{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:47:24Z","timestamp":1792442844966,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.arcmed.2019.05.009","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T17:03:32Z","timestamp":1559581412000},"page":"44-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Irisin vs. Treadmill Exercise in Post Myocardial Infarction Cardiac Rehabilitation in Rats"],"prefix":"10.1016","volume":"50","author":[{"given":"Passainte S.","family":"Hassaan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham Zakaria","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Zahran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2019.05.009_bib1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0140-6736(10)61853-3","article-title":"Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries","volume":"376","author":"Alwan","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.arcmed.2019.05.009_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.me.42.020191.001301","article-title":"The cell biology of acute myocardial ischemia","volume":"42","author":"Jennings","year":"1991","journal-title":"Annu Rev Med"},{"issue":"Suppl","key":"10.1016\/j.arcmed.2019.05.009_bib3","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1136\/hrt.72.3_Suppl.S65","article-title":"Neuroendocrine activation after myocardial infarction","volume":"72","author":"Remes","year":"1994","journal-title":"Br Heart J"},{"key":"10.1016\/j.arcmed.2019.05.009_bib4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0008-6363(98)00264-8","article-title":"Expression of Gi-2\u03b1 and Gs\u03b1 in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction","volume":"41","author":"Peterson","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arcmed.2019.05.009_bib5","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbamcr.2012.08.023","article-title":"Fibroblasts in post-infarction inflammation and cardiac repair","volume":"1833","author":"Chen","year":"2013","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.arcmed.2019.05.009_bib6","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1067\/mhj.2001.119612","article-title":"Changes in vasoconstrictive hormones, natriuretic peptides, and left ventricular remodeling soon after anterior myocardial infarction","volume":"142","author":"White","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.arcmed.2019.05.009_bib7","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib8","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.CIR.0000081780.38477.FA","article-title":"Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) Trial","volume":"108","author":"Giannuzzi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib9","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1161\/01.CIR.95.8.2060","article-title":"Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction: application of magnetic resonance imaging","volume":"95","author":"Dubach","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0735-1097(92)90048-R","article-title":"Myocardial perfusion and regression of coronary artery disease in patients on a regimen of intensive physical exercise and low fat diet","volume":"19","author":"Shuler","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib11","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1161\/CIRCULATIONAHA.107.701466","article-title":"Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery","volume":"116","author":"Suaya","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/dom.12268","article-title":"Characterization of the metabolic effects of irisin on skeletal muscle in\u00a0vitro","volume":"16","author":"Vaughan","year":"2014","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.arcmed.2019.05.009_bib13","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0002-9149(98)00021-6","article-title":"Effects of cardiac rehabilitation and beta-blocker therapy on heart rate variability after first acute myocardial infarction","volume":"81","author":"Malfatto","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.peptides.2013.11.024","article-title":"Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: cardiac muscle produces more irisin than skeletal muscle","volume":"52","author":"Aydin","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.arcmed.2019.05.009_bib15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2019.05.009_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.peptides.2014.01.016","article-title":"Irisin as a muscle-derived hormone stimulating thermogenesis\u2013a critical update","volume":"54","author":"Hofmann","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.arcmed.2019.05.009_bib17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cmet.2012.12.012","article-title":"Exercise metabolism and the molecular regulation of skeletal muscle adaptation","volume":"17","author":"Egan","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.arcmed.2019.05.009_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.peptides.2014.02.008","article-title":"Irisin: a potentially candidate marker for myocardial infarction","volume":"55","author":"Kuloglu","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.arcmed.2019.05.009_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2015.03.009","article-title":"Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway","volume":"409","author":"Shi","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/biof.552210136","article-title":"Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin","volume":"21","author":"Murakami","year":"2004","journal-title":"Biofactors"},{"key":"10.1016\/j.arcmed.2019.05.009_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.intimp.2011.12.001","article-title":"Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K\/Akt\/NF-\u03baB signaling pathways","volume":"12","author":"Qi","year":"2012","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.mce.2015.05.036","article-title":"Dihydromyricetin stimulates irisin secretion partially via the PGC-1\u03b1 pathway","volume":"412","author":"Zhou","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib24","first-page":"101","article-title":"Role of lipistat in protection against isoproterenol induced myocardial necrosis in rats: a biochemcial and histopathological study","volume":"42","author":"Seth","year":"1998","journal-title":"Indian J Physiol Pharmacol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0008-6363(99)00429-0","article-title":"Angiotensin II receptor