{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:00:01Z","timestamp":1774562401530,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.arcmed.2017.03.019","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T17:34:17Z","timestamp":1505756057000},"page":"228-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regenerating Heart Using a Novel Compound and Human Wharton Jelly Mesenchymal Stem Cells"],"prefix":"10.1016","volume":"48","author":[{"given":"Shahram","family":"Rabbani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Imani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Sahebjam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ghiaseddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mahdi","family":"Nassiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalil","family":"Majd Ardakani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Tajik Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahmanshir","family":"Mousanassab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Kheradmandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hossein","family":"Ahmadi Tafti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2017.03.019_bib1","first-page":"e29","article-title":"Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2017.03.019_bib2","first-page":"391","article-title":"Update: Innovation in cardiology (IV). Cardiac tissue engineering and the bioartificial heart","volume":"66","author":"Galvez-Monton","year":"2013","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.arcmed.2017.03.019_bib3","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/CIRCRESAHA.116.304346","article-title":"Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data","volume":"116","author":"Gyongyosi","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.arcmed.2017.03.019_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-bioeng-071910-124701","article-title":"Bioengineering heart muscle: a paradigm for regenerative medicine","volume":"13","author":"Vunjak-Novakovic","year":"2011","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1016\/j.arcmed.2017.03.019_bib5","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.biomaterials.2010.12.026","article-title":"Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration","volume":"32","author":"Shi","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.arcmed.2017.03.019_bib6","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1016\/j.actbio.2012.12.014","article-title":"Preparation and characterization of collagen-based ADSC-carrier sheets for cardiovascular application","volume":"9","author":"Arana","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.arcmed.2017.03.019_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.biomaterials.2014.11.004","article-title":"Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction","volume":"39","author":"Blackburn","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.arcmed.2017.03.019_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1423-0127-19-93","article-title":"Repairing chronic myocardial infarction with autologous mesenchymal stem cells engineered tissue in rat promotes angiogenesis and limits ventricular remodeling","volume":"19","author":"Maureira","year":"2012","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.arcmed.2017.03.019_bib9","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jacc.2009.06.010","article-title":"Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine","volume":"54","author":"Leor","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib10","doi-asserted-by":"crossref","first-page":"e6005","DOI":"10.1371\/journal.pone.0006005","article-title":"Cell therapy attenuates cardiac dysfunction post myocardial infarction: effect of timing, routes of injection and a fibrin scaffold","volume":"4","author":"Nakamuta","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2017.03.019_bib11","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc1391","article-title":"Hyaluronan: from extracellular glue to pericellular cue","volume":"4","author":"Toole","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.arcmed.2017.03.019_bib12","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.carbpol.2012.10.028","article-title":"Hyaluronic acid based scaffolds for tissue engineering\u2013a review","volume":"92","author":"Collins","year":"2013","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.arcmed.2017.03.019_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jbiosc.2014.04.001","article-title":"Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel","volume":"118","author":"Yoon","year":"2014","journal-title":"J Biosci Bioeng"},{"key":"10.1016\/j.arcmed.2017.03.019_bib14","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1016\/S0142-9612(02)00644-0","article-title":"Microtextured substrata alter gene expression, protein localization and the shape of cardiac myocytes","volume":"24","author":"Motlagh","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.arcmed.2017.03.019_bib15","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1016\/j.biomaterials.2008.04.040","article-title":"An adaptable hydrogel array format for 3-dimensional cell culture and analysis","volume":"29","author":"Jongpaiboonkit","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.arcmed.2017.03.019_bib16","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.actbio.2009.04.040","article-title":"Bone marrow stem cells implantation with alpha-cyclodextrin\/MPEG-PCL-MPEG hydrogel improves cardiac function after myocardial infarction","volume":"5","author":"Wang","year":"2009","journal-title":"Acta Biomater"},{"key":"10.1016\/j.arcmed.2017.03.019_bib17","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nbt1014","article-title":"Electromechanical integration of cardiomyocytes derived from human embryonic stem cells","volume":"22","author":"Kehat","year":"2004","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib18","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nbt1327","article-title":"Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts","volume":"25","author":"Laflamme","year":"2007","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0002-9440(10)62041-X","article-title":"Formation of human myocardium in the rat heart from human embryonic stem cells","volume":"167","author":"Laflamme","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.CIR.0000151313.18547.A2","article-title":"Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers","volume":"111","author":"Xue","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2017.03.019_bib21","doi-asserted-by":"crossref","first-page":"876","DOI":"10.4065\/84.10.876","article-title":"Cardiac cell repair therapy: a clinical perspective","volume":"84","author":"Gersh","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.arcmed.2017.03.019_bib22","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1161\/ATVBAHA.110.211755","article-title":"The ATP-binding cassette transporter BCRP1\/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function","volume":"30","author":"Higashikuni","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1096\/fj.11-189605","article-title":"Cardiac dysfunction and impaired compensatory response to pressure overload in mice deficient in stem cell