{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T01:48:02Z","timestamp":1776563282382,"version":"3.51.2"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012527","name":"Ministry of Higher Education Science Research and Innovation","doi-asserted-by":"publisher","award":["RGNS65-047"],"award-info":[{"award-number":["RGNS65-047"]}],"id":[{"id":"10.13039\/100012527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["IN67073"],"award-info":[{"award-number":["IN67073"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024597","name":"Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021795","name":"Cholangiocarcinoma Research Institute, Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016204","name":"Ministry of Higher Education, Science, Research and Innovation, Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Medical Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.arcmed.2026.103383","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:03:01Z","timestamp":1769770981000},"page":"103383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pro-Tumorigenic Roles of Cyclin Dependent Kinase 2 and its Associated Cyclins in Cholangiocarcinoma Progression under High Glucose Condition"],"prefix":"10.1016","volume":"57","author":[{"given":"Cheerapinya","family":"Taebprakhon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-0139","authenticated-orcid":false,"given":"Supannika","family":"Sorin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kullanat","family":"Khawkhiaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchai","family":"Phoomak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wunchana","family":"Seubwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopit","family":"Wongkham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-1129","authenticated-orcid":false,"given":"Charupong","family":"Saengboonmee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcmed.2026.103383_bib0001","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41571-023-00770-1","article-title":"Cholangiocarcinoma - novel biological insights and therapeutic strategies","volume":"20","author":"Ilyas","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0002","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41572-021-00300-2","article-title":"Cholangiocarcinoma","volume":"7","author":"Brindley","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.arcmed.2026.103383_bib0003","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0004","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1200\/GO.20.00030","article-title":"Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma","volume":"6","author":"Kongpetch","year":"2020","journal-title":"JCO Glob Oncol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jcjd.2020.09.008","article-title":"Association of Diabetes Mellitus and Cholangiocarcinoma: Update of Evidence and the Effects of Antidiabetic Medication","volume":"45","author":"Saengboonmee","year":"2021","journal-title":"Can J Diabetes"},{"key":"10.1016\/j.arcmed.2026.103383_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118548","article-title":"NF-\u03baB and STAT3 co-operation enhances high glucose induced aggressiveness of cholangiocarcinoma cells","volume":"262","author":"Saengboonmee","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.arcmed.2026.103383_bib0007","doi-asserted-by":"crossref","first-page":"36","DOI":"10.21037\/tgh-24-8","article-title":"Involvement of interleukin-1\u03b2 in high glucose-activated proliferation of cholangiocarcinoma","volume":"9","author":"Khawkhiaw","year":"2024","journal-title":"Transl Gastroenterol Hepatol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0008","doi-asserted-by":"crossref","first-page":"1734.1744","DOI":"10.1080\/01635581.2021.1961830","article-title":"High Glucose Induced Upregulation of Cyclin a Associating with a Short Survival of Patients with Cholangiocarcinoma: A Potential Target for Treatment of Patients with Diabetes Mellitus","volume":"74","author":"Saengboonmee","year":"2022","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.arcmed.2026.103383_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2024.104324","article-title":"Cyclin-dependent kinase 2 (CDK2) inhibitors and others novel CDK inhibitors (CDKi) in breast cancer: clinical trials, current impact, and future directions","volume":"196","author":"Gerosa","year":"2024","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.36401\/JIPO-24-22","article-title":"Cyclin Dependent Kinase 2 (CDK2) Inhibitors in Oncology Clinical Trials: A Review","volume":"8","author":"House","year":"2025","journal-title":"J Immunother Precis Oncol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0011","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ccell.2021.03.010","article-title":"Targeting cell-cycle machinery in cancer","volume":"39","author":"Suski","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.arcmed.2026.103383_bib0012","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/hep.30704","article-title":"Dependency of Cholangiocarcinoma on Cyclin D-Dependent Kinase Activity","volume":"70","author":"Sittithumcharee","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.arcmed.2026.103383_bib0013","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/1078-0432.CCR-18-0284","article-title":"Combined CDK4\/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma","volume":"25","author":"Song","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.arcmed.2026.103383_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.877194","article-title":"The Acquired Vulnerability Caused by CDK4\/6 Inhibition Promotes Drug Synergism Between Oxaliplatin and Palbociclib in Cholangiocarcinoma","volume":"12","author":"Suppramote","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75578-5","article-title":"Dinaciclib, a cyclin-dependent kinase inhibitor, suppresses cholangiocarcinoma growth by targeting CDK2\/5\/9","volume":"10","author":"Saqub","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.arcmed.2026.103383_bib0016","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.3748\/wjg.v29.i25.4053","article-title":"Molecular profiling reveals potential targets in