{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:18:23Z","timestamp":1792034303634,"version":"4.4.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["Glenn Foundation for Medical Research"],"award-info":[{"award-number":["Glenn Foundation for Medical Research"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.arr.2014.12.011","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T17:09:44Z","timestamp":1420650584000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"special_numbering":"C","title":["Lifelong brain health is a lifelong challenge: From evolutionary principles to empirical evidence"],"prefix":"10.1016","volume":"20","author":[{"given":"Mark P.","family":"Mattson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2014.12.011_bib0005","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1523\/JNEUROSCI.0496-05.2005","article-title":"Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease","volume":"25","author":"Adlard","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0010","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.mad.2011.09.005","article-title":"Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling","volume":"132","author":"Aguiar","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2014.12.011_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ana.21798","article-title":"Age and energy intake interact to modify cell stress pathways and stroke outcome","volume":"67","author":"Arumugam","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0020","doi-asserted-by":"crossref","first-page":"11578","DOI":"10.1523\/JNEUROSCI.2266-11.2011","article-title":"Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes","volume":"31","author":"Barrientos","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0025","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.semcdb.2011.07.002","article-title":"Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?","volume":"22","author":"Bekinschtein","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2014.12.011_bib0030","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.nbd.2011.04.022","article-title":"Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology","volume":"43","author":"Belarbi","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2014.12.011_bib0035","doi-asserted-by":"crossref","first-page":"20130853","DOI":"10.1098\/rsbl.2013.0853","article-title":"Hunter\u2013gatherers have less famine than agriculturalists","volume":"10","author":"Berbesque","year":"2014","journal-title":"Biol. Lett."},{"key":"10.1016\/j.arr.2014.12.011_bib0040","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sc.2010.167","article-title":"Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function","volume":"49","author":"Brown","year":"2011","journal-title":"Spinal Cord"},{"key":"10.1016\/j.arr.2014.12.011_bib0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/1531-8249(199901)45:1<8::AID-ART4>3.0.CO;2-V","article-title":"Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults","volume":"45","author":"Bruce-Keller","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0050","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1523\/JNEUROSCI.23-23-08212.2003","article-title":"Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons","volume":"23","author":"Burkhalter","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0006-8993(94)91857-0","article-title":"NT-3 and BDNF protect CNS neurons against metabolic\/excitotoxic insults","volume":"640","author":"Cheng","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0060","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/ncomms2238","article-title":"Involvement of PGC-1\u03b1 in the formation and maintenance of neuronal dendritic spines","volume":"3","author":"Cheng","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2014.12.011_bib0065","first-page":"R387","article-title":"Five months of fasting in king penguin chicks: body mass loss and fuel metabolism","volume":"249","author":"Cherel","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2014.12.011_bib0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3233\/JAD-131073","article-title":"Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer's disease","volume":"39","author":"Coelho","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2014.12.011_bib0075","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1073\/pnas.0911725107","article-title":"Running enhances spatial pattern separation in mice","volume":"107","author":"Creer","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0080","doi-asserted-by":"crossref","first-page":"162","DOI":"10.7326\/0003-4819-158-3-201302050-00005","article-title":"The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study","volume":"158","author":"Defina","year":"2013","journal-title":"Ann. Intern. Med."},{"issue":"Pt C","key":"10.1016\/j.arr.2014.12.011_bib0085","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuropharm.2013.04.054","article-title":"Shaping neurons: long and short range effects of mature and proBDNF signalling upon neuronal structure","volume":"7","author":"Deinhardt","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2014.12.011_bib0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P","article-title":"Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease","volume":"57","author":"Duan","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.1471-4159.2001.00071.x","article-title":"Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice","volume":"76","author":"Duan","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0100","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1073\/pnas.0536856100","article-title":"Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice","volume":"100","author":"Duan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0105","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2007.12.047","article-title":"Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice","volume":"1199","author":"Duman","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0110","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.expneurol.2014.04.017","article-title":"Intermittent fasting attenuates inflammasome activity in ischemic stroke","volume":"257C","author":"Fann","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/chi.2011.0122","article-title":"Community design and policies for free-range children: creating environments that support routine physical activity","volume":"8","author":"Fenton","year":"2012","journal-title":"Child Obes."