{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:04:59Z","timestamp":1791875099580,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20298"],"award-info":[{"award-number":["20298"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["23158"],"award-info":[{"award-number":["23158"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016580","name":"Kennedy Trust for Rheumatology Research","doi-asserted-by":"publisher","award":["AZT00050"],"award-info":[{"award-number":["AZT00050"]}],"id":[{"id":"10.13039\/100016580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016580","name":"Kennedy Trust for Rheumatology Research","doi-asserted-by":"publisher","award":["AZT00010"],"award-info":[{"award-number":["AZT00010"]}],"id":[{"id":"10.13039\/100016580","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ard.2025.03.016","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T07:03:58Z","timestamp":1746860638000},"page":"1484-1500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-9797","authenticated-orcid":false,"given":"Anna M.","family":"Marzeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-924X","authenticated-orcid":false,"given":"Anja","family":"Schwenzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8363-5673","authenticated-orcid":false,"given":"Bogdan S.","family":"Didov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-3289","authenticated-orcid":false,"given":"Kieran","family":"Woolcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-9772","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby K.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2605-6726","authenticated-orcid":false,"given":"Am\u00e9lie M.","family":"Jul\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Sansom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Cribbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calliope A.","family":"Dendrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyatt W.","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl S.","family":"Goodyear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-2977","authenticated-orcid":false,"given":"Kim S.","family":"Midwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ard.2025.03.016_bib0001","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BFb0116586","article-title":"Endotoxin tolerance-mechanisms and beneficial effects in bacterial infection","volume":"144","author":"Lehner","year":"2002","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"1 Pt 2","key":"10.1016\/j.ard.2025.03.016_bib0002","first-page":"R329","article-title":"Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits","volume":"267","author":"Wakabayashi","year":"1994","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.ard.2025.03.016_bib0003","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/iai.56.5.1352-1357.1988","article-title":"Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages","volume":"56","author":"Freudenberg","year":"1988","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.ard.2025.03.016_bib0004","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2217\/fmb-2018-0026","article-title":"Heterologous effects of infant BCG vaccination: potential mechanisms of immunity","volume":"13","author":"Butkeviciute","year":"2018","journal-title":"Future Microbiol"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0005","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1128\/iai.12.6.1325-1330.1975","article-title":"Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice","volume":"12","author":"Sher","year":"1975","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.ard.2025.03.016_bib0006","first-page":"902","article-title":"Effect of Bacillus Callmette Guerin (BCG) on the receptivity of nude mice to Schistosoma mansoni]","volume":"172","author":"Tribouley","year":"1978","journal-title":"C R Seances Soc Biol Fil"},{"issue":"3","key":"10.1016\/j.ard.2025.03.016_bib0007","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1189\/jlb.5RI0315-096R","article-title":"Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines","volume":"98","author":"Blok","year":"2015","journal-title":"J Leukoc Biol"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0008","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41577-020-0337-y","article-title":"BCG-induced trained immunity: can it offer protection against COVID-19?","volume":"20","author":"O'Neill","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"21","key":"10.1016\/j.ard.2025.03.016_bib0009","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101718118","article-title":"Old vaccines for new infections: exploiting innate immunity to control COVID-19 and prevent future pandemics","volume":"118","author":"Chumakov","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6204","key":"10.1016\/j.ard.2025.03.016_bib0010","doi-asserted-by":"crossref","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ard.2025.03.016_bib0011","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.cell.2016.09.034","article-title":"\u03b2-glucan reverses the epigenetic state of LPS-induced immunological tolerance","volume":"167","author":"Novakovic","year":"2016","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0012","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0013","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2018.09.003","article-title":"The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity","volume":"29","author":"Dom\u00ednguez-Andr\u00e9s","year":"2019","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.ard.2025.03.016_bib0014","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/path.4466","article-title":"Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile","volume":"235","author":"Soler Palacios","year":"2015","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0015","doi-asserted-by":"crossref","first-page":"e1237","DOI":"10.1002\/cti2.1237","article-title":"Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease","volume":"10","author":"McGarry","year":"2021","journal-title":"Clin