{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:14:08Z","timestamp":1759331648857,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.arcmed.2010.09.008","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T04:46:50Z","timestamp":1292474810000},"page":"487-496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concomitant Effects of Nitric Oxide and Carotid Chemoreceptor Stimulation on Brain Glucose in Normoglycemic and Hyperglycemic Rats"],"prefix":"10.1016","volume":"41","author":[{"given":"H\u00e9ctor Rafael","family":"Tejeda-Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio A.","family":"Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Lemus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caridad A.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliseo","family":"Portilla-de Buen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana G.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Roces de \u00c1lvarez-Buylla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2010.09.008_bib1","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.2337\/diacare.26.6.1902","article-title":"Hypoglycemia in diabetes","volume":"26","author":"Cryer","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arcmed.2010.09.008_bib2","first-page":"241","article-title":"Brain glucose sensing, counterregulation, and energy homeostasis","volume":"22","author":"Marty","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.arcmed.2010.09.008_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.smj.0000242866.81791.70","article-title":"Physiological and behavioral aspects of glycemic control and hypoglycemia in diabetes","volume":"100","author":"Boyle","year":"2007","journal-title":"South Med J"},{"key":"10.1016\/j.arcmed.2010.09.008_bib4","doi-asserted-by":"crossref","first-page":"R590","DOI":"10.1152\/ajpregu.00456.2007","article-title":"Nitric oxide\u2019s role in glucose homeostasis","volume":"293","author":"Barnes","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib5","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2337\/diab.46.9.1521","article-title":"Novel glucosensor for hypoglycemic detection localized to the portal vein","volume":"46","author":"Hevener","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2010.09.008_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2337\/diabetes.50.2.399","article-title":"Hypoglycemic detection does not occur in the hepatic artery or liver: findings consistent with a portal vein glucosensor locus","volume":"50","author":"Hevener","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2010.09.008_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0034-5687(88)90093-X","article-title":"Carotid sinus receptors participate in glucose homeostasis","volume":"72","author":"Alvarez-Buylla","year":"1988","journal-title":"Respir Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nn812","article-title":"Low glucose-sensing cells in the carotid body","volume":"5","author":"Pardal","year":"2002","journal-title":"Nature Neurosci"},{"key":"10.1016\/j.arcmed.2010.09.008_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(94)91585-7","article-title":"Changes in blood glucose concentration in the carotid body-sinus modify brain glucose retention","volume":"654","author":"Alvarez-Buylla","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.arcmed.2010.09.008_bib10","first-page":"E921","article-title":"Acute adaptation of carbohydrate metabolism to decreased arterial PO2","volume":"266","author":"Zinker","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2337\/diabetes.49.9.1434","article-title":"Evidence that carotid bodies play an important role in glucoregulation in vivo","volume":"49","author":"Koyama","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2010.09.008_bib12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor","volume":"327","author":"Palmer","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2010.09.008_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0306-4522(94)00437-A","article-title":"Nitric oxide mediates chemoreceptor inhibition in the cat carotid body","volume":"65","author":"Wang","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2010.09.008_bib14","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1152\/jappl.2000.89.3.1005","article-title":"Dual effects of nitric oxide on cat carotid body chemoreception","volume":"89","author":"Iturriaga","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/0-306-46825-5_31","article-title":"Evidence that nitric oxide plays a role in O2 sensing from tissue NO and PO2 measurements in cat carotid body","volume":"475","author":"Buerk","year":"2000","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/0-387-31311-7_45","article-title":"Nitric oxide in brain glucose retention after carotid body receptors stimulation with cyanide in rats","volume":"580","author":"Montero","year":"2006","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0197-0186(03)00125-6","article-title":"Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study","volume":"44","author":"Kino","year":"2004","journal-title":"Neurochem Int"},{"year":"1996","series-title":"Guide for the Care and Use of Laboratory Animals","key":"10.1016\/j.arcmed.2010.09.008_bib18"},{"key":"10.1016\/j.arcmed.2010.09.008_bib19","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/jcbfm.1988.89","article-title":"Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brain","volume":"8","author":"Ueki","year":"1988","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.arcmed.2010.09.008_bib20","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/01.STR.0000077255.15597.69","article-title":"Different expression patterns of Bcl-2, Bcl-xl, and Bax proteins after sublethal forebrain ischemia in C57Black\/Crj6 MOUSE STRIATUM","volume":"34","author":"Wu","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.arcmed.2010.09.008_bib21","first-page":"408","article-title":"Estudio cuantitativo de la actividad quimiorreceptora del seno carot\u00eddeo del perro","volume":"21","author":"Alvarez-Buylla","year":"1951","journal-title":"Arch Inst Cardiol (Mex)"},{"key":"10.1016\/j.arcmed.2010.09.008_bib22","first-page":"29","article-title":"Cardiovascular responses to hypoxia in the spontaneously breathing cat: reflexes originating from carotid and aortic bodies","volume":"16","author":"Serani","year":"1983","journal-title":"Arch Biol Med Exp (Santiago)"},{"key":"10.1016\/j.arcmed.2010.09.008_bib23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0006-8993(00)01942-9","article-title":"Increased cerebral glucose utilization and decreased glucose transporter Glut 1 during chronic hyperglycemia in rat brain","volume":"858","author":"Duelli","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.arcmed.2010.09.008_bib24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2003.09.030","article-title":"Induction of brain glucose uptake by a factor secreted into cerebrospinal