{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:48:29Z","timestamp":1790758109384,"version":"4.1.0"},"reference-count":123,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.arcmed.2020.03.014","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:52:56Z","timestamp":1586479976000},"page":"287-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["An Overview of Nicotinic Cholinergic System Signaling in Neurogenesis"],"prefix":"10.1016","volume":"51","author":[{"given":"Zahra","family":"Shabani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Farajdokht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Sadigh-Eteghad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2020.03.014_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2147","article-title":"How widespread is adult neurogenesis in mammals?","volume":"8","author":"Gould","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1089\/scd.2010.0285","article-title":"Ectopic neurogenesis in the forebrain cholinergic system-related areas of a rat dementia model","volume":"20","author":"Zhang","year":"2010","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.arcmed.2020.03.014_bib3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2020.03.014_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuroscience.2006.12.012","article-title":"Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation","volume":"145","author":"Mudo","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bcp.2013.07.028","article-title":"\u03b17 nicotinic receptor agonist reactivates neurogenesis in adult brain","volume":"86","author":"Narla","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1365-2443.2006.01010.x","article-title":"Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb","volume":"11","author":"Kaneko","year":"2006","journal-title":"Genes Cells"},{"key":"10.1016\/j.arcmed.2020.03.014_bib7","doi-asserted-by":"crossref","first-page":"C567","DOI":"10.1152\/ajpcell.00422.2002","article-title":"Nicotinic acetylcholine receptor \u03b17 regulates cAMP signal within lipid rafts","volume":"285","author":"Oshikawa","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4522(00)00143-3","article-title":"Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures","volume":"98","author":"Coronas","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/syn.20081","article-title":"Alteration of hippocampal cell proliferation in mice lacking the \u03b22 subunit of the neuronal nicotinic acetylcholine receptor","volume":"54","author":"Harrist","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.arcmed.2020.03.014_bib10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neurobiolaging.2004.07.015","article-title":"Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning","volume":"26","author":"Mohapel","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.arcmed.2020.03.014_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.neuro.28.051804.101459","article-title":"Adult neurogenesis in the mammalian central nervous system","volume":"28","author":"Ming","year":"2005","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.arcmed.2020.03.014_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jnr.20116","article-title":"Decreased neurogenesis after cholinergic forebrain lesion in the adult rat","volume":"77","author":"Cooper-Kuhn","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuron.2011.05.004","article-title":"Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain","volume":"70","author":"Ihrie","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.arcmed.2020.03.014_bib15","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nn.3734","article-title":"Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis","volume":"17","author":"Paez-Gonzalez","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib16","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1126\/science.271.5251.978","article-title":"Chain migration of neuronal precursors","volume":"271","author":"Lois","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2020.03.014_bib17","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/nn.2416","article-title":"Adult generation of glutamatergic olfactory bulb interneurons","volume":"12","author":"Brill","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nn1048","article-title":"Becoming a new neuron in the adult olfactory bulb","volume":"6","author":"Carleton","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fncel.2013.00100","article-title":"Wnt signaling in the regulation of adult hippocampal neurogenesis","volume":"7","author":"Varela-Nallar","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/aps.2009.89","article-title":"Understanding of nicotinic acetylcholine receptors","volume":"30","author":"Wu","year":"2009","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.arcmed.2020.03.014_bib21","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.tips.2006.07.004","article-title":"Brain nicotinic acetylcholine receptors: native subtypes and their relevance","volume":"27","author":"Gotti","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib22","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/S0028-3908(00)00156-8","article-title":"Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus","volume":"39","author":"Alkondon","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arcmed.2020.03.014_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2015.02.047","article-title":"Regulation of nicotinic acetylcholine receptors in Alzheimer\u05f3 s disease: A possible role of chaperones","volume":"755","author":"Sadigh-Eteghad","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1074\/jbc.M406281200","article-title":"\u03b1-Conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors","volume":"280","author":"Azam","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2020.03.014_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1124\/mol.66.1.85","article-title":"Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience","volume":"66","author":"Moretti","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1590\/S0102-865020150110000003","article-title":"Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function","volume":"30","author":"Sadigh-Eteghad","year":"2015","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.arcmed.2020.03.014_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/aps.2009.64","article-title":"Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system","volume":"30","author":"Shen","year":"2009","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.arcmed.2020.03.014_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/1568026043451393","article-title":"Physiological roles