{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:52:35Z","timestamp":1791089555120,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["917183711"],"award-info":[{"award-number":["917183711"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["847551"],"award-info":[{"award-number":["847551"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ard.2026.05.005","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:20:32Z","timestamp":1780118432000},"page":"1942-1955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced lipolysis in synovial fibroblasts mark early pathogenic changes in RA-risk individuals"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8483-5539","authenticated-orcid":false,"given":"Marina","family":"Jim\u00e9nez-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke A.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Houtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna F.","family":"Semmelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Zelcer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen G.H.","family":"van de Sande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Dankers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.M.","family":"van Baarsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ard.2026.05.005_bib0001","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantapaa-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.ard.2026.05.005_bib0002","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/1529-0131(200012)43:12<2619::AID-ANR1>3.0.CO;2-V","article-title":"The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis","volume":"43","author":"Tak","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"5 Suppl 39","key":"10.1016\/j.ard.2026.05.005_bib0003","first-page":"S43","article-title":"The consequences of rheumatoid arthritis: quality of life measures in the individual patient","volume":"23","author":"Pollard","year":"2005","journal-title":"Clin Exp Rheumatol."},{"issue":"6","key":"10.1016\/j.ard.2026.05.005_bib0004","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/rheumatology\/keq424","article-title":"The long-term impact of early treatment of rheumatoid arthritis on radiographic progression: a population-based cohort study","volume":"50","author":"Kyburz","year":"2011","journal-title":"Rheumatology (Oxford)."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0005","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3899\/jrheum.130767","article-title":"Joint damage progression in patients with rheumatoid arthritis in clinical remission: do biologics perform better than synthetic antirheumatic drugs?","volume":"41","author":"Ciubotariu","year":"2014","journal-title":"J Rheumatol."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0006","first-page":"3758","article-title":"Can rheumatoid arthritis ever cease to exist: a review of various therapeutic modalities to maintain drug-free remission?","volume":"9","author":"Liu","year":"2017","journal-title":"Am J Transl Res."},{"issue":"2","key":"10.1016\/j.ard.2026.05.005_bib0007","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/1756-185X.13238","article-title":"Dosing down and then discontinuing biologic therapy in rheumatoid arthritis: a review of the literature","volume":"21","author":"Chen","year":"2018","journal-title":"Int J Rheum Dis."},{"issue":"4","key":"10.1016\/j.ard.2026.05.005_bib0008","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/rheumatology\/kev347","article-title":"Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment","volume":"55","author":"Gerlag","year":"2016","journal-title":"Rheumatology (Oxford)."},{"issue":"2","key":"10.1016\/j.ard.2026.05.005_bib0009","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0010","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/annrheumdis-2011-200990","article-title":"EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis","volume":"71","author":"Gerlag","year":"2012","journal-title":"Ann Rheum Dis."},{"issue":"9","key":"10.1016\/j.ard.2026.05.005_bib0011","first-page":"1282","article-title":"Rheumatoid factors antedating clinical rheumatoid arthritis","volume":"18","author":"Aho","year":"1991","journal-title":"J Rheumatol"},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0012","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/ard.2010.139527","article-title":"Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase","volume":"70","author":"van de Sande","year":"2011","journal-title":"Ann Rheum Dis."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0013","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/BOR.0000000000000356","article-title":"Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis","volume":"29","author":"England","year":"2017","journal-title":"Curr Opin Rheumatol."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0014","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/rheumatology\/keu287","article-title":"Strategies to predict rheumatoid arthritis development in at-risk populations","volume":"55","author":"Karlson","year":"2016","journal-title":"Rheumatology (Oxford)."