blockade attenuates the deleterious effects of exercise training on post-MI ventricular remodelling in rats","volume":"46","author":"Jain","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arcmed.2019.05.009_bib26","first-page":"633","article-title":"The electrocardiographic appearances of myocardial infarction in the rat","volume":"41","author":"Hill","year":"1960","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-0736(05)80272-9","article-title":"Power spectral analysis of heart rate variability as a new method for assessing autonomic activity in the rat","volume":"27","author":"Kuwahara","year":"1994","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/10976640009146565","article-title":"In\u00a0Vivo assessment of cardiac remodeling after myocardial infarction in rats by cine\u2013magnetic resonance imaging","volume":"2","author":"Nahrendorf","year":"2000","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.arcmed.2019.05.009_bib29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-2697(77)90043-4","article-title":"A simplification of the protein assay method of lowry et\u00a0al. which is more generally applicable","volume":"83","author":"Peterson","year":"1977","journal-title":"Anal Biochem"},{"key":"10.1016\/j.arcmed.2019.05.009_bib30","series-title":"Tissue processing and microtomy including frozen. Theory and practice of histological techniques","first-page":"85","author":"Anderson","year":"2002"},{"key":"10.1016\/j.arcmed.2019.05.009_bib31","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1091\/mbc.12.9.2730","article-title":"Alpha-smooth muscle actin expression upregulates fibroblast contractile activity","volume":"12","author":"Hinz","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.arcmed.2019.05.009_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib33","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.arcmed.2019.05.009_bib34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/eurjhf\/hfr080","article-title":"AKT signalling in the failing heart","volume":"13","author":"Chaanine","year":"2011","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"10.1016\/j.arcmed.2019.05.009_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4172\/2368-0512.1000055","article-title":"Irisin levels increase during experimentally induced acute myocardial infarction","volume":"3","author":"Sarioglu","year":"2016","journal-title":"Curr Res Cardiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib36","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise","volume":"61","author":"Huh","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.arcmed.2019.05.009_bib37","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/01.CIR.98.15.1510","article-title":"Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart)","volume":"98","author":"Nolan","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib38","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.CIR.84.2.482","article-title":"Cardiovascular neural regulation explored in the frequency domain","volume":"84","author":"Malliani","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib39","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1161\/CIRCULATIONAHA.104.500546","article-title":"Mechanisms and models in heart failure: the biomechanical model and beyond","volume":"111","author":"Mann","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib40","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/01.CIR.82.4.1095","article-title":"Influence of myocardial ischemia and infarction on autonomic innervation of heart","volume":"82","author":"Zipes","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib41","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0008-6363(99)00405-8","article-title":"The bradycardic agent zatebradine enhances baroreflex sensitivity and heart rate variability in rats early after myocardial infarction","volume":"45","author":"Kr\u00fcger","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arcmed.2019.05.009_bib42","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1161\/01.CIR.94.11.2850","article-title":"Impact of reduced heart rate variability on risk for cardiac events: the Framingham Heart Study","volume":"94","author":"Tsuji","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2019.05.009_bib43","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1152\/japplphysiol.01193.2003","article-title":"Expression of MHC-\u03b2 and MCT1 in cardiac muscle after exercise training in myocardial-infarcted rats","volume":"97","author":"Hashimoto","year":"2004","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1139\/apnm-2013-0268","article-title":"Exercise training induced myosin heavy chain isoform alteration in the infarcted heart","volume":"39","author":"Wan","year":"2013","journal-title":"Appl Physiol Nutr Metabol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0008-6363(00)00158-9","article-title":"Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb)","volume":"48","author":"Frangogiannis","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arcmed.2019.05.009_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1755-1536-6-5","article-title":"Function and fate of myofibroblasts after myocardial infarction","volume":"6","author":"Turner","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.arcmed.2019.05.009_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2009.199","article-title":"Myocardial remodeling after infarction: the role of myofibroblasts","volume":"7","author":"Van Den Borne","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.arcmed.2019.05.009_bib48","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.hrthm.2009.02.038","article-title":"Myofibroblasts in diseased hearts: new players in cardiac arrhythmias?","volume":"6","author":"Rohr","year":"2009","journal-title":"Heart Rhythm"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440919301274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440919301274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:47:26Z","timestamp":1759261646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440919301274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0188440919301274"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2019.05.009","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Irisin vs. Treadmill Exercise in Post Myocardial Infarction Cardiac Rehabilitation in Rats","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2019.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}