{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:36Z","timestamp":1792799856419,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23-AR-075112"],"award-info":[{"award-number":["K23-AR-075112"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["W81XWH-16-1-0665"],"award-info":[{"award-number":["W81XWH-16-1-0665"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["28IR-0067"],"award-info":[{"award-number":["28IR-0067"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["NS067420"],"award-info":[{"award-number":["NS067420"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR072582"],"award-info":[{"award-number":["P30 AR072582"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["HL075033"],"award-info":[{"award-number":["HL075033"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["NS113429"],"award-info":[{"award-number":["NS113429"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1ZIAAR041209"],"award-info":[{"award-number":["1ZIAAR041209"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL-164758"],"award-info":[{"award-number":["R01-HL-164758"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000093","name":"Center for Information Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001844","name":"Scleroderma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000179","name":"Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["1ZIBHG000196"],"award-info":[{"award-number":["1ZIBHG000196"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["1ZIAHG200416"],"award-info":[{"award-number":["1ZIAHG200416"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["1ZIAHG200371"],"award-info":[{"award-number":["1ZIAHG200371"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["1ZIJMD000010"],"award-info":[{"award-number":["1ZIJMD000010"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1ZIAHG200362"],"award-info":[{"award-number":["1ZIAHG200362"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13GRNT16850032"],"award-info":[{"award-number":["13GRNT16850032"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["10GRNT4170146"],"award-info":[{"award-number":["10GRNT4170146"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["24POST1198769"],"award-info":[{"award-number":["24POST1198769"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ard.2025.12.015","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:12:24Z","timestamp":1770207144000},"page":"1396-1412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis"],"prefix":"10.1016","volume":"85","author":[{"given":"Urvashi","family":"Kaundal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Suen","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Boyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis M.","family":"Woodford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Shriner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilee","family":"Stenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Ayla","family":"Safran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor A.","family":"Talley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaavya","family":"Gudapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kunishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami A.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen D.","family":"Mayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayo P.","family":"Doumatey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Domsic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley Ann","family":"Saketkoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Schiopu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey A.","family":"Criswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Gladue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Derk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana J.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"S. Louis","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Kafaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avram","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Korman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mullikin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Dell\u2019Orso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Randazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale","family":"Adeyemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Remmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L.","family":"Schwartzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivona","family":"Aksentijevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Rotimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick M.","family":"Wigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Boin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lafyatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravitt","family":"Gourh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ard.2025.12.015_bib0001","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/art.11073","article-title":"Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population","volume":"48","author":"Mayes","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ard.2025.12.015_bib0002","first-page":"1873","article-title":"Race, scleroderma, and survival: why is there a difference?","volume":"32","author":"Mayes","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0003","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10654-005-2210-5","article-title":"Systemic sclerosis mortality in the United States: 1979-1998","volume":"20","author":"Krishnan","year":"2005","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ard.2025.12.015_bib0004","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/art.1780400309","article-title":"Incidence of systemic sclerosis in Allegheny County, Pennsylvania. A twenty-year study of hospital-diagnosed cases, 1963-1982","volume":"40","author":"Steen","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ard.2025.12.015_bib0005","doi-asserted-by":"crossref","first-page":"e8980","DOI":"10.1097\/MD.0000000000008980","article-title":"Clinical and serological features of systemic sclerosis in a multicenter African American cohort: analysis of the genome research in African American scleroderma patients clinical database","volume":"96","author":"Morgan","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ard.2025.12.015_bib0006","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/MD.0b013e31829be125","article-title":"Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature","volume":"92","author":"Gelber","year":"2013","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ard.2025.12.015_bib0007","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00281-015-0505-5","article-title":"Vasculopathy in scleroderma","volume":"37","author":"Asano","year":"2015","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.ard.2025.12.015_bib0008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11926-009-0015-3","article-title":"Is scleroderma a vasculopathy?","volume":"11","author":"Fleming","year":"2009","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.ard.2025.12.015_bib0009","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ard.2025.12.015_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5345673","article-title":"Angiogenesis dysregulation in the pathogenesis of systemic