{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:11:48Z","timestamp":1792444308403,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives de P\u00e9diatrie"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.arcped.2021.02.009","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T03:09:58Z","timestamp":1615518598000},"page":"296-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of GLUT1, IGF-2, VEGF, FGF 1, and angiopoietin 2 in infantile hemangioma"],"prefix":"10.1016","volume":"28","author":[{"given":"Sultan","family":"Aydin K\u00f6ker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Ufuk","family":"K\u00f6m\u00fcro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem Yasin","family":"K\u00f6ksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dclk\u00fc G\u00fcl","family":"\u015eiraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"K\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcped.2021.02.009_bib0185","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1056\/NEJM199907153410307","article-title":"Hemangiomas in children","volume":"341","author":"Drolet","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcped.2021.02.009_bib0190","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1001\/archderm.138.12.1567","article-title":"Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex","volume":"138","author":"Chiller","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0195","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1073\/pnas.102185799","article-title":"Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis","volume":"99","author":"Ritter","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arcped.2021.02.009_bib0200","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bjps.2004.05.029","article-title":"GLUT-1: an extra diagnostic tool to differentiate between haemangiomas and vascular malformations","volume":"58","author":"Leon-Villapalos","year":"2005","journal-title":"Br J Plast Surg"},{"key":"10.1016\/j.arcped.2021.02.009_bib0205","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1172\/JCI117241","article-title":"Cellular markers that distinguish the phases of hemangioma during infancy and childhood","volume":"93","author":"Takahashi","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.arcped.2021.02.009_bib0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/bjd.13388","article-title":"The use of propranolol in the treatment of infantile haemangiomas: an update on potential mechanisms of action","volume":"172","author":"Ji","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0215","series-title":"Vascular birthmarks: hemangiomas and malformations","first-page":"63","author":"Mulliken","year":"1988"},{"key":"10.1016\/j.arcped.2021.02.009_bib0220","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1242\/dev.114.2.521","article-title":"Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation","volume":"114","author":"Breier","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.arcped.2021.02.009_bib0225","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1525-1470.2008.00626.x","article-title":"Infantile hemangiomas: how common are they? A systematic review of the medical literature","volume":"25","author":"Kilcline","year":"2008","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0230","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpeds.2006.12.003","article-title":"Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics","volume":"150","author":"Haggstrom","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.arcped.2021.02.009_bib0235","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1038\/onc.2015.466","article-title":"Diacerein-mediated inhibition of IL-6\/IL-6R signaling induces apoptotic effects on breast cancer","volume":"35","author":"Bharti","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.arcped.2021.02.009_bib0240","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-2952(00)00529-3","article-title":"Angiogenesis: regulators and clinical applications","volume":"61","author":"Liekens","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1756-8722-7-13","article-title":"Signaling pathways in the development of infantile hemangioma","volume":"7","author":"Ji","year":"2014","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0250","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/pbc.25453","article-title":"Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K\/Akt\/eNOS\/VEGF pathway","volume":"62","author":"Pan","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.arcped.2021.02.009_bib0255","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ana.21160","article-title":"Niaspan increases angiogenesis and improves functional recovery after stroke","volume":"62","author":"Chen","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0260","first-page":"1276","article-title":"Angiogenesis characteristics of infantile hemangioma and feasibility observation of transplantation model of human hemangioma on mice","volume":"21","author":"Fu","year":"2017","journal-title":"J Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.arcped.2021.02.009_bib0265","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cyto.2009.11.012","article-title":"Local serum levels of vascular endothelial growth factor in infantile hemangioma: intriguing mechanism of endothelial growth","volume":"49","author":"Przewratil","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.arcped.2021.02.009_bib0270","first-page":"2911","article-title":"Co-suppression of VEGF-A and VEGF-C inhibits development of experimental hemangioma","volume":"10","author":"Huang","year":"2018","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.arcped.2021.02.009_bib0275","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/01.PRS.0000170804.80834.5F","article-title":"Circulating level of vascular endothelial growth factor in differentiating hemangioma from vascular malformation patients","volume":"116","author":"Zhang","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.arcped.2021.02.009_bib0280","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa0903036","article-title":"Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells","volume":"362","author":"Greenberger","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arcped.2021.02.009_bib0285","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.87.6.434","article-title":"Endothelial cell apoptosis in angiogenesis and vessel regression","volume":"87","author":"Dimmeler","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.arcped.2021.02.009_bib0290","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.nano.2014.08.003","article-title":"MRI molecular imaging using GLUT1 antibody-Fe3O4 nanoparticles in the hemangioma animal model for differentiating infantile hemangioma from vascular malformation","volume":"11","author":"Sohn","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.arcped.2021.02.009_bib0295","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0046-8177(00)80192-6","article-title":"GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas","volume":"31","author":"North","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0300","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/stem.1841","article-title":"Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells","volume":"33","author":"Huang","year":"2015","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"10.1016\/j.arcped.2021.02.009_bib0305","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2119\/2004-00045.Bischoff","article-title":"Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression","volume":"10","author":"Yu","year":"2004","journal-title":"Mol Med"},{"key":"10.1016\/j.arcped.2021.02.009_bib0310","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1258\/phleb.2010.010020","article-title":"The role of serum basic fibroblast growth factor, estradiol and urine basic fibroblast growth factor in differentiating infantile haemangiomas from vascular malformations","volume":"26","author":"Yang","year":"2011","journal-title":"Phlebology"},{"key":"10.1016\/j.arcped.2021.02.009_bib0315","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/1076029617710333","article-title":"Circulating levels of vascular endothelial growth factor and basic fibroblastic growth factor in infantile hemangioma versus vascular malformations","volume":"24","author":"El-Raggal","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.arcped.2021.02.009_bib0320","first-page":"313","article-title":"Importance of bFGF (\u201cbasic fibroblast growth factor\u201d) for diagnosis and treatment of hemangiomas","volume":"125","author":"Dosquet","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0325","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jpedsurg.2003.11.043","article-title":"Biomolecular markers and involution of hemangiomas","volume":"39","author":"Frischer","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.arcped.2021.02.009_bib0330","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/exd.13510","article-title":"Salivary levels of angiopoietin-2 in infants with infantile haemangiomas treated with and without systemic propranolol","volume":"27","author":"Seamens","year":"2018","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0335","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1038\/sj.jid.5700413","article-title":"Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice","volume":"126","author":"Perry","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0340","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.arcped.2021.02.009_bib0345","first-page":"1255","article-title":"The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer","volume":"61","author":"Ahmad","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcped.2021.02.009_bib0350","first-page":"2145","article-title":"Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases","volume":"61","author":"Etoh","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.arcped.2021.02.009_bib0355","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0002-9440(10)63998-3","article-title":"Angiopoietin-2 is implicated in the regulation of tumor angiogenesis","volume":"158","author":"Yu","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.arcped.2021.02.009_bib0360","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ccr.2004.09.030","article-title":"Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2","volume":"6","author":"Oliner","year":"2004","journal-title":"Cancer Cell"}],"container-title":["Archives de P\u00e9diatrie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929693X21000257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929693X21000257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:54:10Z","timestamp":1760540050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929693X21000257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0929693X21000257"],"URL":"https:\/\/doi.org\/10.1016\/j.arcped.2021.02.009","relation":{},"ISSN":["0929-693X"],"issn-type":[{"value":"0929-693X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of GLUT1, IGF-2, VEGF, FGF 1, and angiopoietin 2 in infantile hemangioma","name":"articletitle","label":"Article Title"},{"value":"Archives de P\u00e9diatrie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcped.2021.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}