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Soc."},{"key":"10.1016\/j.arr.2011.06.005_bib0350","doi-asserted-by":"crossref","unstructured":"Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J.C., Carrasquillo, M.M., Abraham, R., Hamshere, M.L., Pahwa, J.S., Moskvina, V., Dowzell, K., Jones, N., Stretton, A., Thomas, C., Richards, A., Ivanov, D., Widdowson, C., Chapman, J., Lovestone, S., Powell, J., Proitsi, P., Lupton, M.K., Brayne, C., Rubinsztein, D.C., Gill, M., Lawlor, B., Lynch, A., Brown, K.S., Passmore, P.A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., Smith, A.D., Beaumont, H., Warden, D., Wilcock, G., Love, S., Kehoe, P.G., Hooper, N.M., Vardy, E.R., Hardy, J., Mead, S., Fox, N.C., Rossor, M., Collinge, J., Maier, W., Jessen, F., R\u00fcther, E., Sch\u00fcrmann, B., Heun, R., K\u00f6lsch, H., van den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Fr\u00f6lich, L., Hampel, H., Gallacher, J., H\u00fcll, M., Rujescu, D., Giegling, I., Goate, A.M., Kauwe, J.S., Cruchaga, C., Nowotny, P., Morris, J.C., Mayo, K., Sleegers, K., Bettens, K., Engelborghs, S., De Deyn, P.P., Van Broeckhoven, C., Livingston, G., Bass, N.J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C.E., Tsolaki, M., Singleton, A.B., Guerreiro, R., M\u00fchleisen, T.W., N\u00f6then, M.M., Moebus, S., J\u00f6ckel, K.H., Klopp, N., Wichmann, H.E., Pankratz, V.S., Sando, S.B., Aasly, J.O., Barcikowska, M., Wszolek, Z.K., Dickson, D.W., Graff-Radford, N.R., Petersen, R.C., the Alzheimer's Disease Neuroimaging Initiative, van Duijn, C.M., Breteler, M.M., Ikram, M.A., Destefano, A.L., Fitzpatrick, A.L., Lopez, O., Launer, L.J., Seshadri, S., CHARGE Consortium, Berr, C., Campion, D., Epelbaum, J., Dartigues, J.F., Tzourio, C., Alp\u00e9rovitch, A., Lathrop, M., EADI1 Consortium, Feulner, T.M., Friedrich, P., Riehle, C., Krawczak, M., Schreiber, S., Mayhaus, M., Nicolhaus, S., Wagenpfeil, S., Steinberg, S., Stefansson, H., Stefansson, K., Sn\u00e6dal, J., Bj\u00f6rnsson, S., Jonsson, P.V., Chouraki, V., Genier-Boley, B., Hiltunen, M., Soininen, H., Combarros, O., Zelenika, D., Delepine, M., Bullido, M.J., Pasquier, F., Mateo, I., Frank-Garcia, A., Porcellini, E., Hanon, O., Coto, E., Alvarez, V., Bosco, P., Siciliano, G., Mancuso, M., Panza, F., Solfrizzi, V., Nacmias, B., Sorbi, S., Boss\u00f9, P., Piccardi, P., Arosio, B., Annoni, G., Seripa, D., Pilotto, A., Scarpini, E,. Galimberti, D., Brice, A., Hannequin, D., Licastro, F., Jones, L., Holmans, P.A., Jonsson, T., Riemenschneider, M., Morgan, K., Younkin, S.G., Owen, M.J., O\u2019Donovan, M., Amouyel, P., Williams, J., 2011. Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 43, 429\u2013435.","DOI":"10.1038\/ng.803"},{"key":"10.1016\/j.arr.2011.06.005_bib0355","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/jnnp.61.6.580","article-title":"Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease","volume":"61","author":"Holmes","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0360","first-page":"273","article-title":"Reply","volume":"63","author":"Holmes","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0365","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0006-3223(97)00326-0","article-title":"Apolipoprotein E: depressive illness, depressive symptoms and Alzheimer's disease","volume":"43","author":"Holmes","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0370","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.biopsych.2004.11.035","article-title":"Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression","volume":"57","author":"Holthoff","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0375","first-page":"146","article-title":"Dementia associated mental and behavioral disturbances in elderly people in the community: finding from the first Nakayama study","volume":"75","author":"Ikeda","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0380","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archpsyc.65.8.906","article-title":"Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study","volume":"65","author":"Irie","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0385","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jamda.2009.03.007","article-title":"Apathy: a common psychiatric syndrome in the elderly","volume":"10","author":"Ishii","year":"2009","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.arr.2011.06.005_bib0390","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00019442-200002000-00004","article-title":"Psychosis of Alzheimer's disease and related dementias. Diagnostic criteria for a distinct syndrome","volume":"8","author":"Jeste","year":"2000","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0395","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/0891988706291087","article-title":"Research agenda for DSM-V: diagnostic categories and criteria for neuropsychiatric syndromes in dementia","volume":"19","author":"Jeste","year":"2006","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.arr.2011.06.005_bib0400","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(99)00323-7","article-title":"Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease","volume":"267","author":"Kanai","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2011.06.005_bib0405","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM\u2013IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0410","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/hup.466","article-title":"Differences in behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable?","volume":"18","author":"Kim","year":"2003","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.arr.2011.06.005_bib0415","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4306\/pi.2010.7.2.135","article-title":"Apolipoprotein