{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:22:28Z","timestamp":1782210148547,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.arcmed.2017.11.014","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T21:00:38Z","timestamp":1512075638000},"page":"498-505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lipoamide Inhibits NF1 Deficiency-induced Epithelial-Mesenchymal Transition in Murine Schwann Cells"],"prefix":"10.1016","volume":"48","author":[{"given":"Yuchen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoguo","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanli","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2017.11.014_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1749-6632.1986.tb48061.x","article-title":"The genetic aspects of neurofibromatosis","volume":"486","author":"Carey","year":"1986","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.arcmed.2017.11.014_bib2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/B978-0-444-52902-2.00053-9","article-title":"Neurofibromatosis type 1 (NF1): diagnosis and management","volume":"115","author":"Ferner","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.arcmed.2017.11.014_bib3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/humu.22162","article-title":"Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein (GAP)-related domain of the neurofibromatosis type-1 (NF1) gene","volume":"33","author":"Thomas","year":"2012","journal-title":"Hum Mutat"},{"key":"10.1016\/j.arcmed.2017.11.014_bib4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/humu.22392","article-title":"NF1 molecular characterization and neurofibromatosis type I genotype-phenotype correlation: the French experience","volume":"34","author":"Sabbagh","year":"2013","journal-title":"Hum Mutat"},{"key":"10.1016\/j.arcmed.2017.11.014_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/gcc.20289","article-title":"Spectrum of single- and multiexon NF1 copy number changes in a cohort of 1,100 unselected NF1 patients","volume":"45","author":"Wimmer","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.arcmed.2017.11.014_bib6","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.18632\/oncotarget.2194","article-title":"The NF1 gene revisited - from bench to bedside","volume":"5","author":"Yap","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.arcmed.2017.11.014_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nrc3911","article-title":"A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor","volume":"15","author":"Ratner","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.arcmed.2017.11.014_bib8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.freeradbiomed.2016.06.002","article-title":"Neurofibromin is a novel regulator of Ras\u2013induced reactive oxygen species production in mice and humans","volume":"97","author":"Bessler","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.arcmed.2017.11.014_bib9","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.cellsig.2014.08.029","article-title":"TGF-beta\/NF1\/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence","volume":"26","author":"Kretova","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.arcmed.2017.11.014_bib10","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1111\/j.1600-0625.2009.01017.x","article-title":"Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1","volume":"19","author":"Arima","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.arcmed.2017.11.014_bib11","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1242\/dev.074054","article-title":"Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation","volume":"139","author":"Baek","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.arcmed.2017.11.014_bib12","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1089\/ars.2009.2737","article-title":"Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease","volume":"12","author":"Cannito","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.arcmed.2017.11.014_bib13","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1089\/ars.2009.2739","article-title":"Redox-based escape mechanism from death: the cancer lesson","volume":"11","author":"Pani","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.arcmed.2017.11.014_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10059-013-0034-9","article-title":"Reactive oxygen species and tumor metastasis","volume":"35","author":"Lee","year":"2013","journal-title":"Mol Cells"},{"key":"10.1016\/j.arcmed.2017.11.014_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mc.22014","article-title":"Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells","volume":"53","author":"Das","year":"2014","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.arcmed.2017.11.014_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ccr.2013.02.021","article-title":"ROS links glucose metabolism to breast cancer stem cell and EMT phenotype","volume":"23","author":"Schieber","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.arcmed.2017.11.014_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ccr.2013.01.022","article-title":"Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer","volume":"23","author":"Dong","year":"2013","journal-title":"Cancer Cell"},{"issue":"Suppl 3","key":"10.1016\/j.arcmed.2017.11.014_bib18","doi-asserted-by":"crossref","first-page":"S539","DOI":"10.1245\/s10434-011-2040-5","article-title":"Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon","volume":"19","author":"Kim","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.arcmed.2017.11.014_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10549-013-2440-2","article-title":"Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic","volume":"138","author":"Chandra-Kuntal","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.arcmed.2017.11.014_bib20","doi-asserted-by":"crossref","first-page":"e61677","DOI":"10.1371\/journal.pone.0061677","article-title":"Suppression of mitochondrial complex I influences cell metastatic properties","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2017.11.014_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Genet"},{"key":"10.1016\/j.arcmed.2017.11.014_bib22","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1017\/S1462399409001227","article-title":"Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways","volume":"11","author":"Katz","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.arcmed.2017.11.014_bib23","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1093\/hmg\/9.20.3055","article-title":"Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations","volume":"9","author":"Serra","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.arcmed.2017.11.014_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.semcdb.2016.02.007","article-title":"Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer","volume":"52","author":"Rad","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.arcmed.2017.11.014_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jmg.2006.045906","article-title":"Guidelines for the diagnosis and management of individuals with neurofibromatosis 1","volume":"44","author":"Ferner","year":"2007","journal-title":"J Med Genet"},{"key":"10.1016\/j.arcmed.2017.11.014_bib26","first-page":"1573","article-title":"International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis","volume":"62","author":"Ferner","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2017.11.014_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0092-8674(90)90024-9","article-title":"The neurofibromatosis type 1 gene encodes a protein related to GAP","volume":"62","author":"Xu","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2017.11.014_bib28","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0092-8674(90)90151-4","article-title":"The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins","volume":"63","author":"Ballester","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2017.11.014_bib29","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ng2004","article-title":"Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster","volume":"39","author":"Tong","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.arcmed.2017.11.014_bib30","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.arcmed.2017.11.014_bib31","first-page":"2162","article-title":"Autophagy inhibition promotes epithelial-mesenchymal transition through ROS\/HO-1 pathway in ovarian cancer cells","volume":"6","author":"Zhao","year":"2016","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.arcmed.2017.11.014_bib32","doi-asserted-by":"crossref","first-page":"62559","DOI":"10.18632\/oncotarget.11537","article-title":"Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation","volume":"7","author":"Jung","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.arcmed.2017.11.014_bib33","doi-asserted-by":"crossref","first-page":"64109","DOI":"10.18632\/oncotarget.11627","article-title":"PARP3 controls TGFbeta and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis","volume":"7","author":"Karicheva","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.arcmed.2017.11.014_bib34","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.freeradbiomed.2008.01.004","article-title":"Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction","volume":"44","author":"Li","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.arcmed.2017.11.014_bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1179\/135100001101536472","article-title":"Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis","volume":"6","author":"Persson","year":"2001","journal-title":"Redox Rep"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440917302473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440917302473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:45:42Z","timestamp":1759261542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440917302473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0188440917302473"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2017.11.014","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipoamide Inhibits NF1 Deficiency-induced Epithelial-Mesenchymal Transition in Murine Schwann Cells","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2017.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}