{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:11:47Z","timestamp":1772831507667,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015145","name":"Chevron Brazil Upstream Frade Ltda","doi-asserted-by":"publisher","award":["2002\/06490\u20135"],"award-info":[{"award-number":["2002\/06490\u20135"]}],"id":[{"id":"10.13039\/100015145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015145","name":"Chevron Brazil Upstream Frade Ltda","doi-asserted-by":"publisher","award":["2000\/13996\u20137"],"award-info":[{"award-number":["2000\/13996\u20137"]}],"id":[{"id":"10.13039\/100015145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015145","name":"Chevron Brazil Upstream Frade Ltda","doi-asserted-by":"publisher","award":["1998\/15456\u20138"],"award-info":[{"award-number":["1998\/15456\u20138"]}],"id":[{"id":"10.13039\/100015145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00c3\u00a7\u00c3\u00a3o de Amparo \u00c3\u00a0 Pesquisa do Estado de S\u00c3\u00a3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004899","name":"Faculdade de Medicina de Mar\u00c3\u00adlia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.arcmed.2006.12.011","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T12:54:26Z","timestamp":1181307266000},"page":"551-555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Interleukin-6 Polymorphisms, Helicobacter pylori Infection in Adult Brazilian Patients with Chronic Gastritis and Gastric Adenocarcinoma"],"prefix":"10.1016","volume":"38","author":[{"given":"Luciano Lobo","family":"Gatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommel Rodr\u00edguez","family":"Burbano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio","family":"Zambaldi-Tunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Willian","family":"de-L\u00e1bio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Pimentel","family":"de Assump\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia","family":"de Arruda Cardoso-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer Luiz","family":"Marques-Pay\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2006.12.011_bib1","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2006.12.011_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00008469-200402000-00011","article-title":"Cancer of the gastrointestinal tract: early detection or early prevention?","volume":"13","author":"Rozen","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.arcmed.2006.12.011_bib3","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1053\/gast.1996.v110.pm8964399","article-title":"Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa","volume":"110","author":"Yamaoka","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arcmed.2006.12.011_bib4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1083-4389.2004.00221.x","article-title":"Age at acquisition of Helicobacter pylori infection: comparison of two areas with contrasting risk of gastric cancer","volume":"9","author":"Camargo","year":"2004","journal-title":"Helicobacter"},{"key":"10.1016\/j.arcmed.2006.12.011_bib5","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1128\/IAI.72.8.4416-4423.2004","article-title":"Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori","volume":"72","author":"Kranzer","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.arcmed.2006.12.011_bib6","series-title":"Schistosomes, Liver Flukes and Helicobacter pylori","author":"IARC","year":"1994"},{"key":"10.1016\/j.arcmed.2006.12.011_bib7","doi-asserted-by":"crossref","DOI":"10.3109\/00365529409105356","article-title":"Gastric cancer: a long-term consequence of Helicobacter pylori infection?","author":"Sipponen","year":"1994","journal-title":"Scand J Gastroenterol"},{"issue":"suppl 1","key":"10.1016\/j.arcmed.2006.12.011_bib8","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/00000478-199600001-00003","article-title":"Intestinal and diffuse gastric cancers arise in a different background of Helicobacter pylori gastritis through different gene involvement","volume":"20","author":"Solcia","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.arcmed.2006.12.011_bib9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0344-0338(11)80878-2","article-title":"New elements for an update classification of the carcinomas of the stomach","volume":"191","author":"Carneiro","year":"1995","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.arcmed.2006.12.011_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/cyto.2001.0982","article-title":"Interleukin-6 and network of several cytokines in multiple myeloma. An overview of clinical and experimental data","volume":"16","author":"Lauta","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.arcmed.2006.12.011_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1086\/315257","article-title":"Inflammatory cytokine mRNA expression during early and persistent Helicobacter pylori infection in nonhuman primates","volume":"181","author":"Harris","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.arcmed.2006.12.011_bib12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1128\/CMR.10.4.742","article-title":"A primer on cytokines: sources, receptors, effects, and inducers","volume":"10","author":"Curfs","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.arcmed.2006.12.011_bib13","doi-asserted-by":"crossref","first-page":"18138","DOI":"10.1074\/jbc.M000379200","article-title":"Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation","volume":"275","author":"Terry","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2006.12.011_bib14","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin 6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis","volume":"102","author":"Fishman","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcmed.2006.12.011_bib15","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1053\/gast.1996.v110.pm8964399","article-title":"Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa","volume":"110","author":"Yamaoka","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arcmed.2006.12.011_bib16","doi-asserted-by":"crossref","first-page":"18138","DOI":"10.1074\/jbc.M000379200","article-title":"Cooperative