e4 genotype and depressive symptoms as risk factors for dementia in an older korean population","volume":"7","author":"Kim","year":"2010","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.arr.2011.06.005_bib0420","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-3223(95)00424-6","article-title":"Apolipoprotein E-\u025b4 frequency in geriatric depression","volume":"40","author":"Krishnan","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0425","doi-asserted-by":"crossref","unstructured":"Lambert, J.C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M.J., Tavernier, B., Letenneur, L., Bettens, K., Berr, C., Pasquier, F., Fi\u00e9vet, N., Barberger-Gateau, P., Engelborghs, S., De Deyn, P., Mateo, I., Franck, A., Helisalmi, S., Porcellini, E., Hanon, O., European Alzheimer's Disease Initiative Investigators, de Pancorbo, M.M., Lendon, C., Dufouil, C., Jaillard, C., Leveillard, T., Alvarez, V., Bosco, P., Mancuso, M., Panza, F., Nacmias, B., Boss\u00f9, P., Piccardi, P., Annoni, G., Seripa, D., Galimberti, D., Hannequin, D., Licastro, F., Soininen, H., Ritchie, K., Blanch\u00e9, H., Dartigues, J.F., Tzourio, C., Gut, I., Van Broeckhoven, C., Alp\u00e9rovitch, A., Lathrop, M., Amouyel, P., 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 41, 1094\u20131099.","DOI":"10.1038\/ng.439"},{"key":"10.1016\/j.arr.2011.06.005_bib0430","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1046\/j.1532-5415.2001.49282.x","article-title":"Apathy in Alzheimer's disease","volume":"49","author":"Landes","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2011.06.005_bib0435","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3928\/0048-5713-19901001-07","article-title":"Serotonin and Alzheimer's disease","volume":"20","author":"Lawlor","year":"1990","journal-title":"Psychiatric Ann."},{"key":"10.1016\/j.arr.2011.06.005_bib0440","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1176\/appi.neuropsych.15.1.78","article-title":"Influence of the apolipoprotein E type 4 allele on cerebral glucose metabolism in Alzheimer's disease patients","volume":"15","author":"Lee","year":"2003","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.arr.2011.06.005_bib0445","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.46.2.413","article-title":"Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism","volume":"46","author":"Lehtovirta","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2011.06.005_bib0450","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/jnnp.60.6.644","article-title":"SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E e4 allele","volume":"60","author":"Lehtovirta","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0455","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1001\/archneur.1996.00550070129021","article-title":"Alzheimer disease and frontotemporal dementias. Behavioral distinctions","volume":"53","author":"Levy","year":"1996","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2011.06.005_bib0460","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1176\/jnp.10.3.314","article-title":"Apathy is not depression","volume":"10","author":"Levy","year":"1998","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.arr.2011.06.005_bib0465","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0006-3223(98)00041-9","article-title":"Apolipoprotein E genotype and noncognitive symptoms in Alzheimer's disease","volume":"45","author":"Levy","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0470","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/jnnp.66.2.177","article-title":"Are sex and educational level independent predictors of dementia and Alzheimer's disease? Incidence data from the PAQUID project","volume":"66","author":"Letenneur","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0475","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/089198870201500105","article-title":"Lack of association between the ApoE genotype and depression in Alzheimer's disease","volume":"15","author":"Liu","year":"2002","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.arr.2011.06.005_bib0480","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/WNL.53.4.670","article-title":"Differentiation of vascular dementia from AD on neuropsychological tests","volume":"53","author":"Looi","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2011.06.005_bib0485","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1212\/WNL.49.3.794","article-title":"The apolipoprotein E epsilon 4 allele is not associated with psychotic symptoms or extrapyramidal signs in probable Alzheimer's disease","volume":"49","author":"Lopez","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2011.06.005_bib0490","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/sj.mp.4002088","article-title":"Meta-analyses of genetic studies on major depressive disorder","volume":"13","author":"L\u00f3pez-Le\u00f3n","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0495","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1176\/jnp.9.1.64","article-title":"Depression, delusions, and hallucinations in Alzheimer's disease: no relationship to apolipoprotein E genotype","volume":"9","author":"Lyketsos","year":"1997","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.arr.2011.06.005_bib0500","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1176\/appi.ajp.157.5.708","article-title":"Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging","volume":"157","author":"Lyketsos","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0505","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study","volume":"288","author":"Lyketsos","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2011.06.005_bib0510","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1176\/jnp.3.3.243","article-title":"Apathy: a neuropsychiatric syndrome","volume":"3","author":"Marin","year":"1991","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.arr.2011.06.005_bib0515","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.neuro.26.043002.094919","article-title":"Epidemiology of neurodegeneration","volume":"26","author":"Mayeux","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.arr.2011.06.005_bib0520","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1212\/WNL.53.6.1308","article-title":"APOE genotype as a risk factor for ischemic cerebrovascular disease","volume":"53","author":"McCarron","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2011.06.005_bib0525","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/archneur.55.7.1001","article-title":"Apolipoprotein E genotype and deposits of Ab40 and Ab42 in Alzheimer disease","volume":"55","author":"McNamara","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2011.06.005_bib0530","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S1355617702813182","article-title":"Apathy and executive function in Alzheimer's disease","volume":"8","author":"McPherson","year":"2002","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.arr.2011.06.005_bib0535","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1212\/WNL.46.1.130","article-title":"The spectrum of behavioral changes in Alzheimer's disease","volume":"46","author":"Mega","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2011.06.005_bib0540","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1471-4159.2000.0741008.x","article-title":"Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture","volume":"74","author":"Michikawa","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2011.06.005_bib0545","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1006\/nimg.2000.0741","article-title":"Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients","volume":"13","author":"Migneco","year":"2001","journal-title":"Neuroimage"},{"issue":"Suppl. 7","key":"10.1016\/j.arr.2011.06.005_bib0550","first-page":"55","article-title":"Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: toward a treatment approach","volume":"57","author":"Mintzer","year":"1996","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0555","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0447.2005.00597.x","article-title":"Association between apolipoprotein E epsilon4 allele and apathy in probable Alzheimer's disease","volume":"3","author":"Monastero","year":"2006","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.arr.2011.06.005_bib0560","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1212\/01.WNL.0000036904.73393.E4","article-title":"The incremental direct costs associated with behavioral symptoms in AD","volume":"59","author":"Murman","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2011.06.005_bib0565","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000064926","article-title":"Depression in Alzheimer's disease might be associated with apolipoprotein E e4 allele: frequency in women but not in men","volume":"14","author":"M\u00fcller-Thomsen","year":"2002","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.arr.2011.06.005_bib0570","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00019442-199700510-00012","article-title":"The apolipoprotein E epsilon 4 allele is associated with increased behavioral disturbance in Alzheimer's disease","volume":"5","author":"Murphy","year":"1997","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0575","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ajmg.b.30295","article-title":"The fourth apolipoprotein E haplotype found in the Yoruba of Ibadan","volume":"141B","author":"Murrell","year":"2006","journal-title":"Am. J. Med. Genet. B: Neuropsychiatr. Genet."},{"key":"10.1016\/j.arr.2011.06.005_bib0580","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0006-3223(01)01114-3","article-title":"Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer's disease","volume":"50","author":"Nacmias","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0585","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.arr.2011.06.005_bib0590","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/jnnp.74.10.1398","article-title":"A study of stereotypic behaviours in Alzheimer's disease and frontal and temporal variant frontotemporal dementia","volume":"74","author":"Nyatsanza","year":"2003","journal-title":"J. Neurol. Neurosurg. 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Aging"},{"key":"10.1016\/j.arr.2011.06.005_bib0610","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/JGP.0b013e3181b0fa13","article-title":"Late-life depression, mild cognitive impairment, and dementia: possible continuum?","volume":"18","author":"Panza","year":"2010","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2011.06.005_bib0615","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.ypg.0000128768.37838.17","article-title":"Enhanced APOE2 transmission rates in families with autistic probands","volume":"14","author":"Persico","year":"2004","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.arr.2011.06.005_bib0620","doi-asserted-by":"crossref","first-page":"12260","DOI":"10.1073\/pnas.92.26.12260","article-title":"Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease","volume":"92","author":"Poirier","year":"1995","journal-title":"Proc. Natl. Acad. Sci. 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