{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:39:54Z","timestamp":1786984794871,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.arcmed.2023.102843","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T13:31:36Z","timestamp":1688823096000},"page":"102843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Conversion Predictors of Clinically Isolated Syndrome to Multiple Sclerosis in Mexican Patients: A Prospective Study"],"prefix":"10.1016","volume":"54","author":[{"given":"V\u00edctor","family":"Chavarria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-8806","authenticated-orcid":false,"given":"Guillermo","family":"Espinosa-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Sotelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Flores-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Anguiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-8019","authenticated-orcid":false,"given":"Ana Campos","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-1923","authenticated-orcid":false,"given":"Edgar Daniel","family":"Guzm\u00e1n-R\u00edos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleli","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Ordo\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-312X","authenticated-orcid":false,"given":"Benjamin","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2023.102843_bib0001","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple Sclerosis Pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.arcmed.2023.102843_bib0002","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1212\/CON.0000000000000725","article-title":"Multiple Sclerosis Risk Factors and Pathogenesis","volume":"25","author":"Nourbakhsh","year":"2019","journal-title":"Continuum (Minneap Minn)"},{"key":"10.1016\/j.arcmed.2023.102843_bib0003","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1034\/j.1600-0404.2002.1o077.x","article-title":"Varicella, ephemeral breastfeeding and eczema as risk factors for multiple sclerosis in Mexicans","volume":"105","author":"Tarrats","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.arcmed.2023.102843_bib0004","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.msard.2019.03.027","article-title":"CSF oligoclonal bands and normal appearing white matter periventricular damage in patients with clinically isolated syndrome suggestive of MS","volume":"31","author":"Pardini","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.arcmed.2023.102843_bib0005","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.arcmed.2023.102843_bib0006","first-page":"S1","article-title":"Clinically Isolated Syndromes: Clinical Characteristics, Differential Diagnosis, and Management","volume":"52","author":"Efendi","year":"2015","journal-title":"Noro Psikiyatr Ars"},{"key":"10.1016\/j.arcmed.2023.102843_bib0007","article-title":"Conversion of clinically isolated syndrome to multiple sclerosis: a prospective multi-center study in Eastern India","volume":"5","author":"Banerjee","year":"2019","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"10.1016\/j.arcmed.2023.102843_bib0008","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/00207454.2018.1446954","article-title":"Does vitamin D deficiency predict early conversion of clinically isolated syndrome? A preliminary Egyptian study","volume":"128","author":"Shaheen","year":"2018","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.arcmed.2023.102843_bib0009","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/brain\/awm329","article-title":"Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis","volume":"131","author":"Fisniku","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.arcmed.2023.102843_bib0010","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1212\/WNL.0000000000003078","article-title":"The 11-year long-term follow-up study from the randomized BENEFIT CIS trial","volume":"87","author":"Kappos","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.arcmed.2023.102843_bib0011","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1177\/1352458512442438","article-title":"Effects of interferon beta-1b on cognitive performance in patients with a first event suggestive of multiple sclerosis","volume":"18","author":"Penner","year":"2012","journal-title":"Mult Scler"},{"key":"10.1016\/j.arcmed.2023.102843_bib0012","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00415-009-5063-0","article-title":"Clinical predictors of early second event in patients with clinically isolated syndrome","volume":"256","author":"Mowry","year":"2009","journal-title":"J Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0013","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(11)70274-5","article-title":"Clinically isolated syndromes","volume":"11","author":"Miller","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0014","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neuron.2018.01.021","article-title":"Multiple Sclerosis: Mechanisms and Immunotherapy","volume":"97","author":"Baecher-Allan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.arcmed.2023.102843_bib0015","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3389\/fimmu.2020.00760","article-title":"B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers","volume":"11","author":"van Langelaar","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0016","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3389\/fimmu.2019.01564","article-title":"Immunological Aspects of Approved MS Therapeutics","volume":"10","author":"Rommer","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0017","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jneuroim.2008.09.003","article-title":"The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis","volume":"205","author":"Frisullo","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0018","first-page":"e34158","article-title":"The High Prevalence of the Varicella Zoster Virus in Patients With Relapsing-Remitting Multiple Sclerosis: A Case-Control Study in the North of Iran","volume":"9","author":"Najafi","year":"2016","journal-title":"Jundishapur J Microbiol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0019","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-214555","article-title":"Detection