{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:14:01Z","timestamp":1790612041564,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010665","name":"Horizon 2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["847551"],"award-info":[{"award-number":["847551"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022115","name":"Dutch Arthritis Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006315","name":"ReumaNederland","doi-asserted-by":"publisher","award":["0801034"],"award-info":[{"award-number":["0801034"]}],"id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ard.2025.01.042","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T19:09:01Z","timestamp":1739646541000},"page":"547-553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictors of arthritis development in individuals at risk of rheumatoid arthritis: a 5-year follow-up study from a large cohort"],"prefix":"10.1016","volume":"84","author":[{"given":"Giulia","family":"Frazzei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.M.","family":"Landew\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlijn","family":"Wagenaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte A.","family":"van de Stadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirkjan","family":"van Schaardenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander W.","family":"Tas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"van Vollenhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ard.2025.01.042_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J Autoimmun"},{"issue":"5","key":"10.1016\/j.ard.2025.01.042_bib0002","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/ard.2010.139527","article-title":"Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase","volume":"70","author":"van de Sande","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.ard.2025.01.042_bib0003","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1086\/342407","article-title":"Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis","volume":"71","author":"Jawaheer","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"6","key":"10.1016\/j.ard.2025.01.042_bib0004","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/art.24572","article-title":"Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important","volume":"60","author":"Lundstr\u00f6m","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.ard.2025.01.042_bib0005","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/498651","article-title":"Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4","volume":"77","author":"Plenge","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1016\/j.ard.2025.01.042_bib0006","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/annrheumdis-2020-217066","article-title":"Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting","volume":"80","author":"Bemis","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.01.042_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.899372","article-title":"Preclinical autoimmune disease: a comparison of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and type 1 diabetes","volume":"13","author":"Frazzei","year":"2022","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.ard.2025.01.042_bib0008","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantap\u00e4\u00e4-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ard.2025.01.042_bib0009","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.ard.2025.01.042_bib0010","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/ard.2008.105759","article-title":"Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study","volume":"69","author":"Bos","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.ard.2025.01.042_bib0011","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/art.40562","article-title":"Triple positivity for anti-citrullinated protein autoantibodies, rheumatoid factor, and anti-carbamylated protein antibodies conferring high specificity for rheumatoid arthritis: implications for very early identification of at-risk individuals","volume":"70","author":"Verheul","year":"2018","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"10.1016\/j.ard.2025.01.042_bib0012","first-page":"1830","article-title":"Smoking and risk of rheumatoid arthritis","volume":"20","author":"Heli\u00f6vaara","year":"1993","journal-title":"J Rheumatol"},{"issue":"7","key":"10.1016\/j.ard.2025.01.042_bib0013","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/acr.23837","article-title":"Impact and timing of smoking cessation on reducing risk of rheumatoid arthritis among women in the Nurses\u2019 Health Studies","volume":"71","author":"Liu","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"23","key":"10.1016\/j.ard.2025.01.042_bib0014","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1001\/jama.2018.7028","article-title":"Association of stress-related disorders with subsequent autoimmune disease","volume":"319","author":"Song","year":"2018","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.ard.2025.01.042_bib0015","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1136\/annrheumdis-2015-207991","article-title":"T cell subsets: an immunological biomarker to predict progression to clinical arthritis in ACPA-positive individuals","volume":"75","author":"Hunt","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ard.2025.01.042_bib0016","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1038\/s41598-020-60314-w","article-title":"T-cell subset abnormalities predict progression along the inflammatory arthritis disease continuum: implications for management","volume":"10","author":"Ponchel","year":"2020","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.ard.2025.01.042_bib0017","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1136\/annrheumdis-2012-202127","article-title":"A prediction rule for the development of arthritis in seropositive arthralgia patients","volume":"72","author":"van de Stadt","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.ard.2025.01.042_bib0018","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1136\/annrheumdis-2015-208138","article-title":"Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis","volume":"75","author":"van Steenbergen","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.ard.2025.01.042_bib0019","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/annrheumdis-2020-217215","article-title":"Ultrasound erosions in the feet best predict progression to inflammatory arthritis in anti-CCP positive at-risk individuals without clinical synovitis","volume":"79","author":"Di Matteo","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ard.2025.01.042_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103217","article-title":"Prevention of rheumatoid arthritis: a systematic literature review of preventive strategies in at-risk individuals","volume":"22","author":"Frazzei","year":"2023","journal-title":"Autoimmun Rev"},{"issue":"2","key":"10.1016\/j.ard.2025.01.042_bib0021","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/annrheumdis-2017-212763","article-title":"Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study","volume":"78","author":"Gerlag","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"10348","key":"10.1016\/j.ard.2025.01.042_bib0022","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(22)01193-X","article-title":"Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial","volume":"400","author":"Krijbolder","year":"2022","journal-title":"Lancet"},{"issue":"10429","key":"10.1016\/j.ard.2025.01.042_bib0023","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(23)02649-1","article-title":"Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial","volume":"403","author":"Cope","year":"2024","journal-title":"Lancet"},{"issue":"10429","key":"10.1016\/j.ard.2025.01.042_bib0024","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S0140-6736(23)02650-8","article-title":"Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial","volume":"403","author":"Rech","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ard.2025.01.042_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000419","article-title":"Functional limitations in the phase of clinically suspect arthralgia are as serious as in early clinical arthritis; a longitudinal study","volume":"3","author":"Ten Brinck","year":"2017","journal-title":"RMD Open"},{"issue":"10","key":"10.1016\/j.ard.2025.01.042_bib0026","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/annrheumdis-2021-220884","article-title":"EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis","volume":"80","author":"Mankia","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.ard.2025.01.042_bib0027","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-001768","article-title":"A core set of risk factors in individuals at risk of rheumatoid arthritis: a systematic literature review informing the EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis","volume":"7","author":"Mankia","year":"2021","journal-title":"RMD Open"},{"issue":"9","key":"10.1016\/j.ard.2025.01.042_bib0028","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ard.2025.01.042_bib0029","article-title":"When and how should we use imaging in individuals at risk of rheumatoid arthritis?","volume":"9","author":"Harnden","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"11","key":"10.1016\/j.ard.2025.01.042_bib0030","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1002\/art.39297","article-title":"Autoantibodies in prediction of the development of rheumatoid arthritis among healthy relatives of patients with the disease","volume":"67","author":"Ramos-Remus","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"10.1016\/j.ard.2025.01.042_bib0031","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1136\/annrheumdis-2014-205227","article-title":"Predicting the development of clinical arthritis in anti-CCP positive individuals with non-specific musculoskeletal symptoms: a prospective observational cohort study","volume":"74","author":"Rakieh","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.ard.2025.01.042_bib0032","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11926-016-0563-2","article-title":"The roles of cigarette smoking and the lung in the transitions between phases of preclinical rheumatoid arthritis","volume":"18","author":"Sparks","year":"2016","journal-title":"Curr Rheumatol Rep"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725001955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725001955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T20:02:41Z","timestamp":1744228961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496725001955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0003496725001955"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2025.01.042","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictors of arthritis development in individuals at risk of rheumatoid arthritis: a 5-year follow-up study from a large cohort","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2025.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Alliance of Associations for Rheumatology (EULAR). Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}