"778","article-title":"Nitrated and oxidized plasma proteins in smokers and lung cancer patients","volume":"61","author":"Pignatelli","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2006.07.003_bib31","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/path.1284","article-title":"Expression of haem oxygenase in cirrhotic rat liver","volume":"199","author":"Wei","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib32","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3748\/wjg.v12.i4.588","article-title":"Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis","volume":"12","author":"Goh","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib33","doi-asserted-by":"crossref","first-page":"L346","DOI":"10.1152\/ajplung.00385.2001","article-title":"Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome","volume":"283","author":"Carter","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.510300148","article-title":"Nitric oxide in liver injury","volume":"30","author":"Clemens","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.arcmed.2006.07.003_bib35","series-title":"Liver Diseases: Biochemical Mechanisms and New Therapeutic Insights","first-page":"127","article-title":"Role of nitric oxide in liver disorders","author":"Muriel","year":"2006"},{"key":"10.1016\/j.arcmed.2006.07.003_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.etp.2006.03.002","article-title":"Chronic bile duct obstruction induces changes in plasma and hepatic levels of cytokines and nitric oxide in the rat","volume":"58","author":"Fernandez-Martinez","year":"2006","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.arcmed.2006.07.003_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0024-3205(98)00252-5","article-title":"Evidence for in vivo peroxynitrite production in human chronic hepatitis","volume":"63","author":"Cuzzocrea","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.arcmed.2006.07.003_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0168-8278(00)80080-X","article-title":"Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease","volume":"32","author":"Garcia-Monzon","year":"2000","journal-title":"J Hepatol"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440906003006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440906003006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:32:39Z","timestamp":1759260759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440906003006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0188440906003006"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2006.07.003","relation":{},"ISSN":["0188-4409"],"issn-type":[{"type":"print","value":"0188-4409"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitrotyrosine Formation and Heme Oxygenase-1 Expression in Endotoxemic Cirrhotic Rats","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2006.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}