sclerosis","volume":"2017","author":"Cantatore","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ard.2025.12.015_bib0011","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006569","article-title":"VEGF and Notch in tip and stalk cell selection","volume":"3","author":"Blanco","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ard.2025.12.015_bib0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.rdc.2008.01.001","article-title":"The pathology of scleroderma vascular disease","volume":"34","author":"Fleming","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.ard.2025.12.015_bib0013","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13075-019-1842-x","article-title":"Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study","volume":"21","author":"Park","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ard.2025.12.015_bib0014","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1136\/annrheumdis-2015-208121","article-title":"Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry","volume":"75","author":"Matucci-Cerinic","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s12016-022-08945-x","article-title":"Renal disease and systemic sclerosis: an update on scleroderma renal crisis","volume":"64","author":"Cole","year":"2023","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.ard.2025.12.015_bib0016","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3949\/ccjm.86a.18109","article-title":"Cardiovascular complications of systemic sclerosis: what to look for","volume":"86","author":"Mani","year":"2019","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.ard.2025.12.015_bib0017","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","author":"Tyndall","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0018","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/1529-0131(199809)41:9<1613::AID-ART11>3.0.CO;2-O","article-title":"Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis","volume":"41","author":"Steen","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ard.2025.12.015_bib0019","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ard.2025.12.015_bib0020","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/ard.2010.134742","article-title":"Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis","volume":"70","author":"Dees","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0021","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1073\/pnas.1813006116","article-title":"Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma","volume":"116","author":"Tsou","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ard.2025.12.015_bib0022","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5021\/ad.2019.31.4.365","article-title":"The significance of NOTCH pathway in the development of fibrosis in systemic sclerosis","volume":"31","author":"Zmorzy\u0144ski","year":"2019","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0023","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1080\/1744666X.2021.2000391","article-title":"The role of the Notch pathway in the pathogenesis of systemic sclerosis: clinical implications","volume":"17","author":"Seguro Paula","year":"2021","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.ard.2025.12.015_bib0024","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12929-021-00732-8","article-title":"Notch-ing up knowledge on molecular mechanisms of skin fibrosis: focus on the multifaceted Notch signalling pathway","volume":"28","author":"Condorelli","year":"2021","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ard.2025.12.015_bib0025","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.jid.2024.03.024","article-title":"The \u03b2-secretase BACE1 drives fibroblast activation in systemic sclerosis through the APP\/\u03b2-catenin\/notch signaling axis","volume":"144","author":"Wasson","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0026","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41584-018-0099-0","article-title":"New insights into the genetics and epigenetics of systemic sclerosis","volume":"14","author":"Angiolilli","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0027","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1073\/pnas.1906593116","article-title":"HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry","volume":"117","author":"Gourh","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ard.2025.12.015_bib0028","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/art.40541","article-title":"Brief report: whole-exome sequencing to identify rare variants and gene networks that increase susceptibility to scleroderma in African Americans","volume":"70","author":"Gourh","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0029","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000564","article-title":"A genome-wide association study of hypertension and blood pressure in African Americans","volume":"5","author":"Adeyemo","year":"2009","journal-title":"PLoS Genet"},{"issue":"6","key":"10.1016\/j.ard.2025.12.015_bib91","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1073\/pnas.88.6.2065","article-title":"FVB\/N: an inbred mouse strain preferable for transgenic analyses","volume":"88","author":"Taketo","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ard.2025.12.015_bib0031","doi-asserted-by":"crossref","first-page":"D977","DOI":"10.1093\/nar\/gkac1010","article-title":"The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource","volume":"51","author":"Sollis","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ard.2025.12.015_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002091","article-title":"Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis","volume":"7","author":"Allanore","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0033","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/ng.565","article-title":"Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus","volume":"42","author":"Radstake","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/7a52649c-0942-4bd8-a5d3-3cdacca03cd8","article-title":"Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy","volume":"7","author":"Gorlova","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0035","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1093\/hmg\/ddt248","article-title":"A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci","volume":"22","author":"Martin","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0036","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1136\/annrheumdis-2016-210645","article-title":"Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis","volume":"76","author":"Terao","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0037","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0378-1119(96)00857-8","article-title":"Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3","volume":"189","author":"Sugaya","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.ard.2025.12.015_bib0038","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0167-5699(00)01664-9","article-title":"The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment","volume":"21","author":"Yung