of neuronal nicotinic receptor subtypes: new insights on the nicotinic modulation of neurotransmitter release, synaptic transmission and plasticity","volume":"4","author":"Sher","year":"2004","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.arcmed.2020.03.014_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuron.2011.03.014","article-title":"Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses","volume":"70","author":"Miwa","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.arcmed.2020.03.014_bib30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tips.2004.04.006","article-title":"Nicotinic acetylcholine receptors and the regulation of neuronal signalling","volume":"25","author":"Dajas-Bailador","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib31","first-page":"e1290","article-title":"Nicotinic acetylcholine receptors in mitochondria: subunit composition, function and signaling","volume":"3","author":"Skok","year":"2016","journal-title":"Neurotransmitter"},{"key":"10.1016\/j.arcmed.2020.03.014_bib32","doi-asserted-by":"crossref","first-page":"C903","DOI":"10.1152\/ajpcell.00216.2010","article-title":"Upregulation of nuclear factor-\u03baB expression by SLURP-1 is mediated by \u03b17-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases","volume":"299","author":"Chernyavsky","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-0-387-78748-0_3","article-title":"Molecular mechanisms underlying the motivational effects of nicotine","volume":"55","author":"Brunzell","year":"2009","journal-title":"Nebr Symp Motiv"},{"key":"10.1016\/j.arcmed.2020.03.014_bib34","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00702-016-1580-z","article-title":"Astrocytic and microglial nicotinic acetylcholine receptors: An overlooked issue in Alzheimer\u2019s disease","volume":"123","author":"Sadigh-Eteghad","year":"2016","journal-title":"J Neural Transm"},{"key":"10.1016\/j.arcmed.2020.03.014_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer's disease: targeting the cholinergic system","volume":"14","author":"H Ferreira-Vieira","year":"2016","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/npp.2010.104","article-title":"Modes and models of forebrain cholinergic neuromodulation of cognition","volume":"36","author":"Hasselmo","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.arcmed.2020.03.014_bib37","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.biopsych.2011.06.019","article-title":"Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer's disease","volume":"71","author":"Grothe","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.arcmed.2020.03.014_bib38","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/cercor\/bhp232","article-title":"Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease","volume":"20","author":"Grothe","year":"2010","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.arcmed.2020.03.014_bib39","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00415-014-7439-z","article-title":"Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer\u2019s disease dementia","volume":"261","author":"Grothe","year":"2014","journal-title":"J Neurol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib40","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neurobiolaging.2013.09.029","article-title":"Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease","volume":"35","author":"Teipel","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.arcmed.2020.03.014_bib41","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0140-6736(76)91936-X","article-title":"Selective loss of central cholinergic neurons in Alzheimer's disease","volume":"308","author":"Davies","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.arcmed.2020.03.014_bib42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(77)91780-9","article-title":"Necropsy evidence of central cholinergic deficits in senile dementia","volume":"309","author":"Perry","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.arcmed.2020.03.014_bib43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.npep.2018.12.003","article-title":"Alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease","volume":"73","author":"Ma","year":"2019","journal-title":"Neuropeptides"},{"key":"10.1016\/j.arcmed.2020.03.014_bib44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jmhi.2014.01.001","article-title":"Beta-amyloid exhibits antagonistic effects on alpha 7 nicotinic acetylcholine receptors in orchestrated manner","volume":"8","author":"Sadigh-Eteghad","year":"2014","journal-title":"J Med Hypotheses Ideas"},{"key":"10.1016\/j.arcmed.2020.03.014_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/npjparkd.2016.1","article-title":"Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson\u2019s disease","volume":"2","author":"Perez-Lloret","year":"2016","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.arcmed.2020.03.014_bib46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.parkreldis.2019.02.017","article-title":"Overview of the cholinergic contribution to gait, balance and falls in Parkinson's disease","volume":"63","author":"Morris","year":"2019","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.arcmed.2020.03.014_bib47","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/ana.25430","article-title":"Cholinergic system changes of falls and freezing of gait in Parkinson's disease","volume":"85","author":"Bohnen","year":"2019","journal-title":"Ann Neurol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib48","doi-asserted-by":"crossref","first-page":"e26460","DOI":"10.1371\/journal.pone.0026460","article-title":"Bilateral fronto-parietal integrity in young chronic cigarette smokers: a diffusion tensor imaging study","volume":"6","author":"Liao","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.arcmed.2020.03.014_bib49","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/glia.23101","article-title":"Cholinergic signaling in myelination","volume":"65","author":"Fields","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.arcmed.2020.03.014_bib50","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1177\/1352458512471879","article-title":"Nicotine might have a protective effect in the etiology of multiple sclerosis","volume":"19","author":"Hedstr\u00f6m","year":"2013","journal-title":"Mult Scler"},{"key":"10.1016\/j.arcmed.2020.03.014_bib51","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41380-018-0219-x","article-title":"Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics","volume":"24","author":"Dulawa","year":"2019","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.arcmed.2020.03.014_bib52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(84)90354-8","article-title":"Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions","volume":"306","author":"Baghdoyan","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib53","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1126\/science.172.3983.601","article-title":"Acetylcholine