{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:34:11Z","timestamp":1793363651961,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016580","name":"Kennedy Trust for Rheumatology Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018208","name":"Cure JM Foundation","doi-asserted-by":"publisher","award":["MREC 01\/3\/022"],"award-info":[{"award-number":["MREC 01\/3\/022"]}],"id":[{"id":"10.13039\/100018208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["23202"],"award-info":[{"award-number":["23202"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["21593"],"award-info":[{"award-number":["21593"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N003322\/1"],"award-info":[{"award-number":["MR\/N003322\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R013926\/1"],"award-info":[{"award-number":["MR\/R013926\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019256","name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","doi-asserted-by":"publisher","award":["18IR33"],"award-info":[{"award-number":["18IR33"]}],"id":[{"id":"10.13039\/501100019256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Children's Charity","doi-asserted-by":"publisher","award":["W1143"],"award-info":[{"award-number":["W1143"]}],"id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Children's Charity","doi-asserted-by":"publisher","award":["W1183"],"award-info":[{"award-number":["W1183"]}],"id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ard.2025.07.015","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T11:09:13Z","timestamp":1754737753000},"page":"1706-1720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6225-9373","authenticated-orcid":false,"given":"Aris E.","family":"Syntakas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-393X","authenticated-orcid":false,"given":"Melissa","family":"Kartawinata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9922-8896","authenticated-orcid":false,"given":"Nia M.L.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-8028","authenticated-orcid":false,"given":"Huong D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-0557","authenticated-orcid":false,"given":"Charalampia","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-3682","authenticated-orcid":false,"given":"Muthana Al","family":"Obaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-2428","authenticated-orcid":false,"given":"Clarissa","family":"Pilkington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Glackin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-2540","authenticated-orcid":false,"given":"Christopher B.","family":"Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-0511","authenticated-orcid":false,"given":"Adam P.","family":"Croft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-9204","authenticated-orcid":false,"given":"Simon","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-2624","authenticated-orcid":false,"given":"Mario","family":"Cortina-Borja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-5526","authenticated-orcid":false,"given":"Olumide","family":"Ogunbiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-1849","authenticated-orcid":false,"given":"Ashirwad","family":"Merve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-1429","authenticated-orcid":false,"given":"Lucy R.","family":"Wedderburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-8066","authenticated-orcid":false,"given":"Meredyth G. Ll","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ard.2025.07.015_bib0001","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/BOR.0000000000000816","article-title":"Updates on interferon in juvenile dermatomyositis: pathogenesis and therapy","volume":"33","author":"Kim","year":"2021","journal-title":"Curr Opin Rheumatol"},{"issue":"6","key":"10.1016\/j.ard.2025.07.015_bib0002","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41584-023-00967-9","article-title":"Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care","volume":"19","author":"Papadopoulou","year":"2023","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.ard.2025.07.015_bib0003","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1136\/ard-2022-223469","article-title":"Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis","volume":"82","author":"Wilkinson","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ard.2025.07.015_bib0004","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1186\/ar4311","article-title":"Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis","volume":"15","author":"Nistala","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.ard.2025.07.015_bib0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/nan.12528","article-title":"Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features","volume":"45","author":"Yasin","year":"2019","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"10.1016\/j.ard.2025.07.015_bib0006","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/annrheumdis-2013-203396","article-title":"Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease","volume":"74","author":"Varsani","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ard.2025.07.015_bib0007","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20070075","article-title":"Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis","volume":"204","author":"Arnold","year":"2007","journal-title":"J Exp Med"},{"issue":"19","key":"10.1016\/j.ard.2025.07.015_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910393","article-title":"Macrophages in the context of muscle regeneration and duchenne muscular dystrophy","volume":"25","author":"Hernandez-Torres","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ard.2025.07.015_bib0009","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12950-024-00422-w","article-title":"Macrophage involvement in idiopathic inflammatory myopathy: pathogenic mechanisms and therapeutic prospects","volume":"21","author":"Li","year":"2024","journal-title":"J Inflamm (Lond)"},{"issue":"1","key":"10.1016\/j.ard.2025.07.015_bib0010","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1038\/s41467-024-49460-1","article-title":"IFN\u03b3 causes mitochondrial dysfunction and oxidative stress in myositis","volume":"15","author":"Abad","year":"2024","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.ard.2025.07.015_bib0011","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jid.2021.12.014","article-title":"Research techniques made simple: spatial transcriptomics","volume":"142","author":"Pi\u00f1eiro","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ard.2025.07.015_bib0012","article-title":"Region of interest localization, tissue storage time, and antibody binding density-a technical note on the GeoMx\u00ae Digital Spatial Profiler","volume":"23","author":"B\u00f6ning","year":"2024","journal-title":"Immunooncol Technol"},{"issue":"12","key":"10.1016\/j.ard.2025.07.015_bib0013","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1136\/ard.2011.153718","article-title":"Efficacy of