{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:46:20Z","timestamp":1771209980234,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.arcmed.2016.11.008","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T13:46:53Z","timestamp":1488548813000},"page":"506-514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats"],"prefix":"10.1016","volume":"47","author":[{"given":"Hatice Adiguzel","family":"Dundar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muge","family":"Kiray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Kir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efsun","family":"Kolatan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Bagriyanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekiye","family":"Altun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safiye","family":"Aktas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulya","family":"Ellidokuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamer","family":"Mutafoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Olgun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2016.11.008_bib1","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1056\/NEJM199506293322602","article-title":"Female sex and drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer","volume":"332","author":"Lipshultz","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcmed.2016.11.008_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrcardio.2009.197","article-title":"Natriuretic peptides in heart failure: should therapy be guided by BNP levels?","volume":"7","author":"O'Donoghue","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib3","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/cncr.11407","article-title":"Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials","volume":"97","author":"Swain","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.arcmed.2016.11.008_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0163-7258(90)90088-J","article-title":"Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity","volume":"47","author":"Keizer","year":"1990","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.arcmed.2016.11.008_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol Rev"},{"key":"10.1016\/j.arcmed.2016.11.008_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00003495-199447020-00002","article-title":"Anthracycline antibiotics in cancer therapy focus on drug resistance","volume":"47","author":"Booser","year":"1994","journal-title":"Drugs"},{"key":"10.1016\/j.arcmed.2016.11.008_bib7","first-page":"H909","article-title":"Myocardial adrenergic changes at two stages of heart failure due to adriamycin treatment in rats","volume":"260","author":"Tong","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1011003030287","article-title":"Effects of acetyl-l-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat","volume":"26","author":"Calabrese","year":"2001","journal-title":"Neurochem Res"},{"key":"10.1016\/j.arcmed.2016.11.008_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nutres.2008.11.004","article-title":"Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycero-phosphocholine, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance","volume":"29","author":"Suchy","year":"2009","journal-title":"Nutr Res"},{"key":"10.1016\/j.arcmed.2016.11.008_bib10","doi-asserted-by":"crossref","first-page":"10771","DOI":"10.1073\/pnas.91.23.10771","article-title":"Oxidative damage and mitochondrial decay in aging","volume":"91","author":"Shigenaga","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arcmed.2016.11.008_bib11","doi-asserted-by":"crossref","first-page":"16019","DOI":"10.1073\/pnas.0508053102","article-title":"Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss","volume":"102","author":"Kalinec","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arcmed.2016.11.008_bib12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000240020","article-title":"Evaluation of the effect of acetyl L-carnitine on experimental cisplatin nephrotoxicity","volume":"55","author":"Tufekci","year":"2009","journal-title":"Chemotherapy"},{"key":"10.1016\/j.arcmed.2016.11.008_bib13","doi-asserted-by":"crossref","first-page":"619185","DOI":"10.1155\/2012\/619185","article-title":"Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-\u03b2\/Smad p53 pathway in rat model","volume":"2012","author":"Al-Shabanah","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.arcmed.2016.11.008_bib14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1440-1681.2006.04425.x","article-title":"Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus","volume":"33","author":"Al-Majed","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1755-5922.12189","article-title":"Spironolactone attenuates doxorubicin-induced cardiotoxicity in rats","volume":"34","author":"Liu","year":"2016","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.arcmed.2016.11.008_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cbi.2015.12.010","article-title":"Doxorubicin toxicity changes myocardial energy metabolism in rats","volume":"244","author":"Wu","year":"2016","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.arcmed.2016.11.008_bib17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1177\/0748233711434957","article-title":"The effects of exposure to electromagnetic field on rat myocardium","volume":"29","author":"Kiray","year":"2013","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.arcmed.2016.11.008_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12011-007-0049-1","article-title":"Ultrastructural changes in the kidney of rats with acute exposure to cadmium and effects of exogenous