liberation from cerebral cortex during paradoxical (REM) sleep","volume":"172","author":"Jasper","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2020.03.014_bib54","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00702-012-0888-6","article-title":"Functional evaluation of central cholinergic circuits in patients with Parkinson\u2019s disease and REM sleep behavior disorder: a TMS study","volume":"120","author":"Nardone","year":"2013","journal-title":"J Neural Transm"},{"key":"10.1016\/j.arcmed.2020.03.014_bib55","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.scog.2014.12.001","article-title":"Smoking in schizophrenia: cognitive impact of nicotine and relationship to smoking motivators","volume":"2","author":"Beck","year":"2015","journal-title":"Schizophr Res Cogn"},{"key":"10.1016\/j.arcmed.2020.03.014_bib56","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/(SICI)1096-9861(19970630)383:2<163::AID-CNE4>3.0.CO;2-Z","article-title":"GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat","volume":"383","author":"Gritti","year":"1997","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib57","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1111\/j.1447-0594.2010.00588.x","article-title":"Acetylcholine\u2013dopamine balance hypothesis in the striatum: An update","volume":"10","author":"Aosaki","year":"2010","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.arcmed.2020.03.014_bib58","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0306-4522(83)90108-2","article-title":"Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1\u2013Ch6)","volume":"10","author":"Mesulam","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib59","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1073\/pnas.76.10.5392","article-title":"Evidence for a cholinergic projection to neocortex from neurons in basal forebrain","volume":"76","author":"Johnston","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arcmed.2020.03.014_bib60","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0301-0082(86)90016-X","article-title":"The cholinergic systems in brain and spinal cord","volume":"26","author":"Kasa","year":"1986","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib61","series-title":"The mouse nervous system","first-page":"684","article-title":"The basal forebrain cholinergic projection system in mice","author":"Zaborszky","year":"2012"},{"key":"10.1016\/j.arcmed.2020.03.014_bib62","series-title":"Understanding the role of cholinergic tone in the pedunculopontine tegmental nucleus","author":"Rosborough","year":"2014"},{"key":"10.1016\/j.arcmed.2020.03.014_bib63","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0306-4522(01)00389-X","article-title":"The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study","volume":"108","author":"Mechawar","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib64","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0306-4522(84)90083-6","article-title":"Cortical projections arising from the basal forebrain: a study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase","volume":"13","author":"Rye","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3727\/000000007783464443","article-title":"Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases","volume":"16","author":"Pisati","year":"2007","journal-title":"Cell Transplant"},{"key":"10.1016\/j.arcmed.2020.03.014_bib66","series-title":"Regulation of mitochondrial biogenesis by nitric oxide during neural stem cell proliferation","year":"2011"},{"key":"10.1016\/j.arcmed.2020.03.014_bib67","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1242\/dev.088005","article-title":"Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain","volume":"140","author":"Berg","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.arcmed.2020.03.014_bib68","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1460-9568.2011.07611.x","article-title":"Neurotransmitters couple brain activity to subventricular zone neurogenesis","volume":"33","author":"Young","year":"2011","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib69","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1126\/science.1248903","article-title":"Hippocampal neurogenesis regulates forgetting during adulthood and infancy","volume":"344","author":"Akers","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2020.03.014_bib70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature00850","article-title":"Transmitter-evoked local calcium release stabilizes developing dendrites","volume":"418","author":"Lohmann","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.arcmed.2020.03.014_bib71","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2014.12.041","article-title":"Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus","volume":"1601","author":"John","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib72","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ncomms2101","article-title":"Monosynaptic inputs to new neurons in the dentate gyrus","volume":"3","author":"Vivar","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.arcmed.2020.03.014_bib73","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib74","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.cellbio.042308.113256","article-title":"Signaling in adult neurogenesis","volume":"25","author":"Suh","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib75","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1523\/JNEUROSCI.22-09-03656.2002","article-title":"Nicotine self-administration impairs hippocampal plasticity","volume":"22","author":"Abrous","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib76","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1152\/jn.00886.2012","article-title":"The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the \u03b13\u03b24 subtype","volume":"109","author":"Sharma","year":"2012","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib77","doi-asserted-by":"crossref","first-page":"776","DOI":"10.5966\/sctm.2012-0103","article-title":"Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by \u03b17 nicotinic receptor agonist","volume":"2","author":"Narla","year":"2013","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.arcmed.2020.03.014_bib78","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2008.09.059","article-title":"Fibroblast growth factor-2 and its receptor expression in proliferating precursor cells