},{"issue":"3","key":"10.1016\/j.ard.2026.05.005_bib0015","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/art.38273","article-title":"Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis","volume":"66","author":"de Hair","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ard.2026.05.005_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102923","article-title":"Synovial gene signatures associated with the development of rheumatoid arthritis in at risk individuals: a prospective study","volume":"133","author":"de Jong","year":"2022","journal-title":"J Autoimmun."},{"issue":"2","key":"10.1016\/j.ard.2026.05.005_bib0017","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000471","article-title":"Synovial fibroblasts in 2017","volume":"3","author":"Ospelt","year":"2017","journal-title":"RMD Open."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0018","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13059-021-02460-6","article-title":"Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability","volume":"22","author":"Ge","year":"2021","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.ard.2026.05.005_bib0019","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/er.2017-00211","article-title":"Metabolic flexibility as an adaptation to energy resources and requirements in health and disease","volume":"39","author":"Smith","year":"2018","journal-title":"Endocr Rev."},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrrheum.2017.37","article-title":"Metabolic regulation of inflammation","volume":"13","author":"Gaber","year":"2017","journal-title":"Nat Rev Rheumatol."},{"key":"10.1016\/j.ard.2026.05.005_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.725641","article-title":"Spontaneously resolving joint inflammation is characterised by metabolic agility of fibroblast-like synoviocytes","volume":"12","author":"Falconer","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.ard.2026.05.005_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102974","article-title":"Altered lipid metabolism in synovial fibroblasts of individuals at risk of developing rheumatoid arthritis","volume":"134","author":"de Jong","year":"2023","journal-title":"J Autoimmun."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0023","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"10.1016\/j.ard.2026.05.005_bib0024","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1634\/stemcells.2006-0504","article-title":"Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and\/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations","volume":"25","author":"Sudo","year":"2007","journal-title":"Stem Cells."},{"key":"10.1016\/j.ard.2026.05.005_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1431399","article-title":"Hypoxia inhibits osteogenesis and promotes adipogenesis of fibroblast-like synoviocytes via upregulation of leptin in patients with rheumatoid arthritis","volume":"2022","author":"Ding","year":"2022","journal-title":"J Immunol Res."},{"key":"10.1016\/j.ard.2026.05.005_bib0026","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2174\/1874312901105010100","article-title":"The normal synovium","volume":"5","author":"Smith","year":"2011","journal-title":"Open Rheumatol J."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0027","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41584-024-01202-9","article-title":"Impaired adipocyte-mediated regulation of fibroblasts in inflammatory arthritis","volume":"21","author":"Webster","year":"2025","journal-title":"Nat Rev Rheumatol."},{"issue":"6","key":"10.1016\/j.ard.2026.05.005_bib0028","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/physiolgenomics.00009.2019","article-title":"Computational deconvolution of synovial tissue cellular composition: presence of adipocytes in synovial tissue decreased during arthritis pathogenesis and progression","volume":"51","author":"Wang","year":"2019","journal-title":"Physiol Genomics."},{"issue":"6","key":"10.1016\/j.ard.2026.05.005_bib0029","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrrheum.2017.53","article-title":"Inflammation and fibrosis in adipose tissue of osteoarthritic joints","volume":"13","author":"Ioan-Facsinay","year":"2017","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0030","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1038\/s41467-024-52586-x","article-title":"Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis","volume":"15","author":"Faust","year":"2024","journal-title":"Nat Commun."},{"issue":"9","key":"10.1016\/j.ard.2026.05.005_bib0031","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ard.2026.05.005_bib0032","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/ard.2010.139550","article-title":"Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials","volume":"70","author":"van de Sande","year":"2011","journal-title":"Ann Rheum Dis."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0033","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/1529-0131(199808)41:8<1481::AID-ART19>3.0.CO;2-O","article-title":"Asymptomatic synovitis precedes clinically manifest arthritis","volume":"41","author":"Kraan","year":"1998","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.ard.2026.05.005_bib0034","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/ard.62.4.303","article-title":"Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints","volume":"62","author":"Smith","year":"2003","journal-title":"Ann Rheum Dis."},{"issue":"20","key":"10.1016\/j.ard.2026.05.005_bib0035","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA."},{"issue":"3","key":"10.1016\/j.ard.2026.05.005_bib0036","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/ard.2003.013276","article-title":"Activation of the STAT1 pathway in rheumatoid arthritis","volume":"63","author":"Kasperkovitz","year":"2004","journal-title":"Ann Rheum Dis."},{"issue":"19","key":"10.1016\/j.ard.2026.05.005_bib0037","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics."},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0038","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gr.213611.116","article-title":"Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly","volume":"27","author":"Schneider","year":"2017","journal-title":"Genome Res."},{"issue":"12","key":"10.1016\/j.ard.2026.05.005_bib0039","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"12","key":"10.1016\/j.ard.2026.05.005_bib0040","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/bioinformatics\/bty895","article-title":"Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences","volume":"35","author":"Zhu","year":"2019","journal-title":"Bioinformatics."},{"issue":"43","key":"10.1016\/j.ard.2026.05.005_bib0041","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0042","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS."},{"key":"10.1016\/j.ard.2026.05.005_bib0043","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"issue":"14","key":"10.1016\/j.ard.2026.05.005_bib0044","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1021\/jacs.1c10836","article-title":"Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes","volume":"144","author":"Grabner","year":"2022","journal-title":"J Am Chem Soc."},{"key":"10.1016\/j.ard.2026.05.005_bib0045","article-title":"Identification of stable reference genes for quantitative real-time PCR in human fibroblasts from lymph nodes and synovium","author":"Rasouli","year":"2024","journal-title":"bioRxiv"},{"issue":"7","key":"10.1016\/j.ard.2026.05.005_bib0046","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.tips.2018.03.010","article-title":"ER Stress: a therapeutic target in rheumatoid arthritis?","volume":"39","author":"Rahmati","year":"2018","journal-title":"Trends Pharmacol Sci."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0047","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3346\/jkms.2014.29.1.2","article-title":"Role of endoplasmic reticulum stress in rheumatoid arthritis pathogenesis","volume":"29","author":"Park","year":"2014","journal-title":"J Korean Med Sci."},{"issue":"6","key":"10.1016\/j.ard.2026.05.005_bib0048","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tem.2014.04.001","article-title":"PPARgamma and the global map of adipogenesis and beyond","volume":"25","author":"Lefterova","year":"2014","journal-title":"Trends Endocrinol Metab."},{"issue":"Pt 2","key":"10.1016\/j.ard.2026.05.005_bib0049","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/BJ20050636","article-title":"The G0\/G1 switch gene 2 is a novel PPAR target gene","volume":"392","author":"Zandbergen","year":"2005","journal-title":"Biochem J."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0050","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1128\/MCB.06154-11","article-title":"Peroxisome proliferator-activated receptor gamma-dependent regulation of lipolytic nodes and metabolic flexibility","volume":"32","author":"Rodriguez-Cuenca","year":"2012","journal-title":"Mol Cell Biol."},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0051","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4161\/cbt.28251","article-title":"Mice lacking G0S2 are lean and cold-tolerant","volume":"15","author":"Ma","year":"2014","journal-title":"Cancer Biol Ther."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0052","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","article-title":"Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors","volume":"9","author":"Bottini","year":"2013","journal-title":"Nat Rev Rheumatol."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0053","article-title":"RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts","volume":"12","author":"O'Byrne","year":"2026","journal-title":"RMD Open."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0054","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2016.62","article-title":"The unfolded protein response in immunity and inflammation","volume":"16","author":"Grootjans","year":"2016","journal-title":"Nat Rev Immunol."},{"issue":"12","key":"10.1016\/j.ard.2026.05.005_bib0055","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and aging","volume":"21","author":"Kaushik","year":"2015","journal-title":"Nat Med."},{"key":"10.1016\/j.ard.2026.05.005_bib0056","article-title":"The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis","volume":"10","author":"Barker","year":"2023","journal-title":"Front Med (Lausanne)."},{"key":"10.1016\/j.ard.2026.05.005_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102373","article-title":"The immunobiology of mTOR in autoimmunity","volume":"110","author":"Suto","year":"2020","journal-title":"J Autoimmun"},{"issue":"3","key":"10.1016\/j.ard.2026.05.005_bib0058","first-page":"435","article-title":"Lipid droplets and the management of cellular stress","volume":"92","author":"Jarc","year":"2019","journal-title":"Yale J Biol Med."},{"issue":"5","key":"10.1016\/j.ard.2026.05.005_bib0059","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.201311051","article-title":"Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites","volume":"204","author":"Pol","year":"2014","journal-title":"J Cell Biol."