{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:46:07Z","timestamp":1792190767432,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["SIP20220935"],"award-info":[{"award-number":["SIP20220935"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["20221007"],"award-info":[{"award-number":["20221007"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["SIP20230935"],"award-info":[{"award-number":["SIP20230935"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.arcmed.2024.102958","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T12:44:47Z","timestamp":1706532287000},"page":"102958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Repositioning FDA-Approved Drug Against Chagas Disease and Cutaneous Leishmaniosis by Structure-Based Virtual Screening"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-7361","authenticated-orcid":false,"given":"Alfredo","family":"Juarez-Saldivar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"G\u00f3mez-Escobedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Corral-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Fabiola","family":"Chac\u00f3n-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Horta-Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7128-849X","authenticated-orcid":false,"given":"Luvia","family":"Sanchez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenci k.","family":"Vazquez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-7066","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Nogueda-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-4167","authenticated-orcid":false,"given":"Gildardo","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2024.102958_bib0001","doi-asserted-by":"crossref","first-page":"750","DOI":"10.12688\/f1000research.11120.1","article-title":"Leishmaniasis: a review","volume":"6","author":"Torres-Guerrero","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.arcmed.2024.102958_bib0002","first-page":"129","article-title":"Trypanosoma cruzi Genome 15 Years Later: What Has Been Accomplished?","volume":"5","author":"Ramirez","year":"2020","journal-title":"Trop Med Infect Dis"},{"key":"10.1016\/j.arcmed.2024.102958_bib0003","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.3390\/molecules25122799","article-title":"Challenges in Chagas Disease Drug Development","volume":"25","author":"Francisco","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arcmed.2024.102958_bib0004","article-title":"Interventions for American cutaneous and mucocutaneous leishmaniasis","volume":"8","author":"Pinart","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.arcmed.2024.102958_bib0005","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1002\/1873-3468.12904","article-title":"Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi","volume":"591","author":"V\u00e1zquez","year":"2017","journal-title":"FEBS Lett"},{"key":"10.1016\/j.arcmed.2024.102958_bib0006","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/1061186X.2017.1289539","article-title":"Recent developments in trans-sialidase inhibitors of Trypanosoma cruzi","volume":"25","author":"Kashif","year":"2017","journal-title":"J Drug Target"},{"key":"10.1016\/j.arcmed.2024.102958_bib0007","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biochi.2019.08.015","article-title":"Evaluation of clan CD C11 peptidase PNT1 and other Leishmania mexicana cysteine peptidases as potential drug targets","volume":"166","author":"Grewal","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.arcmed.2024.102958_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116577","article-title":"Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease","volume":"58","author":"Beltran-Hortelano","year":"2022","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.arcmed.2024.102958_bib0009","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.2174\/0929867328666210913090928","article-title":"Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents","volume":"29","author":"V\u00e1zquez-Jim\u00e9nez","year":"2022","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.arcmed.2024.102958_bib0010","doi-asserted-by":"crossref","first-page":"10062","DOI":"10.1073\/pnas.96.18.10062","article-title":"Crystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexane","volume":"96","author":"Gao","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.arcmed.2024.102958_bib0011","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1371\/journal.pntd.0000001","article-title":"Perturbation of the dimer interface of triosephosphate isomerase and its effect on Trypanosoma cruzi","volume":"1","author":"Olivares-Illana","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.arcmed.2024.102958_bib0012","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1007\/s00044-021-02809-3","article-title":"Expanding the chemical space of aryloxy-naphthoquinones as potential anti-Chagasic agents: synthesis and trypanosomicidal activity","volume":"30","author":"Becerra","year":"2021","journal-title":"Med Chem Res"},{"key":"10.1016\/j.arcmed.2024.102958_bib0013","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1017\/S0031182019000234","article-title":"Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi","volume":"146","author":"Sim\u00f5es-Silva","year":"2019","journal-title":"Parasitology"},{"key":"10.1016\/j.arcmed.2024.102958_bib0014","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.3390\/ijms21124270","article-title":"Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling","volume":"21","author":"Ju\u00e1rez-Saldivar","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.arcmed.2024.102958_bib0015","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.3390\/ijms22115943","article-title":"Virtual Screening of FDA-Approved Drugs against Triose Phosphate Isomerase from Entamoeba histolytica and Giardia lamblia Identifies Inhibitors of Their Trophozoite Growth Phase","volume":"22","author":"Ju\u00e1rez-Saldivar","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.arcmed.2024.102958_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003773","article-title":"Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach","volume":"9","author":"Beig","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.arcmed.2024.102958_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007481","article-title":"Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069","volume":"14","author":"Say\u00e9","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.arcmed.2024.102958_bib0018","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pt.2014.04.003","article-title":"Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects","volume":"30","author":"Patterson","year":"2014","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.arcmed.2024.102958_bib0019","article-title":"The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice","volume":"893634","author":"Canavaci","year":"2014","journal-title":"Mediators Inflammation"},{"key":"10.1016\/j.arcmed.2024.102958_bib0020","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3181\/00379727-216-44192","article-title":"In pursuit of drugs for American trypanosomiasis: evaluation of some \"standards\" in a mouse model","volume":"216","author":"Kinnamon","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.arcmed.2024.102958_bib0021","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bpj.2015.06.031","article-title":"How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics","volume":"109","author":"Kurkcuoglu","year":"2015","journal-title":"Biophys J"},{"key":"10.1016\/j.arcmed.2024.102958_bib0022","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3934\/microbiol.2020010","article-title":"Study of therapeutic effect of different concentrations of imatinib on Balb\/c model of cutaneous leishmaniasis","volume":"6","author":"Moslehi","year":"2020","journal-title":"AIMS Microbiol"},{"key":"10.1016\/j.arcmed.2024.102958_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00436-017-5635-3","article-title":"Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana","volume":"117","author":"Chac\u00f3n-Vargas","year":"2018","journal-title":"Parasitol Res"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440924000110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440924000110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:36:03Z","timestamp":1778675763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440924000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0188440924000110"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2024.102958","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repositioning FDA-Approved Drug Against Chagas Disease and Cutaneous Leishmaniosis by Structure-Based Virtual Screening","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2024.102958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102958"}}