{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:28:26Z","timestamp":1778124506000,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":199,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MEC- CAR\/30011\/2017"],"award-info":[{"award-number":["PTDC\/MEC- CAR\/30011\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIM\/ 04501\/2020"],"award-info":[{"award-number":["UID\/BIM\/ 04501\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/NEU\/04539\/2019"],"award-info":[{"award-number":["UID\/NEU\/04539\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/ 04539\/2020"],"award-info":[{"award-number":["UIDB\/ 04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.arcmed.2022.02.001","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:43:09Z","timestamp":1645058589000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reduced Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Heart Failure with Reduced Ejection Fraction"],"prefix":"10.1016","volume":"53","author":[{"given":"Jos\u00e9","family":"Lopes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-0011","authenticated-orcid":false,"given":"Manuel","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-7956","authenticated-orcid":false,"given":"Suiane","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"Gouveia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-8705","authenticated-orcid":false,"given":"Ilda P.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristine","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-3466","authenticated-orcid":false,"given":"Bruno Bernardes","family":"de Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Viamonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-1493","authenticated-orcid":false,"given":"Fernando","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2022.02.001_bib0001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3904\/kjim.2018.428","article-title":"Update on heart failure management and future directions","volume":"34","author":"Choi","year":"2019","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mayocpiqo.2018.12.006","article-title":"Rethinking Endothelial Dysfunction as a Crucial Target in Fighting Heart Failure","volume":"3","author":"Premer","year":"2019","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0003","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.3390\/ijms20133198","article-title":"Endothelial dysfunction in chronic heart failure: Assessment, findings, significance, and potential therapeutic targets","volume":"20","author":"Alem","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0004","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ijir.2009.59","article-title":"The endothelial cell in health and disease: its function, dysfunction, measurement and therapy","volume":"22","author":"Schwartz","year":"2010","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0005","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jacc.2006.02.078","article-title":"Circulating Endothelial Cells in Cardiovascular Disease","volume":"48","author":"Boos","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0006","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/ndt\/gfm680","article-title":"Circulating endothelial cells in renal disease: Markers and mediators of vascular damage","volume":"23","author":"Woywodt","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a006692","article-title":"Human endothelial progenitor cells","volume":"2","author":"Yoder","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0008","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCRESAHA.120.315895","article-title":"Hematopoiesis and cardiovascular disease","author":"Poller","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01713-8","article-title":"Improvement in circulating endothelial progenitor cells pool after cardiac resynchronization therapy: Increasing the list of benefits","volume":"11","author":"Crist\u00f3v\u00e3o","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/bbrj.bbrj_41_18","article-title":"Analysis of endothelial progenitor subpopulation cells, oxidative DNA damage, and their role in coronary artery disease","volume":"2","author":"Shaik","year":"2018","journal-title":"Biomed Biotechnol Res J"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0011","article-title":"Characterization of circulating endothelial cells in acute myocardial infarction","volume":"4","author":"Damani","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0012","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/rth2.12158","article-title":"Circulating endothelial cells as biomarker for cardiovascular diseases","volume":"3","author":"Farinacci","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0013","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0014","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/jcm5070062","article-title":"Heart Failure: Diagnosis, Management and Utilization","volume":"5","author":"Inamdar","year":"2016","journal-title":"J Clin Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0015","first-page":"3021","article-title":"2018 ESC\/ESHGuidelines for themanagement ofarterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)","author":"Mancia","year":"2018","journal-title":"J Hypertens"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0016","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12933-016-0413-6","article-title":"Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study","volume":"15","author":"Ahmed","year":"2016","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0017","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/01.CIR.0000136813.89036.21","article-title":"CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure","volume":"110","author":"Valgimigli","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0018","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijcard.2006.07.191","article-title":"Circulating endothelial progenitor cells in congestive heart failure","volume":"119","author":"Nonaka-Sarukawa","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0019","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ebiom.2016.01.018","article-title":"Pattern of endothelial progenitor cells and apoptotic endothelial cell-derived microparticles in chronic heart failure patients with preserved and reduced left ventricular ejection fraction","volume":"4","author":"Berezin","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0020","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12265-018-9810-4","article-title":"Endothelial progenitor cells in heart failure: An authentic expectation for potential future use and a lack of universal definition","volume":"11","author":"Djohan","year":"2018","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0021","article-title":"Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation","volume":"8","author":"Giannitsi","year":"2019","journal-title":"JRSM Cardiovasc Dis"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0022","first-page":"204","article-title":"Endothelial Progenitor Cells in Cardiovascular Disorders","author":"Shantsila","year":"2018","journal-title":"Aging Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0023","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2217\/bmm.11.92","article-title":"Endothelial progenitor cells in cardiovascular disease and chronic inflammation: from biomarker to therapeutic agent","volume":"5","author":"Grisar","year":"2011","journal-title":"Biomark Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0024","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejheart.2005.06.010","article-title":"Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin","volume":"8","author":"Chong","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1155\/2011\/757840","article-title":"Circulating endothelial cells in patients with heart failure and left ventricular dysfunction","volume":"31","author":"Mart\u00ednez-Sales","year":"2011","journal-title":"Dis Markers"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0026","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/HJH.0000000000000162","article-title":"Prevalence, awareness, treatment and control of hypertension and salt intake in Portugal: Changes over a decade the PHYSA study","volume":"32","author":"Polonia","year":"2014","journal-title":"J Hypertens"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0027","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/j.1582-4934.2010.01195.x","article-title":"Circulating stem cell vary with NYHA stage in heart failure patients","volume":"15","author":"Fortini","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0028","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1160\/TH04-12-0795","article-title":"Circulating endothelial cells in acute ischaemic stroke","volume":"94","author":"Nadar","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0029","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood-2004-03-1106","article-title":"Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes","volume":"105","author":"Lee","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0030","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/infdis\/jiaa528","article-title":"Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19","volume":"222","author":"Guervilly","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21767\/2386-5180.1000139","article-title":"Different Obese Phenotypes and Progenitor Endothelial Cell Dysfunction: The Missed Link to Cardiovascular Risk","volume":"04","author":"Berezin","year":"2016","journal-title":"Ann Clin Lab Res"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0032","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4172\/2168-9296.1000179","article-title":"Obesity Paradox\u201d in Heart Failure: The Possible Role of Progenitor Endothelial Cell Dysfunction","volume":"06","author":"Berezin","year":"2017","journal-title":"Cell Dev Biol"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0033","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1253\/circj.CJ-13-0976","article-title":"Endothelial progenitor cells in morbid obesity: Pathogenetic implications","volume":"78","author":"Graziani","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0034","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1096\/fj.201500175","article-title":"Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow","volume":"30","author":"Van Den Berg","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0035","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.repc.2019.02.016","article-title":"Effects of exercise on endothelial progenitor cells in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials","volume":"38","author":"Cavalcante","year":"2019","journal-title":"Rev Port Cardiol"},{"key":"10.1016\/j.arcmed.2022.02.001_bib0036","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/sctm.16-0360","article-title":"Endothelial Progenitors: A Consensus Statement on Nomenclature","volume":"6","author":"Medina","year":"2017","journal-title":"Stem Cells Transl Med"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440922000133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440922000133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:28:58Z","timestamp":1777523338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440922000133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0188440922000133"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2022.02.001","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Heart Failure with Reduced Ejection Fraction","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2022.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}