of varicella-zoster virus DNA during medullary and brainstem relapses in multiple sclerosis","volume":"2016","author":"Torkildsen","year":"2016","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.arcmed.2023.102843_bib0020","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jmv.20777","article-title":"Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis","volume":"79","author":"Mancuso","year":"2007","journal-title":"J Med Virol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0021","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ana.21316","article-title":"Varicella-zoster virus in cerebrospinal fluid at relapses of multiple sclerosis","volume":"63","author":"Sotelo","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0022","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.clineuro.2013.12.020","article-title":"The participation of varicella zoster virus in relapses of multiple sclerosis","volume":"119","author":"Sotelo","year":"2014","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.arcmed.2023.102843_bib0023","doi-asserted-by":"crossref","first-page":"e7638","DOI":"10.1371\/journal.pone.0007638","article-title":"IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome","volume":"4","author":"Brettschneider","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2023.102843_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102575","article-title":"Demographic and clinical characterization of multiple sclerosis in Mexico: The REMEMBer study","volume":"46","author":"Bertado-Cortes","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.arcmed.2023.102843_bib0025","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1212\/WNL.0000000000013016","article-title":"Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome: A MAGNIMS Study","volume":"98","author":"Filippi","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.arcmed.2023.102843_bib0026","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fneur.2019.00188","article-title":"Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis","volume":"10","author":"Schwenkenbecher","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0027","first-page":"103","article-title":"The number needed to treat (NNT) and the number needed to harm (NNH)","volume":"38","author":"Suter","year":"2015","journal-title":"Med Monatsschr Pharm"},{"key":"10.1016\/j.arcmed.2023.102843_bib0028","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s40263-019-00647-x","article-title":"Drug Treatment of Clinically Isolated Syndrome","volume":"33","author":"F\u00f6rster","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.arcmed.2023.102843_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.118067","article-title":"Long-term outcomes in patients presenting with optic neuritis: Analyses of the MSBase registry","volume":"430","author":"Kenney","year":"2021","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.arcmed.2023.102843_bib0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10072-018-3582-0","article-title":"Health-related quality of life in clinically isolated syndrome and risk of conversion to multiple sclerosis","volume":"40","author":"Baldin","year":"2019","journal-title":"Neurol Sci"},{"key":"10.1016\/j.arcmed.2023.102843_bib0031","first-page":"15","article-title":"Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study","volume":"55","author":"Cinar","year":"2018","journal-title":"Noro Psikiyatr Ars"},{"key":"10.1016\/j.arcmed.2023.102843_bib0032","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/1352458514568827","article-title":"Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study","volume":"21","author":"Kuhle","year":"2015","journal-title":"Mult Scler"},{"key":"10.1016\/j.arcmed.2023.102843_bib0033","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.arcmed.2023.102843_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000089230","article-title":"Multiple sclerosis in Latin America","volume":"26","author":"Corona","year":"2006","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.arcmed.2023.102843_bib0035","article-title":"Prevalence of multiple sclerosis in Latin America and its relationship with European migration","volume":"2","author":"Correa","year":"2016","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"10.1016\/j.arcmed.2023.102843_bib0036","first-page":"10857","article-title":"Natural Course of Clinically Isolated Syndrome: A Longitudinal Analysis Using a","volume":"8","author":"Hou","year":"2018","journal-title":"Markov Model. Sci Rep"},{"key":"10.1016\/j.arcmed.2023.102843_bib0037","first-page":"118","article-title":"Frequency distribution of the first clinical symptoms in the Iranian population with multiple sclerosis","volume":"11","author":"Gharagozli","year":"2012","journal-title":"Iran J Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0038","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1590\/1516-3180.2016.0200270117","article-title":"Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study","volume":"135","author":"Cavenaghi","year":"2017","journal-title":"Sao Paulo Med J"},{"key":"10.1016\/j.arcmed.2023.102843_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102262","article-title":"Conversion of clinically isolated syndrome to multiple sclerosis: a prospective study","volume":"44","author":"Kolcava","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.arcmed.2023.102843_bib0040","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/s41598-021-81826-z","article-title":"Using advanced analysis of multifocal visual-evoked potentials to evaluate the risk of clinical progression in patients with radiologically isolated syndrome","volume":"11","author":"Miguel","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.arcmed.2023.102843_bib0041","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S2352-4642(18)30026-9","article-title":"MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study","volume":"2","author":"Fadda","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.arcmed.2023.102843_bib0042","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3389\/fimmu.2019.01821","article-title":"Central