{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:59:12Z","timestamp":1784329152800,"version":"3.55.0"},"reference-count":197,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health\/NINDS","doi-asserted-by":"crossref","award":["NS079345"],"award-info":[{"award-number":["NS079345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"VA Merit Review","award":["BX002346"],"award-info":[{"award-number":["BX002346"]}]},{"name":"Chinese 12th Five science and technology support program","award":["2013BAI07B01"],"award-info":[{"award-number":["2013BAI07B01"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.arr.2016.11.002","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T09:46:08Z","timestamp":1479548768000},"page":"39-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Stem cell therapies in age-related neurodegenerative diseases and stroke"],"prefix":"10.1016","volume":"34","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehana K.","family":"Leak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2016.11.002_bib0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jalz.2012.02.001","article-title":"Alzheimer's disease facts and figures","volume":"8","author":"Alzheimer\u2019s Associationnon","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2016.11.002_bib0010","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jalz.2015.02.003","article-title":"Alzheimer's disease facts and figures","volume":"11","author":"Alzheimer\u2019s Associationnon","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2016.11.002_bib0015","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neuron.2014.02.007","article-title":"Gliotransmitters travel in time and space","volume":"81","author":"Araque","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2016.11.002_bib0020","first-page":"221","article-title":"Aging, neurogenesis, and caloric restriction in different model organisms","volume":"4","author":"Arslan-Ergul","year":"2013","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2016.11.002_bib0025","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0030","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1161\/STROKEAHA.109.547869","article-title":"Relative risks for stroke by age, sex, and population based on follow-up of 18 European populations in the MORGAM Project","volume":"40","author":"Asplund","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2016.11.002_bib0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jns.2007.06.012","article-title":"Neural stem\/precursor cells for the treatment of ischemic stroke","volume":"265","author":"Bacigaluppi","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2016.11.002_bib0040","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/01.WCB.0000071883.63724.A7","article-title":"Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery","volume":"23","author":"Badan","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2016.11.002_bib0045","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1634\/stemcells.2006-0561","article-title":"Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration","volume":"25","author":"Bae","year":"2007","journal-title":"Stem Cells (Dayton Ohio)"},{"key":"10.1016\/j.arr.2016.11.002_bib0050","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.0611112104","article-title":"Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia","volume":"104","author":"Baker","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2016.11.002_bib0055","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.5966\/sctm.2013-0178","article-title":"Intra-arterial immunoselected CD34+ stem cells for acute ischemic stroke","volume":"3","author":"Banerjee","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2010.10.063","article-title":"Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats","volume":"1367","author":"Bao","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.5214\/ans.0972.7531.1118209","article-title":"Cell based therapies in Parkinson's disease","volume":"18","author":"Behari","year":"2011","journal-title":"Ann. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.diff.2016.01.005","article-title":"Isolation, culture and analysis of adult subependymal neural stem cells","author":"Belenguer","year":"2016","journal-title":"Differentiation"},{"key":"10.1016\/j.arr.2016.11.002_bib0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00401-009-0522-3","article-title":"Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease","volume":"118","author":"Bell","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2016.11.002_bib0080","doi-asserted-by":"crossref","first-page":"8654","DOI":"10.1523\/JNEUROSCI.1615-07.2007","article-title":"Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia","volume":"27","author":"Berninger","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0085","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.clineuro.2012.10.015","article-title":"Stem cell therapy: a clinical trial of stroke","volume":"115","author":"Bhasin","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.arr.2016.11.002_bib0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1474-4422(04)00966-4","article-title":"Autologous haematopoietic-stem-cell transplantation for multiple sclerosis","volume":"4","author":"Blanco","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0095","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.nbd.2009.10.003","article-title":"Optimizing the success of cell transplantation therapy for stroke","volume":"37","author":"Bliss","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2016.11.002_bib0100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/cercor\/bhq107","article-title":"Neuronal network formation from reprogrammed early postnatal rat cortical glial cells","volume":"21","author":"Blum","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.arr.2016.11.002_bib0105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/scrt440","article-title":"Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models","volume":"5","author":"Blurton-Jones","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0110","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult mammalian neural stem cells and neurogenesis: five decades later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2016.11.002_bib0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jcyt.2013.02.006","volume":"15","author":"Bourin","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arr.2016.11.002_bib0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2016.11.002_bib0125","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature05293","article-title":"Cell