{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:47:05Z","timestamp":1793278025659,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067677"],"award-info":[{"award-number":["UH2-AR067677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067676"],"award-info":[{"award-number":["UH2-AR067676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067679"],"award-info":[{"award-number":["UH2-AR067679"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067688"],"award-info":[{"award-number":["UH2-AR067688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-DK131482-01"],"award-info":[{"award-number":["RO1-DK131482-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067685"],"award-info":[{"award-number":["UH2-AR067685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19-AI144306-06"],"award-info":[{"award-number":["U19-AI144306-06"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067694"],"award-info":[{"award-number":["UH2-AR067694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067690"],"award-info":[{"award-number":["UH2-AR067690"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067681"],"award-info":[{"award-number":["UH2-AR067681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM2-AR067678"],"award-info":[{"award-number":["UM2-AR067678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067691"],"award-info":[{"award-number":["UH2-AR067691"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2-AR067689"],"award-info":[{"award-number":["UH2-AR067689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI1802222"],"award-info":[{"award-number":["R01-AI1802222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ard.2026.03.004","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:02:27Z","timestamp":1777406547000},"page":"1324-1340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression"],"prefix":"10.1016","volume":"85","author":[{"given":"Paul J.","family":"Hoover","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Eisenhaure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Hodgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Apruzzese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujal I.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haniya","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rollin","family":"Leavitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun W.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Danaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak A.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddarth","family":"Gurajala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine C.","family":"Berthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Horisberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Barnas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Izmirly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Michael","family":"Belmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Furie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Aranow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Guthridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dall\u2019Era","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wofsy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane L.","family":"Kamen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Kalunian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Payan-Schober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hildeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Steve","family":"Woodle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim","family":"Putterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kretzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Raychaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Anolik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Petri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill P.","family":"Buyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Hacohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-8203","authenticated-orcid":false,"given":"Arnon","family":"Arazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ard.2026.03.004_bib0001","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2215\/CJN.05780616","article-title":"Update on lupus nephritis","volume":"12","author":"Almaani","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"10.1016\/j.ard.2026.03.004_bib0002","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.34067\/KID.0000000000000230","article-title":"Management of lupus nephritis: new treatments and updated guidelines","volume":"4","author":"Avasare","year":"2023","journal-title":"Kidney360"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0003","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13075-024-03275-z","article-title":"Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network","volume":"26","author":"Izmirly","year":"2024","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.ard.2026.03.004_bib0004","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.kint.2017.11.023","article-title":"Revision of the International Society of Nephrology\/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices","volume":"93","author":"Bajema","year":"2018","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000389","article-title":"Prediction of prognosis and renal outcome in lupus nephritis","volume":"7","author":"Parodis","year":"2020","journal-title":"Lupus Sci Med"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0006","doi-asserted-by":"crossref","first-page":"122","DOI":"10.34067\/KID.0005512021","article-title":"Beyond ISN\/RPS lupus nephritis classification: adding chronicity index to clinical variables predicts kidney survival","volume":"3","author":"Moroni","year":"2022","journal-title":"Kidney360"},{"issue":"7","key":"10.1016\/j.ard.2026.03.004_bib0007","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/acr2.11269","article-title":"Renal mononuclear phagocytes in lupus nephritis","volume":"3","author":"Davidson","year":"2021","journal-title":"ACR Open