{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:18:25Z","timestamp":1793866705754,"version":"4.6.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.arcmed.2024.103004","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T17:10:14Z","timestamp":1715015414000},"page":"103004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Presymptomatic Testing for Huntington's Disease in Mexico: 28 Years of Experience"],"prefix":"10.1016","volume":"55","author":[{"given":"Adriana","family":"Ochoa-Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-3096","authenticated-orcid":false,"given":"David Jos\u00e9","family":"D\u00e1vila-Ortiz de Montellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-2096","authenticated-orcid":false,"given":"Mireya","family":"Ch\u00e1vez-Oliveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaneth","family":"Rodr\u00edguez-Agudelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Longoria-Ibarrola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luisa","family":"Sosa-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Catherine","family":"Boll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"Jara-Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Yescas-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Guerrero-Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-3636","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Ram\u00edrez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2024.103004_bib0001","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/practneurol-2021-003074","article-title":"Huntington's disease: diagnosis and management","volume":"22","author":"Stoker","year":"2022","journal-title":"Pract Neurol"},{"key":"10.1016\/j.arcmed.2024.103004_bib0002","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jmg.25.9.577","article-title":"Considerations in using linkage analysis as a presymptomatic test for Huntington's disease","volume":"25","author":"Farrer","year":"1988","journal-title":"J Med Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0003","first-page":"609","article-title":"Implicaciones del diagn\u00f3stico gen\u00e9tico presintom\u00e1tico","volume":"133","author":"Salamanca-G\u00f3mez","year":"1997","journal-title":"Gac Med Mex"},{"key":"10.1016\/j.arcmed.2024.103004_bib0004","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","author":"THsDCR","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.arcmed.2024.103004_bib0005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5694\/j.1326-5377.2000.tb123984.x","article-title":"Genetic testing for Alzheimer's disease","volume":"172","author":"Panegyres","year":"2000","journal-title":"Med J Aust"},{"key":"10.1016\/j.arcmed.2024.103004_bib0006","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1212\/01.WNL.0000032255.75650.C2","article-title":"French Group for Presymptomatic Testing in Neurogenetic Disorders Presymptomatic testing in Huntington's disease and autosomal dominant cerebellar ataxias","volume":"59","author":"Goizet","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.arcmed.2024.103004_bib0007","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/ajmg.a.32915","article-title":"Genetic counseling and cardiac care in predictively tested hypertrophic cardiomyopathy mutation carriers: the patients\u2019 perspective","volume":"149A","author":"Christiaans","year":"2009","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.arcmed.2024.103004_bib0008","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/jmg.31.7.555","article-title":"Guidelines for the molecular genetics predictive test in Huntington's disease","volume":"31","author":"Went","year":"1994","journal-title":"J Med Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0009","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1399-0004.2012.01900.x","article-title":"Recommendations for the predictive genetic test in Huntington's disease","volume":"83","author":"MacLeod","year":"2013","journal-title":"Clin Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0010","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1017\/S1138741600004637","article-title":"Psychometric properties of a Spanish version of the Beck Anxiety Inventory (BAI) in general population","volume":"11","author":"Magan","year":"2008","journal-title":"Span J Psychol"},{"key":"10.1016\/j.arcmed.2024.103004_bib0011","first-page":"26","article-title":"Standardization of Beck's depression inventory for Mexico City inhabitants","volume":"21","author":"Jurado","year":"1998","journal-title":"Salud Mental"},{"key":"10.1016\/j.arcmed.2024.103004_bib0012","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.arcmed.2024.103004_bib0013","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ymgme.2010.12.001","article-title":"Experience over fifteen years with a protocol for predictive testing for Huntington disease","volume":"102","author":"Dufrasne","year":"2011","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.arcmed.2024.103004_bib0014","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000526260","article-title":"Clinical and Molecular Findings of Intermediate Allele Carriers in the HTT Gene from the Mexican Mestizo Population","volume":"22","author":"Ramirez-Garcia","year":"2022","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.arcmed.2024.103004_bib0015","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1086\/302374","article-title":"A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease","volume":"64","author":"Almqvist","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0016","doi-asserted-by":"crossref","first-page":"e00881","DOI":"10.1002\/mgg3.881","article-title":"Predictive testing for Huntington disease over 24 years: Evolution of the profile of the participants and analysis of symptoms","volume":"7","author":"Ramond","year":"2019","journal-title":"Mol Genet Genomic Med"},{"issue":"2","key":"10.1016\/j.arcmed.2024.103004_bib0017","article-title":"Gender differences in the utilization of health care services","volume":"49","author":"Bertakis","year":"2000","journal-title":"J Fam Pract"},{"key":"10.1016\/j.arcmed.2024.103004_bib0018","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1186\/s12913-021-07020-z","article-title":"Use of primary and hospital care health services by chronic patients according to risk level by adjusted morbidity groups","volume":"21","author":"Barrio-Cortes","year":"2021","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.arcmed.2024.103004_bib0019","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s10897-018-0233-9","article-title":"The Changing Age of Individuals Seeking Presymptomatic Genetic Testing for Huntington Disease","volume":"27","author":"Holman","year":"2018","journal-title":"J Genet Couns"},{"key":"10.1016\/j.arcmed.2024.103004_bib0020","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1038\/ejhg.2016.81","article-title":"22 Years of predictive testing for Huntington's disease: the experience of the UK Huntington's Prediction Consortium","volume":"24","author":"Baig","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0021","unstructured":"INEGI. Censo de Poblaci\u00f3n y Vivienda 2020. In: INEGI, ed. Subsistema de Informaci\u00f3n Demogr\u00e1fica y Social. https:\/\/www.inegi.org.mx\/programas\/ccpv\/20202021. (Accesed December 14, 2023)."