},{"issue":"5700","key":"10.1016\/j.ard.2026.05.005_bib0060","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science."},{"issue":"3","key":"10.1016\/j.ard.2026.05.005_bib0061","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cmet.2010.02.003","article-title":"The G(0)\/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase","volume":"11","author":"Yang","year":"2010","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.ard.2026.05.005_bib0062","doi-asserted-by":"crossref","DOI":"10.1111\/1756-185X.70138","article-title":"The evaluation of PNPLA2, ATGL, and G0S2 levels in serum and PBMCs of the newly diagnosed and the chronic patients with rheumatoid arthritis","volume":"28","author":"Gholizadeh","year":"2025","journal-title":"Int J Rheum Dis."},{"issue":"7","key":"10.1016\/j.ard.2026.05.005_bib0063","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/cdd.2014.26","article-title":"G0\/G1 switch gene 2 has a critical role in adipocyte differentiation","volume":"21","author":"Choi","year":"2014","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.ard.2026.05.005_bib0064","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2337\/db13-1422","article-title":"Targeted disruption of G0\/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ard.2026.05.005_bib0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The biochemistry and physiology of mitochondrial fatty acid \u03b2-oxidation and its genetic disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu Rev Physiol."},{"issue":"2","key":"10.1016\/j.ard.2026.05.005_bib0066","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.yexcr.2017.03.032","article-title":"Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts","volume":"354","author":"Akoumi","year":"2017","journal-title":"Exp Cell Res."},{"issue":"10","key":"10.1016\/j.ard.2026.05.005_bib0067","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.2174\/138920012803762729","article-title":"Fatty acids - induced lipotoxicity and inflammation","volume":"13","author":"Savary","year":"2012","journal-title":"Curr Drug Metab."},{"issue":"1","key":"10.1016\/j.ard.2026.05.005_bib0068","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2009.03.011","article-title":"As a matter of fat","volume":"10","author":"Brookheart","year":"2009","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0069","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1194\/jlr.R067595","article-title":"The role of ER stress in lipid metabolism and lipotoxicity","volume":"57","author":"Han","year":"2016","journal-title":"J Lipid Res."},{"issue":"12","key":"10.1016\/j.ard.2026.05.005_bib0070","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1194\/jlr.R066514","article-title":"Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment","volume":"57","author":"Ertunc","year":"2016","journal-title":"J Lipid Res."},{"issue":"10","key":"10.1016\/j.ard.2026.05.005_bib0071","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2010.07.004","article-title":"Rheumatoid arthritis progression mediated by activated synovial fibroblasts","volume":"16","author":"Neumann","year":"2010","journal-title":"Trends Mol Med."},{"issue":"suppl_2","key":"10.1016\/j.ard.2026.05.005_bib0072","doi-asserted-by":"crossref","first-page":"ii64","DOI":"10.1093\/rheumatology\/kew347","article-title":"Stable activation of fibroblasts in rheumatic arthritis\u2014causes and consequences","volume":"55","author":"Korb-Pap","year":"2016","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"10.1016\/j.ard.2026.05.005_bib0073","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/art.10556","article-title":"Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment","volume":"46","author":"Kraan","year":"2002","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.ard.2026.05.005_bib0074","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s12276-022-00725-z","article-title":"Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis","volume":"54","author":"Koh","year":"2022","journal-title":"Exp Mol Med."},{"issue":"7","key":"10.1016\/j.ard.2026.05.005_bib0075","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/ard.2009.122374","article-title":"Total cholesterol and LDL levels decrease before rheumatoid arthritis","volume":"69","author":"Myasoedova","year":"2010","journal-title":"Ann Rheum Dis."},{"issue":"11","key":"10.1016\/j.ard.2026.05.005_bib0076","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1136\/annrheumdis-2012-201709","article-title":"Dyslipidaemia in patients with seropositive arthralgia predicts the development of arthritis","volume":"71","author":"van de Stadt","year":"2012","journal-title":"Ann Rheum Dis."}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726002815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726002815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:10:18Z","timestamp":1791087018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496726002815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0003496726002815"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2026.05.005","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced lipolysis in synovial fibroblasts mark early pathogenic changes in RA-risk individuals","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2026.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}