Transl Immunology"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0016","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13075-015-0748-5","article-title":"Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate","volume":"17","author":"de Andres","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ard.2025.03.016_bib0017","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molimm.2017.01.009","article-title":"Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification","volume":"83","author":"Lin","year":"2017","journal-title":"Mol Immunol"},{"key":"10.1016\/j.ard.2025.03.016_bib0018","article-title":"Inhibition of histone H3 lysine-27 demethylase activity relieves rheumatoid arthritis symptoms via repression of IL6 transcription in macrophages","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ard.2025.03.016_bib0019","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"1-2","key":"10.1016\/j.ard.2025.03.016_bib0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ard.2025.03.016_bib0021","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1189\/jlb.0108030","article-title":"Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance","volume":"84","author":"Aneja","year":"2008","journal-title":"J Leukoc Biol"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0022","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.celrep.2014.11.020","article-title":"Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions","volume":"9","author":"Austermann","year":"2014","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.ard.2025.03.016_bib0023","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm.1987","article-title":"Tenascin-C is an endogenous activator of toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease","volume":"15","author":"Midwood","year":"2009","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.ard.2025.03.016_bib0024","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41584-020-00570-2","article-title":"Location, location, location: how the tissue microenvironment affects inflammation in RA","volume":"17","author":"Buckley","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.ard.2025.03.016_bib0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-2776(08)60598-2","article-title":"Role of macrophage migration inhibitory factor in the regulation of the immune response","volume":"66","author":"Metz","year":"1997","journal-title":"Adv Immunol"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0026","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4049\/jimmunol.0802189","article-title":"van den Pangaart PS, de Kruif MD, van 't Veer C, van der Poll T. In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands","volume":"183","author":"de Vos","year":"2009","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0027","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-017-01718-7","article-title":"Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers","volume":"8","author":"Zuliani-Alvarez","year":"2017","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.ard.2025.03.016_bib0028","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/art.21273","article-title":"RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3","volume":"52","author":"Brentano","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0029","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/art.20746","article-title":"Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis","volume":"52","author":"Jou","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ard.2025.03.016_bib0030","article-title":"Influence of genetic copy number variants of the human GLUT3 glucose transporter gene SLC2A3 on protein expression, glycolysis and rheumatoid arthritis risk: a genetic replication study","volume":"19","author":"Simpfendorfer","year":"2019","journal-title":"Mol Genet Metab Rep"},{"key":"10.1016\/j.ard.2025.03.016_bib0031","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fendo.2018.00313","article-title":"Role of tumor-derived chemokines in osteolytic bone metastasis","volume":"9","author":"Coniglio","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"10.1016\/j.ard.2025.03.016_bib0032","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1189\/jlb.0513305","article-title":"RelB: an outlier in leukocyte biology","volume":"94","author":"Millet","year":"2013","journal-title":"J Leukoc Biol"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0033","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/s41397-020-0168-z","article-title":"Analysis of association of ADORA2A and ADORA3 polymorphisms genotypes\/haplotypes with efficacy and toxicity of methotrexate in patients with rheumatoid arthritis","volume":"20","author":"Grk","year":"2020","journal-title":"Pharmacogenomics J"},{"issue":"8016","key":"10.1016\/j.ard.2025.03.016_bib0034","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41586-024-07501-1","article-title":"A disease-associated gene desert directs macrophage inflammation through ETS2","volume":"630","author":"Stankey","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ard.2025.03.016_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.816839","article-title":"Inflammasome and its therapeutic targeting in rheumatoid arthritis","volume":"12","author":"Jiang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ard.2025.03.016_bib0036","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3389\/fimmu.2019.00791","article-title":"Oligomeric S100A4 is associated with monocyte innate immune memory and bypass of tolerance to subsequent stimulation with lipopolysaccharides","volume":"10","author":"Neidhart","year":"2019","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.ard.2025.03.016_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102942","article-title":"The myristoylated alanine-rich C-kinase substrates (MARCKS): a membrane-anchored mediator