{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:45:30Z","timestamp":1786193130945,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","award":["815372"],"award-info":[{"award-number":["815372"]}],"id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ard.2025.10.011","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:55:43Z","timestamp":1762595743000},"page":"457-466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-1715","authenticated-orcid":false,"given":"Lihi","family":"Eder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane M.","family":"Caucheteux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Thib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshini","family":"Ganatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ritchlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Jurisica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Piguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ard.2025.10.011_bib0001","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1136\/annrheumdis-2016-210724","article-title":"Efficacy and safety of abatacept, a T-cell modulator, in a randomised, double-blind, placebo-controlled, phase III study in psoriatic arthritis","volume":"76","author":"Mease","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0002","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/annrheumdis-2016-209709","volume":"76","author":"Mease","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"16","key":"10.1016\/j.ard.2025.10.011_bib0003","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1056\/NEJMoa1615975","article-title":"Tofacitinib or adalimumab versus placebo for psoriatic arthritis","volume":"377","author":"Mease","year":"2017","journal-title":"N Engl J Med"},{"issue":"9894","key":"10.1016\/j.ard.2025.10.011_bib0004","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0140-6736(13)60594-2","article-title":"Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial","volume":"382","author":"McInnes","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0005","first-page":"41","article-title":"Potential difficult-to-treat psoriatic arthritis real-world prevalence and contributing factors","volume":"43","author":"Alp","year":"2025","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0006","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003809","article-title":"Difficult-to-treat psoriatic arthritis (D2T PsA): a scoping literature review informing a GRAPPA research project","volume":"10","author":"Singla","year":"2024","journal-title":"RMD Open"},{"issue":"12","key":"10.1016\/j.ard.2025.10.011_bib0007","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1093\/rheumatology\/keac078","article-title":"Defining imaging sub-phenotypes of psoriatic arthritis: integrative analysis of imaging data and gene expression in a PsA patient cohort","volume":"61","author":"Eder","year":"2022","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.1016\/j.ard.2025.10.011_bib0008","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/25785826.2024.2388343","article-title":"Unraveling immune cell heterogeneity in autoimmune arthritis: insights from single-cell RNA sequencing","volume":"47","author":"Nakajima","year":"2024","journal-title":"Immunol Med"},{"issue":"10136","key":"10.1016\/j.ard.2025.10.011_bib0009","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"Veale","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ard.2025.10.011_bib0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/art.41156","article-title":"Polyfunctional, proinflammatory, tissue-resident memory phenotype and function of synovial interleukin-17A+CD8+ T cells in psoriatic arthritis","volume":"72","author":"Steel","year":"2020","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0011","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13075-021-02714-5","article-title":"Characterizing memory T helper cells in patients with psoriasis, subclinical, or early psoriatic arthritis using a machine learning algorithm","volume":"24","author":"den Braanker","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ard.2025.10.011_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109679","article-title":"Distinct innate and adaptive immunity phenotypic profile at the circulating single-cell level in psoriatic arthritis","volume":"253","author":"Fragoulis","year":"2023","journal-title":"Clin Immunol"},{"issue":"9","key":"10.1016\/j.ard.2025.10.011_bib0013","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/art.42124","article-title":"Peripheral gammadelta T cells regulate neutrophil expansion and recruitment in experimental psoriatic arthritis","volume":"74","author":"Nguyen","year":"2022","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"10.1016\/j.ard.2025.10.011_bib0014","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003995","article-title":"Association between musculoskeletal sonographic features and response to treatment in patients with psoriatic arthritis","volume":"10","author":"Gutierrez","year":"2024","journal-title":"RMD Open"},{"issue":"2","key":"10.1016\/j.ard.2025.10.011_bib0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/cyto.b.21858","article-title":"Multi-site reproducibility of a human immunophenotyping assay in whole blood and peripheral blood mononuclear cells preparations using CyTOF technology coupled with Maxpar Pathsetter, an automated data analysis system","volume":"98","author":"Bagwell","year":"2020","journal-title":"Cytometry B Clin Cytom"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0016","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2531248","article-title":"Longitudinal data analysis for discrete and continuous outcomes","volume":"42","author":"Zeger","year":"1986","journal-title":"Biometrics"},{"issue":"12","key":"10.1016\/j.ard.2025.10.011_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015004","article-title":"Aptamer-based multiplexed proteomic technology for biomarker discovery","volume":"5","author":"Gold","year":"2010","journal-title":"PLOS ONE"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0018","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22116-0","article-title":"Assessment of variability in the plasma 7k SomaScan proteomics assay","volume":"12","author":"Candia","year":"2022","journal-title":"Sci Rep"},{"issue":"D1","key":"10.1016\/j.ard.2025.10.011_bib0019","doi-asserted-by":"crossref","first-page":"D663","DOI":"10.1093\/nar\/gkad1027","article-title":"PathDIP 5: improving coverage and making enrichment analysis more biologically meaningful","volume":"52","author":"Pastrello","year":"2024","journal-title":"Nucleic Acids Res"},{"issue":"24","key":"10.1016\/j.ard.2025.10.011_bib0020","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1093\/bioinformatics\/btp595","article-title":"NAViGaTOR: network analysis, visualization and graphing Toronto","volume":"25","author":"Brown","year":"2009","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.ard.2025.10.011_bib0021","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"issue":"18","key":"10.1016\/j.ard.2025.10.011_bib0022","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1002\/pmic.201600044","article-title":"Multiple testing corrections in quantitative proteomics: a useful but blunt tool","volume":"16","author":"Pascovici","year":"2016","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.ard.2025.10.011_bib0023","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jid.2024.08.039","article-title":"Imaging mass cytometry in psoriatic disease reveals immune profile heterogeneity in skin and synovial tissue","volume":"145","author":"Eder","year":"2025","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0024","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ard.2025.10.011_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107523","article-title":"CytoMAP: a spatial analysis toolbox reveals features of myeloid cell organization in lymphoid tissues","volume":"31","author":"Stoltzfus","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.ard.2025.10.011_bib0026","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/9927964","article-title":"Circulating immune landscape profiling in psoriasis vulgaris and psoriatic arthritis by mass cytometry","volume":"2024","author":"Sang","year":"2024","journal-title":"J Immunol Res"},{"key":"10.1016\/j.ard.2025.10.011_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.104985","article-title":"High-dimensional profiling of regulatory T cells in psoriasis reveals an impaired skin-trafficking property","volume":"100","author":"Lee","year":"2024","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0028","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13075-022-02956-x","article-title":"Four emerging immune cellular blood phenotypes associated with disease duration and activity established in psoriatic arthritis","volume":"24","author":"Skougaard","year":"2022","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.ard.2025.10.011_bib0029","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/art.41652","article-title":"Tissue-resident memory CD8+ T cells from skin differentiate psoriatic arthritis from psoriasis","volume":"73","author":"Leijten","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47310-5","article-title":"Increased frequency of activated CD8(+) T cell effectors in patients with psoriatic arthritis","volume":"9","author":"Diani","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0031","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1038\/s41467-020-18513-6","article-title":"Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis","volume":"11","author":"Penkava","year":"2020","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.ard.2025.10.011_bib0032","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1111\/jcmm.14531","article-title":"The pathological role of Wnt5a in psoriasis and psoriatic arthritis","volume":"23","author":"Tian","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0033","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12967-025-06174-2","article-title":"Wnt signaling as a translational target in rheumatoid and psoriatic arthritis","volume":"23","author":"Riitano","year":"2025","journal-title":"J Transl Med"},{"key":"10.1016\/j.ard.2025.10.011_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.120084","article-title":"VEGF in psoriatic arthritis: systematic review and meta-analysis","volume":"567","author":"Di Lorenzo","year":"2025","journal-title":"Clin Chim Acta"},{"issue":"11","key":"10.1016\/j.ard.2025.10.011_bib0035","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41577-024-01040-6","article-title":"A guide to adaptive immune memory","volume":"24","author":"Lam","year":"2024","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.ard.2025.10.011_bib0036","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/annrheumdis-2018-214138","article-title":"Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis","volume":"78","author":"Wade","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.ard.2025.10.011_bib0037","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3899\/jrheum.180195","article-title":"Using acute-phase reactants to inform the development of instruments for the updated psoriatic arthritis core outcome measurement set","volume":"46","author":"Elmamoun","year":"2019","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.ard.2025.10.011_bib0038","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.reuma.2023.06.001","article-title":"DKK-1 in psoriatic arthritis: correlation with disease activity and enthesopathy","volume":"20","author":"Wahba","year":"2024","journal-title":"Reumatol Clin (Engl Ed)"},{"issue":"2","key":"10.1016\/j.ard.2025.10.011_bib0039","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140508","article-title":"Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1","volume":"132","author":"Sung","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ard.2025.10.011_bib0040","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.3389\/fimmu.2019.02293","article-title":"WNT\/beta-Catenin signaling pathway regulating T cell-inflammation in the tumor microenvironment","volume":"10","author":"Li","year":"2019","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.ard.2025.10.011_bib0041","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ni.3371","article-title":"The cellular composition of the human immune system is shaped by age and cohabitation","volume":"17","author":"Carr","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ard.2025.10.011_bib0042","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12979-019-0165-8","article-title":"Age related human T cell subset evolution and senescence","volume":"16","author":"Li","year":"2019","journal-title":"Immun Ageing"},{"issue":"3","key":"10.1016\/j.ard.2025.10.011_bib0043","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/rheumatology\/kead284","article-title":"Predictors of DAPSA28 remission in patients with psoriatic arthritis initiating a first TNF inhibitor: results from 13 European registries","volume":"63","author":"Linde","year":"2024","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"10.1016\/j.ard.2025.10.011_bib0044","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1007\/s10067-024-07193-y","article-title":"Factors predicting treatment response to biological and targeted synthetic disease-modifying antirheumatic drugs in psoriatic arthritis - a systematic review and meta-analysis","volume":"43","author":"Kunzler","year":"2024","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ard.2025.10.011_bib0045","doi-asserted-by":"crossref","DOI":"10.3899\/jrheum.2025-0145","article-title":"Association of contextual factors with sonographic inflammatory and structural phenotypes in psoriatic arthritis patients: a cross-sectional study","author":"Ribeiro","year":"2025","journal-title":"J Rheumatol"},{"issue":"10","key":"10.1016\/j.ard.2025.10.011_bib0046","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3899\/jrheum.210349","article-title":"Does age matter in psoriatic arthritis? A narrative review","volume":"49","author":"Fragoulis","year":"2022","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ard.2025.10.011_bib0047","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3389\/fimmu.2017.01403","article-title":"CD4 T-cell dysregulation in psoriatic arthritis reveals a regulatory role for IL-22","volume":"8","author":"Ezeonyeji","year":"2017","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ard.2025.10.011_bib0048","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/cei.13646","article-title":"CD4(+) LAG-3(+) T cells are decreased in active psoriatic arthritis patients and their restoration in vitro is mediated by TNF inhibitors","volume":"206","author":"Gertel","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ard.2025.10.011_bib0049","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1403680","article-title":"Insufficient PD-1 expression during active autoimmune responses: a deep single-cell proteomics analysis in inflammatory arthritis","volume":"15","author":"Vetsika","year":"2024","journal-title":"Front Immunol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725044504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725044504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:25:31Z","timestamp":1786191931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496725044504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0003496725044504"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2025.10.011","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2025.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}