influence of genetic polymorphisms on interleukin-6 transcriptional regulation","volume":"275","author":"Terry","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2006.12.011_bib17","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1002\/art.11300","article-title":"The \u2212174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families","volume":"48","author":"Ogilvie","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.arcmed.2006.12.011_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric adenocarcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histoclinical classification","volume":"64","author":"Laur\u00e9n","year":"1965","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1016\/j.arcmed.2006.12.011_bib19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P","article-title":"Estimates of the worldwide incidence of 25 major cancers in 1990","volume":"80","author":"Parkin","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.arcmed.2006.12.011_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0889-8553(05)70138-2","article-title":"Helicobacter pylori gastritis and gastric physiology","volume":"29","author":"McColl","year":"2000","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.arcmed.2006.12.011_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0950-3528(95)90049-7","article-title":"Helicobacter pylori as a risk factor for cancer","volume":"9","author":"Webb","year":"1995","journal-title":"Baillieres Clin Gastroenterol"},{"key":"10.1016\/j.arcmed.2006.12.011_bib22","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1016\/S0959-8049(01)00255-6","article-title":"Genetics and the common cancers","volume":"37","author":"Peto","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.arcmed.2006.12.011_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/35077207","article-title":"Cancer genetics","volume":"411","author":"Ponder","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2006.12.011_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/oxfordjournals.bmb.a011664","article-title":"Helicobacter pylori and gastric inflammation","volume":"54","author":"Bodger","year":"1998","journal-title":"Med Bull"},{"key":"10.1016\/j.arcmed.2006.12.011_bib25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0016-5085(03)00899-0","article-title":"A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma","volume":"125","author":"Machado","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arcmed.2006.12.011_bib26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"Interleukin-1 polymorphisms associated with increased risk of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2006.12.011_bib27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/gast.2001.28000","article-title":"Interleukin-1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma","volume":"121","author":"Machado","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arcmed.2006.12.011_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10238-004-0043-2","article-title":"Interleukin-1B polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma","volume":"4","author":"Gatti","year":"2004","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.arcmed.2006.12.011_bib29","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1053\/gast.1996.v110.pm8964399","article-title":"Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa","volume":"110","author":"Yamaoka","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arcmed.2006.12.011_bib30","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1136\/gut.32.12.1473","article-title":"Mucosal tumor necrosis factor \u03b1 and interleukin-6 in patients with Helicobacter pylori associated gastritis","volume":"32","author":"Crabtree","year":"1991","journal-title":"Gut"},{"key":"10.1016\/j.arcmed.2006.12.011_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1046\/j.1523-5378.2001.00017.x","article-title":"Relation between cytokines and Helicobacter pylori in gastric cancer","volume":"6","author":"Yamaoka","year":"2001","journal-title":"Helicobacter"},{"key":"10.1016\/j.arcmed.2006.12.011_bib32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s10120-005-0315-x","article-title":"Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: role of IL-6 as a prognostic factor","volume":"8","author":"Ashizawa","year":"2005","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.arcmed.2006.12.011_bib33","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1158\/1055-9965.1547.13.9","article-title":"Polymorphisms in interleukin-2, -6 and -10 are not associated with gastric cardia or esophageal cancer in a high-risk Chinese population","volume":"13","author":"Savage","year":"2004","journal-title":"Cancer Epidemiol Biomed Prev"},{"key":"10.1016\/j.arcmed.2006.12.011_bib34","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","article-title":"Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms","volume":"124","author":"El-Omar","year":"2003","journal-title":"Gastroenterology"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440907001129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440907001129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:33:16Z","timestamp":1759260796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440907001129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0188440907001129"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2006.12.011","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-6 Polymorphisms, Helicobacter pylori Infection in Adult Brazilian Patients with Chronic Gastritis and Gastric Adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2006.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}