{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:42:25Z","timestamp":1784720545969,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.arcmed.2020.11.001","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T17:13:44Z","timestamp":1606324424000},"page":"277-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy"],"prefix":"10.1016","volume":"52","author":[{"given":"Zhi-Bing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Cai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2020.11.001_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/den.12559","article-title":"Feasibility of deep sedation with a combination of propofol and dexmedetomidine hydrochloride for esophageal endoscopic submucosal dissection","volume":"28","author":"Nonaka","year":"2016","journal-title":"Dig Endosc"},{"key":"10.1016\/j.arcmed.2020.11.001_bib2","first-page":"547","article-title":"[Use of dexmedetomidine hydrochloride as a sedative during local therapy for hepatocellular carcinoma]","volume":"112","author":"Tsubata","year":"2015","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"10.1016\/j.arcmed.2020.11.001_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-3701-5-4","article-title":"Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species","volume":"5","author":"Wang","year":"2015","journal-title":"Cell Biosci"},{"key":"10.1016\/j.arcmed.2020.11.001_bib4","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1349-7006.2011.01927.x","article-title":"Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma","volume":"102","author":"Kusayama","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1016\/j.arcmed.2020.11.001_bib5","doi-asserted-by":"crossref","first-page":"206525","DOI":"10.1155\/2013\/206525","article-title":"Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma","volume":"2013","author":"Guo","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.arcmed.2020.11.001_bib6","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1159\/000445592","article-title":"Exogenous HGF prevents cardiomyocytes from apoptosis after hypoxia via up-regulating cell autophagy","volume":"38","author":"Wang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.arcmed.2020.11.001_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-065X.2010.00995.x","article-title":"Autophagy in immunity and cell-autonomous defense against intracellular microbes","volume":"240","author":"Deretic","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.arcmed.2020.11.001_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.ctdb.2015.07.012","article-title":"Autophagy in cell life and cell death","volume":"114","author":"Anding","year":"2015","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.arcmed.2020.11.001_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/icb.2014.81","article-title":"Autophagy in T-cell development, activation and differentiation","volume":"93","author":"Bronietzki","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.arcmed.2020.11.001_bib10","first-page":"199","article-title":"Cerebral protection effect of dexmedetomidine on septic shock rats mechanism","volume":"28","author":"Li","year":"2020","journal-title":"J Brain Nerv Dis"},{"key":"10.1016\/j.arcmed.2020.11.001_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2344\/0003-3006-56.3.75","article-title":"Psychosedation with dexmedetomidine hydrochloride during minor oral surgery","volume":"56","author":"Taniyama","year":"2009","journal-title":"Anesth Prog"},{"key":"10.1016\/j.arcmed.2020.11.001_bib12","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2460\/ajvr.77.10.1057","article-title":"Effect of dexmedetomidine hydrochloride on tiletamine hydrochloride-zolazepam hydrochloride anesthesia in alpacas","volume":"77","author":"Seddighi","year":"2016","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.arcmed.2020.11.001_bib13","first-page":"477","article-title":"Effect of dexmedetomidine hydrochloride on H2O2-induced oxidative stress and inflammatory response in Kupffer cells]","volume":"41","author":"Shen","year":"2016","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.arcmed.2020.11.001_bib14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12871-017-0410-7","article-title":"Effects of dexmedetomidine on TNF-alpha and interleukin-2 in serum of rats with severe craniocerebral injury","volume":"17","author":"Jiang","year":"2017","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.arcmed.2020.11.001_bib15","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3892\/ijmm.2014.1863","article-title":"Dexmedetomidine suppresses interleukin-1beta-induced interleukin-6 synthesis in rat glial cells","volume":"34","author":"Tanabe","year":"2014","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.arcmed.2020.11.001_bib16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2147\/DDDT.S188436","article-title":"Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in\u00a0vitro via Erk1\/2\/CREB\/BDNF signaling pathways","volume":"13","author":"Tu","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.arcmed.2020.11.001_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/SHK.0000000000001040","article-title":"Blocking liver autophagy accelerates apoptosis and mitochondrial injury in hepatocytes and reduces time to mortality in a murine sepsis model","volume":"50","author":"Oami","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.arcmed.2020.11.001_bib18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1172\/JCI74942","article-title":"PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis","volume":"125","author":"Bueno","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcmed.2020.11.001_bib19","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.arcmed.2020.11.001_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.envpol.2017.03.083","article-title":"Crotonaldehyde induces autophagy-mediated cytotoxicity in human bronchial epithelial cells via PI3K, AMPK and MAPK pathways","volume":"228","author":"Wang","year":"2017","journal-title":"Environ Pollut"},{"key":"10.1016\/j.arcmed.2020.11.001_bib21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.biopha.2017.08.125","article-title":"Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injury","volume":"95","author":"Shen","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.arcmed.2020.11.001_bib22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3892\/mmr.2012.966","article-title":"Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3","volume":"6","author":"Liu","year":"2012","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.arcmed.2020.11.001_bib23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3892\/ol.2016.5387","article-title":"Isoimperatorin induces apoptosis of the SGC-7901 human gastric cancer cell line via the mitochondria-mediated pathway","volume":"13","author":"Tong","year":"2017","journal-title":"Oncol Lett"},{"key":"10.1016\/j.arcmed.2020.11.001_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1423-0127-19-82","article-title":"Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways","volume":"19","author":"Choi","year":"2012","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.arcmed.2020.11.001_bib25","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bjan.2018.09.011","article-title":"Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats]","volume":"69","author":"Zhang","year":"2019","journal-title":"Rev Bras Anestesiol"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440920305038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440920305038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:50:15Z","timestamp":1759261815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440920305038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0188440920305038"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2020.11.001","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IMSS. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}