{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:45:30Z","timestamp":1786193130112,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,3]],"date-time":"2027-08-03T00:00:00Z","timestamp":1817251200000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI161022"],"award-info":[{"award-number":["R01 AI161022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AR079045"],"award-info":[{"award-number":["K01 AR079045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR073752"],"award-info":[{"award-number":["P30 AR073752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD028573"],"award-info":[{"award-number":["S10 OD028573"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR074992"],"award-info":[{"award-number":["P30 AR074992"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG077732"],"award-info":[{"award-number":["R01 AG077732"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ard.2026.02.014","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:49:35Z","timestamp":1773319775000},"page":"1656-1665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel murine model of early calcium pyrophosphate deposition disease based on the TNFRSF11B mutation mimics features of the human disease"],"prefix":"10.1016","volume":"85","author":[{"given":"Chun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Gohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mitton-Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arin K.","family":"Oestreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Veis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3911-2846","authenticated-orcid":false,"given":"Ann K.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mbalaviele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.ard.2026.02.014_bib0001","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1056\/NEJMra1511117","article-title":"Calcium pyrophosphate deposition disease","volume":"374","author":"Rosenthal","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ard.2026.02.014_bib0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/03008207.2010.491928","article-title":"Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK","volume":"52","author":"Costello","year":"2011","journal-title":"Connect Tissue Res"},{"issue":"5","key":"10.1016\/j.ard.2026.02.014_bib0003","doi-asserted-by":"crossref","first-page":"R154","DOI":"10.1186\/ar4337","article-title":"The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes","volume":"15","author":"Rosenthal","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.ard.2026.02.014_bib0004","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.24773","article-title":"Type II collagen levels correlate with mineralization by articular cartilage vesicles","volume":"60","author":"Jubeck","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"5477","key":"10.1016\/j.ard.2026.02.014_bib0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.289.5477.265","article-title":"Role of the mouse ank gene in control of tissue calcification and arthritis","volume":"289","author":"Ho","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ard.2026.02.014_bib0006","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.joca.2018.03.005","article-title":"Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease","volume":"26","author":"Williams","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.ard.2026.02.014_bib0007","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.ard.2026.02.014_bib0008","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/art.41678","article-title":"Effects of the TNFRSF11B mutation associated with calcium pyrophosphate deposition disease in osteoclastogenesis in a murine model","volume":"73","author":"Mitton-Fitzgerald","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"10.1016\/j.ard.2026.02.014_bib0009","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1136\/annrheumdis-2013-205149","article-title":"A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis","volume":"74","author":"Ramos","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.ard.2026.02.014_bib0010","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1136\/annrheumdis-2013-203400","article-title":"Association between low cortical bone mineral density, soft-tissue calcification, vascular calcification and chondrocalcinosis: a case-control study","volume":"73","author":"Abhishek","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.ard.2026.02.014_bib0011","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/art.42798","article-title":"Fractures in patients with acute calcium pyrophosphate crystal arthritis versus matched comparators in a large cohort study","volume":"76","author":"Tedeschi","year":"2024","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"10.1016\/j.ard.2026.02.014_bib0012","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00198-008-0701-4","article-title":"Association between iron overload and osteoporosis in patients with hereditary hemochromatosis","volume":"20","author":"Valenti","year":"2009","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.ard.2026.02.014_bib0013","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10534-021-00305-0","article-title":"An update on magnesium and bone health","volume":"34","author":"Rondanelli","year":"2021","journal-title":"Biometals"},{"issue":"10","key":"10.1016\/j.ard.2026.02.014_bib0014","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/jbmr.3226","article-title":"Hypophosphatasia in adults: clinical assessment and treatment considerations","volume":"32","author":"Shapiro","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"Suppl 8","key":"10.1016\/j.ard.2026.02.014_bib0015","article-title":"Subchondral bone and osteoarthritis: biological and cellular aspects","volume":"23","author":"Henrotin","year":"2012","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.ard.2026.02.014_bib0016","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/rheumatology\/keac539","article-title":"Type H vessels - a bridge connecting subchondral bone remodelling and articular cartilage degeneration in osteoarthritis