{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:22:45Z","timestamp":1761744165009,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"System for Integral Family Development"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.arcmed.2015.07.008","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:37:44Z","timestamp":1438943864000},"page":"495-501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel Association of the R230C Variant of the ABCA1 Gene with High Triglyceride Levels and Low High-density Lipoprotein Cholesterol Levels in Mexican School-age Children with High Prevalence of Obesity"],"prefix":"10.1016","volume":"46","author":[{"given":"Marco Alberto","family":"Gamboa-Mel\u00e9ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Galindo-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Ju\u00e1rez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Enrique","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eulises","family":"Diaz-Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Antonio","family":"\u00c1vila-Arcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abelardo","family":"\u00c1vila-Curiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2015.07.008_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis Model Mech"},{"issue":"Suppl 1","key":"10.1016\/j.arcmed.2015.07.008_bib2","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1590\/S0036-36342010000700004","article-title":"Metabolic syndrome in Mexican adults: results from the National Health and Nutrition Survey 2006","volume":"52","author":"Rojas","year":"2010","journal-title":"Salud Publica Mex"},{"key":"10.1016\/j.arcmed.2015.07.008_bib3","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/j.1742-4658.2011.08170.x","article-title":"Function and regulation of ABCA1\u2013membrane meso-domain organization and reorganization","volume":"278","author":"Nagao","year":"2011","journal-title":"FEBS J"},{"key":"10.1016\/j.arcmed.2015.07.008_bib4","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1161\/01.ATV.0000142804.27420.5b","article-title":"Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease","volume":"24","author":"Brewer","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arcmed.2015.07.008_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.26.061505.111214","article-title":"Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis","volume":"26","author":"Brunham","year":"2006","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.arcmed.2015.07.008_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2337\/db07-0484","article-title":"Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population","volume":"57","author":"Villarreal-Molina","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2015.07.008_bib7","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.2337\/db06-0905","article-title":"The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities","volume":"56","author":"Villarreal-Molina","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2015.07.008_bib8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.atherosclerosis.2010.10.049","article-title":"The non-synonymous Arg230Cys variant (R230C) of the ATP-binding cassette transporter A1 is associated with low HDL cholesterol concentrations in Mexican adults: a population based nation wide study","volume":"216","author":"Aguilar-Salinas","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arcmed.2015.07.008_bib9","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1093\/hmg\/ddq173","article-title":"A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans","volume":"19","author":"Acuna-Alonzo","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.arcmed.2015.07.008_bib10","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.cca.2010.04.025","article-title":"Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children","volume":"411","author":"Flores-Dorantes","year":"2010","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.arcmed.2015.07.008_bib11","series-title":"V Censo de Peso y Talla de los alumnos de las escuelas primarias del Estado de M\u00e9xico","first-page":"48","author":"Avila-Curiel","year":"2014"},{"year":"1988","series-title":"Anthropometric Standardization Reference Manual","author":"Lohman","key":"10.1016\/j.arcmed.2015.07.008_bib12"},{"key":"10.1016\/j.arcmed.2015.07.008_bib13","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents","volume":"85","author":"de Onis","year":"2007","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.arcmed.2015.07.008_bib14","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.arcmed.2015.07.008_bib15","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.2337\/diacare.21.12.2191","article-title":"Correct homeostasis model assessment (HOMA) evaluation uses the computer program","volume":"21","author":"Levy","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arcmed.2015.07.008_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1399-5448.2007.00271.x","article-title":"The metabolic syndrome in children and adolescents\u2014an IDF consensus report","volume":"8","author":"Zimmet","year":"2007","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.arcmed.2015.07.008_bib17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jpeds.2004.06.044","article-title":"Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents","volume":"145","author":"Fernandez","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.arcmed.2015.07.008_bib18","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1056\/NEJMoa031049","article-title":"Obesity and the metabolic syndrome in children and adolescents","volume":"350","author":"Weiss","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcmed.2015.07.008_bib19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3945\/jn.111.152421","article-title":"Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women","volume":"142","author":"Romero-Hidalgo","year":"2012","journal-title":"J Nutr"},{"key":"10.1016\/j.arcmed.2015.07.008_bib20","doi-asserted-by":"crossref","first-page":"e38862","DOI":"10.1371\/journal.pone.0038862","article-title":"Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution","volume":"7","author":"Hunemeier","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2015.07.008_bib21","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1161\/01.ATV.20.8.1983","article-title":"Common and rare ABCA1 variants affecting plasma HDL