{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T17:21:51Z","timestamp":1777742511952,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.arcmed.2020.10.001","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T06:38:18Z","timestamp":1602139098000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers"],"prefix":"10.1016","volume":"52","author":[{"given":"Sanaa A.","family":"El-Benhawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A.","family":"El-Tahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh F.","family":"Nakhla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2020.10.001_bib1","article-title":"Carcinogenicity of night shift work","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.arcmed.2020.10.001_bib2","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/ijc.31655","article-title":"Rotating night shift work and colorectal cancer risk in the nurses' health studies","volume":"143","author":"Papantoniou","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.arcmed.2020.10.001_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40557-018-0221-4","article-title":"The relationship between night work and breast cancer","volume":"30","author":"Lee","year":"2018","journal-title":"Ann Occup Environ Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/occmed\/kqz063","article-title":"Systematic review of shift work and nurses' health","volume":"69","author":"Rosa","year":"2019","journal-title":"Occup Med (Lond)"},{"key":"10.1016\/j.arcmed.2020.10.001_bib5","series-title":"New YorkUnited Nations Scientific Committee on the Effects of Atomic Radiation","article-title":"United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) Sources and Effects of Ionizing Radiation","year":"2000"},{"key":"10.1016\/j.arcmed.2020.10.001_bib6","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00204-020-02752-z","article-title":"Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast","volume":"94","author":"Helm","year":"2020","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.arcmed.2020.10.001_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.smrv.2012.08.003","article-title":"Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation","volume":"17","author":"Haus","year":"2013","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.arcmed.2020.10.001_bib8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1590\/S1517-74912002000300003","article-title":"Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation","volume":"16","author":"Miyaji","year":"2002","journal-title":"Pesqui Odontol Bras"},{"key":"10.1016\/j.arcmed.2020.10.001_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1525-1373.2000.22502.x","article-title":"Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation","volume":"225","author":"Karbownik","year":"2000","journal-title":"PSEBM"},{"key":"10.1016\/j.arcmed.2020.10.001_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.smrv.2012.12.006","article-title":"Neuroendocrine, immune and oxidative stress in shift workers","volume":"17","author":"Faraut","year":"2013","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.arcmed.2020.10.001_bib11","first-page":"809","article-title":"Light exposure at night and rotating night shift associated with circadian disruption of 6-sulfatoxymelatonin","volume":"2","author":"Anjum","year":"2013","journal-title":"Int J Med Res Health Sci"},{"key":"10.1016\/j.arcmed.2020.10.001_bib12","first-page":"1079","article-title":"Night shift work and level of 6- sulfatoxy melatonin and cortisol in men\u201d Cancer Epidemiol Biomarkers","volume":"22","author":"Mirick","year":"2013","journal-title":"Prev"},{"key":"10.1016\/j.arcmed.2020.10.001_bib13","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3109\/07420528.2014.957304","article-title":"Progressive decrease of melatonin production over consecutive days of simulated night work","volume":"31","author":"Dumont","year":"2014","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.arcmed.2020.10.001_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/oemed-2011-100273","article-title":"Night shift work characteristics and 6 sulfatoxy melatonin (MT6s) in rotating night shift nurses and midwives","volume":"69","author":"Peplonska","year":"2012","journal-title":"Occup and Environ Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib15","first-page":"531","article-title":"Risk of breast cancer after night and shift work: current evidence and ongoing studies in Denmark","volume":"17","author":"Hansen","year":"2006","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.arcmed.2020.10.001_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.ede.0000190539.03500.c1","article-title":"Night work and risk of breast cancer","volume":"17","author":"Schernhammer","year":"2006","journal-title":"Epidemiology"},{"key":"10.1016\/j.arcmed.2020.10.001_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/10803548.2010.11076860","article-title":"The effect of bright light on physiological circadian rhythms and subjective alertness of shift work nurses in Iran","volume":"16","author":"Kakooei","year":"2010","journal-title":"Int J Occup Saf Ergon"},{"key":"10.1016\/j.arcmed.2020.10.001_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cdp.2006.03.002","article-title":"Estrogen-signaling pathway: a link between breast cancer and melatonin oncostatic actions","volume":"30","author":"Cos","year":"2006","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/j.arcmed.2020.10.001_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11357-008-9052-5","article-title":"Relationship between oxidative and occupational stress and aging in nurses of an intensive care unit","volume":"30","author":"Casado","year":"2008","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.arcmed.2020.10.001_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2217\/14796694.4.5.637","article-title":"Inflammation and prostate cancer","volume":"4","author":"Vasto","year":"2008","journal-title":"Future Oncol"},{"key":"10.1016\/j.arcmed.2020.10.001_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1179\/135100009X392548","article-title":"24-Hour variation in gene expression of redox pathway enzymes in rat hypothalamus: effect of melatonin treatment","volume":"14","author":"Jimenez-Ortega","year":"2009","journal-title":"Redox Rep"},{"key":"10.1016\/j.arcmed.2020.10.001_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1740-3391-3-15","article-title":"Shift work as an oxidative stressor","volume":"3","author":"Sharifian","year":"2005","journal-title":"J Circadian Rhythms"},{"key":"10.1016\/j.arcmed.2020.10.001_bib23","series-title":"AIP