{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:37:41Z","timestamp":1786113461354,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017239","name":"BeiGene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ard.2026.06.020","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:01:49Z","timestamp":1784088109000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zanubrutinib monotherapy for IgG4-related head and neck disease"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-1907","authenticated-orcid":false,"given":"Matthew C","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Gawde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra","family":"Horomanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Fairchild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem","family":"Mikelov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariani","family":"Deluna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter G","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haziq","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachi","family":"Bopardikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Khalighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L","family":"Franc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrudula","family":"Penta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvesh","family":"Khatri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kip E","family":"Guja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias V","family":"Lanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ard.2026.06.020_bib0001","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"366","author":"Stone","year":"2012","journal-title":"N Engl J Med."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0002","article-title":"Current and future advances in practice: IgG4-related disease","volume":"8","author":"Wallace","year":"2024","journal-title":"Rheumatol Adv Pract."},{"key":"10.1016\/j.ard.2026.06.020_bib0003","doi-asserted-by":"crossref","first-page":"m1067","DOI":"10.1136\/bmj.m1067","article-title":"Advances in the diagnosis and management of IgG4 related disease","volume":"369","author":"Lanzillotta","year":"2020","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0004","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/25785826.2024.2430812","article-title":"Clinical profile of IgG4-related disease in Japan based on the rare disease data registry","volume":"48","author":"Yamamoto","year":"2025","journal-title":"Immunol Med."},{"issue":"7","key":"10.1016\/j.ard.2026.06.020_bib0005","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/ard-2023-223950","article-title":"Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured adults","volume":"82","author":"Wallace","year":"2023","journal-title":"Ann Rheum Dis."},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0006","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1093\/rheumatology\/keae243","article-title":"Increased prevalence of malignancies in patients with IgG4-related disease: implications for clinical care","volume":"64","author":"Keller-Sarmiento","year":"2025","journal-title":"Rheumatology (Oxford)."},{"issue":"10","key":"10.1016\/j.ard.2026.06.020_bib0007","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/ajg.2014.223","article-title":"Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort","volume":"109","author":"Huggett","year":"2014","journal-title":"Am J Gastroenterol."},{"issue":"7","key":"10.1016\/j.ard.2026.06.020_bib0008","first-page":"1277","article-title":"The co-occurrence of IgG4-related disease and malignancy: insights from a prospective cohort study","volume":"43","author":"Guo","year":"2025","journal-title":"Clin Exp Rheumatol."},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0009","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaci.2014.03.034","article-title":"De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease","volume":"134","author":"Mattoo","year":"2014","journal-title":"J Allergy Clin Immunol."},{"issue":"1","key":"10.1016\/j.ard.2026.06.020_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/annrheumdis-2013-204907","article-title":"The diagnostic utility of serum IgG4 concentrations in IgG4-related disease","volume":"74","author":"Carruthers","year":"2015","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/j.ard.2026.06.020_bib0011","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-pathol-012513-104708","article-title":"IgG4-related disease","volume":"9","author":"Mahajan","year":"2014","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"10.1016\/j.ard.2026.06.020_bib0012","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","article-title":"Consensus statement on the pathology of IgG4-related disease","volume":"25","author":"Deshpande","year":"2012","journal-title":"Mod Pathol."},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0013","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jaci.2015.12.1330","article-title":"Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease","volume":"138","author":"Mattoo","year":"2016","journal-title":"J Allergy Clin Immunol."