cholesterol","volume":"20","author":"Wang","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arcmed.2015.07.008_bib22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1751-7176.2010.00263.x","article-title":"Metabolic syndrome risk factors among a sample of overweight and obese Mexican children","volume":"12","author":"Elizondo-Montemayor","year":"2010","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"10.1016\/j.arcmed.2015.07.008_bib23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1399-3046.2008.01032.x","article-title":"Prevalence of metabolic syndrome and obesity in renal transplanted Mexican children","volume":"13","author":"Ramirez-Cortes","year":"2009","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.arcmed.2015.07.008_bib24","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/CIRCULATIONAHA.108.191394","volume":"119","author":"Steinberger","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2015.07.008_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/1471-2458-10-318","article-title":"Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents","volume":"10","author":"Juarez-Lopez","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.arcmed.2015.07.008_bib26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1186\/1471-2458-10-780","article-title":"Prevalence and association between obesity and metabolic syndrome among Chinese elementary school children: a school-based survey","volume":"10","author":"Liu","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.arcmed.2015.07.008_bib27","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jada.2011.08.012","article-title":"Metabolic syndrome in adolescents: issues and opportunities","volume":"111","author":"Kubena","year":"2011","journal-title":"J Am Diet Assoc"},{"issue":"Suppl 1","key":"10.1016\/j.arcmed.2015.07.008_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/jhn.12070","article-title":"School-based individualised lifestyle intervention decreases obesity and the metabolic syndrome in Mexican children","volume":"26","author":"Elizondo-Montemayor","year":"2013","journal-title":"J Hum Nutr Diet"},{"key":"10.1016\/j.arcmed.2015.07.008_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2458-13-88","article-title":"Adiponectin in eutrophic and obese children as a biomarker to predict metabolic syndrome and each of its components","volume":"13","author":"Klunder-Klunder","year":"2013","journal-title":"BMC Public Health"},{"key":"10.1016\/j.arcmed.2015.07.008_bib30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/1471-2458-13-249","article-title":"Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis","volume":"13","author":"Wang","year":"2013","journal-title":"BMC Public Health"},{"key":"10.1016\/j.arcmed.2015.07.008_bib31","doi-asserted-by":"crossref","first-page":"e49285","DOI":"10.1371\/journal.pone.0049285","article-title":"The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study","volume":"7","author":"Villarreal-Molina","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2015.07.008_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.metabol.2012.11.006","article-title":"The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus","volume":"62","author":"Aguilar-Salinas","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.arcmed.2015.07.008_bib33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.clinbiochem.2009.11.003","article-title":"Relationship between obesity and metabolic syndrome among Argentinean elementary school children","volume":"43","author":"Hirschler","year":"2010","journal-title":"Clin Biochem"},{"key":"10.1016\/j.arcmed.2015.07.008_bib34","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.2337\/db11-0550","article-title":"Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population","volume":"61","author":"Gamboa-Melendez","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2015.07.008_bib35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00439-006-0273-3","article-title":"Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors","volume":"120","author":"Martinez-Marignac","year":"2007","journal-title":"Hum Genet"},{"key":"10.1016\/j.arcmed.2015.07.008_bib36","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.2105\/AJPH.2013.301370","article-title":"Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture","volume":"103","author":"Aldrich","year":"2013","journal-title":"Am J Public Health"},{"key":"10.1016\/j.arcmed.2015.07.008_bib37","doi-asserted-by":"crossref","first-page":"e33570","DOI":"10.1371\/journal.pone.0033570","article-title":"Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population","volume":"7","author":"Campbell","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2015.07.008_bib38","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s00125-009-1412-x","article-title":"Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes","volume":"52","author":"Florez","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.arcmed.2015.07.008_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/gepi.1370030608","article-title":"Relationship of prevalence of non-insulin-dependent diabetes mellitus to Amerindian admixture in the Mexican Americans of San Antonio, Texas","volume":"3","author":"Chakraborty","year":"1986","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.arcmed.2015.07.008_bib40","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1002\/art.34650","article-title":"Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations","volume":"64","author":"Sanchez","year":"2012","journal-title":"Arthritis Rheum"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440915002088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440915002088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:43:46Z","timestamp":1759261426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440915002088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0188440915002088"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2015.07.008","relation":{},"ISSN":["0188-4409"],"issn-type":[{"type":"print","value":"0188-4409"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Association of the R230C Variant of the ABCA1 Gene with High Triglyceride Levels and Low High-density Lipoprotein Cholesterol Levels in Mexican School-age Children with High Prevalence of Obesity","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2015.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 IMSS. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}