fluid","volume":"994","author":"Alvarez-Buylla","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.arcmed.2010.09.008_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neulet.2006.10.035","article-title":"Effects of nitric oxide on expressions of nitrosocysteine and calcium-activated potassium channels in the supraoptic nuclei and neural lobe of dehydrated rats","volume":"411","author":"Kadekaro","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.arcmed.2010.09.008_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.arcmed.2006.11.004","article-title":"Effects of acetylcysteine and probucol on contrast medium-induced depression of intrinsic renal glutathione peroxidase activity in diabetic rats","volume":"38","author":"Yen","year":"2007","journal-title":"Arch Med Res"},{"key":"10.1016\/j.arcmed.2010.09.008_bib27","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(03)00406-4","article-title":"Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals","volume":"35","author":"Kleinbongard","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.arcmed.2010.09.008_bib28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0076-6879(96)68016-1","article-title":"Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction","volume":"268","author":"Granger","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.niox.2010.02.003","article-title":"Nitric oxide in the hypothalamus-pituitary axis mediates increases in brain glucose retention induced by carotid chemoreceptor stimulation with cyanide in rats","volume":"22","author":"Cadenas","year":"2010","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.arcmed.2010.09.008_bib30","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2337\/db09-0421","article-title":"Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation","volume":"59","author":"Fioramonti","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2010.09.008_bib31","first-page":"R392","article-title":"Pituitary and adrenals are required for hyperglycemic reflex initiated by stimulation of CBR with cyanide","volume":"272","author":"Alvarez-Buylla","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib32","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.2337\/db07-0122","article-title":"Mechanisms of low-glucose sensitivity in carotid body glomus cells","volume":"56","author":"Garcia-Fernandez","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2010.09.008_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S0100-879X1999000100013","article-title":"The carotid body of the spontaneous insulin-dependent diabetic rat","volume":"32","author":"Clarke","year":"1999","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.arcmed.2010.09.008_bib34","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.1152\/ajpendo.90563.2008","article-title":"Four grams of glucose","volume":"296","author":"Wasserman","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.arcmed.2010.09.008_bib35","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/ATVBAHA.107.160754","article-title":"Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus","volume":"28","author":"Sasaki","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib36","doi-asserted-by":"crossref","first-page":"H2193","DOI":"10.1152\/ajpheart.00190.2007","article-title":"Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS","volume":"293","author":"Bauser-Heaton","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib37","doi-asserted-by":"crossref","first-page":"H134","DOI":"10.1152\/ajpheart.00023.2009","article-title":"NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors","volume":"297","author":"Figueroa","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-1-4419-9280-2_47","article-title":"Carotid body nitric oxide activity in spontaneously diabetic BB rat","volume":"536","author":"Bianchi","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(97)00636-8","article-title":"The role of nitric oxide in the control of plasma glucose concentration in spontaneously hypertensive rats","volume":"233","author":"Tong","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.arcmed.2010.09.008_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cardiores.2003.09.019","article-title":"Nitric oxide in myocardial ischemia\/reperfusion injury","volume":"61","author":"Schulz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arcmed.2010.09.008_bib41","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1007\/s00125-006-0403-4","article-title":"Insulin sensitivity and resistin expression in nitric oxide-deficient rats","volume":"49","author":"Juan","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.arcmed.2010.09.008_bib42","doi-asserted-by":"crossref","first-page":"L57","DOI":"10.1152\/ajplung.00494.2001","article-title":"Inhibitory effects of NO on carotid body: contribution of neural and endothelial nitric oxide synthase isoforms","volume":"284","author":"Valdes","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1089-8603(02)00106-4","article-title":"Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells","volume":"7","author":"Noyman","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.arcmed.2010.09.008_bib44","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jappl.1997.82.1.359","article-title":"Evidence that nitric oxide increases glucose transport in skeletal muscle","volume":"82","author":"Balon","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.arcmed.2010.09.008_bib45","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0014-5793(97)01397-5","article-title":"Nitric oxide synthase activity in mitochondria","volume":"418","author":"Ghafourifar","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.arcmed.2010.09.008_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00001756-200401190-00027","article-title":"Uncoupling of flow and metabolism induced by sodium nitroprusside in rat cerebral cortex","volume":"15","author":"Inoue","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.arcmed.2010.09.008_bib47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1471-4159.2003.01821.x","article-title":"Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection\/neurodegeneration?","volume":"86","author":"Gegg","year":"2003","journal-title":"J Neurochem"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440910002717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440910002717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:37:56Z","timestamp":1759261076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440910002717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0188440910002717"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2010.09.008","relation":{},"ISSN":["0188-4409"],"issn-type":[{"type":"print","value":"0188-4409"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concomitant Effects of Nitric Oxide and Carotid Chemoreceptor Stimulation on Brain Glucose in Normoglycemic and Hyperglycemic Rats","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2010.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}