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Pharmacol."},{"issue":"5","key":"10.1016\/j.arr.2015.10.001_bib0935","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1523\/JNEUROSCI.3902-05.2006","article-title":"P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling","volume":"26","author":"Suadicani","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.arr.2015.10.001_bib0940","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/glia.20071","article-title":"Gap junction channels coordinate the propagation of intercellular Ca2+ signals generated by P2Y receptor activation","volume":"48","author":"Suadicani","year":"2004","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.arr.2015.10.001_bib0945","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1167\/iovs.09-4192","article-title":"Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons","volume":"51","author":"Sugiyama","year":"2010","journal-title":"Invest. 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