death in the nervous system","volume":"443","author":"Bredesen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.arr.2016.11.002_bib0130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/jcbfm.2009.198","article-title":"Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats","volume":"30","author":"Brenneman","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2016.11.002_bib0135","doi-asserted-by":"crossref","first-page":"S336","DOI":"10.1016\/j.jaci.2009.09.032","article-title":"Embryonic and adult stem cell therapy","volume":"125","author":"Brignier","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.arr.2016.11.002_bib0140","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/acn3.246","article-title":"Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease","volume":"2","author":"Buddhala","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0145","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/j.neuroimage.2009.09.041","article-title":"Age-related differences in white matter microstructure: region-specific patterns of diffusivity","volume":"49","author":"Burzynska","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.arr.2016.11.002_bib0150","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/nm1106-1237","article-title":"Stem cells: the good, bad and barely in control","volume":"12","author":"Carson","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4419-0322-8_2","article-title":"Dopamine systems in the forebrain","volume":"651","author":"Cave","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.arr.2016.11.002_bib0160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnins.2014.00016","article-title":"Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons","volume":"8","author":"Cave","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0165","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3727\/096368914X678445","article-title":"ADSC therapy in neurodegenerative disorders","volume":"23","author":"Chan","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3727\/096368914X678409","article-title":"The use of ADSCs as a treatment for chronic stroke","volume":"23","author":"Chan","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0175","doi-asserted-by":"crossref","first-page":"759503","DOI":"10.1155\/2012\/759503","article-title":"Umbilical cord-derived mesenchymal stem cells for hematopoietic stem cell transplantation","volume":"2012","author":"Chao","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.arr.2016.11.002_bib0180","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1007\/s11095-012-0915-1","article-title":"Intranasal treatment of central nervous system dysfunction in humans","volume":"30","author":"Chapman","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0185","doi-asserted-by":"crossref","first-page":"586586","DOI":"10.4061\/2011\/586586","article-title":"Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report","volume":"2011","author":"Chartoff","year":"2011","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.arr.2016.11.002_bib0190","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2007.06.043","article-title":"Age-related decrease of striatal neurogenesis is associated with apoptosis of neural precursors and newborn neurons in rat brain after ischemia","volume":"1166","author":"Chen","year":"2007","journal-title":"Brain Res."},{"issue":"Suppl. 1","key":"10.1016\/j.arr.2016.11.002_bib0195","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.3727\/096368913X672154","article-title":"Multiple cell transplantation based on an intraparenchymal approach for patients with chronic phase stroke","volume":"22","author":"Chen","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0200","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3727\/096368914X678562","article-title":"Intracerebral implantation of autologous peripheral blood stem cells in stroke patients: a randomized phase II study","volume":"23","author":"Chen","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0205","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fnhum.2014.00382","article-title":"Neurorestorative therapy for stroke","volume":"8","author":"Chen","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0210","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/1533317513506776","article-title":"Neural stem cell transplantation improves spatial learning and memory via neuronal regeneration in amyloid-beta precursor protein\/presenilin 1\/tau triple transgenic mice","volume":"29","author":"Chen","year":"2014","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"10.1016\/j.arr.2016.11.002_bib0215","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ana.21995","article-title":"Clinical progression in Parkinson disease and the neurobiology of axons","volume":"67","author":"Cheng","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0220","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainres.2014.10.065","article-title":"Human umbilical cord mesenchymal stem cells protect against ischemic brain injury in mouse by regulating peripheral immunoinflammation","volume":"1594","author":"Cheng","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0225","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1523\/JNEUROSCI.2006-06.2006","article-title":"Stem cell research: the California experience","volume":"26","author":"Chiu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0230","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s13311-011-0066-9","article-title":"Cell-based therapy for neural disorders\u2013anticipating challenges","volume":"8","author":"Chiu","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2016.11.002_bib0235","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/jcbfm.2010.213","article-title":"Intra-arterial injection of neural stem cells using a microneedle technique does not cause microembolic strokes","volume":"31","author":"Chua","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2016.11.002_bib0240","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1292\/jvms.12-0470","article-title":"A comparison of neurosphere differentiation potential of canine bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells","volume":"75","author":"Chung","year":"2013","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.arr.2016.11.002_bib0245","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000368887","article-title":"How