},{"key":"10.1016\/j.arr.2014.12.011_bib0120","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00702-010-0474-8","article-title":"Running wheel activity restores MPTP-induced functional deficits","volume":"118","author":"Fredriksson","year":"2011","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2014.12.011_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1101\/lm.50703","article-title":"Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice","volume":"10","author":"Frick","year":"2003","journal-title":"Learn. Mem."},{"key":"10.1016\/j.arr.2014.12.011_bib0130","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1073\/pnas.91.11.5104","article-title":"Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat","volume":"91","author":"Frim","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archneurol.2009.297","article-title":"Physical exercise, aging, and mild cognitive impairment: a population-based study","volume":"67","author":"Geda","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0140","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1523\/JNEUROSCI.2836-04.2004","article-title":"Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor\/cofilin","volume":"24","author":"Gehler","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0145","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/01.RES.0000250175.14861.77","article-title":"Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow","volume":"99","author":"Gertz","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0150","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2656.2011.01928.x","article-title":"Predicting the potential demographic impact of predators on their prey: a comparative analysis of two carnivore-ungulate systems in Scandinavia","volume":"81","author":"Gervasi","year":"2012","journal-title":"J. Anim. Ecol."},{"key":"10.1016\/j.arr.2014.12.011_bib0155","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1006\/exnr.1999.7242","article-title":"Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity","volume":"161","author":"Glazner","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0160","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2003.10.017","article-title":"Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia","volume":"152","author":"Gobbo","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0165","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1111\/j.1460-9568.2008.06524.x","article-title":"Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition","volume":"28","author":"Gomez-Pinilla","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0170","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainres.2009.06.045","article-title":"Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation","volume":"1288","author":"Griesbach","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0175","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.physbeh.2011.06.005","article-title":"Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males","volume":"104","author":"Griffin","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.arr.2014.12.011_bib0180","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1471-4159.2000.0750314.x","article-title":"Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid","volume":"75","author":"Guo","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0185","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1098\/rstb.2005.1746","article-title":"Weather patterns, food security and humanitarian response in sub-Saharan Africa","volume":"360","author":"Haile","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.arr.2014.12.011_bib0190","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.nbd.2006.12.019","article-title":"Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease","volume":"26","author":"Halagappa","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2014.12.011_bib0195","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1046\/j.1471-4159.2002.01267.x","article-title":"Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease","volume":"83","author":"Haughey","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0200","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.nlm.2012.01.003","article-title":"Environmental enrichment protects against the effects of chronic stress on cognitive and morphological measures of hippocampal integrity","volume":"97","author":"Hutchinson","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.arr.2014.12.011_bib0205","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0167-4943(87)90014-8","article-title":"Dietary restriction: effects on radial maze learning and lipofuscin pigment deposition in the hippocampus and frontal cortex","volume":"6","author":"Idrobo","year":"1987","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.arr.2014.12.011_bib0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2012.06.011","article-title":"Exercise counteracts declining hippocampal function in aging and Alzheimer's disease","volume":"57","author":"Intlekofer","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2014.12.011_bib0215","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease","volume":"25","author":"Jankowsky","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0220","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/neu.2010.1609","article-title":"Intermittent fasting improves functional recovery after rat thoracic contusion spinal cord injury","volume":"28","author":"Jeong","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.arr.2014.12.011_bib0225","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbi.2012.05.015","article-title":"Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection","volume":"26","author":"Jurgens","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2014.12.011_bib0230","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.neurobiolaging.2012.11.023","article-title":"A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease","volume":"34","author":"Kashiwaya","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2014.12.011_bib0235","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0240","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1101\/lm.2283011","article-title":"Running is the neurogenic and neurotrophic stimulus in environmental enrichment","volume":"18","author":"Kobilo","year":"2011","journal-title":"Learn. Mem."