Yu","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.ard.2025.12.015_bib0039","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10654-019-00573-8","article-title":"Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates","volume":"34","author":"Bj\u00f6rk","year":"2019","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ard.2025.12.015_bib0040","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fgene.2018.00352","article-title":"The relationship between population attributable fraction and heritability in genetic studies","volume":"9","author":"Wang","year":"2018","journal-title":"Front Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0041","series-title":"Analytic methods in maternal and child health","article-title":"Measures of Association and Hypotheses Testing","author":"Rosenberg","year":"1998"},{"key":"10.1016\/j.ard.2025.12.015_bib0042","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/ard.2006.066985","article-title":"Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients","volume":"67","author":"Teixeira","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0043","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1101\/gr.097022.109","article-title":"Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation","volume":"19","author":"Reddy","year":"2009","journal-title":"Genome Res"},{"key":"10.1016\/j.ard.2025.12.015_bib0044","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/annrheumdis-2021-221352","article-title":"Large-scale analysis of longitudinal skin gene expression in systemic sclerosis reveals relationships of immune cell and fibroblast activity with skin thickness and a trend towards normalisation over time","volume":"81","author":"Skaug","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0045","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13075-021-02633-5","article-title":"Multiomic study of skin, peripheral blood, and serum: is serum proteome a reflection of disease process at the end-organ level in systemic sclerosis?","volume":"23","author":"Farutin","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ard.2025.12.015_bib0046","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/art.39289","article-title":"Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis","volume":"67","author":"Assassi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0047","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/annrheumdis-2019-215894","article-title":"Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile","volume":"79","author":"Skaug","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0048","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1172\/JCI135439","article-title":"Long noncoding RNA H19X is a key mediator of TGF-\u03b2-driven fibrosis","volume":"130","author":"Pachera","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ard.2025.12.015_bib0049","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1136\/ard-2023-225415","article-title":"Single-cell transcriptomes and chromatin accessibility of endothelial cells unravel transcription factors associated with dysregulated angiogenesis in systemic sclerosis","volume":"83","author":"Huang","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0050","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.cell.2022.03.011","article-title":"LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma","volume":"185","author":"Gur","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ard.2025.12.015_bib0051","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJMoa2210140","article-title":"Nirogacestat, a gamma-secretase inhibitor for desmoid tumors","volume":"388","author":"Gounder","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ard.2025.12.015_bib0052","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1096\/fj.14-267633","article-title":"Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro","volume":"29","author":"Heiss","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.ard.2025.12.015_bib0053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107175","article-title":"Foramen ovale closure is a process of endothelial-to-mesenchymal transition leading to fibrosis","volume":"9","author":"Elliott","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ard.2025.12.015_bib0054","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cellsig.2016.06.022","article-title":"The role of PDGF-B\/TGF-beta1\/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling","volume":"28","author":"Song","year":"2016","journal-title":"Cell Signal"},{"key":"10.1016\/j.ard.2025.12.015_bib0055","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ard.2025.12.015_bib0056","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.ard.2025.12.015_bib0057","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3390\/biomedicines12061331","article-title":"Recent insights into cellular and molecular mechanisms of defective angiogenesis in systemic sclerosis","volume":"12","author":"Romano","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.ard.2025.12.015_bib0058","doi-asserted-by":"crossref","first-page":"9884","DOI":"10.1073\/pnas.0504391102","article-title":"Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice","volume":"102","author":"Carlson","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ard.2025.12.015_bib0059","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1073\/pnas.0802743105","article-title":"Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice","volume":"105","author":"Murphy","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ard.2025.12.015_bib0060","doi-asserted-by":"crossref","first-page":"117ra8","DOI":"10.1126\/scitranslmed.3002670","article-title":"Notch4 normalization reduces blood vessel size in arteriovenous malformations","volume":"4","author":"Murphy","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ard.2025.12.015_bib0061","doi-asserted-by":"crossref","first-page":"18007","DOI":"10.1073\/pnas.1415316111","article-title":"Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels","volume":"111","author":"Murphy","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ard.2025.12.015_bib0062","doi-asserted-by":"crossref","first-page":"eade7280","DOI":"10.1126\/sciadv.ade7280","article-title":"Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation","volume":"9","author":"Huang","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.ard.2025.12.015_bib0063","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-213X-9-72","article-title":"ERG is required for the differentiation of embryonic stem cells along the endothelial lineage","volume":"9","author":"Nikolova-Krstevski","year":"2009","journal-title":"BMC Dev Biol"},{"key":"10.1016\/j.ard.2025.12.015_bib0064","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/s12891-016-1320-4","article-title":"Association of a rare NOTCH4 coding variant with systemic sclerosis: a family-based whole exome sequencing study","volume":"17","author":"Cardinale","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.ard.2025.12.015_bib0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3899\/jrheum.180094","article-title":"Associations of multiple NOTCH4 exonic variants with systemic sclerosis","volume":"46","author":"Zhou","year":"2019","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0066","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189498","article-title":"Gene-level association analysis of systemic sclerosis: a comparison of African-Americans and White