{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:55:50Z","timestamp":1791294950857,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives de P\u00e9diatrie"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.arcped.2018.06.009","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T06:00:13Z","timestamp":1535004013000},"page":"378-382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["CD226 gene polymorphism (rs763361 C>T) is associated with susceptibility to type 1 diabetes mellitus among Egyptian children"],"prefix":"10.1016","volume":"25","author":[{"given":"S.S.","family":"Abu El-Ella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.A.E.H.","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"El-Mekkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"El-Shamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcped.2018.06.009_bib0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11892-015-0655-9","article-title":"Genes affecting \u03b2-cell function in type 1 diabetes","volume":"15","author":"Fl\u00f8yel","year":"2015","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.arcped.2018.06.009_bib0145","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0140-6736(74)91201-X","article-title":"HL-A antigens and diabetes mellitus","volume":"2","author":"Nerup","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.arcped.2018.06.009_bib0150","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2014.12.004","article-title":"Immunogenetics of type 1 diabetes mellitus","volume":"42","author":"Morran","year":"2015","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.arcped.2018.06.009_bib0155","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/gene.2015.43","article-title":"Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies","volume":"16","author":"Maziarz","year":"2015","journal-title":"Genes Immun"},{"key":"10.1016\/j.arcped.2018.06.009_bib0160","doi-asserted-by":"crossref","first-page":"e1002293","DOI":"10.1371\/journal.pgen.1002293","article-title":"A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci","volume":"7","author":"Bradfield","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.arcped.2018.06.009_bib0165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12016-016-8592-1","article-title":"Beyond genetics: what causes type 1 diabetes","volume":"52","author":"Wang","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.arcped.2018.06.009_bib0170","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/rheumatology\/kep470","article-title":"Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases","volume":"49","author":"Maiti","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.arcped.2018.06.009_bib0175","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(00)70060-4","article-title":"DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes","volume":"4","author":"Shibuya","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.arcped.2018.06.009_bib0180","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1084\/jem.20030958","article-title":"CD226 (DNAM1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation","volume":"198","author":"Shibuya","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcped.2018.06.009_bib0185","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1172\/JCI36022","article-title":"NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo","volume":"119","author":"Lakshmikanth","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcped.2018.06.009_bib0190","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/imm.12516","article-title":"Critical roles of co-activation receptor DNAX accessory molecule-1 in natural killer cell immunity","volume":"146","author":"Xiong","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.arcped.2018.06.009_bib0195","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.4049\/jimmunol.174.3.1281","article-title":"CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus","volume":"174","author":"Deng","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.arcped.2018.06.009_bib0200","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1084\/jem.20032206","article-title":"DNAM-1 and PVR regulate monocyte migration through endothelial junctions","volume":"199","author":"Reymond","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.arcped.2018.06.009_bib0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/cmi.2009.108","article-title":"A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions","volume":"7","author":"Xu","year":"2010","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.arcped.2018.06.009_bib0210","doi-asserted-by":"crossref","first-page":"27190","DOI":"10.1074\/jbc.M602359200","article-title":"Mast cell costimulation by CD226\/CD112 (DNAM-1\/Nectin-2): a novel interface in the allergic process","volume":"281","author":"Bachelet","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arcped.2018.06.009_bib0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/gene.2008.82","article-title":"CD226 Gly307Ser association with multiple autoimmune diseases","volume":"10","author":"Hafler","year":"2009","journal-title":"Genes Immun"},{"key":"10.1016\/j.arcped.2018.06.009_bib0220","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1177\/0961203312458840","article-title":"Association between the CD226 rs763361 polymorphism and susceptibility to autoimmune diseases: a meta-analysis","volume":"21","author":"Song","year":"2012","journal-title":"Lupus"},{"key":"10.1016\/j.arcped.2018.06.009_bib0225","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jdermsci.2010.03.015","article-title":"The CD226 Gly307Ser gene polymorphism is associated with severity of psoriasis","volume":"58","author":"Douroudis","year":"2010","journal-title":"J Dermatol Sci"},{"issue":"Suppl 1","key":"10.1016\/j.arcped.2018.06.009_bib0230","first-page":"1","article-title":"Standards of medical care in diabetes","volume":"40","author":"American Diabetes Association","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arcped.2018.06.009_bib0235","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1542\/peds.2012-3494","article-title":"Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents","volume":"131","author":"Copeland","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.arcped.2018.06.009_bib0240","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00296-011-1796-z","article-title":"The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population","volume":"32","author":"Du","year":"2012","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.arcped.2018.06.009_bib0245","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.arcped.2018.06.009_bib0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2350-11-11","article-title":"Allelic variants in the PHTF1-PTPN22, C12orf30 and CD226 regions as candidate susceptibility factors for the type 1 diabetes in the Estonian population","volume":"11","author":"Douroudis","year":"2010","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.arcped.2018.06.009_bib0255","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2015.01.022","article-title":"Association of 32 type 1 diabetes risk loci in Pakistani patients","volume":"108","author":"Kiani","year":"2015","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.arcped.2018.06.009_bib0260","doi-asserted-by":"crossref","first-page":"15249","DOI":"10.4238\/2015.November.25.13","article-title":"Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children","volume":"14","author":"Xi","year":"2015","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.arcped.2018.06.009_bib0265","doi-asserted-by":"crossref","first-page":"694948","DOI":"10.1155\/2014\/694948","article-title":"CD226 rs763361 is associated with the susceptibility to type 1 diabetes and greater frequency of GAD65 autoantibody in a Brazilian cohort","volume":"2014","author":"Mattana","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.arcped.2018.06.009_bib0270","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1074-7613(00)80136-3","article-title":"Physical and functional association of LFA-1 with DNAM-1 adhesion molecule","volume":"11","author":"Shibuya","year":"1999","journal-title":"Immunity"}],"container-title":["Archives de P\u00e9diatrie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929693X18301489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929693X18301489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T15:46:17Z","timestamp":1536594377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929693X18301489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0929693X18301489"],"URL":"https:\/\/doi.org\/10.1016\/j.arcped.2018.06.009","relation":{},"ISSN":["0929-693X"],"issn-type":[{"value":"0929-693X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD226 gene polymorphism (rs763361 C>T) is associated with susceptibility to type 1 diabetes mellitus among Egyptian children","name":"articletitle","label":"Article Title"},{"value":"Archives de P\u00e9diatrie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcped.2018.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}