},{"key":"10.1016\/j.arr.2014.12.011_bib0245","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbi.2011.10.006","article-title":"Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice","volume":"26","author":"Kohman","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2014.12.011_bib0250","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.exger.2008.01.008","article-title":"Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8","volume":"43","author":"Komatsu","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2014.12.011_bib0255","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1079\/PHN2004691","article-title":"A concise overview of national nutrition action plans in the European Union Member States","volume":"8","author":"Lachat","year":"2005","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.arr.2014.12.011_bib0260","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1460-9568.2011.07626.x","article-title":"Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration","volume":"33","author":"Lau","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0265","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cell.2005.01.015","article-title":"Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice","volume":"120","author":"Lazarov","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.arr.2014.12.011_bib0270","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1471-4159.2002.01085.x","article-title":"Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice","volume":"82","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0275","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1073\/pnas.0806720106","article-title":"GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism","volume":"106","author":"Li","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0280","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3233\/JAD-2010-1314","article-title":"GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease","volume":"19","author":"Li","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"6","key":"10.1016\/j.arr.2014.12.011_bib0285","doi-asserted-by":"crossref","first-page":"e66069","DOI":"10.1371\/journal.pone.0066069","article-title":"Chronic intermittent fasting improves cognitive functions and brain structures in mice","volume":"8","author":"Li","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.arr.2014.12.011_bib0620","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2013.12.008","article-title":"Fasting: molecular mechanisms and clinical applications","volume":"19","author":"Longo","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2014.12.011_bib0290","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nature02661","article-title":"Gene regulation and DNA damage in the ageing human brain","volume":"429","author":"Lu","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.arr.2014.12.011_bib0295","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","article-title":"BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?","volume":"89","author":"Lu","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.arr.2014.12.011_bib0300","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainresrev.2008.09.002","article-title":"The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies","volume":"59","author":"Maalouf","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.arr.2014.12.011_bib0305","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1471-4159.2012.07670.x","article-title":"Ketone bodies in epilepsy","volume":"121","author":"McNally","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0310","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1096\/fj.05-5263com","article-title":"Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats","volume":"20","author":"Mager","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2014.12.011_bib0315","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.physbeh.2003.06.001","article-title":"The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat","volume":"80","author":"Marin","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.arr.2014.12.011_bib0320","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/dneu.22009","article-title":"Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL\/6J mice","volume":"72","author":"Marlatt","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.arr.2014.12.011_bib0325","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tem.2013.10.006","article-title":"BDNF mediates adaptive brain and body responses to energetic challenges","volume":"25","author":"Marosi","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.arr.2014.12.011_bib0330","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1210\/en.2007-0161","article-title":"Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess","volume":"148","author":"Martin","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2014.12.011_bib0335","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1073\/pnas.0912955107","article-title":"\u201cControl\u201d laboratory rodents are metabolically morbid: why it matters","volume":"107","author":"Martin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0340","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1046\/j.1471-4159.1995.65041740.x","article-title":"Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons","volume":"65","author":"Mattson","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0345","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cmet.2012.08.012","article-title":"Energy intake and exercise as determinants of brain health and vulnerability to injury and disease","volume":"16","author":"Mattson","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2014.12.011_bib0350","doi-asserted-by":"crossref","first-page":"16647","DOI":"10.1073\/pnas.1413965111","article-title":"Meal frequency and timing in health and disease","volume":"111","author":"Mattson","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0355","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1046\/j.1460-9568.2002.02158.x","article-title":"Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray","volume":"16","author":"Molteni","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0360","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuroscience.2003.09.020","article-title":"Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor","volume":"123","author":"Molteni","year":"2004","journal-title":"Neuroscience"},{"issue":"Suppl. 2","key":"10.1016\/j.arr.2014.12.011_bib0365","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/obr.12107","article-title":"Ultra-processed products are becoming dominant in the global food system","volume":"14","author":"Monteiro","year":"2013","journal-title":"Obes. Rev."