cholangiocarcinoma","volume":"29","author":"Liu","year":"2023","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0017","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s13577-020-00334-w","article-title":"Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient","volume":"33","author":"Sripa","year":"2020","journal-title":"Hum Cell"},{"key":"10.1016\/j.arcmed.2026.103383_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119114","article-title":"High glucose upregulates FOXM1 expression via EGFR\/STAT3 dependent activation to promote progression of cholangiocarcinoma","volume":"271","author":"Detarya","year":"2021","journal-title":"Life Sci"},{"issue":"Database issue","key":"10.1016\/j.arcmed.2026.103383_bib0019","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arcmed.2026.103383_bib0020","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1158\/2159-8290.CD-17-0368","article-title":"Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma","volume":"7","author":"Jusakul","year":"2017","journal-title":"Cancer Discov"},{"issue":"W1","key":"10.1016\/j.arcmed.2026.103383_bib0021","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arcmed.2026.103383_bib0022","article-title":"CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally","volume":"16","author":"Hoffman","year":"2025","journal-title":"Cell Syst"},{"key":"10.1016\/j.arcmed.2026.103383_bib0023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41698-024-00787-4","article-title":"Cyclin E1\/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers","volume":"9","author":"Kim","year":"2025","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0024","doi-asserted-by":"crossref","first-page":"eabc1495","DOI":"10.1126\/science.abc1495","article-title":"CDK4 and CDK6 kinases: From basic science to cancer therapy","volume":"375","author":"Fassl","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.arcmed.2026.103383_bib0025","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.21873\/invivo.13693","article-title":"Anti-Tumor and Chemosensitizing Effects of the CDK Inhibitor Dinaciclib on Cholangiocarcinoma In vitro and In vivo","volume":"38","author":"Sungwan","year":"2024","journal-title":"In vivo"},{"key":"10.1016\/j.arcmed.2026.103383_bib0026","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1038\/s41467-022-30264-0","article-title":"Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.arcmed.2026.103383_bib0027","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-024-02080-z","article-title":"Cyclin-dependent protein kinases and cell cycle regulation in biology and disease","volume":"10","author":"Pellarin","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.arcmed.2026.103383_bib0028","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/gb4184","article-title":"Cyclin-dependent kinases","volume":"15","author":"Malumbres","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0029","doi-asserted-by":"crossref","first-page":"47688","DOI":"10.1074\/jbc.M405938200","article-title":"Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes","volume":"279","author":"Chytil","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcmed.2026.103383_bib0030","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1021\/bi400047u","article-title":"Assembly, activation, and substrate specificity of cyclin D1\/Cdk2 complexes","volume":"52","author":"Jahn","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.arcmed.2026.103383_bib0031","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.tcb.2021.05.001","article-title":"Cyclin E in normal physiology and disease states","volume":"31","author":"Chu","year":"2021","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0032","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.3748\/wjg.v9.i11.2450","article-title":"Expression of p27, cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance","volume":"9","author":"Zhou","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0033","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/hupa.2001.27116","article-title":"Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma","volume":"32","author":"Li","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0034","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ejso.2011.08.139","article-title":"Overexpression of cyclin E isoforms correlates with poor prognosis in rectal cancer","volume":"37","author":"Zhou","year":"2011","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.arcmed.2026.103383_bib0035","first-page":"647","article-title":"Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer","volume":"61","author":"M\u00fcller-Tidow","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcmed.2026.103383_bib0036","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/15384101.2015.1136521","article-title":"Cdk2 regulates metastasis suppressor BRMS1","volume":"15","author":"Caldon","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arcmed.2026.103383_bib0037","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/carcin\/bgv069","article-title":"Cyclin A2 modulates EMT via \u03b2-catenin and phospholipase C pathways","volume":"36","author":"Cheung","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.arcmed.2026.103383_bib0038","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1073\/pnas.1711477115","article-title":"Kinase-independent function of E-type cyclins in liver cancer","volume":"115","author":"Geng","year":"2018","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Archives of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440926000068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0188440926000068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T01:29:13Z","timestamp":1776562153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0188440926000068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0188440926000068"],"URL":"https:\/\/doi.org\/10.1016\/j.arcmed.2026.103383","relation":{},"ISSN":["0188-4409"],"issn-type":[{"value":"0188-4409","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pro-Tumorigenic Roles of Cyclin Dependent Kinase 2 and its Associated Cyclins in Cholangiocarcinoma Progression under High Glucose Condition","name":"articletitle","label":"Article Title"},{"value":"Archives of Medical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcmed.2026.103383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103383"}}