populations","volume":"13","author":"Gorlova","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ard.2025.12.015_bib0067","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajhg.2013.12.002","article-title":"Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis","volume":"94","author":"Mayes","year":"2014","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0068","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/rheumatology\/key281","article-title":"Analysis of the genetic component of systemic sclerosis in Iranian and Turkish populations through a genome-wide association study","volume":"58","author":"Gonz\u00e1lez-Serna","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ard.2025.12.015_bib0069","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/annrheumdis-2018-214127","article-title":"Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases","volume":"78","author":"Acosta-Herrera","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0070","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1038\/s41467-019-12760-y","article-title":"GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways","volume":"10","author":"L\u00f3pez-Isac","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ard.2025.12.015_bib0071","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/s41598-020-58741-w","article-title":"A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn\u2019s disease","volume":"10","author":"Gonz\u00e1lez-Serna","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.ard.2025.12.015_bib0072","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jid.2020.07.039","article-title":"Exome-wide association analysis suggests LRP2BP as a susceptibility gene for endothelial injury in systemic sclerosis in the Han Chinese population","volume":"141","author":"Pu","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0073","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41467-023-44541-z","article-title":"GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcgamma receptor region","volume":"15","author":"Ishikawa","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ard.2025.12.015_bib0074","doi-asserted-by":"crossref","first-page":"eadt0539","DOI":"10.1126\/sciadv.adt0539","article-title":"Diversity and longitudinal records: genetic architecture of disease associations and polygenic risk in the Taiwanese Han population","volume":"11","author":"Liu","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.ard.2025.12.015_bib0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13073-018-0604-8","article-title":"Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations","volume":"10","author":"M\u00e1rquez","year":"2018","journal-title":"Genome Med"},{"key":"10.1016\/j.ard.2025.12.015_bib0076","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.3390\/ijms24044097","article-title":"Current trends in vascular biomarkers for systemic sclerosis: a narrative review","volume":"24","author":"Fioretto","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ard.2025.12.015_bib0077","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cei.13599","article-title":"Endothelial-to-mesenchymal transition in systemic sclerosis","volume":"205","author":"Di Benedetto","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ard.2025.12.015_bib0078","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1128\/MCB.02152-06","article-title":"Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation","volume":"27","author":"Wu","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ard.2025.12.015_bib0079","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/annrheumdis-2016-210229","article-title":"Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis","volume":"76","author":"Manetti","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ard.2025.12.015_bib0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41467-023-44645-6","article-title":"Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis","volume":"15","author":"Ma","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ard.2025.12.015_bib0081","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/CIRCRESAHA.123.323299","article-title":"Characterization of vascular niche in systemic sclerosis by spatial proteomics","volume":"134","author":"Rius Rigau","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.ard.2025.12.015_bib0082","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12931-022-01927-9","article-title":"Notch4 mediates vascular remodeling via ERK\/JNK\/P38 MAPK signaling pathways in hypoxic pulmonary hypertension","volume":"23","author":"Guo","year":"2022","journal-title":"Respir Res"},{"key":"10.1016\/j.ard.2025.12.015_bib0083","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1399-0004.2010.01596.x","article-title":"Molecular diagnosis in hereditary hemorrhagic telangiectasia: findings in a series tested simultaneously by sequencing and deletion\/duplication analysis","volume":"79","author":"McDonald","year":"2011","journal-title":"Clin Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0084","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/1523-1747.ep12555569","article-title":"Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia","volume":"95","author":"Braverman","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ard.2025.12.015_bib0085","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.semarthrit.2018.08.002","article-title":"Near-infrared spectroscopic imaging of the whole hand: a new tool to assess tissue perfusion and peripheral microcirculation in scleroderma","volume":"48","author":"Gargani","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.ard.2025.12.015_bib0086","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0140-6736(22)01692-0","article-title":"Systemic sclerosis","volume":"401","author":"Volkmann","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ard.2025.12.015_bib0087","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature06010","article-title":"A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene","volume":"448","author":"Hakonarson","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ard.2025.12.015_bib0088","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1093\/hmg\/dds225","article-title":"Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3","volume":"21","author":"Cipriani","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0089","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ajhg.2012.08.026","article-title":"Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans","volume":"91","author":"Morris","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ard.2025.12.015_bib0090","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1038\/s41467-021-26783-x","article-title":"Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4","volume":"12","author":"Grosche","year":"2021","journal-title":"Nat Commun"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725046096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496725046096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:35:01Z","timestamp":1782808501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496725046096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":91,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0003496725046096"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2025.12.015","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2025.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}