{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:57:11Z","timestamp":1768521431804,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives de P\u00e9diatrie"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.arcped.2021.09.007","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T01:15:17Z","timestamp":1633482917000},"page":"707-711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety of airway clearance combined with bronchodilator and hypertonic saline in non-hospitalized infants with acute bronchiolitis"],"prefix":"10.1016","volume":"28","author":[{"given":"Vanesa","family":"Gonz\u00e1lez Bellido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Vel\u00e1z Baza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa del Carmen Jimeno","family":"Esteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n Garc\u00eda","family":"Carballo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Nicol\u00e1s Cuenca","family":"Zald\u00edvar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Vin\u00edcius Fagundes","family":"Donadio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arcped.2021.09.007_bib0001","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jped.2013.02.022","article-title":"Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus","volume":"89","author":"Alvarez","year":"2013","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.arcped.2021.09.007_bib0002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000345","article-title":"Effectiveness of chest physiotherapy in infants hospitalized with acute bronchiolitis: a multicenter, randomized, controlled trial","volume":"7","author":"Gajdos","year":"2010","journal-title":"PLoS Med"},{"key":"10.1016\/j.arcped.2021.09.007_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000000831","article-title":"Respiratory syncytial virus bronchiolitis in children up to 5 years of age in spain: epidemiology and comorbidities: an observational study","volume":"94","author":"Gil-Prieto","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.arcped.2021.09.007_bib0004","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.anpedi.2011.11.026","article-title":"Estudio de la eficacia y utilidad de la fisioterapia respiratoria en la bronquiolitis aguda del lactante hospitalizado. Ensayo cl\u00ednico aleatorizado y doble ciego","volume":"77","author":"S\u00e1nchez Bayle","year":"2012","journal-title":"An Pediatr"},{"key":"10.1016\/j.arcped.2021.09.007_bib0005","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/infdis\/jiz240","article-title":"A systematic review of clinical practice guidelines for the diagnosis and management of bronchiolitis","volume":"222","author":"Kirolos","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.arcped.2021.09.007_bib0006","unstructured":"Ministerio de Sanidad Politica Social E Igualdad. Gu\u00eda de Pr\u00e1ctica Cl\u00ednica sobre la Bronquiolitis Aguda. Prevenci\u00f3n. Available from: http:\/\/www.guiasalud.es\/egpc\/bronquiolitis\/completa\/apartado08\/prevencion.html"},{"key":"10.1016\/j.arcped.2021.09.007_bib0007","article-title":"Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old","volume":"2","author":"Roqu\u00e9i Figuls","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.arcped.2021.09.007_bib0008","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4187\/respcare.00721","article-title":"Evaluation of an alternative chest physiotherapy method in infants with respiratory syncytial virus bronchiolitis","volume":"56","author":"Postiaux","year":"2011","journal-title":"Respir Care"},{"key":"10.1016\/j.arcped.2021.09.007_bib0009","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/ppul.23928","article-title":"Hypertonic saline inhalations in bronchiolitis\u2014a cumulative meta-analysis","volume":"53","author":"Heikkil\u00e4","year":"2018","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.arcped.2021.09.007_bib0010","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.arcped.2018.06.004","article-title":"Effects of the use of respiratory physiotherapy in children admitted with acute viral bronchiolitis","volume":"25","author":"Gomes","year":"2018","journal-title":"Arch P\u00e9diatr"},{"key":"10.1016\/j.arcped.2021.09.007_bib0011","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1164\/ajrccm\/145.1.106","article-title":"Observer agreement for respiratory signs and oximetry in infants hospitalized with lower respiratory infections","volume":"145","author":"Wang","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.arcped.2021.09.007_bib0012","article-title":"Nebulised hypertonic saline solution for acute bronchiolitis in infants","volume":"12","author":"Zhang","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.arcped.2021.09.007_bib0013","series-title":"Kinesitherapie respiratoire de l'enfant\u00a0: les techniques de soins guides par l'auscultation pulmonaire","author":"Postiaux","year":"2000"},{"key":"10.1016\/j.arcped.2021.09.007_bib0014","series-title":"Fisioterapia Respiratoria en el ni\u00f1o 1a edicion. Fisioterapia Respiratoria en el