of the cell function","volume":"20","author":"Chen","year":"2021","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ard.2025.03.016_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1285455","article-title":"Immunomodulatory roles of metalloproteinases in rheumatoid arthritis","volume":"14","author":"Bian","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ard.2025.03.016_bib0039","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fimmu.2017.00093","article-title":"Arginine metabolism in myeloid cells shapes innate and adaptive immunity","volume":"8","author":"Rodriguez","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.ard.2025.03.016_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/563818","article-title":"Size matters: molecular weight specificity of hyaluronan effects in cell biology","volume":"2015","author":"Cyphert","year":"2015","journal-title":"Int J Cell Biol"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0041","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13075-015-0637-y","article-title":"KIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis","volume":"17","author":"Yang","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ard.2025.03.016_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.594136","article-title":"Efferocytic defects in early atherosclerosis are driven by GATA2 overexpression in macrophages","volume":"11","author":"Yin","year":"2020","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.ard.2025.03.016_bib0043","article-title":"The role of clock genes in maintaining circadian rhythm and rheumatoid arthritis pathophysiology","volume":"15","author":"Kulkarni","year":"2023","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.ard.2025.03.016_bib0044","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1038\/s41467-024-52586-x","article-title":"Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis","volume":"15","author":"Faust","year":"2024","journal-title":"Nat Commun"},{"issue":"7987","key":"10.1016\/j.ard.2025.03.016_bib0045","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ard.2025.03.016_bib0046","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis","volume":"26","author":"Alivernini","year":"2020","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ard.2025.03.016_bib0047","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","article-title":"Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"10055","key":"10.1016\/j.ard.2025.03.016_bib0048","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ard.2025.03.016_bib0049","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1369\/0022155418757443","article-title":"Internal affairs: tenascin-C as a clinically relevant, endogenous driver of innate immunity","volume":"66","author":"Marzeda","year":"2018","journal-title":"J Histochem Cytochem"},{"issue":"4","key":"10.1016\/j.ard.2025.03.016_bib0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ni1569","article-title":"TRAM couples endocytosis of toll-like receptor 4 to the induction of interferon-beta","volume":"9","author":"Kagan","year":"2008","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.ard.2025.03.016_bib0051","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1128\/CVI.00688-13","article-title":"Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors","volume":"21","author":"Ifrim","year":"2014","journal-title":"Clin Vaccine Immunol"},{"issue":"1-2","key":"10.1016\/j.ard.2025.03.016_bib0052","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ard.2025.03.016_bib0053","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1260839","article-title":"Ferroptosis as an emerging target in rheumatoid arthritis","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ard.2025.03.016_bib0054","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007664","article-title":"Tximeta: reference sequence checksums for provenance identification in RNA-seq","volume":"16","author":"Love","year":"2020","journal-title":"PLoS Comput Biol"},{"issue":"12","key":"10.1016\/j.ard.2025.03.016_bib0055","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"2","key":"10.1016\/j.ard.2025.03.016_bib0056","first-page":"275","article-title":"False discovery rates: a new deal","volume":"18","author":"Stephens","year":"2017","journal-title":"Biostatistics"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0058","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.ard.2025.03.016_bib0060","article-title":"ComBat-seq: batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genom Bioinform"},{"issue":"6","key":"10.1016\/j.ard.2025.03.016_bib0061","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/annrheumdis-2020-219262","article-title":"TNF is a homoeostatic regulator of distinct epigenetically primed human osteoclast precursors","volume":"80","author":"Ansalone","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.03.016_bib0062","unstructured":"BioinfoGP. Venny 2.1 [Internet]. Available from: https:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html, accessed 30 May, 2024."},{"key":"10.1016\/j.ard.2025.03.016_bib0063","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1016\/j.csbj.2021.06.043","article-title":"UCell: robust and scalable single-cell gene signature scoring","volume":"19","author":"Andreatta","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.ard.2025.03.016_bib0064","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"10.1016\/j.ard.2025.03.016_bib0065","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725008830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725008830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:13:19Z","timestamp":1763662399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496725008830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0003496725008830"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2025.03.016","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2025.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}