Conference Proceedings","doi-asserted-by":"crossref","DOI":"10.1063\/1.5004312","article-title":"Effects of Night Shift Working on Some Immunological, Prostate specific antigen, Cortisol level and Malondialdehyde in Male Nurses at Hawler City","author":"Muhammad","year":"2017"},{"key":"10.1016\/j.arcmed.2020.10.001_bib24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.psyneuen.2007.01.008","article-title":"Is the cortisol awakening rise a response to awakening?","volume":"32","author":"Wilhelm","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.arcmed.2020.10.001_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biopsycho.2006.08.008","article-title":"Circadian cortisol profiles and psychological self-reports in shift workers with and without recent change in the shift rotation system","volume":"74","author":"Kudielka","year":"2007","journal-title":"Biol Psychol"},{"key":"10.1016\/j.arcmed.2020.10.001_bib26","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1210\/jc.2009-0370","article-title":"Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: A hypothesis","volume":"94","author":"Anagnostis","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.arcmed.2020.10.001_bib27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40557-016-0135-y","article-title":"Night shift work and inflammatory markers in male workers aged 20\u201339 in a display manufacturing company","volume":"28","author":"Kim","year":"2016","journal-title":"Ann Occup Environ Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/0019-5278.82996","article-title":"Night work and inflammatory markers","volume":"15","author":"Khosro","year":"2011","journal-title":"Indian J Occup Environ Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3109\/07420528.2011.580869","article-title":"Effect of shiftwork on systemic markers of inflammation","volume":"28","author":"Puttonen","year":"2011","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.arcmed.2020.10.001_bib30","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.35371\/aoem.2019.31.e5","article-title":"The effect of shift work on high sensitivity C-reactive protein level among female workers","volume":"31","author":"Kwak","year":"2019","journal-title":"Ann Occup Environ Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib31","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/PSY.0b013e318157cb96","article-title":"C-reactive protein levels and sleep disturbances: observations based on the Northern Finland 1966 Birth Cohort study","volume":"69","author":"Liukkonen","year":"2007","journal-title":"Psychosom Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib32","doi-asserted-by":"crossref","first-page":"E1402","DOI":"10.1073\/pnas.1516953113","article-title":"Circadian misalignment increases cardiovascular disease risk factors in humans","volume":"113","author":"Morris","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arcmed.2020.10.001_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.etap.2005.01.005","article-title":"Oxidative stress in radiology staff","volume":"20","author":"Malekirad","year":"2005","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.arcmed.2020.10.001_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/13510002.2015.1101891","article-title":"Redox status in workers occupationally exposed to long-term low levels of ionizing radiation: A pilot study","volume":"21","author":"Ahmad","year":"2016","journal-title":"Redox Rep"},{"key":"10.1016\/j.arcmed.2020.10.001_bib35","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.arcmed.2020.10.001_bib36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.14235\/bs.2016.872","article-title":"Effects of ionizing and non-ionizing radiation on oxidative stress and the total antioxidant status in humans working in radiation environments","volume":"3","author":"\u00c7el\u0130k","year":"2016","journal-title":"Bezmialem Sci"},{"key":"10.1016\/j.arcmed.2020.10.001_bib37","first-page":"249","article-title":"Chromosomal aberrations and oxidative DNA adduct 8-hydroxy-2-deoxyguanosine as biomarkers of radiotoxicity in radiation workers","volume":"9","author":"El-Benhawy","year":"2016","journal-title":"JRRAS"},{"key":"10.1016\/j.arcmed.2020.10.001_bib38","first-page":"127","article-title":"Melatonin Role in Ameliorating Radiation-induced Skin Damage: From Theory to Practice (A Review of Literature)","volume":"7","author":"Abbaszadeh","year":"2017","journal-title":"J Biomed Phys Eng"},{"key":"10.1016\/j.arcmed.2020.10.001_bib39","article-title":"Effects of power frequency electromagnetic fields on melatonin and sleep in the rat","volume":"5","author":"Dyche","year":"2012","journal-title":"Emerg Health Threats J"},{"key":"10.1016\/j.arcmed.2020.10.001_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/0976-9668.95958","article-title":"Occupational exposure of dentists to electromagnetic fields produced by magnetostrictive cavitrons alters the serum cortisol level","volume":"3","author":"Mortazavi","year":"2012","journal-title":"J Nat Sci Biol Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib41","first-page":"9","article-title":"Radiation-induced inflammation and autoimmune diseases","volume":"5","author":"Yahyapour","year":"2018","journal-title":"Mil Med Res"},{"key":"10.1016\/j.arcmed.2020.10.001_bib42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/antiox8010012","article-title":"Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters","volume":"8","author":"Ahmad","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.arcmed.2020.10.001_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.amjmed.2004.06.045","article-title":"Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors","volume":"118","author":"Hayashi","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.arcmed.2020.10.001_bib44","first-page":"327","article-title":"Assessment of blood serum immunoglobulin and C-reactive protein concentrations in workers of x-ray diagnostics units","volume":"18","author":"K\u0142uci\u0144ski","year":"2005","journal-title":"Int J Occup Med Environ Health"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440919309191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440919309191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:49:18Z","timestamp":1759261758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440919309191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0188440919309191"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2020.10.001","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2020.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}