},{"key":"10.1016\/j.arr.2014.12.011_bib0370","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuroscience.2012.06.007","article-title":"Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL\/6J mice","volume":"219","author":"Mustroph","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2014.12.011_bib0375","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.arr.2014.12.011_bib0380","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jalz.2009.02.006","article-title":"Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice","volume":"5","author":"Nichol","year":"2009","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.arr.2014.12.011_bib0385","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.nbd.2007.11.006","article-title":"Gene\u2013environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice","volume":"29","author":"Nithianantharajah","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2014.12.011_bib0390","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nlm.2014.04.006","article-title":"Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons","volume":"114C","author":"Noble","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.arr.2014.12.011_bib0395","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","article-title":"Review: microglia of the aged brain: primed to be activated and resistant to regulation","volume":"39","author":"Norden","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.arr.2014.12.011_bib0400","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1523\/JNEUROSCI.1069-07.2007","article-title":"Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury","volume":"27","author":"Petzinger","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0405","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.expneurol.2008.04.011","article-title":"Dietary restriction started after spinal cord injury improves functional recovery","volume":"213","author":"Plunet","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2014.12.011_bib0410","doi-asserted-by":"crossref","first-page":"RRN1201","DOI":"10.1371\/currents.RRN1201","article-title":"Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington's disease","volume":"2","author":"Potter","year":"2010","journal-title":"PLoS Curr."},{"key":"10.1016\/j.arr.2014.12.011_bib0415","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11357-010-9173-5","article-title":"Adiponectin protects rat hippocampal neurons against excitotoxicity","volume":"33","author":"Qiu","year":"2011","journal-title":"Age (Dordr.)"},{"issue":"6","key":"10.1016\/j.arr.2014.12.011_bib0420","doi-asserted-by":"crossref","first-page":"e20601","DOI":"10.1371\/journal.pone.0020601","article-title":"Relationship between exercise capacity and brain size in mammals","volume":"6","author":"Raichlen","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.arr.2014.12.011_bib0425","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0921-8734(93)90024-W","article-title":"Biomarkers of aging: correlation of DNA I-compound levels with median lifespan of calorically restricted and ad libitum fed rats and mice","volume":"295","author":"Randerath","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0430","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/7854_2011_134","article-title":"Potential benefits and limitations of enriched environments and cognitive activity on age-related behavioural decline","volume":"10","author":"Redolat","year":"2012","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0435","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2009.02.030","article-title":"Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat: possible role of galanin","volume":"1266","author":"Reiss","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0440","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuropharm.2014.01.037","article-title":"Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain","volume":"81","author":"Revilla","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2014.12.011_bib0445","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1002\/jnr.22443","article-title":"Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury","volume":"88","author":"Rich","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0450","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2008.05.062","article-title":"Food restriction induces long-lasting recovery of spatial memory deficits following global ischemia in delayed matching and non-matching-to-sample radial arm maze tasks","volume":"156","author":"Roberge","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2014.12.011_bib0455","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2011.06.059","article-title":"Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2","volume":"192","author":"Robinet","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2014.12.011_bib0460","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2174\/156720511797633214","article-title":"Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer's disease","volume":"8","author":"Rodr\u00edguez","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0465","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroscience.2011.02.055","article-title":"The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA","volume":"180","author":"Sartori","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2014.12.011_bib0470","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1076\/jcen.25.5.625.14576","article-title":"Cognitive reserve and lifestyle","volume":"25","author":"Scarmeas","year":"2003","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.arr.2014.12.011_bib0475","doi-asserted-by":"crossref","first-page":"17587","DOI":"10.1523\/JNEUROSCI.3241-13.2013","article-title":"How do immune cells support and shape the brain in health, disease, and aging?","volume":"33","author":"Schwartz","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0480","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/WAD.0b013e318211c83c","article-title":"Relationship between education and dementia: an updated systematic review","volume":"25","author":"Sharp","year":"2011","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.arr.2014.12.011_bib0485","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1096\/fj.02-0819fje","article-title":"Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction","volume":"17","author":"Shimokawa","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2014.12.011_bib0490","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbr.2011.04.002","article-title":"The impact of environmental enrichment in laboratory rats \u2013 behavioural and neurochemical aspects","volume":"222","author":"Simpson","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0495","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/40864","article-title":"cAMP-induced switching in turning direction of nerve growth