antigen-1","volume":"26","author":"Rosenblatt-Velin","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.arcmed.2017.03.019_bib24","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"7","author":"Zhou","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.arcmed.2017.03.019_bib25","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","article-title":"Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord","volume":"22","author":"Wang","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.arcmed.2017.03.019_bib26","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.jacc.2014.07.974","article-title":"Experimental cell therapy: the search for the best stem cell continues","volume":"64","author":"Badimon","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12015-012-9418-z","article-title":"The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton's jelly of the human umbilical cord","volume":"9","author":"Bongso","year":"2013","journal-title":"Stem Cell Rev"},{"key":"10.1016\/j.arcmed.2017.03.019_bib28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/scrt477","article-title":"Are serum-free and xeno-free culture conditions ideal for large scale clinical grade expansion of Wharton's jelly derived mesenchymal stem cells? A comparative study","volume":"5","author":"Swamynathan","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.arcmed.2017.03.019_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/scrt394","article-title":"Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms","volume":"5","author":"Santos Nascimento","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.arcmed.2017.03.019_bib30","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1182\/blood-2007-03-078774","article-title":"Immunogenicity of umbilical cord tissue derived cells","volume":"111","author":"Cho","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.arcmed.2017.03.019_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12015-010-9166-x","article-title":"Human Wharton's jelly stem cells have unique transcriptome profiles compared to human embryonic stem cells and other mesenchymal stem cells","volume":"7","author":"Fong","year":"2011","journal-title":"Stem Cell Rev"},{"key":"10.1016\/j.arcmed.2017.03.019_bib32","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1634\/stemcells.2007-1028","article-title":"Immune properties of human umbilical cord Wharton's jelly-derived cells","volume":"26","author":"Weiss","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.arcmed.2017.03.019_bib33","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1056\/NEJMhpr063086","article-title":"FDA regulation of stem-cell-based therapies","volume":"355","author":"Halme","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcmed.2017.03.019_bib34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/cbin.10421","article-title":"Ultrastructural maturation of human bone marrow mesenchymal stem cells-derived cardiomyocytes under alternative induction of 5-azacytidine","volume":"39","author":"Piryaei","year":"2015","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.arcmed.2017.03.019_bib35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/bbrc.2001.5737","article-title":"Human endomucin is an endothelial marker","volume":"288","author":"Liu","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.arcmed.2017.03.019_bib36","first-page":"9","article-title":"Intratumor microvessel density as a prognostic factor in cancer","volume":"147","author":"Weidner","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib37","doi-asserted-by":"crossref","first-page":"979","DOI":"10.7150\/ijbs.15071","article-title":"BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats","volume":"12","author":"Hang","year":"2016","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.arcmed.2017.03.019_bib38","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/01.RES.82.11.1224","article-title":"Complement gene expression by rabbit heart: upregulation by ischemia and reperfusion","volume":"82","author":"Yasojima","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.arcmed.2017.03.019_bib39","doi-asserted-by":"crossref","first-page":"385102","DOI":"10.1088\/0957-4484\/23\/38\/385102","article-title":"Minimally invasive injectable short nanofibers of poly(glycerol sebacate) for cardiac tissue engineering","volume":"23","author":"Ravichandran","year":"2012","journal-title":"Nanotechnology"},{"key":"10.1016\/j.arcmed.2017.03.019_bib40","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1159\/000356581","article-title":"Cardiac fibroblasts recruit Th17 cells infiltration into myocardium by secreting CCL20 in CVB3-induced acute viral myocarditis","volume":"32","author":"Yu","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.arcmed.2017.03.019_bib41","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1634\/stemcells.2007-0417","article-title":"Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells","volume":"25","author":"Can","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.arcmed.2017.03.019_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000331714","article-title":"Integration properties of Wharton's jelly-derived novel mesenchymal stem cells into ventricular slices of murine hearts","volume":"28","author":"Lupu","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.arcmed.2017.03.019_bib43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/CIRCIMAGING.112.979633","article-title":"Infarct size determines myocardial uptake of CD34+ cells in the peri-infarct zone: results from a study of (99m)Tc-extametazime-labeled cell visualization integrated with cardiac magnetic resonance infarct imaging","volume":"6","author":"Musialek","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.arcmed.2017.03.019_bib44","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.jacc.2013.09.014","article-title":"Reply: The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE)","volume":"62","author":"Bartunek","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2017.03.019_bib45","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3727\/096368912X657675","article-title":"Human umbilical cord perivascular cells exhibit enhanced cardiomyocyte reprogramming and cardiac function after experimental acute myocardial infarction","volume":"22","author":"Yannarelli","year":"2013","journal-title":"Cell Transplant"},{"key":"10.1016\/j.arcmed.2017.03.019_bib46","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/MCA.0b013e3283640f00","article-title":"Wharton's jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction","volume":"24","author":"Zhang","year":"2013","journal-title":"Coron Artery Dis"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440917300875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440917300875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:45:03Z","timestamp":1759261503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440917300875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0188440917300875"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2017.03.019","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regenerating Heart Using a Novel Compound and Human Wharton Jelly Mesenchymal Stem Cells","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2017.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}