{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:54:19Z","timestamp":1791212059579,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Council for Science and Technology","award":["CB177624"],"award-info":[{"award-number":["CB177624"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.arcmed.2015.01.005","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T12:07:10Z","timestamp":1422965230000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Epigenetic Alterations Caused by Nutritional Stress During Fetal Programming of the Endocrine Pancreas"],"prefix":"10.1016","volume":"46","author":[{"given":"Tonantzin C.","family":"Sosa-Larios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Cerb\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2015.01.005_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcmed.2015.01.005_bib2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BJ20091861","article-title":"Mechanisms involved in the developmental programming of adulthood disease","volume":"427","author":"Warner","year":"2010","journal-title":"Biochem J"},{"key":"10.1016\/j.arcmed.2015.01.005_bib3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2012.02.010","article-title":"Diabetes mellitus and the \u03b2 cell: the last ten years","volume":"148","author":"Ashcroft","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2015.01.005_bib4","doi-asserted-by":"crossref","first-page":"1824S","DOI":"10.3945\/ajcn.110.000729","article-title":"Maternal malnutrition programs the endocrine pancreas in progeny","volume":"94","author":"Reusens","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib5","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00125-003-1131-7","article-title":"For debate: fetal and early post-natal growth restriction lead to diabetes, the metabolic syndrome and renal failure","volume":"46","author":"Hales","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.arcmed.2015.01.005_bib6","doi-asserted-by":"crossref","first-page":"E663","DOI":"10.1152\/ajpendo.00461.2004","article-title":"Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in the offspring of maternal protein restricted rats","volume":"288","author":"Guan","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.arcmed.2015.01.005_bib7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1677\/joe.0.1750757","article-title":"Gender-specific programming of insulin secretion and action","volume":"175","author":"Sugden","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib8","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1210\/endo.140.10.7042","article-title":"A low protein diet\u00a0alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor II","volume":"140","author":"Petrik","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.arcmed.2015.01.005_bib9","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1093\/jn\/133.9.2820","article-title":"Taurine supplementation of a low protein diet fed to rat dams normalizes the vascularization of the fetal endocrine pancreas","volume":"133","author":"Boujendar","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1677\/joe.1.06754","article-title":"Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific","volume":"191","author":"Chamson-Reig","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1071-55760300134-5","article-title":"Fetal growth restriction and consequences for the offspring in animal models","volume":"10","author":"Holemans","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.arcmed.2015.01.005_bib12","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1093\/jn\/131.10.3030","article-title":"Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation","volume":"132","author":"Arantes","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/10284150701308693","article-title":"Protein restriction during lactation alters the autonomic nervous system control on glucose-induced insulin secretion in adult rats","volume":"10","author":"Gravena","year":"2007","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.arcmed.2015.01.005_bib14","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1017\/S0007114511004855","article-title":"Emergence of ageing-related changes in insulin secretion by pancreatic islets of male rat offspring of mothers fed a low-protein diet","volume":"107","author":"Morimoto","year":"2012","journal-title":"Br J Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1017\/S2040174412000463","article-title":"Developmental programming of aging of isolated pancreatic islet glucose-stimulated insulin secretion in female offspring of mothers fed low-protein diets in pregnancy and\/or lactation","volume":"3","author":"Morimoto","year":"2012","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.arcmed.2015.01.005_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1042\/CS20030350","article-title":"Programming of defective rat pancreatic beta-cell function in offspring from mothers fed a low-protein diet during gestation and the suckling periods","volume":"107","author":"Heywood","year":"2004","journal-title":"Clin Sci"},{"key":"10.1016\/j.arcmed.2015.01.005_bib17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.semcdb.2012.06.002","article-title":"Epigenetic regulation of pancreas development and function","volume":"23","author":"Avrahami","year":"2012","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib18","first-page":"18","article-title":"The epigenotype","volume":"1","author":"Waddington","year":"1942","journal-title":"Endeavour"},{"key":"10.1016\/j.arcmed.2015.01.005_bib19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1095\/biolreprod.109.080952","article-title":"Animal models to study environmental