of the subventricular zone in the adult rat brain","volume":"447","author":"Frinchi","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.arcmed.2020.03.014_bib79","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/mcne.1995.1035","article-title":"FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain","volume":"6","author":"Palmer","year":"1995","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib80","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00702-009-0207-z","article-title":"The FGF-2\/FGFRs neurotrophic system promotes neurogenesis in the adult brain","volume":"116","author":"Mudo","year":"2009","journal-title":"J Neural Transm"},{"key":"10.1016\/j.arcmed.2020.03.014_bib81","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1096-9861(19970310)379:2<226::AID-CNE5>3.0.CO;2-5","article-title":"Comparative localization of fibroblast growth factor receptor-1,-2, and-3 mRNAs in the rat brain: In situ hybridization analysis","volume":"379","author":"Belluardo","year":"1997","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib82","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000082136","article-title":"Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone","volume":"26","author":"Zheng","year":"2004","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib83","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1096\/fj.201600932R","article-title":"Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons","volume":"31","author":"Deflorio","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.arcmed.2020.03.014_bib84","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00018-014-1818-6","article-title":"A nuclear odyssey: fibroblast growth factor-2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system","volume":"72","author":"F\u00f6rthmann","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib85","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yexmp.2015.11.003","article-title":"Nuclear staining of fgfr-2\/stat-5 and runx-2 in mucinous breast cancer","volume":"100","author":"May","year":"2016","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib86","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jcb.10606","article-title":"Integrative nuclear FGFR1 signaling (INFS) as a part of a universal \u201cfeed-forward-and-gate\u201d signaling module that controls cell growth and differentiation","volume":"90","author":"Stachowiak","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.arcmed.2020.03.014_bib87","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbr.2016.09.007","article-title":"ChAT-positive neurons participate in subventricular zone neurogenesis after middle cerebral artery occlusion in mice","volume":"316","author":"Wang","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib88","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12975-017-0541-7","article-title":"Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone","volume":"8","author":"Wang","year":"2017","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib89","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1039\/b902617g","article-title":"Targeting novel integrative nuclear FGFR1 signaling by nanoparticle-mediated gene transfer stimulates neurogenesis in the adult brain","volume":"1","author":"Stachowiak","year":"2009","journal-title":"Integr Biol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib90","series-title":"Nicotinic Acetylcholine Receptor Signaling in Neuroprotection","first-page":"73","article-title":"Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection","author":"Morioka","year":"2018"},{"key":"10.1016\/j.arcmed.2020.03.014_bib91","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yebeh.2008.08.020","article-title":"Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy","volume":"14","author":"Kuruba","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.arcmed.2020.03.014_bib92","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12035-011-8207-z","article-title":"The interesting interplay between interneurons and adult hippocampal neurogenesis","volume":"44","author":"Masiulis","year":"2011","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib93","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1523\/JNEUROSCI.3362-09.2009","article-title":"Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain","volume":"29","author":"Deng","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib94","series-title":"A study of the effects of nicotine on hippocampal and striatal histomorphology, neurogenesis and neurobehaviours in adult male wistar rats","author":"Ijomone","year":"2015"},{"key":"10.1016\/j.arcmed.2020.03.014_bib95","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuroscience.2006.06.035","article-title":"Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats","volume":"142","author":"Kotani","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib96","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.1523\/JNEUROSCI.0931-10.2010","article-title":"Endogenous signaling through \u03b17-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus","volume":"30","author":"Campbell","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib97","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainresbull.2005.06.018","article-title":"Input from the medial septum regulates adult hippocampal neurogenesis","volume":"67","author":"Van der Borght","year":"2005","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.arcmed.2020.03.014_bib98","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2010.11.091","article-title":"The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis","volume":"1373","author":"Rennie","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib99","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuroscience.2003.08.054","article-title":"Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates","volume":"122","author":"Goldbart","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.arcmed.2020.03.014_bib100","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1523\/JNEUROSCI.22-22-09868.2002","article-title":"Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus","volume":"22","author":"Nakagawa","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib101","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/mcne.1996.0595","article-title":"The adult rat hippocampus contains primordial neural stem cells","volume":"8","author":"Palmer","year":"1997","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib102","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/(SICI)1097-4695(199901)38:1<65::AID-NEU5>3.0.CO;2-Q","article-title":"Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures","volume":"38","author":"Takahashi","year":"1999","journal-title":"J Neurobiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib103","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.1065.03.2004","article-title":"Activation of cAMP signaling facilitates the morphological maturation of newborn neurons in adult hippocampus","volume":"24","author":"Fujioka","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib104","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/7449","article-title":"Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective","volume":"5","author":"Young","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.arcmed.2020.03.014_bib105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cbi.2008.04.004","article-title":"Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis","volume":"175","author":"Kotani","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.arcmed.2020.03.014_bib106","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1073\/pnas.87.11.4320","article-title":"Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation","volume":"87","author":"Lamph","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.arcmed.2020.03.014_bib107","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.phymed.2012.09.012","article-title":"Cognition-enhancing and neuroprotective activities of the standardized extract of Betula platyphylla bark and its major diarylheptanoids","volume":"19","author":"Lee","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.arcmed.2020.03.014_bib108","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bcp.2011.11.009","article-title":"Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics","volume":"83","author":"Bitner","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib109","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnmol.2015.00046","article-title":"A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis","volume":"8","author":"Ortega-Mart\u00ednez","year":"2015","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib110","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0896-6273(01)00516-5","article-title":"Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons","volume":"32","author":"Chang","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.arcmed.2020.03.014_bib111","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1471-4159.2001.00602.x","article-title":"Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells","volume":"79","author":"Nakayama","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.arcmed.2020.03.014_bib112","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0169-328X(00)00246-1","article-title":"Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus","volume":"85","author":"Kenny","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.arcmed.2020.03.014_bib113","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.expneurol.2004.11.016","article-title":"Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats","volume":"192","author":"Scharfman","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib114","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1471-4159.2002.01085.x","article-title":"Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice","volume":"82","author":"Lee","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.arcmed.2020.03.014_bib115","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1007\/s12035-015-9344-6","article-title":"Simvastatin enhances spatial memory and long-term potentiation in hippocampal CA1 via upregulation of \u03b17 nicotinic acetylcholine receptor","volume":"53","author":"Chen","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib116","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fphar.2018.00362","article-title":"Simvastatin Enhances Activity and Trafficking of \u03b17 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways","volume":"9","author":"Chen","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib117","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2015.05.020","article-title":"Simvastatin prevents \u03b2-amyloid25\u201335-impaired neurogenesis in hippocampal dentate gyrus through \u03b17nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate","volume":"97","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arcmed.2020.03.014_bib118","doi-asserted-by":"crossref","first-page":"13541","DOI":"10.1074\/jbc.M008035200","article-title":"\u03b17 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A \u03b2-amyloid-induced neurotoxicity","volume":"276","author":"Kihara","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2020.03.014_bib119","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1478-811X-7-20","article-title":"Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation","volume":"7","author":"Resende","year":"2009","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.arcmed.2020.03.014_bib120","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1038\/npp.2014.128","article-title":"Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment","volume":"39","author":"Li","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.arcmed.2020.03.014_bib121","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1523\/JNEUROSCI.4248-11.2012","article-title":"Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis","volume":"32","author":"Bracko","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.arcmed.2020.03.014_bib122","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0014-2999(00)00064-9","article-title":"Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases","volume":"393","author":"Perry","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.arcmed.2020.03.014_bib123","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00213-012-2841-7","article-title":"Galantamine increases hippocampal insulin-like growth factor 2 expression via \u03b17 nicotinic acetylcholine receptors in mice","volume":"225","author":"Kita","year":"2013","journal-title":"Psychopharmacology"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440919308112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440919308112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:48:24Z","timestamp":1759261704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440919308112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":123,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0188440919308112"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2020.03.014","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Overview of Nicotinic Cholinergic System Signaling in Neurogenesis","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2020.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}