can you mend a broken brain? Neurorestorative approaches to stroke recovery","volume":"38","author":"Corbett","year":"2014","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.arr.2016.11.002_bib0250","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/pr.2011.67","article-title":"Transplantation of umbilical cord-derived mesenchymal stem cells as a novel strategy to protect the central nervous system: technical aspects, preclinical studies, and clinical perspectives","volume":"71","author":"Dalous","year":"2012","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0255","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3727\/096368912X655091","article-title":"Neural stem cells and stroke","volume":"22","author":"Ding","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0260","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neuroscience.2014.05.064","article-title":"Aging causes exacerbated ischemic brain injury and failure of sevoflurane post-conditioning: role of B-cell lymphoma-2","volume":"275","author":"Dong","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2016.11.002_bib0265","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1080\/13825585.2011.638976","article-title":"Adaptation to stroke using a model of successful aging","volume":"19","author":"Donnellan","year":"2012","journal-title":"Neuropsychol. Dev. Cogn. B"},{"key":"10.1016\/j.arr.2016.11.002_bib0270","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2217\/rme.14.43","article-title":"Stem cell therapies for Parkinson's disease: are trials just around the corner?","volume":"9","author":"Drouin-Ouellet","year":"2014","journal-title":"Regen. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0275","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.acthis.2014.05.002","article-title":"Comparison of administration routes for adipose-derived stem cells in the treatment of middle cerebral artery occlusion in rats","volume":"116","author":"Du","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.arr.2016.11.002_bib0280","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.tripleo.2008.12.006","article-title":"Advances in hematologic stem cell transplant: an update for oral health care providers","volume":"107","author":"Epstein","year":"2009","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.arr.2016.11.002_bib0285","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/cercor\/bhs379","article-title":"Accelerating cortical thinning: unique to dementia or universal in aging?","volume":"24","author":"Fjell","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.arr.2016.11.002_bib0290","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnagi.2014.00030","article-title":"Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer's disease","volume":"6","author":"Garcia","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0295","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1089\/scd.2012.0633","article-title":"Cell and gene therapy in Alzheimer's disease","volume":"22","author":"Glat","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.arr.2016.11.002_bib0300","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35081564","article-title":"Alpha-synuclein and neurodegenerative diseases","volume":"2","author":"Goedert","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0305","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of aging in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"10.1016\/j.arr.2016.11.002_bib0310","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1474-4422(11)70097-7","article-title":"Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomized, controlled trial","volume":"10","author":"Gross","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0315","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.stem.2013.12.001","article-title":"In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model","volume":"14","author":"Guo","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2016.11.002_bib0320","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/scrt159","article-title":"Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke","volume":"4","author":"Gutierrez-Fernandez","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0325","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1517\/14712598.2015.1040386","article-title":"Adipose tissue-derived mesenchymal stem cells as a strategy to improve recovery after stroke","volume":"15","author":"Gutierrez-Fernandez","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0330","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.2009.05118.x","article-title":"The progression of pathology in Parkinson's disease","volume":"1184","author":"Halliday","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.arr.2016.11.002_bib0335","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40035-015-0039-8","article-title":"Development of stem cell-based therapy for Parkinson's disease","volume":"4","author":"Han","year":"2015","journal-title":"Transl. Neurodegener"},{"key":"10.1016\/j.arr.2016.11.002_bib0340","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-2141.2010.08296.x","article-title":"An introduction to induced pluripotent stem cells","volume":"151","author":"Hanley","year":"2010","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.arr.2016.11.002_bib0345","doi-asserted-by":"crossref","first-page":"9745315","DOI":"10.1155\/2016\/9745315","article-title":"Insights into the biology and therapeutic applications of neural stem cells","volume":"2016","author":"Harris","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.arr.2016.11.002_bib0350","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/aps.2012.188","article-title":"Autophagy in aging and aging-associated diseases","volume":"34","author":"He","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.arr.2016.11.002_bib0355","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2016.11.002_bib0360","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nprot.2010.188","article-title":"Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex","volume":"6","author":"Heinrich","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.arr.2016.11.002_bib0365","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1067\/mai.2003.133","article-title":"28: Embryonic and adult stem cell therapy","volume":"111","author":"Henningson","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.arr.2016.11.002_bib0370","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00423-011-0762-2","article-title":"Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?","volume":"396","author":"Hilfiker","year":"2011","journal-title":"Langenbecks Arch. Surg."