Rheumatol"},{"issue":"10","key":"10.1016\/j.ard.2026.03.004_bib0008","doi-asserted-by":"crossref","first-page":"F1391","DOI":"10.1152\/ajprenal.00318.2013","article-title":"Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease","volume":"305","author":"Kassianos","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ard.2026.03.004_bib0009","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13075-016-0989-y","article-title":"CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis","volume":"18","author":"Olmes","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s40620-015-0252-7","article-title":"Role of renal expression of CD68 in the long-term prognosis of proliferative lupus nephritis","volume":"30","author":"Dias","year":"2017","journal-title":"J Nephrol"},{"issue":"7","key":"10.1016\/j.ard.2026.03.004_bib0011","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41590-019-0398-x","article-title":"The immune cell landscape in kidneys of patients with lupus nephritis","volume":"20","author":"Arazi","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ard.2026.03.004_bib0012","doi-asserted-by":"crossref","unstructured":"Gurajala S, Sugiarto N, Curtis M, Eisenhaure T, Arazi A, Fava A, et al. A population-scale atlas of blood and tissue in lupus nephritis. bioRxiv, 2025:2025.08.11.669754.","DOI":"10.1101\/2025.08.11.669754"},{"issue":"13","key":"10.1016\/j.ard.2026.03.004_bib68","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0013","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13059-019-1663-x","article-title":"PAGA: Graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells","volume":"20","author":"Wolf","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.ard.2026.03.004_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2026.03.022","article-title":"Organ injury in systemic autoimmunity is mediated by stem-like CD8+ T cells arising from tissue-draining lymph nodes","author":"Al Souz","year":"2026","journal-title":"Immunity"},{"issue":"6460","key":"10.1016\/j.ard.2026.03.004_bib0014","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.aat5031","article-title":"Spatiotemporal immune zonation of the human kidney","volume":"365","author":"Stewart","year":"2019","journal-title":"Science"},{"issue":"6335","key":"10.1016\/j.ard.2026.03.004_bib0015","doi-asserted-by":"crossref","first-page":"eaah4573","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.ard.2026.03.004_bib0016","first-page":"2822","article-title":"Serial renal biopsy in systemic lupus erythematosus","volume":"27","author":"Bajaj","year":"2000","journal-title":"J Rheumatol"},{"issue":"3","key":"10.1016\/j.ard.2026.03.004_bib0017","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.kint.2016.05.017","article-title":"A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis","volume":"90","author":"Anders","year":"2016","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0018","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2023-000932","article-title":"Remission of lupus nephritis: The trajectory of histological response in successfully treated patients","volume":"10","author":"Malvar","year":"2023","journal-title":"Lupus Sci Med"},{"issue":"7","key":"10.1016\/j.ard.2026.03.004_bib0019","doi-asserted-by":"crossref","first-page":"935","DOI":"10.34067\/KID.0000000000000161","article-title":"Non-full house membranous lupus nephritis represents a clinically distinct subset","volume":"4","author":"Ye","year":"2023","journal-title":"Kidney360"},{"key":"10.1016\/j.ard.2026.03.004_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fneph.2024.1417026","article-title":"Evidence based treatment for lupus nephritis: Present perspectives and challenges","volume":"4","author":"Xagas","year":"2024","journal-title":"Front Nephrol"},{"issue":"3","key":"10.1016\/j.ard.2026.03.004_bib0021","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41587-021-01066-4","article-title":"Co-varying neighborhood analysis identifies cell populations associated with phenotypes of interest from single-cell transcriptomics","volume":"40","author":"Reshef","year":"2022","journal-title":"Nat Biotechnol"},{"issue":"11","key":"10.1016\/j.ard.2026.03.004_bib0022","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20241873","article-title":"A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis","volume":"222","author":"Hoover","year":"2025","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.ard.2026.03.004_bib0025","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.4049\/jimmunol.1700148","article-title":"Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists","volume":"199","author":"Metcalf","year":"2017","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.ard.2026.03.004_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2025.01.002","article-title":"Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair","volume":"58","author":"De Ponti","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.ard.2026.03.004_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2025.152786","article-title":"CAR T-cell therapy in SLE: A systematic review","volume":"74","author":"Nordmann-Gomes","year":"2025","journal-title":"Semin Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.ard.2026.03.004_bib0026","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.4049\/jimmunol.1103324","article-title":"Lymphotoxin beta receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands","volume":"188","author":"Wimmer","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ard.2026.03.004_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156412","article-title":"BTLA and HVEM: Emerging players in the tumor microenvironment and cancer progression","volume":"172","author":"Mohamed","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.ard.2026.03.004_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1605948","article-title":"CD97\/ADGRE5 inhibits LPS induced NF-kappaB activation through PPAR-gamma upregulation in macrophages","volume":"2016","author":"Wang","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0029","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/antib13010024","article-title":"Anti-CD99 antibody