cones","volume":"388","author":"Song","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.arr.2014.12.011_bib0500","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2012.09.013","article-title":"Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats","volume":"28","author":"Speisman","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2014.12.011_bib0505","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev-med-042010-113026","article-title":"Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome","volume":"63","author":"Stanhope","year":"2012","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.arr.2014.12.011_bib0510","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/hipo.20577","article-title":"Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice","volume":"19","author":"Stranahan","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.arr.2014.12.011_bib0515","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.neurobiolaging.2008.10.016","article-title":"Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice","volume":"31","author":"Stranahan","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2014.12.011_bib0520","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00702-008-0092-x","article-title":"Physical activity, exercise, depression and anxiety disorders","volume":"116","author":"Str\u00f6hle","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2014.12.011_bib0525","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI200318797","article-title":"d-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease","volume":"112","author":"Tieu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2014.12.011_bib0530","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3233\/JAD-130698","article-title":"Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort","volume":"38","author":"Tolppanen","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2014.12.011_bib0535","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2014.12.011_bib0540","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"van Praag","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.arr.2014.12.011_bib0545","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nlme.1996.3735","article-title":"Postoperative environmental enrichment attenuates fimbria-fornix lesion-induced impairments in Morris maze performance","volume":"67","author":"van Rijzingen","year":"1997","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.arr.2014.12.011_bib0550","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1742-2094-11-85","article-title":"Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment","volume":"11","author":"Vasconcelos","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2014.12.011_bib0555","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/7854_2012_220","article-title":"All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis","volume":"15","author":"Vivar","year":"2013","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.arr.2014.12.011_bib0560","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tics.2013.08.001","article-title":"Bridging animal and human models of exercise-induced brain plasticity","volume":"17","author":"Voss","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.arr.2014.12.011_bib0565","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/jn\/133.6.1921","article-title":"Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats","volume":"133","author":"Wan","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.arr.2014.12.011_bib0570","doi-asserted-by":"crossref","first-page":"H1186","DOI":"10.1152\/ajpheart.00932.2003","article-title":"Dietary supplementation with 2-deoxy-d-glucose improves cardiovascular and neuroendocrine stress adaptation in rats","volume":"287","author":"Wan","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.arr.2014.12.011_bib0575","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/jnc.12656","article-title":"Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability","volume":"129","author":"Wan","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2014.12.011_bib0580","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1093\/nar\/gkm605","article-title":"Defective DNA, base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment","volume":"35","author":"Weissman","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.arr.2014.12.011_bib0585","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1\u03b1\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2014.12.011_bib0590","doi-asserted-by":"crossref","first-page":"R234","DOI":"10.1186\/gb-2007-8-11-r234","article-title":"Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender","volume":"8","author":"Xu","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.arr.2014.12.011_bib0595","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.0b013e3181ea1597","article-title":"Physical activities and future risk of Parkinson disease","volume":"75","author":"Xu","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2014.12.011_bib0600","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182190d09","article-title":"Midlife overweight and obesity increase late-life dementia risk: a population-based twin study","volume":"76","author":"Xu","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2014.12.011_bib0605","doi-asserted-by":"crossref","first-page":"28191","DOI":"10.1074\/jbc.M109.082883","article-title":"Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1","volume":"285","author":"Yang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2014.12.011_bib0610","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12017-013-8270-x","article-title":"BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic\/apyrimidinic endonuclease 1","volume":"16","author":"Yang","year":"2014","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.arr.2014.12.011_bib0615","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<830::AID-JNR8>3.0.CO;2-2","article-title":"Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism","volume":"57","author":"Yu","year":"1999","journal-title":"J. Neurosci. Res."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163715000021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163715000021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:09:19Z","timestamp":1717675759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163715000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":124,"alternative-id":["S1568163715000021"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2014.12.011","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lifelong brain health is a lifelong challenge: From evolutionary principles to empirical evidence","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2014.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}