},{"issue":"1","key":"10.1016\/j.ard.2026.06.020_bib0014","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jaci.2020.05.022","article-title":"CD4(+) and CD8(+) cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG(4)-related disease","volume":"147","author":"Perugino","year":"2021","journal-title":"J Allergy Clin Immunol."},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2019.07.004","article-title":"B lymphocytes directly contribute to tissue fibrosis in patients with IgG(4)-related disease","volume":"145","author":"Della-Torre","year":"2020","journal-title":"J Allergy Clin Immunol."},{"issue":"6","key":"10.1016\/j.ard.2026.06.020_bib0016","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/annrheumdis-2014-206605","article-title":"Rituximab for IgG4-related disease: a prospective, open-label trial","volume":"74","author":"Carruthers","year":"2015","journal-title":"Ann Rheum Dis."},{"issue":"12","key":"10.1016\/j.ard.2026.06.020_bib0017","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1056\/NEJMoa2409712","article-title":"Inebilizumab for treatment of IgG4-related disease","volume":"391","author":"Stone","year":"2025","journal-title":"N Engl J Med."},{"issue":"7","key":"10.1016\/j.ard.2026.06.020_bib0018","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.4169","article-title":"Association of immunoglobulin levels, infectious risk, and mortality with rituximab and hypogammaglobulinemia","volume":"1","author":"Barmettler","year":"2018","journal-title":"JAMA Netw Open."},{"issue":"6","key":"10.1016\/j.ard.2026.06.020_bib0019","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11926-015-0513-4","article-title":"The prediction and monitoring of toxicity associated with long-term systemic glucocorticoid therapy","volume":"17","author":"Harris","year":"2015","journal-title":"Curr Rheumatol Rep."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0020","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/mr\/roac097","article-title":"Glucocorticoids in the treatment of IgG4-related disease-Prospects for new international treatment guidelines","volume":"33","author":"Yoshifuji","year":"2023","journal-title":"Mod Rheumatol."},{"issue":"4","key":"10.1016\/j.ard.2026.06.020_bib0021","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/rheumatology\/kez380","article-title":"Glucocorticoids and steroid sparing medications monotherapies or in combination for IgG4-RD: a systematic review and network meta-analysis","volume":"59","author":"Omar","year":"2020","journal-title":"Rheumatology (Oxford)."},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0022","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00296-026-06083-7","article-title":"Azathioprine as maintenance therapy for IgG4-related diseases: a retrospective case series and case-based review of the literature","volume":"46","author":"Reisch","year":"2026","journal-title":"Rheumatol Int."},{"issue":"1","key":"10.1016\/j.ard.2026.06.020_bib0023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5152\/ArchRheumatol.2026.25136","article-title":"Comparison of efficacy and safety of different medication protocols in patients with immunoglobulin G4-related disease based on follow-up time: a systematic review and network meta-analysis","volume":"41","author":"Liu","year":"2026","journal-title":"Arch Rheumatol."},{"issue":"8","key":"10.1016\/j.ard.2026.06.020_bib0024","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tips.2024.06.006","article-title":"BTK inhibitors: past, present, and future","volume":"45","author":"Cool","year":"2024","journal-title":"Trends Pharmacol Sci."},{"key":"10.1016\/j.ard.2026.06.020_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1130595","article-title":"Zanubrutinib for the treatment of lymphoid malignancies: current status and future directions","volume":"13","author":"Wolska-Washer","year":"2023","journal-title":"Front Oncol"},{"issue":"8","key":"10.1016\/j.ard.2026.06.020_bib0026","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S2665-9913(23)00184-4","article-title":"Obexelimab in IgG4-related disease: B-cell inhibition as a novel therapeutic approach","volume":"5","author":"Alexander","year":"2023","journal-title":"Lancet Rheumatol."},{"issue":"1","key":"10.1016\/j.ard.2026.06.020_bib0027","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.41120","article-title":"The 2019 American College of Rheumatology\/European League Against Rheumatism classification criteria for IgG4-related disease","volume":"72","author":"Wallace","year":"2020","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.ard.2026.06.020_bib0028","first-page":"3974","article-title":"Conventional MRI techniques combined with MR sialography on T2-3D-DRIVE in Sjogren syndrome","volume":"8","author":"Ren","year":"2015","journal-title":"Int J Clin Exp Med."},{"key":"10.1016\/j.ard.2026.06.020_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/417052","article-title":"Magnetic resonance sialography findings of submandibular ducts imaging","volume":"2013","author":"Karaca Erdogan","year":"2013","journal-title":"Biomed Res Int."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0030","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2020-001516","article-title":"Application of the OMERACT grey-scale ultrasound scoring system for salivary glands in a single-centre cohort of patients with suspected Sjogren\u2019s syndrome","volume":"7","author":"Fana","year":"2021","journal-title":"RMD Open."