ni\u00f1o 1a edicion","first-page":"307","author":"Postiaux","year":"1999"},{"key":"10.1016\/j.arcped.2021.09.007_bib0015","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4187\/respcare.01067","article-title":"Prolonged slow expiration technique in infants: effects on tidal volume, peak expiratory flow, and expiratory reserve volume","volume":"56","author":"Lanza","year":"2011","journal-title":"Respir Care"},{"key":"10.1016\/j.arcped.2021.09.007_bib0016","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/ppul.21016","article-title":"Inter-observer agreement between physicians, nurses, and respiratory therapists for respiratory clinical evaluation in bronchiolitis","volume":"44","author":"Gajdos","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.arcped.2021.09.007_bib0017","first-page":"241","article-title":"Propiedades psicom\u00e9tricas de las escalas de gravedad de obstrucci\u00f3n bronquial en pediatr\u00eda. Revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis","volume":"115","author":"La","year":"2017","journal-title":"Arch Argent Pediatr"},{"key":"10.1016\/j.arcped.2021.09.007_bib0018","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/S1413-35552012005000018","article-title":"Chest physical therapy is effective in reducing the clinical score in bronchiolitis: randomized controlled trial","volume":"16","author":"Gomes","year":"2012","journal-title":"Brazilian J Phys Ther"},{"key":"10.1016\/j.arcped.2021.09.007_bib0019","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00431-011-1562-y","article-title":"Chest physiotherapy using passive expiratory techniques does not reduce bronchiolitis severity: a randomised controlled trial","volume":"171","author":"Rochat","year":"2012","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.arcped.2021.09.007_bib0020","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1590\/S1679-45082014AO3230","article-title":"Comparative analysis of the effects of two chest physical therapy interventions in patients with bronchiolitis during hospitalization period","volume":"12","author":"Remondini","year":"2014","journal-title":"Einstein (Sao Paulo)"},{"key":"10.1016\/j.arcped.2021.09.007_bib0021","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1590\/S1806-37132009000900007","article-title":"Comparison of the effects that two different respiratory physical therapy techniques have on cardiorespiratory parameters in infants with acute viral bronchiolitis","volume":"35","author":"Pupin","year":"2009","journal-title":"J Bras Pneumol"},{"key":"10.1016\/j.arcped.2021.09.007_bib0022","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/adc.2003.033100","article-title":"Chest physiotherapy, gastro-oesophageal reflux, and arousal in infants with cystic fibrosis","volume":"89","author":"Button","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.arcped.2021.09.007_bib0023","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ppul.23495","article-title":"Effectiveness of airway clearance techniques in children hospitalized with acute bronchiolitis","volume":"52","author":"Van Ginderdeuren","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.arcped.2021.09.007_bib0024","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1590\/S0103-05822011000400020","article-title":"An\u00e1lise dos sintomas, sinais cl\u00ednicos e suporte de oxig\u00eanio em pacientes com bronquiolite antes e ap\u00f3s fisioterapia respirat\u00f3ria durante a interna\u00e7\u00e3o hospitalar","volume":"29","author":"de Castro","year":"2011","journal-title":"Rev Paul Pediatr"},{"key":"10.1016\/j.arcped.2021.09.007_bib0025","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.4187\/respcare.01890","article-title":"Chest physical therapy in acute viral bronchiolitis: an updated review","volume":"58","author":"Postiaux","year":"2013","journal-title":"Respir Care"},{"key":"10.1016\/j.arcped.2021.09.007_bib0026","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/archdischild-2020-319048","article-title":"Hypertonic saline in bronchiolitis: An updated meta-analysis","volume":"106","author":"Heikkil\u00e4","year":"2021","journal-title":"Arch Dis Child"}],"container-title":["Archives de P\u00e9diatrie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929693X2100155X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929693X2100155X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:54:51Z","timestamp":1760540091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929693X2100155X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0929693X2100155X"],"URL":"https:\/\/doi.org\/10.1016\/j.arcped.2021.09.007","relation":{},"ISSN":["0929-693X"],"issn-type":[{"value":"0929-693X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of airway clearance combined with bronchodilator and hypertonic saline in non-hospitalized infants with acute bronchiolitis","name":"articletitle","label":"Article Title"},{"value":"Archives de P\u00e9diatrie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arcped.2021.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}