},{"key":"10.1016\/j.arcmed.2024.103004_bib0022","doi-asserted-by":"crossref","first-page":"295","DOI":"10.20344\/amp.10526","article-title":"Twenty Years of a Pre-Symptomatic Testing Protocol for Late-Onset Neurological Diseases in Portugal","volume":"32","author":"Paneque","year":"2019","journal-title":"Acta Med Port"},{"key":"10.1016\/j.arcmed.2024.103004_bib0023","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/cge.13529","article-title":"The choice not to undergo genetic testing for Huntington disease: Results from the PHAROS study","volume":"96","author":"Anderson","year":"2019","journal-title":"Clin Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0024","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10897-017-0085-8","article-title":"Prospective Evaluation of Predictive DNA Testing for Huntington's Disease in a Large German Center","volume":"26","author":"Ibisler","year":"2017","journal-title":"J Genet Couns"},{"key":"10.1016\/j.arcmed.2024.103004_bib0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/cge.12090","article-title":"Prenatal testing for Huntington's disease in the Netherlands from 1998 to 2008","volume":"85","author":"van Rij","year":"2014","journal-title":"Clin Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0026","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0738-3991(98)00086-X","article-title":"Predictive testing for Huntington's disease: a challenge for persons at risk and for professionals","volume":"35","author":"Evers-Kiebooms","year":"1998","journal-title":"Patient Educ Couns"},{"key":"10.1016\/j.arcmed.2024.103004_bib0027","doi-asserted-by":"crossref","first-page":"579","DOI":"10.9788\/TP2016.2-11","article-title":"Depression as the middle-and long-term impact for pre-symptomatic testing of late-onset neurodegenerative disorders","volume":"24","author":"L\u00eado","year":"2016","journal-title":"Temas em Psicologia"},{"key":"10.1016\/j.arcmed.2024.103004_bib0028","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/1516-4446-2014-1617","article-title":"Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy","volume":"38","author":"Ledo","year":"2016","journal-title":"Braz J Psychiatry"},{"key":"10.1016\/j.arcmed.2024.103004_bib0029","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/B978-0-12-801893-4.00007-9","article-title":"Preclinical motor manifestations of Huntington disease","volume":"144","author":"McGarry","year":"2017","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.arcmed.2024.103004_bib0030","article-title":"Mild Cognitive Impairment as an Early Landmark in Huntington's Disease","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.arcmed.2024.103004_bib0031","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1007\/s10897-018-0257-1","article-title":"What to Do with a Second Chance in Life? Long-Term Experiences of Non-carriers of Huntington's Disease","volume":"27","author":"Winnberg","year":"2018","journal-title":"J Genet Couns"},{"key":"10.1016\/j.arcmed.2024.103004_bib0032","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s10897-018-0274-0","article-title":"Perspectives on Genetic Testing and Return of Results from the First Cohort of Presymptomatically Tested Individuals At Risk of Huntington Disease","volume":"27","author":"Stuttgen","year":"2018","journal-title":"J Genet Couns"},{"key":"10.1016\/j.arcmed.2024.103004_bib0033","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1136\/jmg.38.4.e12","article-title":"New problems in testing for Huntington's disease: the issue of intermediate and reduced penetrance alleles","volume":"38","author":"Maat-Kievit","year":"2001","journal-title":"J Med Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0034","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ejhg.2008.146","article-title":"Long-term outcome of presymptomatic testing in Huntington disease","volume":"17","author":"Gargiulo","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0035","first-page":"513","article-title":"Attitudes regarding molecular diagnosis in Mexican families at risk of inheriting Huntington's disease","volume":"28","author":"Alonso","year":"1997","journal-title":"Arch Med Res"},{"key":"10.1016\/j.arcmed.2024.103004_bib0036","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0033291700030841","article-title":"Attitudes of families to some aspects of Huntington's chorea","volume":"9","author":"Barette","year":"1979","journal-title":"Psychol Med"},{"key":"10.1016\/j.arcmed.2024.103004_bib0037","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/gtmb.2009.0032","article-title":"Presymptomatic diagnosis in Huntington's disease: the Mexican experience","volume":"13","author":"Alonso","year":"2009","journal-title":"Genet Test Mol Biomarkers"},{"key":"10.1016\/j.arcmed.2024.103004_bib0038","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ejhg.2008.142","article-title":"Problems assessing uptake of Huntington disease predictive testing and a proposed solution","volume":"17","author":"Tassicker","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0039","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1399-0004.2010.01538.x","article-title":"Uptake of Huntington disease predictive testing in a complete population","volume":"80","author":"Morrison","year":"2011","journal-title":"Clin Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.brainresbull.2006.10.023","article-title":"Predictive testing for Huntington's disease","volume":"72","author":"Tibben","year":"2007","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.arcmed.2024.103004_bib0041","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10897-015-9840-x","article-title":"Analysis of the Reasons for Non-Uptake of Predictive Testing for Huntington's Disease in Spain: A Qualitative Study","volume":"24","author":"Rivera-Navarro","year":"2015","journal-title":"J Genet Couns"},{"key":"10.1016\/j.arcmed.2024.103004_bib0042","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ajmg.b.30600","article-title":"Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease","volume":"147","author":"Penziner","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.arcmed.2024.103004_bib0043","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ejhg.2012.147","article-title":"When access is an issue: exploring barriers to predictive testing for Huntington disease in British Columbia, Canada","volume":"21","author":"Hawkins","year":"2013","journal-title":"Eur J Hum Genet"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440924000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440924000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T19:06:37Z","timestamp":1719342397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440924000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0188440924000572"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2024.103004","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presymptomatic Testing for Huntington's Disease in Mexico: 28 Years of Experience","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2024.103004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103004"}}