intravenous Ig therapy in juvenile dermatomyositis","volume":"70","author":"Lam","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.ard.2025.07.015_bib0014","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/mus.20898","article-title":"Quantification of normal range of inflammatory changes in morphologically normal pediatric muscle","volume":"37","author":"Varsani","year":"2008","journal-title":"Muscle Nerve"},{"issue":"2","key":"10.1016\/j.ard.2025.07.015_bib0015","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"issue":"11","key":"10.1016\/j.ard.2025.07.015_bib0016","doi-asserted-by":"crossref","first-page":"btad672","DOI":"10.1093\/bioinformatics\/btad672","article-title":"aPEAR: an R package for autonomous visualization of pathway enrichment networks","volume":"39","author":"Kerseviciute","year":"2023","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.ard.2025.07.015_bib0017","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0046-8177(89)90128-7","article-title":"Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies","volume":"20","author":"Emslie-Smith","year":"1989","journal-title":"Hum Pathol"},{"issue":"4","key":"10.1016\/j.ard.2025.07.015_bib0018","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0002-9440(10)62513-8","article-title":"Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies","volume":"159","author":"Englund","year":"2001","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.ard.2025.07.015_bib0019","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/art.10140","volume":"46","author":"Englund","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.ard.2025.07.015_bib0020","first-page":"605","article-title":"MHC class I overexpression on muscles in early juvenile dermatomyositis","volume":"31","author":"Li","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ard.2025.07.015_bib0021","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"issue":"18","key":"10.1016\/j.ard.2025.07.015_bib0022","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ard.2025.07.015_bib0023","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","article-title":"INTERFEROME v2.0: an updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.ard.2025.07.015_bib0024","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41598-021-04302-8","article-title":"Transcriptomes of peripheral blood mononuclear cells from juvenile dermatomyositis patients show elevated inflammation even when clinically inactive","volume":"12","author":"Roberson","year":"2022","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ard.2025.07.015_bib0025","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/nan.12498","article-title":"Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis","volume":"45","author":"Soponkanaporn","year":"2019","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"7","key":"10.1016\/j.ard.2025.07.015_bib0026","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12841","article-title":"Respiratory chain dysfunction in perifascicular muscle fibres in patients with dermatomyositis is associated with mitochondrial DNA depletion","volume":"48","author":"Hedberg-Oldfors","year":"2022","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"7","key":"10.1016\/j.ard.2025.07.015_bib0027","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/art.23012","article-title":"International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: a tool for potential use in clinical trials","volume":"57","author":"Wedderburn","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.ard.2025.07.015_bib0028","doi-asserted-by":"crossref","first-page":"e1193","DOI":"10.1212\/WNL.0000000000008128","article-title":"Identification of distinctive interferon gene signatures in different types of myositis","volume":"93","author":"Pinal-Fernandez","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.ard.2025.07.015_bib0029","first-page":"1","article-title":"Deep RNA sequencing of muscle tissue reveals absence of viral signatures in dermatomyositis","volume":"5","author":"Corman","year":"2024","journal-title":"Free Neuropathol"},{"issue":"11","key":"10.1016\/j.ard.2025.07.015_bib0030","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1002\/art.24936","article-title":"Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis","volume":"60","author":"Bilgic","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"1-2","key":"10.1016\/j.ard.2025.07.015_bib0031","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2119\/2006-00085.Baechler","article-title":"An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity","volume":"13","author":"Baechler","year":"2007","journal-title":"Mol Med"},{"issue":"1","key":"10.1016\/j.ard.2025.07.015_bib0032","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12969-021-00637-8","article-title":"JAK inhibitors: a potential treatment for JDM in the context of the role of interferon-driven pathology","volume":"19","author":"Ll Wilkinson","year":"2021","journal-title":"Pediatr Rheumatol Online J"},{"issue":"3","key":"10.1016\/j.ard.2025.07.015_bib0033","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s11926-012-0247-5","article-title":"Endoplasmic reticulum stress in skeletal muscle homeostasis and disease","volume":"14","author":"Rayavarapu","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"10.1016\/j.ard.2025.07.015_bib0034","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.2353\/ajpath.2009.090196","article-title":"Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis","volume":"175","author":"Li","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ard.2025.07.015_bib0035","first-page":"awaf118","article-title":"Mitochondrial damage is associated with an early immune response in inclusion body myositis","author":"Kleefeld","year":"2025","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.ard.2025.07.015_bib0036","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/s41380-023-02251-4","article-title":"Mitochondrial DNA damage triggers spread of Parkinson\u2019s disease-like pathology","volume":"28","author":"Tresse","year":"2023","journal-title":"Mol Psychiatry"},{"issue":"12","key":"10.1016\/j.ard.2025.07.015_bib0037","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat Metab"},{"key":"10.1016\/j.ard.2025.07.015_bib0038","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41927","article-title":"Nuclear genetic regulation of the human mitochondrial transcriptome","volume":"8","author":"Ali","year":"2019","journal-title":"Elife"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725042487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725042487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:01:01Z","timestamp":1777190461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496725042487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0003496725042487"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2025.07.015","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2025.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}