metallo-thionein","volume":"119","author":"Kukner","year":"2007","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.arcmed.2016.11.008_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0025-6196(12)65305-1","article-title":"Assessment of diastolic function of the heart, background and current applications of Doppler echocardiography. I. Physiologic and pathophysiology features","volume":"64","author":"Nishimure","year":"1989","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.arcmed.2016.11.008_bib20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/MPH.0b013e3181580ea2","article-title":"Late echocardiography assessment of systolic and diastolic function of the left ventricle in pediatric cancer survivors after anthracycline therapy","volume":"29","author":"Santin","year":"2007","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib21","first-page":"563","article-title":"Comparison of plasmatic levels of B-natriuretic peptide with echocardiographic indicators of left ventricle function after doxorubicin therapy","volume":"52","author":"Elbl","year":"2006","journal-title":"Vnitr Lek"},{"key":"10.1016\/j.arcmed.2016.11.008_bib22","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1161\/CIRCULATIONAHA.111.021774","article-title":"Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms","volume":"124","author":"Scott","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2016.11.008_bib23","first-page":"234","article-title":"Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats","volume":"16","author":"Argun","year":"2016","journal-title":"Anatol J Cardiol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jsps.2010.07.008","article-title":"Role of carnitine in cancer chemotherapy-induced multiple organ toxicity","volume":"18","author":"Sayed-Ahmed","year":"2010","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.arcmed.2016.11.008_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000323621","article-title":"Evaluation of the effect of acetyl L-carnitine on experimental cisplatin ototoxicity and neurotoxicity","volume":"57","author":"Gunes","year":"2011","journal-title":"Chemotherapy"},{"key":"10.1016\/j.arcmed.2016.11.008_bib26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11064-009-0076-8","article-title":"Protective effects of acetyl-L-carnitine on cisplatin cytotoxicity and oxidative stress in neuroblastoma","volume":"35","author":"Altun","year":"2010","journal-title":"Neurochem Res"},{"key":"10.1016\/j.arcmed.2016.11.008_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1043-6618(03)00185-3","article-title":"Erdosteine prevents doxorubicin-induced cardiotoxicity in rats","volume":"48","author":"Yagmurca","year":"2003","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.arcmed.2016.11.008_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10557-007-6052-0","article-title":"Preventive cardioprotection of erythropoetin against doxorubicin-induced cardiomyopathy","volume":"21","author":"Chen","year":"2007","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.arcmed.2016.11.008_bib29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1124\/jpet.111.185892","article-title":"Oxidative stress and myocardial gene alterations associated with doxorubicin-induced cardiotoxicity in rats persist for 2 months after treatment cessation","volume":"339","author":"Richard","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.arcmed.2016.11.008_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/152308601750100641","article-title":"Apoptosis in adriamycin cardiomyopathy and its modulation by probucol","volume":"3","author":"Kumar","year":"2001","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.arcmed.2016.11.008_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10565-007-9016-z","article-title":"The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats","volume":"24","author":"Hamza","year":"2008","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib32","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.jacc.2007.02.060","article-title":"Potentiation of doxorubicin cardiotoxicity by iron loading in a rodent model","volume":"49","author":"Panjrath","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ejphar.2010.09.085","article-title":"Cisplatin-induced cardiotoxicity: mechanisms and cardioprotective strategies","volume":"650","author":"El-Awady","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib34","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1210\/me.2009-0402","article-title":"Androgen receptor counteracts doxorubicin-induced cardiotoxicity in male mice","volume":"24","author":"Ikeda","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.arcmed.2016.11.008_bib35","doi-asserted-by":"crossref","first-page":"434195","DOI":"10.1155\/2012\/434195","article-title":"Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats","volume":"2012","author":"Ashour","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.arcmed.2016.11.008_bib36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pbb.2011.09.002","article-title":"Acetyl-L-carnitine and \u03b1-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy","volume":"100","author":"Zaitone","year":"2012","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440916301898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440916301898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:44:27Z","timestamp":1759261467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440916301898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0188440916301898"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2016.11.008","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2016.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}