},{"key":"10.1016\/j.arr.2016.11.002_bib0375","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/ageing\/afp223","article-title":"Ageing, neurodegeneration and Parkinson's disease","volume":"39","author":"Hindle","year":"2010","journal-title":"Age Ageing"},{"key":"10.1016\/j.arr.2016.11.002_bib0380","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.expneurol.2004.05.008","article-title":"Lost in translation: taking neuroprotection from animal models to clinical trials","volume":"188","author":"Hoyte","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0385","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arr.2016.11.002_bib0390","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1634\/stemcells.2006-0686","article-title":"Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis","volume":"25","author":"Hung","year":"2007","journal-title":"Stem Cells"},{"issue":"Suppl. 1","key":"10.1016\/j.arr.2016.11.002_bib0395","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.arr.2010.08.006","article-title":"Ageing and neurodegenerative diseases","volume":"9","author":"Hung","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2016.11.002_bib0400","article-title":"Accelerating stem cell trials for Alzheimer's disease","author":"Hunsberger","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0405","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3109\/14653249.2010.549122","article-title":"Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy","volume":"13","author":"Ikegame","year":"2011","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arr.2016.11.002_bib0410","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.nbt.2014.04.004","article-title":"iPSCs, aging and age-related diseases","volume":"31","author":"Isobe","year":"2014","journal-title":"N Biotechnol."},{"key":"10.1016\/j.arr.2016.11.002_bib0415","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1161\/STROKEAHA.107.483008","article-title":"Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia\/ischemia in rats","volume":"38","author":"Iwai","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2016.11.002_bib0420","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11010-011-0806-5","article-title":"Induction of pluripotent stem cells transplantation therapy for ischemic stroke","volume":"354","author":"Jiang","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.arr.2016.11.002_bib0425","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.3727\/096368912X658818","article-title":"Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of the lesion artery in patients with stroke in the territory of the middle cerebral artery","volume":"22","author":"Jiang","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0430","article-title":"Aging affects new cell production in the adult hippocampus: a quantitative anatomic review","author":"Jinno","year":"2015","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.arr.2016.11.002_bib0435","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-3-540-68976-8_10","article-title":"Autotransplantation of bone marrow-derived stem cells as a therapy for neurodegenerative diseases","author":"Kan","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.arr.2016.11.002_bib0440","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12015-010-9190-x","article-title":"Mesenchymal stem cells stimulate endogenous neurogenesis in the subventricular zone of adult mice","volume":"7","author":"Kan","year":"2011","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.arr.2016.11.002_bib0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2012.09.031","article-title":"Clinical experience with stem cells and other cell therapies in neurological diseases","volume":"324","author":"Karussis","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2016.11.002_bib0450","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3233\/JAD-130572","article-title":"Can we teach old dogs new tricks? Neuroprotective cell therapy in Alzheimer's and Parkinson's disease","volume":"37","author":"Kazmerova","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2016.11.002_bib0455","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neures.2007.02.016","article-title":"Effect of human embryonic stem cell-derived neuronal precursor cell transplantation into the cerebral infarct model of rat with exercise","volume":"58","author":"Kim","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0460","doi-asserted-by":"crossref","first-page":"e45757","DOI":"10.1371\/journal.pone.0045757","article-title":"The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2016.11.002_bib0465","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1745-6215-14-317","article-title":"Intravenous transplantation of mesenchymal stem cells preconditioned with early phase stroke serum: current evidence and study protocol for a randomized trial","volume":"14","author":"Kim","year":"2013","journal-title":"Trials"},{"key":"10.1016\/j.arr.2016.11.002_bib0470","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.gdata.2015.11.017","article-title":"Transcriptome sequencing of hematopoietic stem cells and chronic myelgenous leukemia stem cells","volume":"7","author":"Kim","year":"2016","journal-title":"Genomics Data"},{"key":"10.1016\/j.arr.2016.11.002_bib0475","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.CIR.0000124062.31102.57","article-title":"Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms","volume":"109","author":"Kinnaird","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2016.11.002_bib0480","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainres.2008.06.087","article-title":"Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats","volume":"1229","author":"Koh","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0485","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.trsl.2013.11.009","article-title":"Adipose stem cells: biology and clinical applications for tissue repair and regeneration","volume":"163","author":"Kokai","year":"2014","journal-title":"Transl. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0490","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1212\/WNL.55.4.565","article-title":"Transplantation of cultured human neuronal cells for patients with stroke","volume":"55","author":"Kondziolka","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2016.11.002_bib0495","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3171\/jns.2005.103.1.0038","article-title":"Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial","volume":"103","author":"Kondziolka","year":"2005","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.arr.2016.11.002_bib0500","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0092-8674(01)00328-2","article-title":"Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell","volume":"105","author":"Krause","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.arr.2016.11.002_bib0505","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/138161210790883741","article-title":"The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders","volume":"16","author":"Lanni","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2016.11.002_bib0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.12.003","article-title":"From apoplexy to stroke: historical perspectives and new research frontiers","volume":"115","author":"Leak","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2016.11.002_bib0515","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neulet.2008.11.059","article-title":"Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model","volume":"450","author":"Lee","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2016.11.002_bib0520","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2010.06.045","article-title":"The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease","volume":"481","author":"Lee","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2016.11.002_bib0525","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/stem.277","article-title":"Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.arr.2016.11.002_bib0530","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/stem.1125","article-title":"Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid beta ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses","volume":"30","author":"Lee","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.arr.2016.11.002_bib0535","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/jcbfm.2009.238","article-title":"Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study","volume":"30","author":"Li","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2016.11.002_bib0540","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yexmp.2015.01.016","article-title":"Intranasal delivery of stem cells as therapy for central nervous system disease","volume":"98","author":"Li","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.arr.2016.11.002_bib0545","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/TP.0b013e318195742e","article-title":"Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke","volume":"87","author":"Liao","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.arr.2016.11.002_bib0550","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000233255","article-title":"Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: implications of anti-inflammation and angiogenesis","volume":"24","author":"Liao","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.arr.2016.11.002_bib0555","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12015-010-9193-7","article-title":"The potential of adipose stem cells in regenerative medicine","volume":"7","author":"Lindroos","year":"2011","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.arr.2016.11.002_bib0560","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pneurobio.2013.11.007","article-title":"Cell based therapies for ischemic stroke: from basic science to bedside","volume":"115","author":"Liu","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2016.11.002_bib0565","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.arr.2016.11.002_bib0570","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.3727\/096368913X672181","article-title":"Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice","volume":"22","author":"Ma","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0575","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/cne.10714","article-title":"Marked loss of myelinated nerve fibers in the human brain with age","volume":"462","author":"Marner","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0580","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12015-013-9443-6","article-title":"Progress in stem cell therapy for major human neurological disorders","volume":"9","author":"Martinez-Morales","year":"2013","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.arr.2016.11.002_bib0585","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.stemcr.2016.01.010","article-title":"Functional neurons generated from T cell-derived induced pluripotent stem cells for neurological disease modeling","volume":"6","author":"Matsumoto","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.arr.2016.11.002_bib0590","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3727\/096368910X557191","article-title":"The effect of two- and three-dimensional cell culture on the chondrogenic potential of human adipose-derived mesenchymal stem cells after subcutaneous transplantation with an injectable hydrogel","volume":"20","author":"Merceron","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0595","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2016.11.002_bib0600","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1212\/WNL.0b013e31826959d2","article-title":"Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy","volume":"79","author":"Misra","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2016.11.002_bib0605","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1126\/science.1114758","article-title":"Direct isolation of satellite cells for skeletal muscle regeneration","volume":"309","author":"Montarras","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.arr.2016.11.002_bib0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2016.11.002_bib0615","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neurobiolaging.2013.08.007","article-title":"A 2-process model for neuropathology of Alzheimer's disease","volume":"35","author":"Mungas","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2016.11.002_bib0620","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4252\/wjsc.v7.i1.126","article-title":"Adult human neural stem cell therapeutics: current developmental status and prospect","volume":"7","author":"Nam","year":"2015","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.arr.2016.11.002_bib0625","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/ncb2843","article-title":"In