Nervous System Inflammatory Aggregates in the Theiler's Virus Model of Progressive Multiple Sclerosis","volume":"10","author":"DiSano","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0043","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000116820","article-title":"Enumeration of T, B and natural killer peripheral blood cells of patients with multiple sclerosis and controls","volume":"32","author":"Kreuzfelder","year":"1992","journal-title":"Eur Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0044","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12883-017-0915-1","article-title":"Peripheral blood lymphocytes immunophenotyping predicts disease activity in clinically isolated syndrome patients","volume":"17","author":"Posova","year":"2017","journal-title":"BMC Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0045","doi-asserted-by":"crossref","first-page":"e2559","DOI":"10.1371\/journal.pone.0002559","article-title":"Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis","volume":"3","author":"Kuenz","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.arcmed.2023.102843_bib0046","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.msard.2018.12.019","article-title":"The proportion of peripheral regulatory T cells in patients with Multiple Sclerosis: A meta-analysis","volume":"28","author":"Li","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.arcmed.2023.102843_bib0047","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00401-017-1744-4","article-title":"Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients","volume":"134","author":"van Nierop","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0048","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3389\/fimmu.2017.00753","article-title":"Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes","volume":"8","author":"Arellano","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0049","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jns.2016.07.052","article-title":"Interleukin 17 alone is not a discriminant biomarker in early demyelinating spectrum disorders","volume":"368","author":"Lebrun","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.arcmed.2023.102843_bib0050","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2353\/ajpath.2008.070690","article-title":"Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis","volume":"172","author":"Tzartos","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0051","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/jnnp.2008.146357","article-title":"Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis","volume":"80","author":"Vogt","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.arcmed.2023.102843_bib0052","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00415-006-0299-4","article-title":"Antimyelin antibodies in clinically isolated syndromes correlate with inflammation in MRI and CSF","volume":"254","author":"Kuhle","year":"2007","journal-title":"J Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0053","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0404.2007.00872.x","article-title":"Anti-myelin antibodies in clinically isolated syndrome indicate the risk of multiple sclerosis in a Swiss cohort","volume":"116","author":"Greeve","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.arcmed.2023.102843_bib0054","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1177\/1352458507077622","article-title":"Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS","volume":"13","author":"Tomassini","year":"2007","journal-title":"Mult Scler"},{"key":"10.1016\/j.arcmed.2023.102843_bib0055","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/jnnp.2007.133330","article-title":"Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica","volume":"79","author":"Jarius","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.arcmed.2023.102843_bib0056","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3390\/medicina58091178","article-title":"Factors Related to the Progression of Clinically Isolated Syndrome to Multiple Sclerosis: A Retrospective Study in Lithuania","volume":"58","author":"Balnyt\u0117","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.arcmed.2023.102843_bib0057","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ana.21886","article-title":"Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis","volume":"67","author":"Lunemann","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.arcmed.2023.102843_bib0058","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/infdis\/jir239","article-title":"Increased risk of multiple sclerosis following herpes zoster: a nationwide, population-based study","volume":"204","author":"Kang","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.arcmed.2023.102843_bib0059","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.clineuro.2008.07.007","article-title":"Association of a history of varicella virus infection with multiple sclerosis","volume":"111","author":"Rodriguez-Violante","year":"2009","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.arcmed.2023.102843_bib0060","doi-asserted-by":"crossref","first-page":"e1641","DOI":"10.1212\/WNL.0000000000012726","article-title":"Effect of Changes in MS Diagnostic Criteria Over 25 Years on Time to Treatment and Prognosis in Patients With Clinically Isolated Syndrome","volume":"97","author":"Tintore","year":"2021","journal-title":"Neurology"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440923000814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440923000814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:52:43Z","timestamp":1759261963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440923000814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0188440923000814"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2023.102843","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conversion Predictors of Clinically Isolated Syndrome to Multiple Sclerosis in Mexican Patients: A Prospective Study","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2023.102843","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102843"}}