{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:14:13Z","timestamp":1761743653576,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.arcmed.2012.05.004","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T18:30:55Z","timestamp":1339525855000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vardenafil Ameliorates Calcium Mobilization in Pulmonary Artery Smooth Muscle Cells from Hypoxic Pulmonary Hypertensive Mice"],"prefix":"10.1016","volume":"43","author":[{"given":"Wen-Sheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2012.05.004_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/07853890600622143","article-title":"Pulmonary arterial hypertension","volume":"38","author":"Raiesdana","year":"2006","journal-title":"Ann Med"},{"key":"10.1016\/j.arcmed.2012.05.004_bib2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1378\/chest.08-0820","article-title":"Pulmonary vascular involvement in COPD","volume":"134","author":"Peinado","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.arcmed.2012.05.004_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1183\/09031936.00128706","article-title":"The effects of hypoxia on the cells of the pulmonary vasculature","volume":"30","author":"Pak","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arcmed.2012.05.004_bib4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/10739680600930305","article-title":"Ca2+ channels and chronic hypoxia","volume":"13","author":"Shimoda","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.arcmed.2012.05.004_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(24)01321-8","article-title":"Calcium movements, distribution, and functions in smooth muscle","volume":"49","author":"Karaki","year":"1997","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.arcmed.2012.05.004_bib6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s12325-009-0064-z","article-title":"Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension","volume":"26","author":"Montani","year":"2009","journal-title":"Adv Ther"},{"key":"10.1016\/j.arcmed.2012.05.004_bib7","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1056\/NEJMct0904473","article-title":"Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension","volume":"361","author":"Archer","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcmed.2012.05.004_bib8","doi-asserted-by":"crossref","first-page":"H247","DOI":"10.1152\/ajpheart.01309.2010","article-title":"Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms","volume":"301","author":"Rexhaj","year":"2011","journal-title":"Am J\u00a0Physiol Heart Circ Physiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib9","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1172\/JCI45023","article-title":"Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice","volume":"121","author":"Hara","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcmed.2012.05.004_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.vph.2009.03.003","article-title":"Effects of U50,488H on hypoxia pulmonary hypertension and its underlying mechanism","volume":"51","author":"Li","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib11","doi-asserted-by":"crossref","first-page":"H1551","DOI":"10.1152\/ajpheart.00131.2005","article-title":"Endothelin-1 increases intracellular Ca2+ in rabbit pulmonary artery smooth muscle cells through phospholipase C","volume":"289","author":"Ko","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00408-010-9277-9","article-title":"Sleep quality, depression, and quality of life in patients with pulmonary hypertension","volume":"189","author":"Batal","year":"2011","journal-title":"Lung"},{"key":"10.1016\/j.arcmed.2012.05.004_bib13","first-page":"L536","article-title":"Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors","volume":"266","author":"Rabe","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1465-9921-11-12","article-title":"Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis","volume":"11","author":"Ryerson","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.arcmed.2012.05.004_bib15","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1743-6109.2008.01107.x","article-title":"Cardiovascular effects of phosphodiesterase type 5 inhibitors","volume":"6","author":"Vlachopoulos","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.arcmed.2012.05.004_bib16","doi-asserted-by":"crossref","first-page":"9M","DOI":"10.1016\/S0002-9149(03)00824-5","article-title":"Overview of phosphodiesterase 5 inhibition in erectile dysfunction","volume":"92","author":"Rosen","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.athoracsur.2005.06.040","article-title":"Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression","volume":"81","author":"Tsai","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.arcmed.2012.05.004_bib18","first-page":"1488","article-title":"Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study","volume":"44","author":"Ghofrani","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/CRD.0b013e3181cd2c9e","article-title":"Pulmonary arterial hypertension: pathobiology, diagnosis, treatment, and emerging therapies","volume":"18","author":"Rosenblum","year":"2010","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.arcmed.2012.05.004_bib20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1124\/jpet.105.092544","article-title":"Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta","volume":"316","author":"Teixeira","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.arcmed.2012.05.004_bib21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejphar.2006.05.005","article-title":"Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum","volume":"541","author":"Lau","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.bjp.0707357","article-title":"Role of InsP3 and ryanodine receptors in the activation of capacitative Ca2+ entry by store depletion or hypoxia in canine pulmonary arterial smooth muscle cells","volume":"152","author":"Ng","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib23","doi-asserted-by":"crossref","first-page":"C22","DOI":"10.1152\/ajpcell.2001.280.1.C22","article-title":"Heterogeneity of calcium stores and elementary release events in canine pulmonary arterial smooth muscle cells","volume":"280","author":"Janiak","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/bjp.2008.71","article-title":"Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG","volume":"154","author":"Maas","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"suppl 1","key":"10.1016\/j.arcmed.2012.05.004_bib25","first-page":"S172","article-title":"Purinergic signalling","volume":"147","author":"Burnstock","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.RES.80.2.170","article-title":"Electrophysiological consequences of purinergic receptor stimulation in isolated rat pulmonary arterial myocytes","volume":"80","author":"Hartley","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.arcmed.2012.05.004_bib27","first-page":"L450","article-title":"Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes","volume":"271","author":"Guibert","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/bjp.2008.141","article-title":"Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets","volume":"154","author":"Toque","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib29","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0022-5347(01)63299-3","article-title":"Effects of sildenafil on the relaxation of human corpus cavernosum tissue in\u00a0vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes","volume":"159","author":"Ballard","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.arcmed.2012.05.004_bib30","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1021\/jm0300577","article-title":"The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6] pyrido[3,4-b]indole-1,4-dione analogues","volume":"46","author":"Daugan","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.arcmed.2012.05.004_bib31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/sj.ijir.3900726","article-title":"The phosphodiesterase inhibitory selectivity and the in\u00a0vitro and in\u00a0vivo potency of the new PDE5 inhibitor vardenafil","volume":"13","author":"Saenz de Tejada","year":"2001","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.arcmed.2012.05.004_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1517\/14656566.6.1.75","article-title":"Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction","volume":"6","author":"Doggrell","year":"2005","journal-title":"Expert Opin Pharmacother"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440912001294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440912001294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:40:15Z","timestamp":1759261215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440912001294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0188440912001294"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2012.05.004","relation":{},"ISSN":["0188-4409"],"issn-type":[{"type":"print","value":"0188-4409"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vardenafil Ameliorates Calcium Mobilization in Pulmonary Artery Smooth Muscle Cells from Hypoxic Pulmonary Hypertensive Mice","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2012.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}