vivo reprogramming of astrocytes to neuroblasts in the adult brain","volume":"15","author":"Niu","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2016.11.002_bib0630","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"Ohab","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0635","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(02)01177-1","article-title":"Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia","volume":"335","author":"Ohta","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2016.11.002_bib0640","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.biocel.2013.02.013","article-title":"Adipose-derived stem cells: fatty potentials for therapy","volume":"45","author":"Ong","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2016.11.002_bib0645","doi-asserted-by":"crossref","first-page":"282147","DOI":"10.1155\/2014\/282147","article-title":"Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells","volume":"2014","author":"Orio","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.arr.2016.11.002_bib0650","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1479-5876-6-54","article-title":"Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice","volume":"6","author":"Oyamada","year":"2008","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0655","doi-asserted-by":"crossref","first-page":"4702674","DOI":"10.1155\/2016\/4702674","article-title":"Cartilage regeneration in human with adipose tissue-derived stem cells: current status in clinical implications","volume":"2016","author":"Pak","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.arr.2016.11.002_bib0660","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0531-5565(02)00151-1","article-title":"Aging and the human neocortex","volume":"38","author":"Pakkenberg","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2016.11.002_bib0665","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.arr.2016.11.002_bib0670","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/156720206775541732","article-title":"Accelerated delimitation of the infarct zone by capillary-derived nestin-positive cells in aged rats","volume":"3","author":"Popa-Wagner","year":"2006","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0675","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00401-006-0164-7","article-title":"Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats","volume":"113","author":"Popa-Wagner","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2016.11.002_bib0680","first-page":"221","article-title":"Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: a pilot study","volume":"136","author":"Prasad","year":"2012","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0685","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/STROKEAHA.114.007028","article-title":"Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial","volume":"45","author":"Prasad","year":"2014","journal-title":"Stroke"},{"issue":"Suppl. 1","key":"10.1016\/j.arr.2016.11.002_bib0690","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.3727\/096368914X684961","article-title":"A two-year follow-up study of cotransplantation with neural stem\/progenitor cells and mesenchymal stromal cells in ischemic stroke patients","volume":"23","author":"Qiao","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0695","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10517-005-0229-y","article-title":"Cell therapy of brain stroke","volume":"139","author":"Rabinovich","year":"2005","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0700","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pneurobio.2010.10.007","article-title":"Energy metabolism in adult neural stem cell fate","volume":"93","author":"Rafalski","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2016.11.002_bib0705","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/dgd.12072","article-title":"Comparing brain-derived neurotrophic factor and ciliary neurotrophic factor secretion of induced neurotrophic factor secreting cells from human adipose and bone marrow-derived stem cells","volume":"55","author":"Razavi","year":"2013","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.arr.2016.11.002_bib0710","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbadis.2011.10.011","article-title":"Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics","volume":"1822","author":"Reddy","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2016.11.002_bib0715","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrn2978","article-title":"The stem cell potential of glia: lessons from reactive gliosis","volume":"12","author":"Robel","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0720","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics\u20132012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2016.11.002_bib0725","first-page":"281","article-title":"Age-associated changes on axonal regeneration and functional outcome after spinal cord injury in rats","volume":"53","author":"Roozbehi","year":"2015","journal-title":"Acta Med. Iran."},{"key":"10.1016\/j.arr.2016.11.002_bib0730","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1517\/14712590903321439","article-title":"Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases","volume":"9","author":"Sadan","year":"2009","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0735","first-page":"201","article-title":"Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases","volume":"11","author":"Sadan","year":"2009","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.arr.2016.11.002_bib0740","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature08982","article-title":"Linking functional decline of telomeres, mitochondria and stem cells during aging","volume":"464","author":"Sahin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.arr.2016.11.002_bib0745","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/cbin.10331","article-title":"Potential of bone marrow mesenchymal stem cells in management of Alzheimer's disease in female rats","volume":"38","author":"Salem","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.arr.2016.11.002_bib0750","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/jnr.10337","article-title":"Neural cells derived from adult bone marrow and umbilical cord blood","volume":"69","author":"Sanchez-Ramos","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0755","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1602\/neurorx.1.4.406","article-title":"Cell