development","volume":"62","author":"Liu","year":"2023","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"10.1016\/j.ard.2026.02.014_bib0017","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/art.1780340717","article-title":"Transforming growth factor \u03b21 stimulates inorganic pyrophosphate elaboration by porcine cartilage","volume":"34","author":"Rosenthal","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.ard.2026.02.014_bib0018","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jor.20331","article-title":"Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis","volume":"25","author":"Furman","year":"2007","journal-title":"J Orthop Res"},{"issue":"3","key":"10.1016\/j.ard.2026.02.014_bib0019","doi-asserted-by":"crossref","first-page":"e2153","DOI":"10.1038\/cddis.2016.58","article-title":"Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.ard.2026.02.014_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035979","article-title":"Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice","volume":"7","author":"Bonar","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ard.2026.02.014_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002427","article-title":"Excessive osteocytic FGF23 secretion contributes to pyrophosphate accumulation and mineralization defect in Hyp mice","volume":"14","author":"Murali","year":"2016","journal-title":"PLoS Biol"},{"issue":"8","key":"10.1016\/j.ard.2026.02.014_bib0022","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.bpj.2013.02.052","article-title":"Accumulation of exogenous activated TGF-\u03b2 in the superficial zone of articular cartilage","volume":"104","author":"Albro","year":"2013","journal-title":"Biophys J"},{"key":"10.1016\/j.ard.2026.02.014_bib0023","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-59745-401-8_18","article-title":"Generation of osteoclasts in vitro, and assay of osteoclast activity","volume":"135","author":"Takahashi","year":"2007","journal-title":"Methods Mol Med"},{"issue":"6","key":"10.1016\/j.ard.2026.02.014_bib0024","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/art.1780370624","volume":"37","author":"Terkeltaub","year":"1994","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.ard.2026.02.014_bib0025","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.joca.2021.01.006","article-title":"Optimization of histologic grading schemes in spontaneous and surgically-induced murine models of osteoarthritis","volume":"29","author":"Armstrong","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.ard.2026.02.014_bib0026","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1158\/1078-0432.CCR-22-1681","article-title":"ENPP1 immunobiology as a therapeutic target","volume":"29","author":"Ruiz-Fern\u00e1ndez de C\u00f3rdoba","year":"2023","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.ard.2026.02.014_bib0027","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/art.1780190116","article-title":"Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure","volume":"19","author":"Bennett","year":"1976","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.ard.2026.02.014_bib0028","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41419-023-05928-4","article-title":"Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis"},{"issue":"3","key":"10.1016\/j.ard.2026.02.014_bib0029","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00223-021-00866-9","article-title":"The bone cartilage interface and osteoarthritis","volume":"109","author":"Boyde","year":"2021","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"10.1016\/j.ard.2026.02.014_bib0030","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1172\/JCI70050","article-title":"Bone marrow mesenchymal stem cells and TGF-\u03b2 signaling in bone remodeling","volume":"124","author":"Crane","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ard.2026.02.014_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116868","article-title":"Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts","volume":"176","author":"Bourne","year":"2023","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.ard.2026.02.014_bib0032","doi-asserted-by":"crossref","first-page":"65","DOI":"10.11005\/jbm.2018.25.2.65","article-title":"Differential role of transforming growth factor-beta in an osteoarthritic or a healthy joint","volume":"25","author":"van der Kraan","year":"2018","journal-title":"J Bone Metab"},{"issue":"9","key":"10.1016\/j.ard.2026.02.014_bib0033","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.joca.2024.03.113","article-title":"Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis?","volume":"32","author":"Dvir-Ginzberg","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ard.2026.02.014_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2024.1429124","article-title":"Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models","volume":"18","author":"Obeidat","year":"2024","journal-title":"Front Neuroanat"},{"issue":"8","key":"10.1016\/j.ard.2026.02.014_bib0035","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1161\/CIRCRESAHA.116.307509","article-title":"The importance of biological sex and estrogen in rodent models of cardiovascular health and disease","volume":"118","author":"Blenck","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.ard.2026.02.014_bib0036","article-title":"The translational value of calcium pyrophosphate deposition disease experimental mouse models","volume":"11","author":"Luisetto","year":"2024","journal-title":"Front Med (Lausanne)"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726000890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726000890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:26:37Z","timestamp":1786191997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496726000890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0003496726000890"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2026.02.014","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel murine model of early calcium pyrophosphate deposition disease based on the TNFRSF11B mutation mimics features of the human disease","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2026.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}