therapy triggers macrophage-dependent ewing cell death in vitro and myeloid cell recruitment in vivo","volume":"13","author":"O'Neill","year":"2024","journal-title":"Antibodies (Basel)"},{"key":"10.1016\/j.ard.2026.03.004_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117638","article-title":"SEMA7A orchestrates the colorectal cancer tumor microenvironment via PlexinC1: Coordinating angiogenesis and macrophage M2 polarization","volume":"245","author":"Zhang","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ard.2026.03.004_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2018.12.027","article-title":"IL-16 regulates macrophage polarization as a target gene of mir-145\u20133p","volume":"107","author":"Huang","year":"2019","journal-title":"Mol Immunol"},{"key":"10.1016\/j.ard.2026.03.004_bib0032","article-title":"New aspects of kidney fibrosis-from mechanisms of injury to modulation of disease","volume":"8","author":"Moeller","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ard.2026.03.004_bib0033","article-title":"The role of parietal epithelial cells in the pathogenesis of podocytopathy","volume":"13","author":"Li","year":"2022","journal-title":"Front Physiol"},{"issue":"24","key":"10.1016\/j.ard.2026.03.004_bib0034","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1039\/C9AN01358J","article-title":"Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis","volume":"144","author":"Chen","year":"2019","journal-title":"Analyst"},{"issue":"9B","key":"10.1016\/j.ard.2026.03.004_bib0035","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1111\/j.1582-4934.2009.00766.x","article-title":"Tweak induces proliferation in renal tubular epithelium: A role in uninephrectomy induced renal hyperplasia","volume":"13","author":"Sanz","year":"2009","journal-title":"J Cell Mol Med"},{"issue":"9","key":"10.1016\/j.ard.2026.03.004_bib0036","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1172\/JCI23486","article-title":"TWEAK induces liver progenitor cell proliferation","volume":"115","author":"Jakubowski","year":"2005","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0037","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/cbin.11230","article-title":"TWEAK promotes hepatic stellate cell migration through activating EGFR\/Src and PI3K\/AKT pathways","volume":"44","author":"Zhang","year":"2020","journal-title":"Cell Biol Int"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0038","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12931-015-0207-5","article-title":"TWEAK enhances TGF-beta-induced epithelial-mesenchymal transition in human bronchial epithelial cells","volume":"16","author":"Itoigawa","year":"2015","journal-title":"Respir Res"},{"issue":"8","key":"10.1016\/j.ard.2026.03.004_bib0039","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.ajpath.2020.04.010","article-title":"Galectin-9 Is a novel regulator of epithelial restitution","volume":"190","author":"Robinson","year":"2020","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13075-018-1519-x","article-title":"A unique role for galectin-9 in angiogenesis and inflammatory arthritis","volume":"20","author":"O'Brien","year":"2018","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.ard.2026.03.004_bib0041","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1091\/mbc.11.7.2485","article-title":"Integrin alpha5\/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation","volume":"11","author":"Kuwada","year":"2000","journal-title":"Mol Biol Cell"},{"issue":"31","key":"10.1016\/j.ard.2026.03.004_bib0042","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1038\/sj.onc.1209460","article-title":"Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: Pro-oncogenic effects mediated by PI3-kinase and NF-kappa B","volume":"25","author":"Han","year":"2006","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.ard.2026.03.004_bib0043","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.3390\/ijms20112792","article-title":"Fibronectin promotes cell growth and migration in human renal cell carcinoma cells","volume":"20","author":"Ou","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"20","key":"10.1016\/j.ard.2026.03.004_bib0044","first-page":"5307","article-title":"Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer","volume":"59","author":"Carriero","year":"1999","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.ard.2026.03.004_bib0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/thoraxjnl-2011-200508","article-title":"Brightling CE, Sayers I. uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium","volume":"67","author":"Stewart","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.ard.2026.03.004_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.818616","article-title":"Modulation of cellular function by the urokinase receptor signalling: A mechanistic view","volume":"10","author":"Alfano","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.ard.2026.03.004_bib0047","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41419-018-0391-6","article-title":"The role of osteopontin in the progression of solid organ tumour","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0048","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4161\/cbt.10.1.12161","article-title":"Osteopontin but not osteonectin favors the metastatic growth of pancreatic cancer cell lines","volume":"10","author":"Zhivkova-Galunska","year":"2010","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0049","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12935-022-02749-x","article-title":"SPP1 facilitates cell migration and invasion by targeting COL11A1 in lung adenocarcinoma","volume":"22","author":"Yi","year":"2022","journal-title":"Cancer Cell Int"},{"issue":"2","key":"10.1016\/j.ard.2026.03.004_bib0050","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1080\/21655979.2021.2020391","article-title":"Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers","volume":"13","author":"Zeng","year":"2022","journal-title":"Bioengineered"},{"issue":"11","key":"10.1016\/j.ard.2026.03.004_bib0051","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.61.11.26","article-title":"COL8A2 