therapy for stroke","volume":"1","author":"Savitz","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.arr.2016.11.002_bib0760","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000086518","article-title":"Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study","volume":"20","author":"Savitz","year":"2005","journal-title":"Cerebrovasc. Dis. (Basel Switzerland)"},{"key":"10.1016\/j.arr.2016.11.002_bib0765","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1468-1331.2009.02793.x","article-title":"Perspectives on recent advances in the understanding and treatment of Parkinson's disease","volume":"16","author":"Schapira","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0770","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/7854_2014_317","article-title":"Clinical and pathological features of Parkinson's disease","volume":"22","author":"Schneider","year":"2015","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0775","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/glia.20722","article-title":"Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain","volume":"56","author":"Shen","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.arr.2016.11.002_bib0780","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cbin.10029","article-title":"Dopaminergic cells, derived from a high efficiency differentiation protocol from umbilical cord derived mesenchymal stem cells, alleviate symptoms in a Parkinson's disease rodent model","volume":"37","author":"Shetty","year":"2013","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.arr.2016.11.002_bib0785","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/stem.659","article-title":"Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1alpha in an Alzheimer's disease mouse model","volume":"29","author":"Shin","year":"2011","journal-title":"Stem Cells (Dayton Ohio)"},{"key":"10.1016\/j.arr.2016.11.002_bib0790","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00019052-199402000-00008","article-title":"Stroke in the elderly","volume":"7","author":"Shuaib","year":"1994","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.arr.2016.11.002_bib0795","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pneurobio.2006.11.009","article-title":"Advances in the treatment of Parkinson's disease","volume":"81","author":"Singh","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2016.11.002_bib0800","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/jnr.22627","article-title":"Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans","volume":"89","author":"Sobrino","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0805","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nbt.1510","article-title":"Recurrent chromosomal abnormalities in human embryonic stem cells","volume":"26","author":"Spits","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.arr.2016.11.002_bib0810","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mam.2015.06.007","article-title":"Being human: the role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer's disease models","volume":"43\u201344","author":"Sproul","year":"2015","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0815","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/1567205054367919","article-title":"Possible use of autologous stem cell therapies for Alzheimer's disease","volume":"2","author":"Sugaya","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0820","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nprot.2010.199","article-title":"Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells","volume":"6","author":"Sugii","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.arr.2016.11.002_bib0825","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainres.2006.05.109","article-title":"Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease","volume":"1106","author":"Suon","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0830","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1089\/scd.2015.0160","article-title":"Intravenous autologous bone marrow mononuclear cell transplantation for stroke: phase1\/2a clinical trial in a homogeneous group of stroke patients","volume":"24","author":"Taguchi","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.arr.2016.11.002_bib0835","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.arr.2016.11.002_bib0840","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.scr.2014.10.001","article-title":"Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2","volume":"13","author":"Takamatsu","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0845","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/cns.12386","article-title":"Opportunities and challenges: stem cell-based therapy for the treatment of ischemic stroke","volume":"21","author":"Tang","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0850","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/156720207780637199","article-title":"Current advances in the treatment of Parkinson's disease with stem cells","volume":"4","author":"Trzaska","year":"2007","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0855","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.1092436","article-title":"Defining the epithelial stem cell niche in skin","volume":"303","author":"Tumbar","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.arr.2016.11.002_bib0860","doi-asserted-by":"crossref","first-page":"11275","DOI":"10.3390\/ijms150711275","article-title":"Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat","volume":"15","author":"Urdzikova","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2016.11.002_bib0865","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.trsl.2009.07.006","article-title":"Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease","volume":"155","author":"Venkataramana","year":"2010","journal-title":"Transl. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0870","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2013.10.018","article-title":"White matter plasticity in adulthood","volume":"276","author":"Wang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2016.11.002_bib0875","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2967\/jnumed.112.111112","article-title":"PET demonstrates functional recovery after transplantation of induced pluripotent stem cells in a rat model of cerebral ischemic injury","volume":"54","author":"Wang","year":"2013","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.arr.2016.11.002_bib0880","first-page":"4715","article-title":"Bone marrow mesenchymal stem cells ameliorate neurological deficits and blood-brain barrier dysfunction after intracerebral hemorrhage in spontaneously hypertensive rats","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.arr.2016.11.002_bib0885","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1038\/srep09621","article-title":"Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2016.11.002_bib0890","doi-asserted-by":"crossref","first-page":"3206807","DOI":"10.1155\/2016\/3206807","article-title":"Advances in adipose-derived stem cells isolation, characterization, and application in regenerative tissue engineering","volume":"2016","author":"Wankhade","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.arr.2016.11.002_bib0895","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3727\/096368912X657251","article-title":"Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice","volume":"22","author":"Wei","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0900","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1037\/a0029857","article-title":"The natural history of cognitive decline in Alzheimer's disease","volume":"27","author":"Wilson","year":"2012","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.arr.2016.11.002_bib0905","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.00054.2003","article-title":"Embryonic stem cells: prospects for developmental biology and cell therapy","volume":"85","author":"Wobus","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2016.11.002_bib0910","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/gt.2010.152","article-title":"VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease","volume":"18","author":"Xiong","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0915","first-page":"1","article-title":"Deaths: final data for 2013","volume":"64","author":"Xu","year":"2016","journal-title":"Natl. Vital Stat. Rep."},{"key":"10.1016\/j.arr.2016.11.002_bib0920","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10571-013-9922-y","article-title":"Comparison of the neural differentiation potential of human mesenchymal stem cells from amniotic fluid and adult bone marrow","volume":"33","author":"Yan","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.arr.2016.11.002_bib0925","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s11064-011-0402-9","article-title":"Human umbilical cord-derived Schwann-like cell transplantation combined with neurotrophin-3 administration in dyskinesia of rats with spinal cord injury","volume":"36","author":"Yan-Wu","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0930","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jnr.22614","article-title":"Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke","volume":"89","author":"Yang","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0935","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/ar.22526","article-title":"Enriched environment and white matter in aging brain","volume":"295","author":"Yang","year":"2012","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.arr.2016.11.002_bib0940","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1161\/STROKEAHA.111.000821","article-title":"Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke","volume":"44","author":"Yang","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2016.11.002_bib0945","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.brainres.2006.12.061","article-title":"Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease","volume":"1142","author":"Ye","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2016.11.002_bib0950","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3727\/096368915X686940","article-title":"Adipose tissue-derived stem cells in neural regenerative medicine","volume":"24","author":"Yeh","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.arr.2016.11.002_bib0955","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/cns.12025","article-title":"Transplantation of human retinal pigment epithelium cells in the treatment for Parkinson disease","volume":"18","author":"Yin","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0960","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/scrt224","article-title":"Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurologic function in a rat model of middle cerebral artery occlusion","volume":"4","author":"Yuan","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2016.11.002_bib0965","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12035-014-8640-x","article-title":"Neural stem cell transplants improve cognitive function without altering amyloid pathology in an APP\/PS1 double transgenic model of Alzheimer's disease","volume":"50","author":"Zhang","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2016.11.002_bib0970","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jcyt.2013.01.007","article-title":"Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy","volume":"15","author":"Zhou","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arr.2016.11.002_bib0975","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1159\/000374040","article-title":"Human umbilical cord-derived mesenchymal stem cells improve learning and memory function in hypoxic-ischemic brain-damaged rats via an IL-8-mediated secretion mechanism rather than differentiation pattern induction","volume":"35","author":"Zhou","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.arr.2016.11.002_bib0980","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.arr.2016.11.002_bib0985","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2014.04.011","article-title":"Induced pluripotent stem (iPS) cells: a new source for cell-based therapeutics","volume":"185","author":"de Lazaro","year":"2014","journal-title":"J. Control. Release"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163716301477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163716301477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T05:16:45Z","timestamp":1657775805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163716301477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":197,"alternative-id":["S1568163716301477"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2016.11.002","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stem cell therapies in age-related neurodegenerative diseases and stroke","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2016.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}