},{"issue":"8","key":"10.1016\/j.ard.2026.06.020_bib0031","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1093\/rheumatology\/keab876","article-title":"Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjogren\u2019s syndrome: an OMERACT reliability exercise","volume":"61","author":"Hocevar","year":"2022","journal-title":"Rheumatology (Oxford)."},{"issue":"D1","key":"10.1016\/j.ard.2026.06.020_bib0032","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.ard.2026.06.020_bib0033","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17602-9","article-title":"High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease","volume":"7","author":"Higgs","year":"2017","journal-title":"Sci Rep."},{"issue":"10","key":"10.1016\/j.ard.2026.06.020_bib0034","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1136\/ard-2023-224363","article-title":"Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease","volume":"82","author":"Li","year":"2023","journal-title":"Ann Rheum Dis."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0035","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/annrheumdis-2016-209139","article-title":"Lesional CD4+ IFN-gamma+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis","volume":"76","author":"Maehara","year":"2017","journal-title":"Ann Rheum Dis."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2022.03.034","article-title":"Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG(4)-related disease and Kimura disease","volume":"150","author":"Munemura","year":"2022","journal-title":"J Allergy Clin Immunol."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2023.08.019","article-title":"Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD","volume":"153","author":"Aoyagi","year":"2024","journal-title":"J Allergy Clin Immunol."},{"issue":"1","key":"10.1016\/j.ard.2026.06.020_bib0038","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201800050","article-title":"The expansion in lymphoid organs of IL-4(+) BATF(+) T follicular helper cells is linked to IgG4 class switching in vivo","volume":"1","author":"Maehara","year":"2018","journal-title":"Life Sci Alliance."},{"key":"10.1016\/j.ard.2026.06.020_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.651357","article-title":"Peripheral TIGIT+ T follicular helper cells that produce high levels of interleukin-21 via OX40 represent disease activity in IgG4-related disease","volume":"12","author":"Akiyama","year":"2021","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.ard.2026.06.020_bib0040","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jaci.2023.11.916","article-title":"Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease","volume":"153","author":"Koga","year":"2024","journal-title":"J Allergy Clin Immunol."},{"issue":"17","key":"10.1016\/j.ard.2026.06.020_bib0041","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167602","article-title":"Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease","volume":"8","author":"Lu","year":"2023","journal-title":"JCI Insight."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0042","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/MPA.0b013e3181577553","article-title":"Circulating naive and CD4+CD25 high regulatory T cells in patients with autoimmune pancreatitis","volume":"36","author":"Miyoshi","year":"2008","journal-title":"Pancreas."},{"issue":"5","key":"10.1016\/j.ard.2026.06.020_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2017.07.024","article-title":"Expansion of blood IgG(4)(+) B, T(H)2, and regulatory T cells in patients with IgG(4)-related disease","volume":"141","author":"Heeringa","year":"2018","journal-title":"J Allergy Clin Immunol."},{"key":"10.1016\/j.ard.2026.06.020_bib0044","first-page":"suppl 9","article-title":"Treatment with Rilzabrutinib was associated with rapid and sustained reduction in disease activity in patients with IgG4-RD previously treated or na\u00efve to B cell depletion","volume":"77","author":"Stone","year":"2025","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.ard.2026.06.020_bib0045","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/mr\/roac098","article-title":"B-Cell depletion therapy in IgG4-related disease: state of the art and future perspectives","volume":"33","author":"Lanzillotta","year":"2023","journal-title":"Mod Rheumatol."},{"issue":"16","key":"10.1016\/j.ard.2026.06.020_bib0046","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172335","article-title":"A phase II study of Bruton\u2019s tyrosine kinase inhibition for the prevention of anaphylaxis","volume":"133","author":"Suresh","year":"2023","journal-title":"J Clin Invest."}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726003675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496726003675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:30:22Z","timestamp":1785958222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496726003675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"alternative-id":["S0003496726003675"],"URL":"https:\/\/doi.org\/10.1016\/j.ard.2026.06.020","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zanubrutinib monotherapy for IgG4-related head and neck disease","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ard.2026.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}]}}