regulates the fate of corneal endothelial cells","volume":"61","author":"Hwang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ard.2026.03.004_bib0052","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/bjc.2015.237","article-title":"Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma","volume":"113","author":"Yu","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ard.2026.03.004_bib0053","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.2147\/OTT.S237174","article-title":"Overexpression of GAS6 promotes cell proliferation and invasion in bladder cancer by activation of the PI3K\/AKT pathway","volume":"13","author":"Mao","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0054","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jcp.20265","article-title":"Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor","volume":"204","author":"Sainaghi","year":"2005","journal-title":"J Cell Physiol"},{"issue":"5","key":"10.1016\/j.ard.2026.03.004_bib0055","doi-asserted-by":"crossref","first-page":"L834","DOI":"10.1152\/ajplung.00031.2018","article-title":"DPP4 inhibition by sitagliptin attenuates LPS-induced lung injury in mice","volume":"315","author":"Kawasaki","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"22","key":"10.1016\/j.ard.2026.03.004_bib0056","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1111\/bph.15967","article-title":"Targeting cluster of differentiation 26 \/dipeptidyl peptidase 4 (CD26\/DPP4) in organ fibrosis","volume":"180","author":"Ohm","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ard.2026.03.004_bib0057","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.922644","article-title":"Sitagliptin inhibits extracellular matrix accumulation and proliferation in lung fibroblasts","volume":"26","author":"Liu","year":"2020","journal-title":"Med Sci Monit"},{"issue":"775","key":"10.1016\/j.ard.2026.03.004_bib0058","doi-asserted-by":"crossref","first-page":"eadl1666","DOI":"10.1126\/scitranslmed.adl1666","article-title":"Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells","volume":"16","author":"Danaher","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ard.2026.03.004_bib0070","doi-asserted-by":"crossref","unstructured":"Chirag Raparia, Paul Hoover, Junting Ai, Marcus Clark, Sujal Shah, Accelerating Medicines Partnership (AMP) RA\/SLE Network, betty diamond, Nir Hacohen, Arnon Arazi, Anne NMN Davidson. Spatially Distinct Macrophage Subsets Drive Myofibroblast Heterogeneity and Maladaptive Fibrosis in Lupus Nephritis. bioRxiv 2026.04.27.719870. https:\/\/doi.org\/10.64898\/2026.04.27.719870.","DOI":"10.64898\/2026.04.27.719870"},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0059","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1038\/s41467-022-31772-9","article-title":"Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration","volume":"13","author":"Balzer","year":"2022","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.ard.2026.03.004_bib0060","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41590-024-01792-2","article-title":"Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy","volume":"25","author":"Chen","year":"2024","journal-title":"Nat Immunol"},{"issue":"35","key":"10.1016\/j.ard.2026.03.004_bib0061","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304190120","article-title":"The spread of interferon-gamma in melanomas is highly spatially confined, driving nongenetic variability in tumor cells","volume":"120","author":"Centofanti","year":"2023","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.ard.2026.03.004_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2025.11.020","article-title":"Positioning and reversible suppression of CCR7(+) dendritic cells in perivascular tumor niches shape cancer immunity","volume":"59","author":"Zitti","year":"2026","journal-title":"Immunity"},{"issue":"21","key":"10.1016\/j.ard.2026.03.004_bib0063","doi-asserted-by":"crossref","DOI":"10.1172\/JCI192669","article-title":"Immune cell quantification of in situ inflammation partitions human lupus nephritis into mechanistic subtypes","volume":"135","author":"Casella","year":"2025","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.ard.2026.03.004_bib0064","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/s41590-025-02291-8","article-title":"Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease","volume":"26","author":"Sultana","year":"2025","journal-title":"Nat Immunol"},{"issue":"9","key":"10.1016\/j.ard.2026.03.004_bib0065","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1681\/ASN.2006010089","article-title":"Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys","volume":"17","author":"Sagrinati","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.ard.2026.03.004_bib0066","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1093\/rheumatology\/keae436","article-title":"Short- and long-term outcomes of patients with pure membranous lupus nephritis compared with patients with proliferative disease","volume":"64","author":"Kharouf","year":"2025","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"10.1016\/j.ard.2026.03.004_bib0067","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/rheumatology\/keaa103","article-title":"Outcomes of membranous and proliferative lupus nephritis - analysis of a single-centre cohort with more than 30 years of follow-up","volume":"59","author":"Farinha","year":"2020","journal-title":"Rheumatology (Oxford)"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726001494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726001494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:58:07Z","timestamp":1785887887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496726001494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0003496726001494"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2026.03.004","relation":{"has-preprint":[{"id-type":"doi","id":"10.64898\/2025.12.17.694954","asserted-by":"object"}]},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2026.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}