epigenetics","volume":"82","author":"Rosenfeld","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.arcmed.2015.01.005_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.arcmed.2015.01.005_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0959-437X(02)00287-3","article-title":"Histone methylation in transcriptional control","volume":"12","author":"Kouzarides","year":"2002","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.arcmed.2015.01.005_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature07756","article-title":"Small RNAs in transcriptional gene silencing and genome defense","volume":"457","author":"Moazed","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2015.01.005_bib23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrendo.2009.102","article-title":"Epigenetic mechanisms that underpin metabolic and cardiovascular diseases","volume":"5","author":"Gluckman","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib24","doi-asserted-by":"crossref","first-page":"e6953","DOI":"10.1371\/journal.pone.0006953","article-title":"Insulin gene expression is regulated by DNA methylation","volume":"4","author":"Kuroda","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2015.01.005_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tem.2009.10.002","article-title":"Epigenetic mechanisms in the development of type 2 diabetes","volume":"21","author":"Pinney","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.arcmed.2015.01.005_bib26","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/db09-1003","article-title":"Epigenetics: a molecular link between environmental factors and type 2 diabetes","volume":"58","author":"Ling","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2015.01.005_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 A resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2015.01.005_bib28","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s00018-013-1297-1","article-title":"Developmental and environmental programming of the endocrine pancreas: consequences for type 2 diabetes","volume":"70","author":"Sandovici","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.arcmed.2015.01.005_bib29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.reprotox.2006.08.012","article-title":"Epigenetic gene regulation: linking early developmental environment to adult disease","volume":"23","author":"Dolinoy","year":"2007","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib30","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1242\/jcs.015123","article-title":"Mammalian cytosine methylation at a glance","volume":"122","author":"Ooi","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.arcmed.2015.01.005_bib31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature02017","article-title":"Binary switches and modification cassettes in histone biology and beyond","volume":"425","author":"Fische","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2015.01.005_bib32","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1242\/jcs.00493","article-title":"An epigenetic road map for histone lysine methylation","volume":"116","author":"Lachner","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.arcmed.2015.01.005_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1756-8935-4-9","article-title":"Generation of bivalent chromatin domains during cell fate decisions","volume":"4","author":"De Gobbi","year":"2011","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.arcmed.2015.01.005_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","article-title":"A bivalent chromatin structure marks key developmental genes in embryonic stem cells","volume":"125","author":"Bernstein","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2015.01.005_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/CCO.0b013e328333dcbb","article-title":"MicroRNAs and cancer epigenetics: a macrorevolution","volume":"22","author":"Davalos","year":"2010","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib36","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4161\/epi.21238","article-title":"Epigenetics: the missing link to understanding \u03b2-cell dysfunction in the pathogenesis of type 2 diabetes","volume":"7","author":"Gilbert","year":"2012","journal-title":"Epigenetics"},{"issue":"suppl 3","key":"10.1016\/j.arcmed.2015.01.005_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1463-1326.2012.01653.x","article-title":"Metabolic programming of insulin action and secretion","author":"Martin-Gronert","year":"2012","journal-title":"Diabetes Obes Metab"},{"issue":"suppl 3","key":"10.1016\/j.arcmed.2015.01.005_bib38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1463-1326.2012.01656.x","article-title":"MicroRNAs in pancreas development","author":"Dumortier","year":"2012","journal-title":"Diabetes Obes Metab"},{"issue":"suppl 33","key":"10.1016\/j.arcmed.2015.01.005_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","author":"Jaenisch","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.arcmed.2015.01.005_bib40","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1073\/pnas.1019007108","article-title":"Maternal diet and aging alter the epigenetic control of a promoter\u2013enhancer interaction at the Hnf4a gene in rat pancreatic islets","volume":"108","author":"Sandovici","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arcmed.2015.01.005_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.siny.2006.10.009","article-title":"Postnatal nutrition and adult health programming","volume":"12","author":"Neu","year":"2007","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.arcmed.2015.01.005_bib42","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1017\/S000711450769196X","volume":"97","author":"Lillycrop","year":"2007","journal-title":"Br J Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2012.01.001","article-title":"Connecting threads: epigenetics and metabolism","volume":"148","author":"Katada","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2015.01.005_bib44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1017\/S0007114507894438","article-title":"Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR\u03b1 promoter of the offspring","volume":"100","author":"Lillycrop","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3945\/an.113.003798","article-title":"PPAR-\u03b1 as a key nutritional and environmental sensor for metabolic adaptation","volume":"4","author":"Contreras","year":"2013","journal-title":"Adv Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.nutr.012809.104751","article-title":"Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease","volume":"30","author":"Burdge","year":"2010","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.arcmed.2015.01.005_bib47","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1128\/MCB.01179-08","article-title":"Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure","volume":"29","author":"Evans-Molina","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib48","doi-asserted-by":"crossref","first-page":"25440","DOI":"10.1074\/jbc.M113.486852","article-title":"Peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) and its target genes are downstream effectors of FoxO1 protein in islet \u03b2-cells: mechanism of \u03b2-cell compensation and failure","volume":"288","author":"Gupta","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2015.01.005_bib49","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1202845","article-title":"Chromatin \u201cprepattern\u201d and histone modifiers in a fate choice for liver and pancreas","volume":"332","author":"Xu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2015.01.005_bib50","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1101\/gad.1742509","article-title":"Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a\/Arf expression and regeneration in diabetes mellitus","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.arcmed.2015.01.005_bib51","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1101\/gr.101709.109","article-title":"Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program","volume":"20","author":"van Arensbergen","year":"2010","journal-title":"Genome Res"},{"key":"10.1016\/j.arcmed.2015.01.005_bib52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/dev.02770","article-title":"Pancreas and beta-cell development: from the actual to the possible","volume":"134","author":"Murtaugh","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.arcmed.2015.01.005_bib53","first-page":"2316","article-title":"Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1","volume":"118","author":"Park","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcmed.2015.01.005_bib54","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nature09491","article-title":"Chronic high-fat diet in fathers programs \u03b2-cell dysfunction in female rat offspring","volume":"467","author":"Ng","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2015.01.005_bib55","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1463-1326.2012.01654.x","article-title":"Emerging roles of non-coding RNAs in pancreatic beta-cell function and dysfunction","volume":"3","author":"Guay","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.arcmed.2015.01.005_bib56","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion","volume":"432","author":"Poy","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2015.01.005_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00592-010-0226-0","article-title":"Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study","volume":"48","author":"Kong","year":"2011","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.arcmed.2015.01.005_bib58","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.2337\/db13-1431","article-title":"Maternal protein restriction leads to pancreatic failure in offspring: role of misexpressed microRNA-375","volume":"63","author":"Dumortier","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2015.01.005_bib59","doi-asserted-by":"crossref","first-page":"32084","DOI":"10.1074\/jbc.M700899200","article-title":"Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy","volume":"282","author":"Keller","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2015.01.005_bib60","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1172\/JCI74237","article-title":"Maternal diet-induced microRNAs and mTOR underlie \u03b2 cell dysfunction in offspring","volume":"124","author":"Alejandro","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcmed.2015.01.005_bib61","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.4161\/cc.20036","article-title":"mTORC1 signaling and regulation of pancreatic \u03b2-cell mass","volume":"11","author":"Blandino-Rosano","year":"2012","journal-title":"Cell Cycle"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440915000119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440915000119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:43:51Z","timestamp":1759261431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440915000119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0188440915000119"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2015.01.005","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic Alterations Caused by Nutritional Stress During Fetal Programming of the Endocrine Pancreas","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2015.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}